A simple correction for ties when censoring times depend on covariates.

abstract：:We analyse the effect of using prevalence rates based on populations with different sizes in the power of spatial independence tests. We compare the well known spatial correlation Moran's index to three indexes obtained after adjusting for population density, one proposed by Oden, another proposed by Waldhör, and a th...

journal_title：Statistics in medicine

authors： Assunção RM,Reis EA

更新日期：1999-08-30 00:00:00

abstract：:Estimates of relative efficacy between alternative treatments are crucial for decision making in health care. Bayesian mixed treatment comparison models provide a powerful methodology to obtain such estimates when head-to-head evidence is not available or insufficient. In recent years, this methodology has become wide...

journal_title：Statistics in medicine

authors： Schmitz S,Adams R,Walsh C

更新日期：2013-07-30 00:00:00

abstract：:A method has been developed for simultaneously comparing the usefulness of many treatments of established value for symptomatic medical conditions. Medical assessment of outcome is not employed. Instead patients are required to assess treatments prescribed during the course of ordinary general practice rather than und...

journal_title：Statistics in medicine

authors： Charlton JR,D'Souza MF,Tooley M,Silver R

更新日期：1985-01-01 00:00:00

abstract：:In a variety of biomedical applications, particularly those involving screening for infectious diseases, testing individuals (e.g. blood/urine samples, etc.) in pools has become a standard method of data collection. This experimental design, known as group testing (or pooled testing), can provide a large reduction in ...

journal_title：Statistics in medicine

authors： Chen P,Tebbs JM,Bilder CR

更新日期：2009-10-15 00:00:00

abstract：:The matched case-control designs are commonly used to control for potential confounding factors in genetic epidemiology studies especially epigenetic studies with DNA methylation. Compared with unmatched case-control studies with high-dimensional genomic or epigenetic data, there have been few variable selection metho...

journal_title：Statistics in medicine

authors： Sun H,Wang S

更新日期：2013-05-30 00:00:00

abstract：:Experimental designs with repeated measures allow response patterns over time (or dose) to be modelled and compared between different homogeneous groups. Issues in data analysis often focus on the pattern of variation of the repeated measures, the appropriateness of a univariate or multivariate analysis, and the shape...

journal_title：Statistics in medicine

authors： Stanek EJ 3rd,Kline G

更新日期：1991-01-01 00:00:00

abstract：:It is often of interest to use observational data to estimate the causal effect of a target exposure or treatment on an outcome. When estimating the treatment effect, it is essential to appropriately adjust for selection bias due to observed confounders using, for example, propensity score weighting. Selection bias du...

journal_title：Statistics in medicine

authors： Parast L,Griffin BA

更新日期：2020-08-15 00:00:00

abstract：:The relative concentration index (RCI) and the absolute concentration index (ACI) have been widely used for monitoring health disparities with ranked health determinants. The RCI has been extended to allow value judgments about inequality aversion by Pereira in 1998 and by Wagstaff in 2002. Previous studies of the ext...

journal_title：Statistics in medicine

authors： Yu M,Liu B,Li Y,Zou ZJ,Breen N

更新日期：2019-01-15 00:00:00

abstract：:The Spearman (rho(s)) and Kendall (tau) rank correlation coefficient are routinely used as measures of association between non-normally distributed random variables. However, confidence limits for rho(s) are only available under the assumption of bivariate normality and for tau under the assumption of asymptotic norma...

journal_title：Statistics in medicine

authors： Rosner B,Glynn RJ

更新日期：2007-02-10 00:00:00

abstract：:Virtually all clinical trials collect multiple endpoints that are usually correlated. Many methods have been proposed to control the family-wise type I error rate (FWER), but these methods often disregard the correlation among the endpoints, such as the commonly used Bonferroni correction, Holm procedure, Wiens' Bonfe...

