A functional multiple imputation approach to incomplete longitudinal data.

abstract：:Geocoding a study population as completely as possible is an important data assimilation component of many spatial epidemiologic studies. Unfortunately, complete geocoding is rare in practice. The failure of a substantial proportion of study subjects' addresses to geocode has consequences for spatial analyses, some of...

journal_title：Statistics in medicine

authors： Zimmerman DL,Fang X,Mazumdar S

更新日期：2008-09-20 00:00:00

abstract：:Antimicrobial resistance has become one of the main public health burdens of the last decades, and monitoring the development and spread of non-wild-type isolates has therefore gained increased interest. Monitoring is performed based on the minimum inhibitory concentration (MIC) values, which are collected through the...

journal_title：Statistics in medicine

authors： Jaspers S,Aerts M,Verbeke G,Beloeil PA

更新日期：2014-01-30 00:00:00

abstract：:Many split-mouth trials are characterized by the pairing of site-specific outcome and baseline data within each segment of a subject's mouth. However when the response variable of interest is binary, methods of statistical analysis for this design are not well developed. In this paper we present several analytic appro...

journal_title：Statistics in medicine

authors： Donner A,Zou GY

更新日期：2007-08-15 00:00:00

abstract：:Comparative effectiveness research represents the kind of research that arguably more directly affects clinical practice and policy. It includes observational studies, clinical trials, and systematic syntheses of existing literature. In this commentary, I argue for the ongoing and critical role of randomization in com...

journal_title：Statistics in medicine

authors： Lauer MS

更新日期：2012-11-10 00:00:00

abstract：:In many medical and health studies, high-dimensional data are often encountered. Principal component analysis (PCA) is a commonly used technique to reduce such data to a few components that includes most of the information provided by the original data. However, PCA is known to be very sensitive to some abnormal obser...

journal_title：Statistics in medicine

authors： Fung WK,Gu H,Xiang L,Yau KK

更新日期：2007-06-15 00:00:00

abstract：:The use of outcome-dependent sampling with longitudinal data analysis has previously been shown to improve efficiency in the estimation of regression parameters. The motivating scenario is when outcome data exist for all cohort members but key exposure variables will be gathered only on a subset. Inference with outcom...

journal_title：Statistics in medicine

authors： Zelnick LR,Schildcrout JS,Heagerty PJ

更新日期：2018-06-15 00:00:00

abstract：:Random forest is a supervised learning method that combines many classification or regression trees for prediction. Here we describe an extension of the random forest method for building event risk prediction models in survival analysis with competing risks. In case of right-censored data, the event status at the pred...

journal_title：Statistics in medicine

authors： Mogensen UB,Gerds TA

更新日期：2013-08-15 00:00:00

abstract：:Statistical methods for analyzing recurrent events have attracted significant attention. The majority of existing works consider situations in which subjects are observed over time periods and events of interest that occurred during the course of follow-up are recorded. In some applications, a subject may leave the st...

journal_title：Statistics in medicine

authors： Su PF,Zhong J,Ou HT

更新日期：2019-04-15 00:00:00

abstract：:To compare the survival functions based on right-truncated data, Lagakos et al. proposed a weighted logrank test based on a reverse time scale. This is in contrast to Bilker and Wang, who suggested a semi-parametric version of the Mann-Whitney test by assuming that the distribution of truncation times is known or can ...

journal_title：Statistics in medicine

authors： Chi Y,Tsai WY,Chiang CL

更新日期：2007-02-20 00:00:00

abstract：:A three-component, competing-risk mortality model, developed for animal survival data, fits human life table data for all ages over a range of mean life spans from 16 to 74 years. The competing risks are a novel exponentially-decreasing hazard, dominant during immaturity; a constant hazard, dominant during adulthood; ...

journal_title：Statistics in medicine

authors： Siler W

更新日期：1983-07-01 00:00:00

abstract：:Confounding is a major concern in observational studies. To adjust for confounding bias, the potential confounder(s) for a study must first be identified and measured. But this is not always possible. The unmeasured factors may also exhibit effect modification, and this further complicates the situation. In this paper...

