Abstract:
:Estimates of analyte concentrations, obtained by immunoassay, have error distributions which are generally underestimated. Better estimates, which take into account the distribution of the response metameter of the calibration curve and uncertainties associated with the location of the fitted curve, have been obtained by computer simulation using practical immunoassay data. The increased use of curve-fitting software in automated immunoassay equipment has prompted the investigation of reported analyte concentration distributions for three commonly used functions, namely the logit-log, the 4-parameter logistic and the four-parameter Amersham models. The stimulation model is of potential value for a variety of situations.
journal_name
Stat Medjournal_title
Statistics in medicineauthors
Kay C,Nix AB,Kemp KW,Rowlands RJ,Richards G,Groom GV,Griffiths K,Wilson DWdoi
10.1002/sim.4780050208subject
Has Abstractpub_date
1986-03-01 00:00:00pages
183-92issue
2eissn
0277-6715issn
1097-0258journal_volume
5pub_type
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pub_type: 临床试验,杂志文章,随机对照试验
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