A Bayesian multivariate joint frailty model for disease recurrences and survival.

abstract：:The case-control study is a simple and an useful method to characterize the effect of a gene, the effect of an exposure, as well as the interaction between the two. The control-free case-only study is yet an even simpler design, if interest is centered on gene-environment interaction only. It requires the sometimes pl...

journal_title：Statistics in medicine

authors： Lee WC,Wang LY,Cheng KF

更新日期：2010-10-30 00:00:00

abstract：:Repeated cross-sectional samples are common in national surveys of health like the National Health Interview Survey (NHIS). Because population health outcomes generally evolve slowly, pooling data across years can improve the precision of current-year annual estimates of disease prevalence and other health outcomes. P...

journal_title：Statistics in medicine

authors： Lockwood JR,McCaffrey DF,Setodji CM,Elliott MN

更新日期：2011-02-28 00:00:00

abstract：:Combinatorial drugs have been widely applied in disease treatment, especially chemotherapy for cancer, due to its improved efficacy and reduced toxicity compared with individual drugs. The study of combinatorial drugs requires efficient experimental designs and proper follow-up statistical modeling techniques. Linear ...

journal_title：Statistics in medicine

authors： Xiao Q,Wang L,Xu H

更新日期：2019-01-30 00:00:00

abstract：:Proportional odds regression models for multinomial probabilities based on ordered categories have been generalized in two somewhat different directions. Models having scale as well as location parameters for adjustment of boundaries (on an unobservable, underlying continuum) between categories have been employed in t...

journal_title：Statistics in medicine

authors： Cox C

更新日期：1995-06-15 00:00:00

abstract：:Studies involving longitudinal binary responses are widely applied in the health and biomedical sciences research and frequently analyzed by generalized estimating equations (GEE) method. This article proposes an alternative goodness-of-fit test based on the nonparametric smoothing approach for assessing the adequacy ...

journal_title：Statistics in medicine

authors： Lin KC,Chen YJ,Shyr Y

更新日期：2008-09-30 00:00:00

abstract：:We consider using observational data to estimate the effect of a treatment on disease recurrence, when the decision to initiate treatment is based on longitudinal factors associated with the risk of recurrence. The effect of salvage androgen deprivation therapy (SADT) on the risk of recurrence of prostate cancer is in...

journal_title：Statistics in medicine

authors： Kennedy EH,Taylor JM,Schaubel DE,Williams S

更新日期：2010-11-10 00:00:00

abstract：:The use of logistic models for independent binary data has relied first on asymptotic theory and later on exact distributions for small samples. However, the use of logistic models for dependent analysis based on exact analysis is not as common. Moreover, attention is usually given to one-stage clustering. In this pap...

journal_title：Statistics in medicine

authors： Troxler S,Lalonde T,Wilson JR

更新日期：2011-04-15 00:00:00

abstract：:Although radical changes in drug regulation are rare (e.g., the Federal Food, Drug and Cosmetic Act of 1938 and the 1962 amendment to the Act creating an effectiveness requirement), regulations and guidance do evolve significantly in the face of new problems and accumulating experience. Recent changes have been driven...

journal_title：Statistics in medicine

authors： Temple R

更新日期：2002-10-15 00:00:00

abstract：:Quality of life (QOL) assessment is a key component of many clinical studies and frequently requires the use of single global summary measures that capture the overall balance of findings from a potentially wide-ranging assessment of QOL issues. We propose and evaluate an irregular multilevel latent variable model sui...

journal_title：Statistics in medicine

authors： Kifley A,Heller GZ,Beath KJ,Bulger D,Ma J,Gebski V

更新日期：2012-05-20 00:00:00

abstract：:We consider the problem of identifying a subgroup of patients who may have an enhanced treatment effect in a randomized clinical trial, and it is desirable that the subgroup be defined by a limited number of covariates. For this problem, the development of a standard, pre-determined strategy may help to avoid the well...

