Ratio of geometric means to analyze continuous outcomes in meta-analysis: comparison to mean differences and ratio of arithmetic means using empiric data and simulation.

abstract：:In multiple-record systems estimation it is usually assumed that all registration relate to the same population. In this paper, we develop a method which can be used when the registrations relate to different populations, in the sense that they cover, for example, different time periods or regions. We show that under ...

journal_title：Statistics in medicine

authors： Zwane EN,van der Pal-de Bruin K,van der Heijden PG

更新日期：2004-07-30 00:00:00

abstract：:Sexually transmitted infections (STIs) with Chlamydia trachomatis, Neisseria gonorrhoeae, and Trichomonas vaginalis are among the most common infectious diseases in the United States, disproportionately affecting young women. Because a significant portion of the infections present no symptoms, infection control relies...

journal_title：Statistics in medicine

authors： Li Z,Liu H,Tu W

更新日期：2015-09-10 00:00:00

abstract：BACKGROUND:It has been recommended that onset of antidepressant action be assessed using survival analyses with assessments taken at least twice per week. However, such an assessment schedule is problematic to implement. The present study assessed the feasibility of comparing onset of action between treatments using a ...

journal_title：Statistics in medicine

authors： Mallinckrodt CH,Detke MJ,Kaiser CJ,Watkin JG,Molenberghs G,Carroll RJ

更新日期：2006-07-30 00:00:00

abstract：:Subjects in randomized controlled trials do not always comply to the treatment condition they have been assigned to. This may cause the estimated effect of the intervention to be biased and also affect efficiency, coverage of confidence intervals, and statistical power. In cluster randomized trials non-compliance may ...

journal_title：Statistics in medicine

authors： Moerbeek M,Schie SV

更新日期：2019-11-20 00:00:00

abstract：:In a long-running longitudinal study using complex machinery to obtain measurements, it is sometimes necessary to replace the machine. This can result in lack of continuity in the measurements that can overwhelm any treatment effect or time trend. We propose a Bayesian procedure implemented using Markov chain Monte Ca...

journal_title：Statistics in medicine

authors： Ambrosius WT,Hui SL

更新日期：2004-09-30 00:00:00

abstract：:New combination regimens evaluated in phase II cancer clinical trials often show promising results compared to the standard therapy for a disease system. Selection of patients with a better prognosis can be a prominent factor for this optimism. For most disease systems, prognostic variables that are related to the out...

journal_title：Statistics in medicine

authors： Mazumdar M,Fazzari M,Panageas KS

更新日期：2001-03-30 00:00:00

abstract：:Appropriate quantification of added usefulness offered by new markers included in risk prediction algorithms is a problem of active research and debate. Standard methods, including statistical significance and c statistic are useful but not sufficient. Net reclassification improvement (NRI) offers a simple intuitive w...

journal_title：Statistics in medicine

authors： Pencina MJ,D'Agostino RB Sr,Steyerberg EW

更新日期：2011-01-15 00:00:00

abstract：:We survey models for analysing repeated observations on an ordered categorical response variable. The models presented are univariate models that permit correlation among repeated measurements. The models describe simultaneously the dependence of marginal response distributions on values of explanatory variables and o...

journal_title：Statistics in medicine

authors： Agresti A

更新日期：1989-10-01 00:00:00

abstract：:Selection of dose for cancer patients treated with radiation therapy (RT) must balance the increased efficacy with the increased toxicity associated with higher dose. Historically, a single dose has been selected for a population of patients (e.g., all stage III non-small cell lung cancer). However, the availability o...

journal_title：Statistics in medicine

authors： Schipper MJ,Taylor JM,TenHaken R,Matuzak MM,Kong FM,Lawrence TS

更新日期：2014-12-30 00:00:00

abstract：:Spatial scan statistics are widely used for count data to detect geographical disease clusters of high or low incidence, mortality or prevalence and to evaluate their statistical significance. Some data are ordinal or continuous in nature, however, so that it is necessary to dichotomize the data to use a traditional s...

