Testing whether genetic variation explains correlation of quantitative measures of gene expression, and application to genetic network analysis.

abstract：:Huntington's disease (HD) is a neurodegenerative disorder with a dominant genetic mode of inheritance caused by an expansion of CAG repeats on chromosome 4. Typically, a longer sequence of CAG repeat length is associated with increased risk of experiencing earlier onset of HD. Previous studies of the association betwe...

journal_title：Statistics in medicine

authors： Ma Y,Wang Y

更新日期：2014-04-15 00:00:00

abstract：:A trial of Duchenne muscular dystrophy involved tracking boys of all ages through a one-year baseline period, followed by a one-year trial of leucine versus placebo treatment. In this paper we develop a model for a total-muscle-strength score that uses the data of the extended baseline period in the evaluation of the ...

journal_title：Statistics in medicine

authors： Madsen KS,Miller JP,Province MA

更新日期：1986-05-01 00:00:00

abstract：:We propose a two-step procedure to personalize drug dosage over time under the framework of a log-linear mixed-effect model. We model patients' heterogeneity using subject-specific random effects, which are treated as the realizations of an unspecified stochastic process. We extend the conditional quadratic inference ...

journal_title：Statistics in medicine

authors： Zhu X,Qu A

更新日期：2016-10-30 00:00:00

abstract：:In the pharmaceutical industry, an assay method is considered validated if the accuracy and precision for an assay meet some acceptable limits. This paper discusses the assessment of assay precision in terms of the estimation of total variability of an assay from a one-way random effects model which is often considere...

journal_title：Statistics in medicine

authors： Chow SC,Tse SK

更新日期：1991-10-01 00:00:00

abstract：:In natural history studies of chronic disease, it is of interest to understand the evolution of key variables that measure aspects of disease progression. This is particularly true for immunological variables among persons infected with the human immunodeficiency virus (HIV). The natural time scale for such studies is...

journal_title：Statistics in medicine

authors： Vittinghoff E,Malani HM,Jewell NP

更新日期：1994-06-15 00:00:00

abstract：:Many neuroscientists are interested in how connectomes (graphical representations of functional connectivity between areas of the brain) change in relation to covariates. In statistics, changes like this are analyzed using regression, where the outcomes or dependent variables are regressed onto the covariates. However...

journal_title：Statistics in medicine

authors： Yang D,Deych E,Shands B,Campbell MC,Perlmutter JS,Petersen S,Schlaggar BL,Shannon W

更新日期：2019-12-20 00:00:00

abstract：:In randomised trials, continuous endpoints are often measured with some degree of error. This study explores the impact of ignoring measurement error and proposes methods to improve statistical inference in the presence of measurement error. Three main types of measurement error in continuous endpoints are considered:...

journal_title：Statistics in medicine

authors： Nab L,Groenwold RHH,Welsing PMJ,van Smeden M

更新日期：2019-11-30 00:00:00

abstract：:This paper, arising out of an event to honour the statistical and scientific contributions of Professor Peter Armitage, is concerned with research strategies and needs for chronic disease prevention. A few highlights from recent intervention trials for the prevention of cancer, cardiovascular disease, fractures and di...

journal_title：Statistics in medicine

authors： Prentice RL

更新日期：2004-11-30 00:00:00

abstract：:The coefficient of individual equivalence is a permutation-based measure of agreement between two observers making replicated readings on each subject. It compares the observed disagreement between the observers to the expected disagreement under individual equivalence. Individual equivalence of observers requires tha...

journal_title：Statistics in medicine

authors： Pan Y,Haber M,Gao J,Barnhart HX

更新日期：2012-09-10 00:00:00

abstract：:Data on alcohol availability and problems in all cities in Los Angeles County were collected from several different sources and linked together to form a Local Alcohol Availability Database (LAAD). The two major purposes of the project are to provide a city-level alcohol availability and alcohol-related problems datab...

