Nonparametric sequential evaluation of diagnostic biomarkers.

Abstract:

:We consider evaluation and comparison of the diagnostic accuracy of biomarkers with continuous test outcomes, possibly correlated due to repeated measurements. We develop nonparametric group sequential testing procedures to evaluate and compare the area of biomarkers under their receiver operating characteristic curves, with either independent or paired test outcomes. These procedures rely on the construction of a two-dimensional statistic of Whitehead (Statist. Med. 1999; 18:2271-2286) so that design methods based on Brownian motion can be applied.

journal_name

Stat Med

journal_title

Statistics in medicine

authors

Liu A,Wu C,Schisterman EF

doi

10.1002/sim.3203

subject

Has Abstract

pub_date

2008-05-10 00:00:00

pages

1667-78

issue

10

eissn

0277-6715

issn

1097-0258

journal_volume

27

pub_type

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