The Integrated Calibration Index (ICI) and related metrics for quantifying the calibration of logistic regression models.

abstract：:We studied the problem of testing a hypothesized distribution in survival regression models when the data is right censored and survival times are influenced by covariates. A modified chi-squared type test, known as Nikulin-Rao-Robson statistic, is applied for the comparison of accelerated failure time models. This st...

journal_title：Statistics in medicine

authors： Tahir MR,Tran QX,Nikulin MS

更新日期：2017-05-30 00:00:00

abstract：:The purpose of this paper is to show that the sensitivity and specificity estimates obtained by 'discrepant analysis' are biased. Discrepant analysis is a widely used technique that attempts to provide estimates of sensitivity and specificity in the presence of an imperfect gold standard. Many researchers have applied...

journal_title：Statistics in medicine

authors： Hadgu A

更新日期：1997-06-30 00:00:00

abstract：:In this paper, we consider a full likelihood method to analyze continuous longitudinal responses with non-ignorable non-monotone missing data. We consider a transition probability model for the missingness mechanism. A first-order Markov dependence structure is assumed for both the missingness mechanism and observed d...

journal_title：Statistics in medicine

authors： Liao K,Freres DR,Troxel AB

更新日期：2012-12-10 00:00:00

abstract：:Correlation is inherent in longitudinal studies due to the repeated measurements on subjects, as well as due to time-dependent covariates in the study. In the National Longitudinal Study of Adolescent to Adult Health (Add Health), data were repeatedly collected on children in grades 7-12 across four waves. Thus, obser...

journal_title：Statistics in medicine

authors： Irimata KM,Broatch J,Wilson JR

更新日期：2019-05-30 00:00:00

abstract：:We consider the design of both cohort and case-control studies in which an initial ('stage 1') sample of complete data on an error-free disease indicator (D), a correct ('gold standard') dichotomous exposure measurement (X) and an error-prone exposure measurement (Z) are available. We calculate the amount of additiona...

journal_title：Statistics in medicine

authors： Dahm PF,Gail MH,Rosenberg PS,Pee D

更新日期：1995-12-15 00:00:00

abstract：:This paper discusses design considerations and the role of randomization-based inference in randomized community intervention trials. We stress that longitudinal follow-up of cohorts within communities often yields useful information on the effects of intervention on individuals, whereas cross-sectional surveys can us...

journal_title：Statistics in medicine

authors： Gail MH,Mark SD,Carroll RJ,Green SB,Pee D

更新日期：1996-06-15 00:00:00

abstract：:Sam Greenhouse joined the Census Bureau as a clerk at an interesting time period for the agency. The first use of sampling in the decennial census occurred in 1940. There was a major expansion of the amount of data collected. The organization of the Census Bureau underwent radical changes, including the growth of the ...

journal_title：Statistics in medicine

authors： Keller J,Clark CZ

更新日期：2003-11-15 00:00:00

abstract：:In many practical applications, count data often exhibit greater or less variability than allowed by the equality of mean and variance, referred to as overdispersion/underdispersion, and there are several reasons that may lead to the overdispersion/underdispersion such as zero inflation and mixture. Moreover, if the c...

journal_title：Statistics in medicine

authors： Chen XD,Fu YZ,Wang XR

更新日期：2013-04-15 00:00:00

abstract：:Statistical inference based on correlated count measurements are frequently performed in biomedical studies. Most of existing sample size calculation methods for count outcomes are developed under the Poisson model. Deviation from the Poisson assumption (equality of mean and variance) has been widely documented in pra...

journal_title：Statistics in medicine

authors： Li D,Zhang S,Cao J

更新日期：2019-12-10 00:00:00

abstract：:Rationalization of antibiotic therapy in the management of infectious diseases is helped by a knowledge of the patterns of sensitivity and resistance of bacteria to antibiotics and their possible changes both in time and from one hospital unit to another. In this paper we present the results regarding the sensitivitie...

journal_title：Statistics in medicine

authors： Bonetto C,Giannerini S,Giovagnoli A

更新日期：2006-10-30 00:00:00

abstract：:The present study investigates the performance of several statistical tests to detect publication bias in diagnostic meta-analysis by means of simulation. While bivariate models should be used to pool data from primary studies in diagnostic meta-analysis, univariate measures of diagnostic accuracy are preferable for t...