journal_title：Statistics in medicine

authors： MacKinnon DP,Scribner R,Taft KA

更新日期：1995-03-15 00:00:00

abstract：:When the event time of interest depends on the censoring time, conventional two-sample test methods, such as the log-rank and Wilcoxon tests, can produce an invalid test result. We extend our previous work on estimation using auxiliary variables to adjust for dependent censoring via multiple imputation, to the compari...

journal_title：Statistics in medicine

authors： Hsu CH,Taylor JM

更新日期：2009-02-01 00:00:00

abstract：:Generalized relative and absolute risk models, in which various functions of time and age modify the excess relative or absolute risk of radiation-induced cancer, are fitted to the Japanese atomic bomb survivor cancer incidence data set. Among generalized relative risk models, those in which a product of powers of tim...

journal_title：Statistics in medicine

authors： Little MP,Muirhead CR,Charles MW

更新日期：1999-01-15 00:00:00

abstract：:In a phase I clinical trial in cancer patients, the drug involved had one known main adverse effect, which also occurs spontaneously in cancer patients with a fairly high frequency. Experiments in rats have shown marked effects of the drug on tumour growth in high doses, but also dose-dependent toxicity. Consequently,...

journal_title：Statistics in medicine

authors： Møller S

更新日期：1995-05-15 00:00:00

abstract：:This paper describes a method for estimating the risk from a disease over a set of contiguous geographical regions, when data on a potentially important covariate, such as race, are not available. Conditions under which the extra margin can be recovered are suggested. An application to prostate cancer mortality among ...

journal_title：Statistics in medicine

authors： Byers S,Besag J

更新日期：2000-09-15 00:00:00

abstract：:In time-to-event analysis, the traditional summary measures have been based on the hazard function, survival function, quantile event time, restricted mean event time, and residual lifetime. Under competing risks, furthermore, typical summary measures have been the cause-specific hazard function and cumulative inciden...

journal_title：Statistics in medicine

authors： Jia Y,Jeong JH

更新日期：2021-01-06 00:00:00

abstract：:Longitudinal designs are important in medical research and in many other disciplines. Complete longitudinal studies, in which each subject is evaluated at each measurement occasion, are often very expensive and motivate a search for more efficient designs. Recently developed statistical methods foster the use of inten...

journal_title：Statistics in medicine

authors： Helms RW

更新日期：1992-10-01 00:00:00

abstract：:A new, intuitive method has recently been proposed to explore treatment-covariate interactions in survival data arising from two treatment arms of a clinical trial. The method is based on constructing overlapping subpopulations of patients with respect to one (or more) covariates of interest and in observing the patte...

journal_title：Statistics in medicine

authors： Bonetti M,Zahrieh D,Cole BF,Gelber RD

更新日期：2009-04-15 00:00:00

abstract：:Continuous-time multistate survival models can be used to describe health-related processes over time. In the presence of interval-censored times for transitions between the living states, the likelihood is constructed using transition probabilities. Models can be specified using parametric or semiparametric shapes fo...

journal_title：Statistics in medicine

authors： Machado RJM,van den Hout A

更新日期：2018-05-10 00:00:00

abstract：:We consider the problem of comparing cumulative incidence functions of non-mortality events in the presence of informative coarsening and the competing risk of death. We extend frequentist-based hypothesis tests previously developed for non-informative coarsening and propose a novel Bayesian method based on comparing ...

journal_title：Statistics in medicine

authors： Shardell M,Scharfstein DO,Vlahov D,Galai N

更新日期：2008-12-10 00:00:00

abstract：:In this paper, we consider pooling schemes in which samples are to be tested in two-stages. We show that when batch size is limited as well as pool size, selection schemes tend to be more efficient and flexible. Formulae for the efficiencies of square arrays in all dimensions and for all selection schemes are given in...