journal_title：Statistics in medicine

authors： Jung I,Kulldorff M,Klassen AC

更新日期：2007-03-30 00:00:00

abstract：:Equal allocation of patients to treatment in a randomized clinical trial may have disadvantages ethically if the new treatment is believed to be at least as beneficial as the standard treatment. Others have considered, in a non-sequential setting, unbalanced randomized designs which allocate fewer patients to the pote...

journal_title：Statistics in medicine

authors： Lesser ML

更新日期：1982-07-01 00:00:00

abstract：:Algorithms for identifying public health threats or disease outbreaks are vulnerable to false alarms arising from sudden shifts in health-care utilization or data participation. This paper describes a method of reducing false alerts in automated public health surveillance algorithms, and in particular, automated syndr...

journal_title：Statistics in medicine

authors： Peter W,Najmi AH,Burkom HS

更新日期：2011-06-30 00:00:00

abstract：:Data on alcohol availability and problems in all cities in Los Angeles County were collected from several different sources and linked together to form a Local Alcohol Availability Database (LAAD). The two major purposes of the project are to provide a city-level alcohol availability and alcohol-related problems datab...

journal_title：Statistics in medicine

authors： MacKinnon DP,Scribner R,Taft KA

更新日期：1995-03-15 00:00:00

abstract：:Lung function tests are used both clinically, in assessing disease, and epidemiologically, in identifying those factors which influence the growth and aging process of the lungs. The user must beware of several common pitfalls in the use of these tests, however. First, the commonly used tests of lung function can only...

journal_title：Statistics in medicine

authors： Buist AS,Vollmer WM

更新日期：1988-01-01 00:00:00

abstract：:Interpretation of the Mantoux test for tuberculous infection can be complicated by cross-reactions caused by infection with non-specific mycobacteria. Thus, the distribution of positive indurations is a mixture of two distributions. To estimate tuberculous infection prevalence, the marginal distribution of indurations...

journal_title：Statistics in medicine

authors： Nagelkerke NJ,Borgdorff MW,Kim SJ

更新日期：2001-04-15 00:00:00

abstract：:Health surveillance involves collecting public health data on chronic and infectious diseases to detect changes in disease incidence rates in order to improve public health. Timely detection of disease clusters is essential in prospective public health surveillance. Most existing health surveillance research is based ...

journal_title：Statistics in medicine

authors： Jiang W,Han SW,Tsui KL,Woodall WH

更新日期：2011-02-28 00:00:00

abstract：:Estimates of relative efficacy between alternative treatments are crucial for decision making in health care. Bayesian mixed treatment comparison models provide a powerful methodology to obtain such estimates when head-to-head evidence is not available or insufficient. In recent years, this methodology has become wide...

journal_title：Statistics in medicine

authors： Schmitz S,Adams R,Walsh C

更新日期：2013-07-30 00:00:00

abstract：:We consider the use of the assurance method in clinical trial planning. In the assurance method, which is an alternative to a power calculation, we calculate the probability of a clinical trial resulting in a successful outcome, via eliciting a prior probability distribution about the relevant treatment effect. This i...

journal_title：Statistics in medicine

authors： Ren S,Oakley JE

更新日期：2014-01-15 00:00:00

abstract：:The standard analysis of clinical trials stratified by centre is to include centres as fixed effects, but if many centres contribute small numbers of patients, this approach results in a loss of power. Assuming no treatment by centre interaction, we used simulation to examine power and coverage of confidence intervals...

journal_title：Statistics in medicine

authors： Pickering RM,Weatherall M

更新日期：2007-12-30 00:00:00

abstract：:The sample size required for a cluster randomised trial is inflated compared with an individually randomised trial because outcomes of participants from the same cluster are correlated. Sample size calculations for longitudinal cluster randomised trials (including stepped wedge trials) need to take account of at least...