journal_title：Statistics in medicine

authors： Foster JC,Taylor JM,Ruberg SJ

更新日期：2011-10-30 00:00:00

abstract：:Residuals in normal regression are used to assess a model's goodness-of-fit (GOF) and discover directions for improving the model. However, there is a lack of residuals with a characterized reference distribution for censored regression. In this article, we propose to diagnose censored regression with normalized rando...

journal_title：Statistics in medicine

authors： Li L,Wu T,Feng C

更新日期：2020-12-13 00:00:00

abstract：:Estimating the causal effect of quitting smoking on time to death or first myocardial infarction requires that one control for the differences in risk factors between individuals who elect to quite at each time t versus those who elect to continue smoking at time t. In this paper we examine the limitations of standard...

journal_title：Statistics in medicine

authors： Mark SD,Robins JM

更新日期：1993-09-15 00:00:00

abstract：:In this paper, we consider pooling schemes in which samples are to be tested in two-stages. We show that when batch size is limited as well as pool size, selection schemes tend to be more efficient and flexible. Formulae for the efficiencies of square arrays in all dimensions and for all selection schemes are given in...

journal_title：Statistics in medicine

authors： Sudbury A

更新日期：2010-09-20 00:00:00

abstract：:A method for detecting deviations from the Loewe additive drug combination reference model for in vitro drug combination experimentation is described. It is often difficult to fit a response surface model to drug combination data, especially in situations where the experimental design contains a sparse set of combinat...

journal_title：Statistics in medicine

authors： Novick SJ

更新日期：2013-12-20 00:00:00

abstract：:This paper describes compliance with the completion of a quality of life questionnaire in the Breast Cancer Prevention Trial, a large multi-centre randomized trial that is studying the efficacy of Tamoxifen in preventing breast cancer. In the first 4875 women enrolled in the control arm of the study, there was a very ...

journal_title：Statistics in medicine

authors： Ganz PA,Day R,Costantino J

更新日期：1998-03-15 00:00:00

abstract：:The application of Bayesian hierarchical models to measure spatial effects in time to event data has not been widely reported. This case study aims to estimate the effect of area of residence on waiting times to coronary artery bypass graft (CABG) and to assess the role of important individual specific covariates (age...

journal_title：Statistics in medicine

authors： Crook AM,Knorr-Held L,Hemingway H

更新日期：2003-09-30 00:00:00

abstract：:Measures that quantify the impact of heterogeneity in univariate meta-analysis, including the very popular I(2) statistic, are now well established. Multivariate meta-analysis, where studies provide multiple outcomes that are pooled in a single analysis, is also becoming more commonly used. The question of how to quan...

journal_title：Statistics in medicine

authors： Jackson D,White IR,Riley RD

更新日期：2012-12-20 00:00:00

abstract：:Randomized clinical trial designs commonly include one or more planned interim analyses. At these times an external monitoring committee reviews the accumulated data and determines whether it is scientifically and ethically appropriate for the study to continue. With failure-time endpoints, it is common to schedule an...

journal_title：Statistics in medicine

authors： Bagiella E,Heitjan DF

更新日期：2001-07-30 00:00:00

abstract：:In genetic association studies, mixed effects models have been widely used in detecting the pleiotropy effects which occur when one gene affects multiple phenotype traits. In particular, bivariate mixed effects models are useful for describing the association of a gene with a continuous trait and a binary trait. Howev...

journal_title：Statistics in medicine

authors： Zhang Q,Yi GY

更新日期：2020-11-20 00:00:00

abstract：:Algorithms for identifying public health threats or disease outbreaks are vulnerable to false alarms arising from sudden shifts in health-care utilization or data participation. This paper describes a method of reducing false alerts in automated public health surveillance algorithms, and in particular, automated syndr...

