Abstract:
:In monitoring a clinical trial or other observational study with a survival endpoint, sometimes the numbers of patients entering and dying at each time point are presented, but the connections between them are kept confidential. Hence, the exact time to failure or censoring for each individual is missing. We refer to such a study monitoring table with missing pairing information between the entry and death times as a 'broken' survival data set. In this paper we study the problem of estimating the survival distribution from a broken survival data set. We have developed two methods, likelihood-based estimation and self-consistency estimation, to estimate the survival curve parametrically and empirically, respectively. We use simulations to study the properties of these methods, and illustrate them with data from the STELLAR-3 trial.
journal_name
Stat Medjournal_title
Statistics in medicineauthors
Wu Y,Shih WJ,Moore DFdoi
10.1002/sim.2819subject
Has Abstractpub_date
2007-08-30 00:00:00pages
3624-38issue
19eissn
0277-6715issn
1097-0258journal_volume
26pub_type
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