journal_title：Statistics in medicine

authors： Hooper R,Teerenstra S,de Hoop E,Eldridge S

更新日期：2016-11-20 00:00:00

abstract：:The Rvachev-Baroyan-Longini model is a space-time predictive model of the spread of influenza epidemics. It has been applied to 128 cities of the USSR, and more recently, to forecasting the spread of the pandemic of 1968-1969 throughout 52 large cities. It is a deterministic, mass-action, space and time continuous mod...

journal_title：Statistics in medicine

authors： Flahault A,Letrait S,Blin P,Hazout S,Ménarés J,Valleron AJ

更新日期：1988-11-01 00:00:00

abstract：:The most popular model used for survival analysis is the proportional hazards regression model proposed by Cox. This is mainly due to its exceptional simplicity. Nevertheless the fundamental assumption of the Cox model is the proportionality of the hazards. For many applications, however, this assumption is doubtful. ...

journal_title：Statistics in medicine

authors： Berger U,Schäfer J,Ulm K

更新日期：2003-04-15 00:00:00

abstract：:This paper investigates the Bayesian procedures for comparing proportions. These procedures are especially suitable for accepting (or rejecting) the equivalence of two population proportions. Furthermore the Bayesian predictive probabilities provide a natural and flexible tool in monitoring trials, especially for choo...

journal_title：Statistics in medicine

authors： Lecoutre B,Derzko G,Grouin JM

更新日期：1995-05-15 00:00:00

abstract：:We investigate a binary partitioning algorithm in the case of a continuous repeated measures outcome. The procedure is based on the use of the likelihood ratio statistic to evaluate the performance of individual splits. The procedure partitions a set of longitudinal data into two mutually exclusive groups based on an ...

journal_title：Statistics in medicine

authors： Abdolell M,LeBlanc M,Stephens D,Harrison RV

更新日期：2002-11-30 00:00:00

abstract：:Relative survival is used to estimate patient survival excluding causes of death not related to the disease of interest. Rather than using cause of death information from death certificates, which is often poorly recorded, relative survival compares the observed survival to that expected in a matched group from the ge...

journal_title：Statistics in medicine

authors： Lambert PC,Smith LK,Jones DR,Botha JL

更新日期：2005-12-30 00:00:00

abstract：:The sojourn time, time spent in the preclinical detectable phase (PCDP) for chronic diseases, for example, breast cancer, plays an important role in the design and assessment of screening programmes. Traditional methods to estimate it usually assume a uniform incidence rate of preclinical disease from a randomized con...

journal_title：Statistics in medicine

authors： Duffy SW,Chen HH,Tabar L,Day NE

更新日期：1995-07-30 00:00:00

abstract：:In monitoring a clinical trial or other observational study with a survival endpoint, sometimes the numbers of patients entering and dying at each time point are presented, but the connections between them are kept confidential. Hence, the exact time to failure or censoring for each individual is missing. We refer to ...

journal_title：Statistics in medicine

authors： Wu Y,Shih WJ,Moore DF

更新日期：2007-08-30 00:00:00

abstract：:This paper presents a statistical analysis of treatment effects in 24-hour ambulatory blood pressure recordings. The statistical models account for circadian rhythms, subject effects, and the effects of treatment with drugs or relaxation therapy. In view of the heterogeneity of the subjects, we fit a separate linear m...

journal_title：Statistics in medicine

authors： Marler MR,Jacob RG,Lehoczky JP,Shapiro AP

更新日期：1988-06-01 00:00:00

abstract：:Current methods for statistical analysis of twin studies focus on continuous and dichotomous data, while only limited methodology exists for analysing multinomial data. As a consequence, investigators are often tempted to collapse multinomial data into two categories simply to facilitate the analysis. We address this ...

journal_title：Statistics in medicine

authors： Bartfay E,Donner A

更新日期：2001-01-30 00:00:00

abstract：:Biomarkers, increasingly used in biomedical studies for the diagnosis and prognosis of acute and chronic diseases, provide insight into the effectiveness of treatments and potential pathways that can be used to guide future treatment targets. The measurement of these markers is often limited by the sensitivity of the ...

journal_title：Statistics in medicine

authors： Lee M,Kong L,Weissfeld L

更新日期：2012-07-30 00:00:00