journal_title：Statistics in medicine

authors： Xie C

更新日期：2012-02-20 00:00:00

abstract：:We develop a simulation-based procedure for determining the required sample size in binomial regression risk assessment studies when response data are subject to misclassification. A Bayesian average power criterion is used to determine a sample size that provides high probability, averaged over the distribution of po...

journal_title：Statistics in medicine

authors： Cheng D,Stamey JD,Branscum AJ

更新日期：2009-02-28 00:00:00

abstract：:Studies in health research are commonly carried out in clustered settings, where the individual response data are correlated within clusters. Estimation and modelling of the extent of between-cluster variation contributes to understanding of the current study and to design of future studies. It is common to express be...

journal_title：Statistics in medicine

authors： Turner RM,Omar RZ,Thompson SG

更新日期：2006-05-15 00:00:00

abstract：:The stability-controlled quasi-experiment (SCQE) is an approach to study the effects of nonrandomized, newly adopted treatments. While covariate adjustment techniques rely on a "no unobserved confounding" assumption, SCQE imposes an assumption on the change in the average nontreatment outcome between successive cohort...

journal_title：Statistics in medicine

authors： Hazlett C,Maokola W,Wulf DA

更新日期：2020-12-10 00:00:00

abstract：:Studies involving longitudinal binary responses are widely applied in the health and biomedical sciences research and frequently analyzed by generalized estimating equations (GEE) method. This article proposes an alternative goodness-of-fit test based on the nonparametric smoothing approach for assessing the adequacy ...

journal_title：Statistics in medicine

authors： Lin KC,Chen YJ,Shyr Y

更新日期：2008-09-30 00:00:00

abstract：:Methodology for the meta-analysis of individual patient data with survival end-points is proposed. Motivated by questions about the reliance on hazard ratios as summary measures of treatment effects, a parametric approach is considered and percentile ratios are introduced as an alternative to hazard ratios. The genera...

journal_title：Statistics in medicine

authors： Siannis F,Barrett JK,Farewell VT,Tierney JF

更新日期：2010-12-20 00:00:00

abstract：:Comparison of two hazard rate functions is important for evaluating treatment effect in studies concerning times to some important events. In practice, it may happen that the two hazard rate functions cross each other at one or more unknown time points, representing temporal changes of the treatment effect. Also, besi...

journal_title：Statistics in medicine

authors： Park KY,Qiu P

更新日期：2014-11-20 00:00:00

abstract：:Standard methods for analysing survival data or case-control data normally concern factors affecting a subject as a whole. However, in a study of a condition that might develop in one or both of a pair of bodily organs information on response and on covariates may be available for each separately. This information can...

journal_title：Statistics in medicine

authors： Whitehead J,Dorse C

更新日期：1988-05-01 00:00:00

abstract：:Quantifying socioeconomic disparities and understanding the roots of inequalities are growing topics in cancer research. However, socioeconomic differences are challenging to investigate mainly due to the lack of accurate data at individual-level, while aggregate indicators are only partially informative. We implement...

journal_title：Statistics in medicine

authors： Mezzetti M,Palli D,Dominici F

更新日期：2020-01-15 00:00:00

abstract：:The need for resource-intensive laboratory assays to assess exposures in many epidemiologic studies provides ample motivation to consider study designs that incorporate pooled samples. In this paper, we consider the case in which specimens are combined for the purpose of determining the presence or absence of a pool-w...

journal_title：Statistics in medicine

authors： Lyles RH,Tang L,Lin J,Zhang Z,Mukherjee B

更新日期：2012-09-28 00:00:00

abstract：:Wittes and Brittain recommended using an 'internal pilot study' to adjust sample size. The approach involves five steps in testing a general linear hypothesis for a general linear univariate model, with Gaussian errors. First, specify the design, hypothesis, desired test size, power, a smallest 'clinically meaningful'...

journal_title：Statistics in medicine

authors： Coffey CS,Muller KE

更新日期：1999-05-30 00:00:00

abstract：:The weighted average treatment effect is a causal measure for the comparison of interventions in a specific target population, which may be different from the population where data are sampled from. For instance, when the goal is to introduce a new treatment to a target population, the question is what efficacy (or ef...

