A recycling framework for the construction of Bonferroni-based multiple tests.

abstract：:New combination regimens evaluated in phase II cancer clinical trials often show promising results compared to the standard therapy for a disease system. Selection of patients with a better prognosis can be a prominent factor for this optimism. For most disease systems, prognostic variables that are related to the out...

journal_title：Statistics in medicine

authors： Mazumdar M,Fazzari M,Panageas KS

更新日期：2001-03-30 00:00:00

abstract：:Motivated by a study for soft tissue sarcoma, this article considers the analysis of diseases recurrence and survival. A multivariate frailty hazard model is established for joint modeling of three correlated time-to-event outcomes: local disease recurrence, distant disease recurrence (metastasis), and death. The goal...

journal_title：Statistics in medicine

authors： Wen S,Huang X,Frankowski RF,Cormier JN,Pisters P

更新日期：2016-11-20 00:00:00

abstract：:In vaccine safety studies, subjects are considered at increased risk for adverse events for a period of time after vaccination known as risk window. To our knowledge, risk windows for vaccine safety studies have tended to be pre-defined and not to use information from the current study. Inaccurate specification of the...

journal_title：Statistics in medicine

authors： Xu S,Zhang L,Nelson JC,Zeng C,Mullooly J,McClure D,Glanz J

更新日期：2011-03-30 00:00:00

abstract：:Estimates of analyte concentrations, obtained by immunoassay, have error distributions which are generally underestimated. Better estimates, which take into account the distribution of the response metameter of the calibration curve and uncertainties associated with the location of the fitted curve, have been obtained...

journal_title：Statistics in medicine

authors： Kay C,Nix AB,Kemp KW,Rowlands RJ,Richards G,Groom GV,Griffiths K,Wilson DW

更新日期：1986-03-01 00:00:00

abstract：:The setting of a quarantine time for an emerging infectious disease will depend on current knowledge concerning incubation times. Methods for the analysis of information on incubation times are investigated with a particular focus on inference regarding a possible maximum incubation time, after which an exposed indivi...

journal_title：Statistics in medicine

authors： Farewell VT,Herzberg AM,James KW,Ho LM,Leung GM

更新日期：2005-11-30 00:00:00

abstract：:Clinical trials of treatments for rare or fatal diseases must often use historical rather than randomized concurrent controls. Randomized trials may not be possible if (1) the number of patients available is quite small, (2) ethical considerations discourage the assignment of patients to control treatments known to be...

journal_title：Statistics in medicine

authors： Hoehler FK,Mantel N,Gehan E,Kahana E,Alter M

更新日期：1984-07-01 00:00:00

abstract：:Meta-analysis is the methodology for combining findings from similar research studies asking the same question. When the question of interest involves multiple outcomes, multivariate meta-analysis is used to synthesize the outcomes simultaneously taking into account the correlation between the outcomes. Likelihood-bas...

journal_title：Statistics in medicine

authors： Ma Y,Mazumdar M

更新日期：2011-10-30 00:00:00

abstract：:Population heterogeneity is frequently observed among patients' treatment responses in clinical trials because of various factors such as clinical background, environmental, and genetic factors. Different subpopulations defined by those baseline factors can lead to differences in the benefit or safety profile of a the...

journal_title：Statistics in medicine

authors： Chiu YD,Koenig F,Posch M,Jaki T

更新日期：2018-12-20 00:00:00

abstract：:The 'landmark' and 'Simon and Makuch' non-parametric estimators of the survival function are commonly used to contrast the survival experience of time-dependent treatment groups in applications such as stem cell transplant versus chemotherapy in leukemia. However, the theoretical survival functions corresponding to th...

journal_title：Statistics in medicine

authors： Bernasconi DP,Rebora P,Iacobelli S,Valsecchi MG,Antolini L

更新日期：2016-03-30 00:00:00

abstract：:We study the group bridge and the adaptive group bridge penalties for competing risks quantile regression with group variables. While the group bridge consistently identifies nonzero group variables, the adaptive group bridge consistently selects variables not only at group level but also at within-group level. We all...

