Abstract:
:The effective dose (ED) is the pharmaceutical dosage required to produce a therapeutic response in a fixed proportion of the patients. When only one drug is considered, the problem is a univariate one and has been well-studied. However, in the multidimensional setting, that is, in the presence of combinations of agents, estimation of the ED becomes more difficult. This study is focused on the plug-in logistic regression estimator of the multidimensional ED. We discuss consistency of such estimators and focus on the problem of simultaneous confidence regions. We develop a bootstrap algorithm to estimate confidence regions for the multidimensional ED. Through simulation, we show that the proposed method gives 95% confidence regions, which have better empirical coverage than the previous method for moderate to large sample sizes. The novel approach is illustrated on a cytotoxicity study on the effect of two toxins in the leukemia cell line HL-60 and a decompression sickness study of the effects of the duration and depth of the dive.
journal_name
Stat Medjournal_title
Statistics in medicineauthors
Jankowski H,Ji X,Stanberry Ldoi
10.1002/sim.6226subject
Has Abstractpub_date
2014-10-30 00:00:00pages
4266-78issue
24eissn
0277-6715issn
1097-0258journal_volume
33pub_type
杂志文章abstract::Multilevel and longitudinal studies are frequently subject to missing data. For example, biomarker studies for oral cancer may involve multiple assays for each participant. Assays may fail, resulting in missing data values that can be assumed to be missing completely at random. Catellier and Muller proposed a data ana...
journal_title:Statistics in medicine
pub_type: 杂志文章
doi:10.1002/sim.6811
更新日期:2016-07-30 00:00:00
abstract::When a cancer patient develops a new tumor it is necessary to determine if it is a recurrence (metastasis) of the original cancer, or an entirely new occurrence of the disease. This is accomplished by assessing the histo-pathology of the lesions. However, there are many clinical scenarios in which this pathological di...
journal_title:Statistics in medicine
pub_type: 杂志文章
doi:10.1002/sim.3866
更新日期:2010-07-10 00:00:00
abstract::In a variety of biomedical applications, particularly those involving screening for infectious diseases, testing individuals (e.g. blood/urine samples, etc.) in pools has become a standard method of data collection. This experimental design, known as group testing (or pooled testing), can provide a large reduction in ...
journal_title:Statistics in medicine
pub_type: 杂志文章
doi:10.1002/sim.3678
更新日期:2009-10-15 00:00:00
abstract::A Non-Parametric Maximum Likelihood approach to the estimation of relative risks in the context of disease mapping is discussed and a NPML approximation to conditional autoregressive models is proposed. NPML estimates have been compared to other proposed solutions (Maximum Likelihood via Monte Carlo Scoring, Hierarchi...
journal_title:Statistics in medicine
pub_type: 杂志文章
doi:10.1002/1097-0258(20000915/30)19:17/18<2539::aid-s
更新日期:2000-09-15 00:00:00
abstract::To update the British growth reference, anthropometric data for weight, height, body mass index (weight/height2) and head circumference from 17 distinct surveys representative of England, Scotland and Wales (37,700 children, age range 23 weeks gestation to 23 years) were analysed by maximum penalized likelihood using ...
journal_title:Statistics in medicine
pub_type: 杂志文章
doi:
更新日期:1998-02-28 00:00:00
abstract::This paper investigates the Bayesian procedures for comparing proportions. These procedures are especially suitable for accepting (or rejecting) the equivalence of two population proportions. Furthermore the Bayesian predictive probabilities provide a natural and flexible tool in monitoring trials, especially for choo...
journal_title:Statistics in medicine
pub_type: 杂志文章
doi:10.1002/sim.4780140924
更新日期:1995-05-15 00:00:00
abstract::The microbiome plays an important role in human health by mediating the path from environmental exposures to health outcomes. The relative abundances of the high-dimensional microbiome data have an unit-sum restriction, rendering standard statistical methods in the Euclidean space invalid. To address this problem, we ...
journal_title:Statistics in medicine
pub_type: 杂志文章
doi:10.1002/sim.8808
更新日期:2021-02-20 00:00:00
abstract::The relative concentration index (RCI) and the absolute concentration index (ACI) have been widely used for monitoring health disparities with ranked health determinants. The RCI has been extended to allow value judgments about inequality aversion by Pereira in 1998 and by Wagstaff in 2002. Previous studies of the ext...