journal_title：Statistics in medicine

authors： Lee WC

更新日期：2011-04-30 00:00:00

abstract：:Quality of life (QOL) assessment is a key component of many clinical studies and frequently requires the use of single global summary measures that capture the overall balance of findings from a potentially wide-ranging assessment of QOL issues. We propose and evaluate an irregular multilevel latent variable model sui...

journal_title：Statistics in medicine

authors： Kifley A,Heller GZ,Beath KJ,Bulger D,Ma J,Gebski V

更新日期：2012-05-20 00:00:00

abstract：:We investigate a binary partitioning algorithm in the case of a continuous repeated measures outcome. The procedure is based on the use of the likelihood ratio statistic to evaluate the performance of individual splits. The procedure partitions a set of longitudinal data into two mutually exclusive groups based on an ...

journal_title：Statistics in medicine

authors： Abdolell M,LeBlanc M,Stephens D,Harrison RV

更新日期：2002-11-30 00:00:00

abstract：:We discuss the use of the trichotomous logistic model to discriminate between patients with gastrointestinal (GI) cancer, patients with benign GI disease and 'normal' subjects, using symptoms and the concentrations of some serum proteins that are potentially indicative of malignancy as covariates. A parsimonious model...

journal_title：Statistics in medicine

authors： Marshall RJ,Chisholm EM

更新日期：1985-07-01 00:00:00

abstract：:The proposed guidelines for the assessment of the effect of new pharmaceutical agents on the QT interval (beginning of QRS complex to end of T wave on the electrocardiogram) are based on the maximum of a series over time of simple one-sided 95 per cent upper confidence bounds. This procedure is typically very conserva...

journal_title：Statistics in medicine

authors： Boos DD,Hoffman D,Kringle R,Zhang J

更新日期：2007-09-10 00:00:00

abstract：:For genome-wide association studies, we propose a new method for identifying significant biological pathways. In this approach, we aggregate data across single-nucleotide polymorphisms to obtain summary measures at the gene level. We then use a hierarchical Bayesian model, which takes the gene-level summary measures a...

journal_title：Statistics in medicine

authors： Shahbaba B,Shachaf CM,Yu Z

更新日期：2012-05-10 00:00:00

abstract：:Identification of the latency period for the effect of a time-varying exposure is key when assessing many environmental, nutritional, and behavioral risk factors. A pre-specified exposure metric involving an unknown latency parameter is often used in the statistical model for the exposure-disease relationship. Likelih...

journal_title：Statistics in medicine

authors： Peskoe SB,Spiegelman D,Wang M

更新日期：2019-03-30 00:00:00

abstract：:We obtained maximum likelihood estimates (MLEs) of the proportion cured pi c and mean log survival time mu t for a sample of 4355 patients with intraocular melanoma whose survival times subsequent to treatment were assumed to follow a log-normal distribution. Following stratification by tumour size, MLEs of pi c and m...

journal_title：Statistics in medicine

authors： Gamel JW,McLean IW,Rosenberg SH

更新日期：1990-08-01 00:00:00

abstract：:In any field in which decisions are subject to measurements, interchangeability between the methods used to obtain these measurements is essential. To consider methods as interchangeable, a certain degree of agreement is needed between the measurements they provide. The concordance correlation coefficient is an index ...

journal_title：Statistics in medicine

authors： Carrasco JL,Jover L

更新日期：2005-12-30 00:00:00

abstract：:We study prevalence-dependent diagnostic accuracy measures, specifically, positive and negative predictive values. These measures permit an assessment of the clinical utility of diagnostic tests across populations with different disease prevalences. In many cases, prevalence may not be known with certainty and the eva...

