Abstract:
:Generalized relative and absolute risk models, in which various functions of time and age modify the excess relative or absolute risk of radiation-induced cancer, are fitted to the Japanese atomic bomb survivor cancer incidence data set. Among generalized relative risk models, those in which a product of powers of time since exposure and attained age modify the relative risk provide the best fit. There are indications that the Armitage-Doll model (in its formulation as a generalized relative risk model) provides a poor fit to the data, possibly in part because of increasing age-adjusted cancer incidence rates in the Japanese cohort. Generalized absolute risk models, and in particular models in which either powers of time since exposure and attained age, or powers of time since exposure and age at exposure modify the excess absolute risk, provide a superior fit to any of the generalized relative risk models for all solid cancer sites analysed together. When six cancer subtypes are examined separately, only for respiratory cancers does this finding remain true, and for two other sites (female breast cancer and thyroid cancer) the generalized relative risk model yields a better fit than the generalized absolute risk model.
journal_name
Stat Medjournal_title
Statistics in medicineauthors
Little MP,Muirhead CR,Charles MWdoi
10.1002/(sici)1097-0258(19990115)18:1<17::aid-sim9subject
Has Abstractpub_date
1999-01-15 00:00:00pages
17-33issue
1eissn
0277-6715issn
1097-0258pii
10.1002/(SICI)1097-0258(19990115)18:1<17::AID-SIM9journal_volume
18pub_type
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pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1999-11-15 00:00:00
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