Abstract:
:In many countries, the monitoring of child growth does not occur in a regular manner, and instead, we may have to rely on sporadic observations that are subject to substantial measurement error. In these countries, it can be difficult to identify patterns of poor growth, and faltering children may miss out on essential health interventions. The contribution of this paper is to provide a framework for pooling together multiple datasets, thus allowing us to overcome the issue of sparse data and provide improved estimates of growth. We use data from multiple longitudinal growth studies to construct a common correlation matrix that can be used in estimation and prediction of child growth. We propose a novel 2-stage approach: In stage 1, we construct a raw matrix via a set of univariate meta-analyses, and in stage 2, we smooth this raw matrix to obtain a more realistic correlation matrix. The methodology is illustrated using data from 16 child growth studies from the Bill and Melinda Gates Foundation's Healthy Birth Growth and Development knowledge integration project and identifies strong correlation for both height and weight between the ages of 4 and 12 years. We use a case study to provide an example of how this matrix can be used to help compute growth measures.
journal_name
Stat Medjournal_title
Statistics in medicineauthors
Anderson C,Xiao L,Checkley Wdoi
10.1002/sim.7696subject
Has Abstractpub_date
2019-08-30 00:00:00pages
3540-3554issue
19eissn
0277-6715issn
1097-0258journal_volume
38pub_type
杂志文章abstract::In this paper, we consider fitting a flexible and interpretable additive regression model in a data-rich setting. We wish to avoid pre-specifying the functional form of the conditional association between each covariate and the response, while still retaining interpretability of the fitted functions. A number of recen...
journal_title:Statistics in medicine
pub_type: 杂志文章
doi:10.1002/sim.7859
更新日期:2019-02-20 00:00:00
abstract::Relative survival is used to estimate patient survival excluding causes of death not related to the disease of interest. Rather than using cause of death information from death certificates, which is often poorly recorded, relative survival compares the observed survival to that expected in a matched group from the ge...
journal_title:Statistics in medicine
pub_type: 杂志文章
doi:10.1002/sim.2399
更新日期:2005-12-30 00:00:00
abstract::The availability of large data sets together with the growth in power and storage capabilities of computers have made the analysis of the spatial distribution of disease rates an increasingly important tool in public health research. Use of existing geographic divisions or groupings tends to result either in unstable ...
journal_title:Statistics in medicine
pub_type: 杂志文章
doi:10.1002/sim.4780121916
更新日期:1993-10-01 00:00:00
abstract::There are many settings in which the distribution of error in a mismeasured covariate varies with the value of another covariate. Take, for example, the case of HIV phylogenetic cluster size, large values of which are an indication of rapid HIV transmission. Researchers wish to find behavioral correlates of HIV phylog...
journal_title:Statistics in medicine
pub_type: 杂志文章
doi:10.1002/sim.7289
更新日期:2017-07-30 00:00:00
abstract::In recent years randomized trials designed to establish non-inferiority of a new treatment as compared to a standard one have been more widely used. Two-sample statistics have been proposed for this equivalence testing problem. However, they are not suited to situations where a long-term survivor fraction is expected....
journal_title:Statistics in medicine
pub_type: 杂志文章
doi:10.1002/sim.1453
更新日期:2003-03-30 00:00:00
abstract::Wittes and Brittain recommended using an 'internal pilot study' to adjust sample size. The approach involves five steps in testing a general linear hypothesis for a general linear univariate model, with Gaussian errors. First, specify the design, hypothesis, desired test size, power, a smallest 'clinically meaningful'...
journal_title:Statistics in medicine
pub_type: 杂志文章
doi:10.1002/(sici)1097-0258(19990530)18:10<1199::aid-s
更新日期:1999-05-30 00:00:00
abstract::Randomized clinical trial designs commonly include one or more planned interim analyses. At these times an external monitoring committee reviews the accumulated data and determines whether it is scientifically and ethically appropriate for the study to continue. With failure-time endpoints, it is common to schedule an...
journal_title:Statistics in medicine
pub_type: 杂志文章
doi:10.1002/sim.843
更新日期:2001-07-30 00:00:00
abstract::It is valuable in many studies to assess both intrarater and interrater agreement. Most measures of intrarater agreement do not adjust for unequal estimates of prevalence between the separate rating occasions for a given rater and measures of interrater agreement typically ignore data from the second set of assessment...