journal_title：Statistics in medicine

authors： Ahn KW,Kim S

更新日期：2018-04-30 00:00:00

abstract：:Correlation is inherent in longitudinal studies due to the repeated measurements on subjects, as well as due to time-dependent covariates in the study. In the National Longitudinal Study of Adolescent to Adult Health (Add Health), data were repeatedly collected on children in grades 7-12 across four waves. Thus, obser...

journal_title：Statistics in medicine

authors： Irimata KM,Broatch J,Wilson JR

更新日期：2019-05-30 00:00:00

abstract：:We consider evaluation and comparison of the diagnostic accuracy of biomarkers with continuous test outcomes, possibly correlated due to repeated measurements. We develop nonparametric group sequential testing procedures to evaluate and compare the area of biomarkers under their receiver operating characteristic curve...

journal_title：Statistics in medicine

authors： Liu A,Wu C,Schisterman EF

更新日期：2008-05-10 00:00:00

abstract：:Statistical inference based on correlated count measurements are frequently performed in biomedical studies. Most of existing sample size calculation methods for count outcomes are developed under the Poisson model. Deviation from the Poisson assumption (equality of mean and variance) has been widely documented in pra...

journal_title：Statistics in medicine

authors： Li D,Zhang S,Cao J

更新日期：2019-12-10 00:00:00

abstract：:Algorithms for identifying public health threats or disease outbreaks are vulnerable to false alarms arising from sudden shifts in health-care utilization or data participation. This paper describes a method of reducing false alerts in automated public health surveillance algorithms, and in particular, automated syndr...

journal_title：Statistics in medicine

authors： Peter W,Najmi AH,Burkom HS

更新日期：2011-06-30 00:00:00

abstract：:The goal of screening programmes for cancer is early detection and treatment with a consequent reduction in mortality from the disease. Screening programmes need to assess the true benefit of screening, that is, the length of time of extension of survival beyond the time of advancement of diagnosis (lead-time). This p...

journal_title：Statistics in medicine

authors： Xu JL,Prorok PC

更新日期：1995-12-30 00:00:00

abstract：:Comparison of two hazard rate functions is important for evaluating treatment effect in studies concerning times to some important events. In practice, it may happen that the two hazard rate functions cross each other at one or more unknown time points, representing temporal changes of the treatment effect. Also, besi...

journal_title：Statistics in medicine

authors： Park KY,Qiu P

更新日期：2014-11-20 00:00:00

abstract：:Genetic markers can be used as instrumental variables, in an analogous way to randomization in a clinical trial, to estimate the causal relationship between a phenotype and an outcome variable. Our purpose is to extend the existing methods for such Mendelian randomization studies to the context of multiple genetic mar...

journal_title：Statistics in medicine

authors： Burgess S,Thompson SG,CRP CHD Genetics Collaboration.,Burgess S,Thompson SG,Andrews G,Samani NJ,Hall A,Whincup P,Morris R,Lawlor DA,Davey Smith G,Timpson N,Ebrahim S,Ben-Shlomo Y,Davey Smith G,Timpson N,Brown M,Ricket

更新日期：2010-05-30 00:00:00

abstract：:Assessment of equivalence or non-inferiority in accuracy between two diagnostic procedures often involves comparisons of paired areas under the receiver operating characteristic (ROC) curves. With some pre-specified clinically meaningful limits, the current approach to evaluating equivalence is to perform the two one-...

journal_title：Statistics in medicine

authors： Liu JP,Ma MC,Wu CY,Tai JY

更新日期：2006-04-15 00:00:00

abstract：:The analysis of multivariate time-to-event (TTE) data can become complicated due to the presence of clustering, leading to dependence between multiple event times. For a long time, (conditional) frailty models and (marginal) copula models have been used to analyze clustered TTE data. In this article, we propose a gene...

journal_title：Statistics in medicine

authors： Tran TMP,Abrams S,Braekers R

更新日期：2020-05-30 00:00:00

abstract：:The most popular model used for survival analysis is the proportional hazards regression model proposed by Cox. This is mainly due to its exceptional simplicity. Nevertheless the fundamental assumption of the Cox model is the proportionality of the hazards. For many applications, however, this assumption is doubtful. ...

