Abstract:
:Many split-mouth trials are characterized by the pairing of site-specific outcome and baseline data within each segment of a subject's mouth. However when the response variable of interest is binary, methods of statistical analysis for this design are not well developed. In this paper we present several analytic approaches that may be taken to the resulting data, showing how the efficiency of statistical inferences can be improved by appropriately incorporating the baseline information. The advantages and disadvantages of the different approaches are discussed in the context of an example from the published literature. The results from a limited simulation study are also presented.
journal_name
Stat Medjournal_title
Statistics in medicineauthors
Donner A,Zou GYdoi
10.1002/sim.2782subject
Has Abstractpub_date
2007-08-15 00:00:00pages
3476-86issue
18eissn
0277-6715issn
1097-0258journal_volume
26pub_type
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