journal_title:Statistics in medicine
pub_type: 杂志文章
doi:10.1002/sim.1138
更新日期:2002-06-30 00:00:00
abstract::Lung function tests are used both clinically, in assessing disease, and epidemiologically, in identifying those factors which influence the growth and aging process of the lungs. The user must beware of several common pitfalls in the use of these tests, however. First, the commonly used tests of lung function can only...
journal_title:Statistics in medicine
pub_type: 杂志文章
doi:10.1002/sim.4780070106
更新日期:1988-01-01 00:00:00
abstract::This paper presents combinatorial (exact) methods that are useful in the analysis of disease cluster data obtained from small environments, such as buildings and neighbourhoods. Maxwell-Boltzmann and Fermi-Dirac occupancy models are compared in terms of appropriateness of representation of disease incidence patterns (...
journal_title:Statistics in medicine
pub_type: 杂志文章
doi:10.1002/sim.4780121906
更新日期:1993-10-01 00:00:00
abstract::The Cochran-Armitage trend test has been used in case-control studies for testing genetic association. As the variance of the test statistic is a function of unknown parameters, e.g. disease prevalence and allele frequency, it must be estimated. The usual estimator combining data for cases and controls assumes they fo...
journal_title:Statistics in medicine
pub_type: 杂志文章
doi:10.1002/sim.2250
更新日期:2006-09-30 00:00:00
abstract::When the accrual rate is low and the treatment period is long, a long observational period is required before information concerning the primary end point, such as binary response, becomes available in the study. Simon's two-stage designs are often employed in Phase II clinical trials to avoid giving patient an ineffe...
journal_title:Statistics in medicine
pub_type: 杂志文章
doi:10.1002/sim.3424
更新日期:2008-12-20 00:00:00
abstract::The treatment effect sizes that can be detected with sufficient power up to the different interim analyses constitute a clinically meaningful criterion for the selection of a group sequential test for a clinical trial. For any pre-specified sequence of effect sizes, it is possible to construct group sequential boundar...
journal_title:Statistics in medicine
pub_type: 杂志文章
doi:10.1002/sim.1751
更新日期:2004-05-15 00:00:00
abstract::In the analysis of survival data, there are often competing events that preclude an event of interest from occurring. Regression analysis with competing risks is typically undertaken using a cause-specific proportional hazards model. However, modern alternative methods exist for the analysis of the subdistribution haz...
journal_title:Statistics in medicine
pub_type: 杂志文章
doi:10.1002/sim.4123
更新日期:2011-03-15 00:00:00
abstract::In failure time studies involving a chronic disease such as cancer, several competing causes of mortality may be operating. Commonly, the conventional statistical technique of Kaplan-Meier, which is only meaningfully interpreted by assuming independence of failure types and the censoring mechanism, is employed in clin...
journal_title:Statistics in medicine
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1002/sim.711
更新日期:2001-03-15 00:00:00
abstract::Statisticians have long argued that randomized controlled trials should be sufficiently large to achieve their purpose, and for common diseases with major public health implications this has brought many benefits. However, there are many instances where it is unrealistic to expect clinicians to provide the information...
journal_title:Statistics in medicine
pub_type: 杂志文章,评审
doi:10.1002/sim.4780140204
更新日期:1995-01-30 00:00:00
abstract::For time-to-event outcomes, a rich literature exists on the bias introduced by covariate measurement error in regression models, such as the Cox model, and methods of analysis to address this bias. By comparison, less attention has been given to understanding the impact or addressing errors in the failure time outcome...
journal_title:Statistics in medicine
pub_type: 杂志文章
doi:10.1002/sim.7554
更新日期:2018-04-15 00:00:00
abstract::We propose the use of Gaussian mixed models to analyse statistically 24 hour ambulatory blood pressure data from clinical trials. We develop specific models and apply them to data from a clinical study that compares two angiotensin-converting enzyme inhibitors. We investigate and discuss computing issues related to th...
journal_title:Statistics in medicine
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1002/sim.4780121803
更新日期:1993-09-30 00:00:00
abstract::Sam Greenhouse joined the Census Bureau as a clerk at an interesting time period for the agency. The first use of sampling in the decennial census occurred in 1940. There was a major expansion of the amount of data collected. The organization of the Census Bureau underwent radical changes, including the growth of the ...
