Sample size to test for interaction between a specific exposure and a second risk factor in a pair-matched case-control study.

abstract：:In noninferiority studies, a limit of indifference is used to express a tolerance in results such that the clinician would regard such results as being acceptable or 'not worse'. We applied this concept to a measure of accuracy, the Receiver Operating Characteristic (ROC) curve, for a sequence of tests. We expressed a...

journal_title：Statistics in medicine

authors： Ahmed AE,Schubert CM,McClish DK

更新日期：2013-07-20 00:00:00

abstract：:Most statistical methodology for phase III clinical trials focuses on the comparison of a single experimental treatment with a control. An increasing desire to reduce the time before regulatory approval of a new drug is sought has led to development of two-stage or sequential designs for trials that combine the defini...

journal_title：Statistics in medicine

authors： Stallard N,Todd S

更新日期：2003-03-15 00:00:00

abstract：:The incremental life expectancy, defined as the difference in mean survival times between two treatment groups, is a crucial quantity of interest in cost-effectiveness analyses. Usually, this quantity is very difficult to estimate from censored survival data with a limited follow-up period. The paper develops estimati...

journal_title：Statistics in medicine

authors： Titman AC

更新日期：2016-09-10 00:00:00

abstract：:The original article to which this Correction refers was published in Statistics in Medicine 2000 19(14): 1901-1914. ...

journal_title：Statistics in medicine

authors： Edwardes MD

更新日期：2000-11-15 00:00:00

abstract：:Within the rich literature on generalized linear models, substantial efforts have been devoted to models for categorical responses that are either completely ordered or completely unordered. Few studies have focused on the analysis of partially ordered outcomes, which arise in practically every area of study, includin...

journal_title：Statistics in medicine

authors： Zhang Q,Ip EH

更新日期：2012-01-13 00:00:00

abstract：:Although the literature on contraceptive failure is vast and is expanding rapidly, our understanding of the relative efficacy of methods is quite limited because of defects in the research design and in the analytical tools used by investigators. Errors in the literature range from simple arithmetical mistakes to outr...

journal_title：Statistics in medicine

authors： Trussell J

更新日期：1991-02-01 00:00:00

abstract：:Writing the variance of the Mantel-Haenszel estimator under the null of homogeneity and inverting the corresponding test, we arrive at an improved confidence interval for the common risk difference in stratified 2 × 2 tables. This interval outperforms a variety of other intervals currently recommended in the literatur...

journal_title：Statistics in medicine

authors： Klingenberg B

更新日期：2014-07-30 00:00:00

abstract：:We present a method to estimate the time-dependent vaccine efficacy from the cohort-specific vaccination coverage and from data on the vaccination status of cases and apply it to a measles epidemic in Germany which involved 529 cases, 88 of whom were vaccinated and 370 unvaccinated (for the remaining 71 cases the vacc...

journal_title：Statistics in medicine

authors： Eichner M,Diebner HH,Schubert C,Kreth HW,Dietz K

更新日期：2002-08-30 00:00:00

abstract：:In the field of cluster detection, a weighted normal model-based scan statistic was recently developed to analyze regional continuous data and to evaluate the clustering pattern of pre-defined cells (such as state, county, tract, school, hospital) that include many individuals. The continuous measures of interest are,...

journal_title：Statistics in medicine

authors： Huang L,Tiwari RC,Pickle LW,Zou Z

更新日期：2010-10-15 00:00:00

abstract：:In this paper, we develop methods to combine multiple biomarker trajectories into a composite diagnostic marker using functional data analysis (FDA) to achieve better diagnostic accuracy in monitoring disease recurrence in the setting of a prospective cohort study. In such studies, the disease status is usually verifi...

journal_title：Statistics in medicine

authors： Li H,Gatsonis C

更新日期：2019-05-20 00:00:00

abstract：:Having a surrogate for a definitive endpoint in a clinical trial can sometimes be useful when it is impractical, invasive or very time consuming to obtain the definitive endpoint. This paper discusses methods for assessing whether the surrogate-endpoint results of a trial can be used in place of definitive-endpoint re...

journal_title：Statistics in medicine

authors： Korn EL,Albert PS,McShane LM

更新日期：2005-01-30 00:00:00

abstract：:The goal of phase I cancer trials is to determine the highest dose of a treatment regimen with an acceptable toxicity rate. Traditional designs for phase I trials, such as the Continual Reassessment Method (CRM) and the 3 + 3 design, require each patient or a cohort of patients to be fully evaluated for the dose-limit...

journal_title：Statistics in medicine

authors： Polley MY

更新日期：2011-07-30 00:00:00

abstract：:For clinical trials with multiple treatment arms or endpoints a variety of sequentially rejective, weighted Bonferroni-type tests have been proposed, such as gatekeeping procedures, fixed sequence tests, and fallback procedures. They allow to map the difference in importance as well as the relationship between the var...

journal_title：Statistics in medicine

authors： Bretz F,Maurer W,Brannath W,Posch M

更新日期：2009-02-15 00:00:00

abstract：:The receiver operating characteristic (ROC) curve is a popular technique with applications, for example, investigating an accuracy of a biomarker to delineate between disease and non-disease groups. A common measure of accuracy of a given diagnostic marker is the area under the ROC curve (AUC). In contrast with the AU...

journal_title：Statistics in medicine

authors： Yu J,Yang L,Vexler A,Hutson AD

更新日期：2016-06-15 00:00:00

abstract：:This paper models monthly AIDS diagnosis counts in terms of smooth secular trend, calendar month effects, and the number of workdays per month. A parameterization of month effects allows separation of true seasonal effects from a linear trend over the calendar year and an arbitrary June effect. There is strong evidenc...

journal_title：Statistics in medicine

authors： Bacchetti P

更新日期：1994-10-15 00:00:00

abstract：:The validity and practical utility of observational medical research depends critically on good study design, excellent data quality, appropriate statistical methods and accurate interpretation of results. Statistical methodology has seen substantial development in recent times. Unfortunately, many of these methodolog...

journal_title：Statistics in medicine

authors： Sauerbrei W,Abrahamowicz M,Altman DG,le Cessie S,Carpenter J,STRATOS initiative.

