Abstract:
:In many epidemiological studies it is common to resort to regression models relating incidence of a disease and its risk factors. The main goal of this paper is to consider inference on such models with error-prone observations and variances of the measurement errors changing across observations. We suppose that the observations follow a bivariate normal distribution and the measurement errors are normally distributed. Aggregate data allow the estimation of the error variances. Maximum likelihood estimates are computed numerically via the EM algorithm. Consistent estimation of the asymptotic variance of the maximum likelihood estimators is also discussed. Test statistics are proposed for testing hypotheses of interest. Further, we implement a simple graphical device that enables an assessment of the model's goodness of fit. Results of simulations concerning the properties of the test statistics are reported. The approach is illustrated with data from the WHO MONICA Project on cardiovascular disease.
journal_name
Stat Medjournal_title
Statistics in medicineauthors
de Castro M,Galea M,Bolfarine Hdoi
10.1002/sim.3343subject
Has Abstractpub_date
2008-11-10 00:00:00pages
5217-34issue
25eissn
0277-6715issn
1097-0258journal_volume
27pub_type
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