journal_title：Statistics in medicine

authors： Sudbury A

更新日期：2010-09-20 00:00:00

abstract：:In recent years, quality control charts have been increasingly applied in the healthcare environment, for example, to monitor surgical performance. Risk-adjusted cumulative (CUSUM) charts that utilize risk scores like the Parsonnet score to estimate the probability of death of a patient from an operation turn out to b...

journal_title：Statistics in medicine

authors： Knoth S,Wittenberg P,Gan FF

更新日期：2019-05-30 00:00:00

abstract：:The use of data from multiple studies or centers for the validation of a clinical test or a multivariable prediction model allows researchers to investigate the test's/model's performance in multiple settings and populations. Recently, meta-analytic techniques have been proposed to summarize discrimination and calibra...

journal_title：Statistics in medicine

authors： Wynants L,Riley RD,Timmerman D,Van Calster B

更新日期：2018-05-30 00:00:00

abstract：:We consider the use of the assurance method in clinical trial planning. In the assurance method, which is an alternative to a power calculation, we calculate the probability of a clinical trial resulting in a successful outcome, via eliciting a prior probability distribution about the relevant treatment effect. This i...

journal_title：Statistics in medicine

authors： Ren S,Oakley JE

更新日期：2014-01-15 00:00:00

abstract：:The analysis of patient-reported outcomes or other psychological traits can be realized using the Rasch measurement model. When the objective of a study is to compare groups of individuals, it is important, before the study, to define a sample size such that the group comparison test will attain a given power. The Ras...

journal_title：Statistics in medicine

authors： Hardouin JB,Blanchin M,Feddag ML,Le Néel T,Perrot B,Sébille V

更新日期：2015-07-20 00:00:00

abstract：:Case-control studies are usually defined to investigate risk factors for a single disease of interest. However, subsequent to data collection, investigators may wish to examine as an 'outcome' a variable that was an exposure in the original study. A naive analysis that disregards the sampling strategy that gave rise t...

journal_title：Statistics in medicine

authors： Reilly M,Torrång A,Klint A

更新日期：2005-12-30 00:00:00

abstract：:The purpose of this paper is to show that the sensitivity and specificity estimates obtained by 'discrepant analysis' are biased. Discrepant analysis is a widely used technique that attempts to provide estimates of sensitivity and specificity in the presence of an imperfect gold standard. Many researchers have applied...

journal_title：Statistics in medicine

authors： Hadgu A

更新日期：1997-06-30 00:00:00

abstract：:Hot-deck imputation is an intuitively simple and popular method of accommodating incomplete data. Users of the method will often use the usual multiple imputation variance estimator which is not appropriate in this case. However, no variance expression has yet been derived for this easily implemented method applied to...

journal_title：Statistics in medicine

authors： Reilly M,Pepe M

更新日期：1997-01-15 00:00:00

abstract：:The time-dependent change of HIV particle load, i.e. HIV dynamics, is likely to be controlled by a multitude of quantitative trait loci (QTL) that interact with each other as well as with various developmental and environmental factors in a coordinated manner. In this article, we have derived a new statistical model f...

journal_title：Statistics in medicine

authors： Wu S,Yang J,Wu R

更新日期：2006-11-30 00:00:00

abstract：:This paper concerns using modified weighted Schoenfeld residuals to test the proportionality of subdistribution hazards for the Fine-Gray model, similar to the tests proposed by Grambsch and Therneau for independently censored data. We develop a score test for the time-varying coefficients based on the modified Schoen...

journal_title：Statistics in medicine

authors： Zhou B,Fine J,Laird G

更新日期：2013-09-30 00:00:00

abstract：:Outcomes research often requires estimating the impact of a binary treatment on a binary outcome in a non-randomized setting, such as the effect of taking a drug on mortality. The data often come from self-selected samples, leading to a spurious correlation between the treatment and outcome when standard binary depend...

journal_title：Statistics in medicine

authors： Bhattacharya J,Goldman D,McCaffrey D

更新日期：2006-02-15 00:00:00