journal_title:Statistics in medicine
pub_type: 传,历史文章,杂志文章
doi:10.1002/sim.1627
更新日期:2003-11-15 00:00:00
abstract::The analysis of patient-reported outcomes or other psychological traits can be realized using the Rasch measurement model. When the objective of a study is to compare groups of individuals, it is important, before the study, to define a sample size such that the group comparison test will attain a given power. The Ras...
journal_title:Statistics in medicine
pub_type: 杂志文章
doi:10.1002/sim.6478
更新日期:2015-07-20 00:00:00
abstract::Nutritional exposures are often measured with considerable error in commonly used surrogate instruments such as the food frequency questionnaire (FFQ) (denoted by Q(i) for the ith subject). The error can be both systematic and random. The diet record (DR) denoted by R(i) for the ith subject is considered an alloyed go...
journal_title:Statistics in medicine
pub_type: 杂志文章
doi:10.1002/sim.3238
更新日期:2008-08-15 00:00:00
abstract::The design of clinical trials often requires knowledge of quantities such as between- and within subject variances about which only imprecise information exists. To provide assurance that the study has the desired power to detect a minimum clinically meaningful difference between treatment groups. Gould, Gould and Shi...
journal_title:Statistics in medicine
pub_type: 杂志文章
doi:10.1002/sim.4780142007
更新日期:1995-10-30 00:00:00
abstract::We provide a Bayesian analysis of data categorized into two levels of age (younger than 50 years, at least 50 years) and three levels of bone mineral density (normal, osteopenia, osteoporosis) for white females at least 20 years old in the third National Health and Nutrition Examination Survey. For the sample, the age...
journal_title:Statistics in medicine
pub_type: 杂志文章
doi:10.1002/sim.1985
更新日期:2005-04-15 00:00:00
abstract::The Response Evaluation Criteria in Solid Tumors are used as standard guidelines for the clinical evaluation of cancer treatments. The assessment is based on the anatomical tumor burden: change in size of target lesions and evolution of nontarget lesions (NTL). Despite unquestionable advantages of this standard tool, ...
journal_title:Statistics in medicine
pub_type: 杂志文章
doi:10.1002/sim.7640
更新日期:2018-06-15 00:00:00
abstract::Among many other uses, positron emission tomography (PET) can be used in studies to estimate the density of a neuroreceptor at each location throughout the brain by measuring the concentration of a radiotracer over time and modeling its kinetics. There are a variety of kinetic models in common usage and these typicall...
journal_title:Statistics in medicine
pub_type: 杂志文章
doi:10.1002/sim.3510
更新日期:2009-03-15 00:00:00
abstract::The National Children's Study is a national household probability sample designed to identify 100,000 children at birth and follow the sampled children for 21 years. Data from the study will support examining numerous hypotheses concerning genetic and environmental effects on the health and development of children. Th...
journal_title:Statistics in medicine
pub_type: 杂志文章
doi:10.1002/sim.3891
更新日期:2010-06-15 00:00:00
abstract::Small but important therapeutic effects of new treatments can be most efficiently detected through the study of large randomized prospective series of patients. Such large scale clinical trials are nowadays commonplace. The alternative is years of polemic and debate surrounding several trials each too small to detect ...
journal_title:Statistics in medicine
pub_type: 杂志文章
doi:10.1002/sim.4780010105
更新日期:1982-01-01 00:00:00
abstract::In many epidemiological studies it is common to resort to regression models relating incidence of a disease and its risk factors. The main goal of this paper is to consider inference on such models with error-prone observations and variances of the measurement errors changing across observations. We suppose that the o...
journal_title:Statistics in medicine
pub_type: 杂志文章
doi:10.1002/sim.3343
更新日期:2008-11-10 00:00:00
abstract::For massive survival data, we propose a subsampling algorithm to efficiently approximate the estimates of regression parameters in the additive hazards model. We establish consistency and asymptotic normality of the subsample-based estimator given the full data. The optimal subsampling probabilities are obtained via m...
journal_title:Statistics in medicine
pub_type: 杂志文章
doi:10.1002/sim.8783
更新日期:2021-01-30 00:00:00
abstract::Recurrent event data occur in many clinical and observational studies, and in these situations, there may exist a terminal event such as death that is related to the recurrent event of interest. In addition, sometimes more than one type of recurrent events may occur, that is, one may encounter multivariate recurrent e...
journal_title:Statistics in medicine
pub_type: 杂志文章
doi:10.1002/sim.4306
更新日期:2011-11-10 00:00:00