journal_title：Statistics in medicine

authors： Berger U,Schäfer J,Ulm K

更新日期：2003-04-15 00:00:00

abstract：:Although the literature on contraceptive failure is vast and is expanding rapidly, our understanding of the relative efficacy of methods is quite limited because of defects in the research design and in the analytical tools used by investigators. Errors in the literature range from simple arithmetical mistakes to outr...

journal_title：Statistics in medicine

authors： Trussell J

更新日期：1991-02-01 00:00:00

abstract：:We examine the properties of several tests for goodness-of-fit for multinomial logistic regression. One test is based on a strategy of sorting the observations according to the complement of the estimated probability for the reference outcome category and then grouping the subjects into g equal-sized groups. A g x c c...

journal_title：Statistics in medicine

authors： Fagerland MW,Hosmer DW,Bofin AM

更新日期：2008-09-20 00:00:00

abstract：:In this paper, we define a modified version τ(b) of Kendall's tau to measure the association in a pair (X,Y) of random variables subject to fixed left censoring due to known lower detection limits. We provide a nonparametric estimator of τ(b) and investigate its asymptotic properties. We then assume an Archimedean cop...

journal_title：Statistics in medicine

authors： Romdhani H,Lakhal-Chaieb L

更新日期：2011-11-20 00:00:00

abstract：:Increasing numbers of economic evaluations are conducted alongside randomised controlled trials. Such studies include factorial trials, which randomise patients to different levels of two or more factors and can therefore evaluate the effect of multiple treatments alone and in combination. Factorial trials can provide...

journal_title：Statistics in medicine

authors： Dakin H,Gray A

更新日期：2017-08-15 00:00:00

abstract：:Results from an analysis of traffic accidents from a study of the police records of four police stations in the Bangkok metropolis are presented. The main emphasis in this study was put on the development of a measure for traffic accident density. The traffic flow was estimated at the various study locations by traine...

journal_title：Statistics in medicine

authors： Ayuthya RS,Böhning D

更新日期：1995-11-15 00:00:00

abstract：:Often multiple outcomes are of interest in each study identified by a systematic review, and in this situation a separate univariate meta-analysis is usually applied to synthesize the evidence for each outcome independently; an alternative approach is a single multivariate meta-analysis model that utilizes any correla...

journal_title：Statistics in medicine

authors： Riley RD,Abrams KR,Lambert PC,Sutton AJ,Thompson JR

更新日期：2007-01-15 00:00:00

abstract：:Subjects in randomized controlled trials do not always comply to the treatment condition they have been assigned to. This may cause the estimated effect of the intervention to be biased and also affect efficiency, coverage of confidence intervals, and statistical power. In cluster randomized trials non-compliance may ...

journal_title：Statistics in medicine

authors： Moerbeek M,Schie SV

更新日期：2019-11-20 00:00:00

abstract：:In the presence of confounding, the consistency assumption required for identification of causal effects may be violated due to misclassification of the outcome variable. We introduce an inverse probability weighted approach to rebalance covariates across treatment groups while mitigating the influence of differential...

journal_title：Statistics in medicine

authors： Gravel CA,Platt RW

更新日期：2018-02-10 00:00:00

abstract：:A review is given of different ways of estimating the error rate of a prediction rule based on a statistical model. A distinction is drawn between apparent, optimum and actual error rates. Moreover it is shown how cross-validation can be used to obtain an adjusted predictor with smaller error rate. A detailed discussi...

journal_title：Statistics in medicine

authors： Van Houwelingen JC,Le Cessie S

更新日期：1990-11-01 00:00:00

abstract：:We discuss a sample size calculation for a pair-matched case-control study to test for interaction between a specific exposure and a second risk factor. The second risk factor could be either binary or continuous. An algorithm for the calculation of sample size is suggested which is based on a logistic regression mode...

journal_title：Statistics in medicine

authors： Qiu P,Moeschberger ML,Cooke GE,Goldschmidt-Clermont PJ

更新日期：2000-04-15 00:00:00