journal_title:Statistics in medicine
pub_type: 杂志文章
doi:10.1002/sim.7952
更新日期:2019-01-15 00:00:00
abstract::We applied a computationally practical form of probit analysis for multiple response variables to data on early childhood development of four psychiatric disorders: disruptive disorders (DD-attention deficit disorders, oppositional defiant disorder, conduct disorder); adjustment disorders (ADJ); emotional disorders (E...
journal_title:Statistics in medicine
pub_type: 杂志文章
doi:10.1002/(sici)1097-0258(19981115)17:21<2487::aid-s
更新日期:1998-11-15 00:00:00
abstract:BACKGROUND:It has been recommended that onset of antidepressant action be assessed using survival analyses with assessments taken at least twice per week. However, such an assessment schedule is problematic to implement. The present study assessed the feasibility of comparing onset of action between treatments using a ...
journal_title:Statistics in medicine
pub_type: 杂志文章
doi:10.1002/sim.2309
更新日期:2006-07-30 00:00:00
abstract::This paper discusses the various philosophies that influence the selection of patients for entry into randomized controlled trials. Although a number of different and often competing issues have to be considered depending upon the trial, keeping entry criteria simple, wide and at times even flexible is usually prefera...
journal_title:Statistics in medicine
pub_type: 杂志文章
doi:10.1002/sim.4780090114
更新日期:1990-01-01 00:00:00
abstract::Multivariate outcomes measured longitudinally over time are common in medicine, public health, psychology and sociology. The typical (saturated) longitudinal multivariate regression model has a separate set of regression coefficients for each outcome. However, multivariate outcomes are often quite similar and many out...
journal_title:Statistics in medicine
pub_type: 杂志文章
doi:10.1002/sim.3589
更新日期:2009-06-15 00:00:00
abstract::For many HIV-infected patients, use of antiretroviral therapy (ART) results in a sustained suppression of plasma viral load to undetectable levels. However, due to lack of antigenic stimulation, this may also result in a gradual loss of cell-mediated immune (CMI) responses that help control HIV infection. In concept, ...
journal_title:Statistics in medicine
pub_type: 杂志文章
doi:10.1002/sim.2555
更新日期:2007-02-10 00:00:00
abstract::Among many other uses, positron emission tomography (PET) can be used in studies to estimate the density of a neuroreceptor at each location throughout the brain by measuring the concentration of a radiotracer over time and modeling its kinetics. There are a variety of kinetic models in common usage and these typicall...
journal_title:Statistics in medicine
pub_type: 杂志文章
doi:10.1002/sim.3510
更新日期:2009-03-15 00:00:00
abstract::Motivated by a study about prompt coronary angiography in myocardial infarction, we propose a method to estimate the causal effect of a treatment in two-arm experimental studies with possible noncompliance in both treatment and control arms. We base the method on a causal model for repeated binary outcomes (before and...
journal_title:Statistics in medicine
pub_type: 杂志文章
doi:10.1002/sim.5856
更新日期:2013-11-10 00:00:00
abstract::Group sequential hypothesis testing is now widely used to analyze prospective data. If Monte Carlo simulation is used to construct the signaling threshold, the challenge is how to manage the type I error probability for each one of the multiple tests without losing control on the overall significance level. This paper...
journal_title:Statistics in medicine
pub_type: 杂志文章
doi:10.1002/sim.6805
更新日期:2016-04-30 00:00:00
abstract::There is an increasing interest in the use of propensity score methods to estimate causal effects in observational studies. However, recent systematic reviews have demonstrated that propensity score methods are inconsistently used and frequently poorly applied in the medical literature. In this study, we compared the ...
journal_title:Statistics in medicine
pub_type: 杂志文章
doi:10.1002/sim.2328
更新日期:2006-06-30 00:00:00
abstract::Methods for multiple informants help to estimate the marginal effect of each multiple source predictor and formally compare the strength of their association with an outcome. We extend multiple informant methods to the case of hierarchical data structures to account for within cluster correlation. We apply the propose...
journal_title:Statistics in medicine
pub_type: 杂志文章
doi:10.1002/sim.5967
更新日期:2014-02-20 00:00:00
abstract::Before introducing a new measurement tool it is necessary to evaluate its performance. Several statistical methods have been developed, or used, to evaluate the reliability and validity of a new assessment method in such circumstances. In this paper we review some commonly used methods. Data from a study that was cond...
journal_title:Statistics in medicine
pub_type: 杂志文章
doi:10.1002/sim.1804
更新日期:2004-05-30 00:00:00
abstract::Genetic markers can be used as instrumental variables, in an analogous way to randomization in a clinical trial, to estimate the causal relationship between a phenotype and an outcome variable. Our purpose is to extend the existing methods for such Mendelian randomization studies to the context of multiple genetic mar...