journal_title：Statistics in medicine

authors： Tao Y,Fu H

更新日期：2019-02-10 00:00:00

abstract：:We have used Monte Carlo methods to compare the type I error properties of the conditional and unconditional versions of the generalized t and the generalized rank-sum tests to those of the independent samples t and Wilcoxon rank-sum tests. Results showed inflated type I errors for the conditional generalized tests bu...

journal_title：Statistics in medicine

authors： Blair RC,Morel JG

更新日期：1992-02-28 00:00:00

abstract：:A targeted poll was undertaken to compare and contrast models of data monitoring of randomized clinical trials sponsored by the National Institutes of Health. In an attempt to represent the institutes which conduct clinical trials, twelve individuals were selected and asked to respond to a questionnaire specifically p...

journal_title：Statistics in medicine

authors： Geller NL,Stylianou M

更新日期：1993-03-01 00:00:00

abstract：:Graphical methods based on the analysis of differences between log cumulative hazard functions are considered for a two-group semi-proportional hazard model which allows for interaction between treatments and covariates. Confidence procedures and test statistics that can be used to test for interaction and for main ef...

journal_title：Statistics in medicine

authors： Dabrowska DM,Doksum KA,Feduska NJ,Husing R,Neville P

更新日期：1992-08-01 00:00:00

abstract：:Systematic reviews often provide recommendations for further research. When meta-analyses are inconclusive, such recommendations typically argue for further studies to be conducted. However, the nature and amount of future research should depend on the nature and amount of the existing research. We propose a method ba...

journal_title：Statistics in medicine

authors： Roloff V,Higgins JP,Sutton AJ

更新日期：2013-01-15 00:00:00

abstract：:In the recent years, studies of hepatitis B (HBV) and hepatitis C virus (HCV) dynamics have drawn great attention as they provide insight into the process of virus elimination/production and of infected cells decay during antiviral treatment. Estimates of viral dynamic parameters may be used to determine the lifetime ...

journal_title：Statistics in medicine

authors： Sypsa V,Hatzakis A

更新日期：2008-12-30 00:00:00

abstract：:Meta-analyses pooling continuous outcomes can use mean differences (MD), standardized MD (MD in pooled standard deviation units, SMD), or ratio of arithmetic means (RoM). Recently, ratio of geometric means using ad hoc (RoGM (ad hoc) ) or Taylor series (RoGM (Taylor) ) methods for estimating variances have been propos...

journal_title：Statistics in medicine

authors： Friedrich JO,Adhikari NK,Beyene J

更新日期：2012-07-30 00:00:00

abstract：:Assay sensitivity has been proposed as a criterion for including psychiatric clinical outcome studies in meta-analyses. The authors assess the performance of assay sensitivity as a method for determining study appropriateness for meta-analysis by calculating expected standard drug vs placebo effect sizes for various c...

journal_title：Statistics in medicine

authors： Gelfand LA,Strunk DR,Tu XM,Noble RE,Derubeis RJ

更新日期：2006-03-30 00:00:00

abstract：:In the last decade or so, pharmaceutical drug development activities in the area of new antibacterial drugs for treating serious bacterial diseases have declined, and at the same time, there are worries that the increased prevalence of antibiotic-resistant bacterial infections, especially the increase in drug-resistan...

journal_title：Statistics in medicine

authors： Huque MF,Valappil T,Soon GG

更新日期：2014-11-10 00:00:00

abstract：:The use of the continual reassessment method (CRM) and other model-based approaches to design Phase I clinical trials has increased owing to the ability of the CRM to identify the maximum tolerated dose better than the 3 + 3 method. However, the CRM can be sensitive to the variance selected for the prior distribution ...

journal_title：Statistics in medicine

authors： Zhang J,Braun TM,Taylor JM

更新日期：2013-06-15 00:00:00