更新日期：2014-12-30 00:00:00

abstract：:Propensity score analysis is widely used in observational studies to adjust for confounding and estimate the causal effect of a treatment on the outcome. When the outcome is survival time, there are special considerations on the definition of the causal estimand, point, and variance estimation that have not been thoro...

journal_title：Statistics in medicine

authors： Mao H,Li L,Yang W,Shen Y

更新日期：2018-11-20 00:00:00

abstract：:Multistate models are increasingly being used to model complex disease profiles. By modelling transitions between disease states, accounting for competing events at each transition, we can gain a much richer understanding of patient trajectories and how risk factors impact over the entire disease pathway. In this arti...

journal_title：Statistics in medicine

authors： Crowther MJ,Lambert PC

更新日期：2017-12-20 00:00:00

abstract：:Unmeasured confounding is a common concern when researchers attempt to estimate a treatment effect using observational data or randomized studies with nonperfect compliance. To address this concern, instrumental variable methods, such as 2-stage predictor substitution (2SPS) and 2-stage residual inclusion (2SRI), have...

journal_title：Statistics in medicine

authors： Wan F,Small D,Mitra N

更新日期：2018-05-30 00:00:00

abstract：:Biological drug products are therapeutic moieties manufactured by a living system or organisms. These are important life-saving drug products for patients with unmet medical needs. Because of expensive cost, only a few patients have access to life-saving biological products. Most of the early biological products will ...

journal_title：Statistics in medicine

authors： Lin JR,Chow SC,Chang CH,Lin YC,Liu JP

更新日期：2013-02-10 00:00:00

abstract：:We consider Cox proportional hazards regression when the covariate vector includes error-prone discrete covariates along with error-free covariates, which may be discrete or continuous. The misclassification in the discrete error-prone covariates is allowed to be of any specified form. Building on the work of Nakamura...

journal_title：Statistics in medicine

authors： Zucker DM,Spiegelman D

更新日期：2008-05-20 00:00:00

abstract：:To update the British growth reference, anthropometric data for weight, height, body mass index (weight/height2) and head circumference from 17 distinct surveys representative of England, Scotland and Wales (37,700 children, age range 23 weeks gestation to 23 years) were analysed by maximum penalized likelihood using ...

journal_title：Statistics in medicine

authors： Cole TJ,Freeman JV,Preece MA

更新日期：1998-02-28 00:00:00

abstract：:Piecewise constant incidence models were developed to estimate the force of infection in women from age- and time-specific antenatal or neonatal seroprevalence data. Differential inclusion of infected women in sero-surveys compared to uninfected women was taken into account, with respect to both changes in inclusion r...

journal_title：Statistics in medicine

authors： Ades AE,Medley GF

更新日期：1994-09-30 00:00:00

abstract：:Although statistical methodology is well-developed for comparing diagnostic tests in terms of their sensitivity and specificity, comparative inference about predictive values is not. In this paper, we consider the analysis of studies comparing operating characteristics of two diagnostic tests that are measured on all ...

journal_title：Statistics in medicine

authors： Kwak M,Um SW,Jung SH

更新日期：2015-07-10 00:00:00

abstract：:Mediation analysis is a standard approach to understanding how and why an intervention works in social and medical sciences. However, the presence of missing data, especially missing not at random data, poses a great challenge for the applicability of this approach in practice. Current methods for handling such missin...

journal_title：Statistics in medicine

authors： Li W,Zhou XH

更新日期：2017-11-10 00:00:00

abstract：:Tree-based methods have become popular for analyzing complex data structures where the primary goal is risk stratification of patients. Ensemble techniques improve the accuracy in prediction and address the instability in a single tree by growing an ensemble of trees and aggregating. However, in the process, individua...

journal_title：Statistics in medicine

authors： Banerjee M,Ding Y,Noone AM

更新日期：2012-07-10 00:00:00

abstract：:Joint models initially dedicated to a single longitudinal marker and a single time-to-event need to be extended to account for the rich longitudinal data of cohort studies. Multiple causes of clinical progression are indeed usually observed, and multiple longitudinal markers are collected when the true latent trait of...

journal_title：Statistics in medicine

authors： Proust-Lima C,Dartigues JF,Jacqmin-Gadda H

更新日期：2016-02-10 00:00:00

abstract：:This paper, arising out of an event to honour the statistical and scientific contributions of Professor Peter Armitage, is concerned with research strategies and needs for chronic disease prevention. A few highlights from recent intervention trials for the prevention of cancer, cardiovascular disease, fractures and di...

journal_title：Statistics in medicine

authors： Prentice RL

更新日期：2004-11-30 00:00:00

abstract：:Given N points or events occurring according to some probability distribution in the unit interval (0, 1), the simple scan statistic is defined to be the maximum number of points in any sub-interval of length d. In many areas, as in epidemiology, it is used to test the null hypothesis that the events are random, again...

journal_title：Statistics in medicine

authors： Nagarwalla N

更新日期：1996-04-15 00:00:00

abstract：:Statistical tests have been proposed for determining whether incident cases of adverse health effects are 'clustered' together. Several procedures, termed 'focused', specifically analyse disease surveillance data around pre-specified putative sources of environmental hazard. Little has been done to compare the perform...

journal_title：Statistics in medicine

authors： Waller LA,Lawson AB

更新日期：1995-11-15 00:00:00