journal_title：Statistics in medicine

authors： Peter W,Najmi AH,Burkom HS

更新日期：2011-06-30 00:00:00

abstract：:Modelling disease clustering over space and time can be helpful in providing indications of possible exposures and planning corresponding public health practices. Though a considerable number of studies focus on modelling spatio-temporal patterns of disease, most of them do not directly model a spatio-temporal cluster...

journal_title：Statistics in medicine

authors： Yan P,Clayton MK

更新日期：2006-03-15 00:00:00

abstract：:Quantifying socioeconomic disparities and understanding the roots of inequalities are growing topics in cancer research. However, socioeconomic differences are challenging to investigate mainly due to the lack of accurate data at individual-level, while aggregate indicators are only partially informative. We implement...

journal_title：Statistics in medicine

authors： Mezzetti M,Palli D,Dominici F

更新日期：2020-01-15 00:00:00

abstract：:The primary goal of a phase I trial is to find the maximally tolerated dose (MTD) of a treatment. The MTD is usually defined in terms of a tolerable probability, q(*), of toxicity. Our objective is to find the highest dose with toxicity risk that does not exceed q(*), a criterion that is often desired in designing pha...

journal_title：Statistics in medicine

authors： Leung DH,Wang YG

更新日期：2002-01-15 00:00:00

abstract：:In observational studies, many continuous or categorical covariates may be related to an outcome. Various spline-based procedures or the multivariable fractional polynomial (MFP) procedure can be used to identify important variables and functional forms for continuous covariates. This is the main aim of an explanatory...

journal_title：Statistics in medicine

authors： Binder H,Sauerbrei W,Royston P

更新日期：2013-06-15 00:00:00

abstract：:A statistical analysis is presented of the intensities of admissions to psychiatric hospitals among women in Denmark who either gave birth to a child in the year 1975 or had an induced abortion in the same year. The models used are time-continuous Markov and semi-Markov processes, and the methods employed include non-...

journal_title：Statistics in medicine

authors： Andersen PK,Rasmussen NK

更新日期：1986-05-01 00:00:00

abstract：:A three-component, competing-risk mortality model, developed for animal survival data, fits human life table data for all ages over a range of mean life spans from 16 to 74 years. The competing risks are a novel exponentially-decreasing hazard, dominant during immaturity; a constant hazard, dominant during adulthood; ...

journal_title：Statistics in medicine

authors： Siler W

更新日期：1983-07-01 00:00:00

abstract：:Clinical trials often assess efficacy by comparing treatments on the basis of two or more event-time outcomes. In the case of cancer clinical trials, progression-free survival (PFS), which is the minimum of the time from randomization to progression or to death, summarizes the comparison of treatments on the hazards f...

journal_title：Statistics in medicine

authors： Finkelstein DM,Schoenfeld DA

更新日期：2014-05-30 00:00:00

abstract：:The Cochran-Armitage trend test has been used in case-control studies for testing genetic association. As the variance of the test statistic is a function of unknown parameters, e.g. disease prevalence and allele frequency, it must be estimated. The usual estimator combining data for cases and controls assumes they fo...

journal_title：Statistics in medicine

authors： Zheng G,Gastwirth JL

更新日期：2006-09-30 00:00:00

abstract：:Comparative calibration is the broad statistical methodology used to assess the calibration of a set of p instruments, each designed to measure the same characteristic, on a common group of individuals. Different from the usual calibration problem, the true underlying quantity measured is unobservable. Many authors ha...

journal_title：Statistics in medicine

authors： Lu Y,Ye K,Mathur AK,Hui S,Fuerst TP,Genant HK

更新日期：1997-08-30 00:00:00

abstract：:Matched-pair designs have been commonly employed in diagnostic, epidemiologic and laboratory studies. For estimation of a ratio of two marginal probabilities in matched-pair data, a Wald-type logarithmic method is computationally simple, but an actual coverage rate is known to be smaller than a nominal one and a lengt...

journal_title：Statistics in medicine

authors： Nam JM

更新日期：2009-10-15 00:00:00