journal_title:Statistics in medicine
pub_type: 杂志文章
doi:10.1002/sim.3843
更新日期:2010-05-30 00:00:00
abstract::Log-linear models for capture-recapture type data are widely used for estimating sizes of populations. Log-linear methods model conditional interactions between the sources. Often, however, the marginal associations are more appropriate and easier for the practitioner to conceptualize. Analyses here of previously publ...
journal_title:Statistics in medicine
pub_type: 杂志文章
doi:10.1002/(sici)1097-0258(19980115)17:1<69::aid-sim7
更新日期:1998-01-15 00:00:00
abstract::Quality of life (QOL) assessment is a key component of many clinical studies and frequently requires the use of single global summary measures that capture the overall balance of findings from a potentially wide-ranging assessment of QOL issues. We propose and evaluate an irregular multilevel latent variable model sui...
journal_title:Statistics in medicine
pub_type: 杂志文章
doi:10.1002/sim.4455
更新日期:2012-05-20 00:00:00
abstract::The asymptotic Pearson's chi-squared test and Fisher's exact test have long been the most used for testing association in 2x2 tables. Unconditional tests preserve the significance level and generally are more powerful than Fisher's exact test for moderate to small samples, but previously were disadvantaged by being co...
journal_title:Statistics in medicine
pub_type: 杂志文章
doi:10.1002/sim.3531
更新日期:2009-03-30 00:00:00
abstract::In this paper, we define a modified version τ(b) of Kendall's tau to measure the association in a pair (X,Y) of random variables subject to fixed left censoring due to known lower detection limits. We provide a nonparametric estimator of τ(b) and investigate its asymptotic properties. We then assume an Archimedean cop...
journal_title:Statistics in medicine
pub_type: 杂志文章
doi:10.1002/sim.4319
更新日期:2011-11-20 00:00:00
abstract::This paper describes a method for estimating the risk from a disease over a set of contiguous geographical regions, when data on a potentially important covariate, such as race, are not available. Conditions under which the extra margin can be recovered are suggested. An application to prostate cancer mortality among ...
journal_title:Statistics in medicine
pub_type: 杂志文章
doi:10.1002/1097-0258(20000915/30)19:17/18<2243::aid-s
更新日期:2000-09-15 00:00:00
abstract::In many countries, the monitoring of child growth does not occur in a regular manner, and instead, we may have to rely on sporadic observations that are subject to substantial measurement error. In these countries, it can be difficult to identify patterns of poor growth, and faltering children may miss out on essentia...
journal_title:Statistics in medicine
pub_type: 杂志文章
doi:10.1002/sim.7696
更新日期:2019-08-30 00:00:00
abstract::For the analysis of time to event data in contraceptive studies when individuals are subject to competing causes for discontinuation, some authors have recently advocated the use of the cumulative incidence rate as a more appropriate measure to summarize data than the complement of the Kaplan-Meier estimate of discont...
journal_title:Statistics in medicine
pub_type: 杂志文章
doi:10.1002/sim.1135
更新日期:2001-12-15 00:00:00
abstract::The general linear mixed model provides a useful approach for analysing a wide variety of data structures which practising statisticians often encounter. Two such data structures which can be problematic to analyse are unbalanced repeated measures data and longitudinal data. Owing to recent advances in methods and sof...
journal_title:Statistics in medicine
pub_type: 杂志文章,评审
doi:10.1002/(sici)1097-0258(19971030)16:20<2349::aid-s
更新日期:1997-10-30 00:00:00
abstract::In this paper we describe Bonferroni-based multiple testing procedures (MTPs) as strategies to split and recycle test mass. Here, 'test mass' refers to (parts of) the nominal level alpha at which the family-wise error rate is controlled. Briefly, test mass is split between different null hypotheses, and whenever a nul...
journal_title:Statistics in medicine
pub_type: 杂志文章
doi:10.1002/sim.3513
更新日期:2009-02-28 00:00:00
abstract::Multistate models are increasingly being used to model complex disease profiles. By modelling transitions between disease states, accounting for competing events at each transition, we can gain a much richer understanding of patient trajectories and how risk factors impact over the entire disease pathway. In this arti...
journal_title:Statistics in medicine
pub_type: 杂志文章
doi:10.1002/sim.7448
更新日期:2017-12-20 00:00:00