journal_title：Statistics in medicine

authors： Li J,Fine JP,Safdar N

更新日期：2007-07-30 00:00:00

abstract：:Although radical changes in drug regulation are rare (e.g., the Federal Food, Drug and Cosmetic Act of 1938 and the 1962 amendment to the Act creating an effectiveness requirement), regulations and guidance do evolve significantly in the face of new problems and accumulating experience. Recent changes have been driven...

journal_title：Statistics in medicine

authors： Temple R

更新日期：2002-10-15 00:00:00

abstract：:Clinical prediction models (CPMs) can inform decision making about treatment initiation, which requires predicted risks assuming no treatment is given. However, this is challenging since CPMs are usually derived using data sets where patients received treatment, often initiated postbaseline as "treatment drop-ins." Th...

journal_title：Statistics in medicine

authors： Sperrin M,Martin GP,Pate A,Van Staa T,Peek N,Buchan I

更新日期：2018-12-10 00:00:00

abstract：:New combination regimens evaluated in phase II cancer clinical trials often show promising results compared to the standard therapy for a disease system. Selection of patients with a better prognosis can be a prominent factor for this optimism. For most disease systems, prognostic variables that are related to the out...

journal_title：Statistics in medicine

authors： Mazumdar M,Fazzari M,Panageas KS

更新日期：2001-03-30 00:00:00

abstract：:Often multiple outcomes are of interest in each study identified by a systematic review, and in this situation a separate univariate meta-analysis is usually applied to synthesize the evidence for each outcome independently; an alternative approach is a single multivariate meta-analysis model that utilizes any correla...

journal_title：Statistics in medicine

authors： Riley RD,Abrams KR,Lambert PC,Sutton AJ,Thompson JR

更新日期：2007-01-15 00:00:00

abstract：:Piecewise constant incidence models were developed to estimate the force of infection in women from age- and time-specific antenatal or neonatal seroprevalence data. Differential inclusion of infected women in sero-surveys compared to uninfected women was taken into account, with respect to both changes in inclusion r...

journal_title：Statistics in medicine

authors： Ades AE,Medley GF

更新日期：1994-09-30 00:00:00

abstract：:The use of the last observation carried forward (LOCF) method for imputing missing outcome data in randomized clinical trials has been much criticized and its shortcomings are well understood. However, only recently have published studies widely started using more appropriate imputation methods. Consequently, meta-ana...

journal_title：Statistics in medicine

authors： Mavridis D,Salanti G,Furukawa TA,Cipriani A,Chaimani A,White IR

更新日期：2019-02-28 00:00:00

abstract：:In this paper, we argue that causal effect models for realistic individualized treatment rules represent an attractive tool for analyzing sequentially randomized trials. Unlike a number of methods proposed previously, this approach does not rely on the assumption that intermediate outcomes are discrete or that models ...

journal_title：Statistics in medicine

authors： Bembom O,van der Laan MJ

更新日期：2008-08-30 00:00:00

abstract：:The effective dose (ED) is the pharmaceutical dosage required to produce a therapeutic response in a fixed proportion of the patients. When only one drug is considered, the problem is a univariate one and has been well-studied. However, in the multidimensional setting, that is, in the presence of combinations of agent...

journal_title：Statistics in medicine

authors： Jankowski H,Ji X,Stanberry L

更新日期：2014-10-30 00:00:00

abstract：:Both the variation of positive responses (negative responses) among individuals and the internal correlation among responses for the same individual affect the precision of the estimate of sensitivity (specificity). To estimate the sensitivity (specificity) of a medical diagnostic test, this paper proposes a Bayesian ...

journal_title：Statistics in medicine

authors： Lui KJ

更新日期：1989-10-01 00:00:00

abstract：:Thomas et al. presented the application of empirical-Bayes methods to the problem of multiple inference in epidemiologic studies. One limitation of their approach, which they noted, was the need to assume exchangeable log relative-risk parameters, and independent relative-risk estimates. Numerical integration was also...

journal_title：Statistics in medicine

authors： Greenland S

更新日期：1992-01-30 00:00:00