journal_title：Statistics in medicine

authors： Bürkner PC,Doebler P

更新日期：2014-08-15 00:00:00

abstract：:Modelling disease clustering over space and time can be helpful in providing indications of possible exposures and planning corresponding public health practices. Though a considerable number of studies focus on modelling spatio-temporal patterns of disease, most of them do not directly model a spatio-temporal cluster...

journal_title：Statistics in medicine

authors： Yan P,Clayton MK

更新日期：2006-03-15 00:00:00

abstract：:Our objective is to develop a model to estimate the relative risk of disease in each area, Ai, i=1, ... , n, of a region and to identify areas of unusually high or low risk. We use a product partition model (PPM) in which we assume that the true relative risks can be partitioned into a number of components or sets of ...

journal_title：Statistics in medicine

authors： Hegarty A,Barry D

更新日期：2008-08-30 00:00:00

abstract：:For robust detection performance, traditional control chart monitoring for biosurveillance is based on input data free of trends, day-of-week effects, and other systematic behaviour. Time series forecasting methods may be used to remove this behaviour by subtracting forecasts from observations to form residuals for al...

journal_title：Statistics in medicine

authors： Burkom HS,Murphy SP,Shmueli G

更新日期：2007-09-30 00:00:00

abstract：:Estimates of analyte concentrations, obtained by immunoassay, have error distributions which are generally underestimated. Better estimates, which take into account the distribution of the response metameter of the calibration curve and uncertainties associated with the location of the fitted curve, have been obtained...

journal_title：Statistics in medicine

authors： Kay C,Nix AB,Kemp KW,Rowlands RJ,Richards G,Groom GV,Griffiths K,Wilson DW

更新日期：1986-03-01 00:00:00

abstract：:Although hypertension is regarded as a causal factor for coronary heart disease (CHD) a reduction in the risk of CHD as a result of lowering blood pressure in mild hypertension could not be demonstrated. This conclusion is based on an overview analysis of all published randomized trials in mild hypertension, including...

journal_title：Statistics in medicine

authors： Holme I

更新日期：1988-11-01 00:00:00

abstract：:The validity and practical utility of observational medical research depends critically on good study design, excellent data quality, appropriate statistical methods and accurate interpretation of results. Statistical methodology has seen substantial development in recent times. Unfortunately, many of these methodolog...

journal_title：Statistics in medicine

authors： Sauerbrei W,Abrahamowicz M,Altman DG,le Cessie S,Carpenter J,STRATOS initiative.

更新日期：2014-12-30 00:00:00

abstract：:The percentile-finding experimental design known variously as 'forced-choice fixed-staircase', 'geometric up-and-down' or 'k-in-a-row' (KR) was introduced by Wetherill four decades ago. To date, KR has been by far the most widely used up-and-down (U&D) design for estimating non-median percentiles; it is implemented mo...

journal_title：Statistics in medicine

authors： Oron AP,Hoff PD

更新日期：2009-06-15 00:00:00

abstract：:During a course of human immunodeficiency virus (HIV-1) infection, the viral load usually increases sharply to a peak following infection and then drops rapidly to a steady state, where it remains until progression to AIDS. This steady state is often referred to as the viral set point. It is believed that the HIV vira...

journal_title：Statistics in medicine

authors： Mei Y,Wang L,Holte SE

更新日期：2008-01-15 00:00:00

abstract：:The recent revision of the Declaration of Helsinki and the existence of many new therapies that affect survival or serious morbidity, and that therefore cannot be denied patients, have generated increased interest in active-control trials, particularly those intended to show equivalence or non-inferiority to the activ...

journal_title：Statistics in medicine

authors： Rothmann M,Li N,Chen G,Chi GY,Temple R,Tsou HH

更新日期：2003-01-30 00:00:00

abstract：:In the recent two decades, data mining methods for signal detection have been developed for drug safety surveillance, using large post-market safety data. Several of these methods assume that the number of reports for each drug-adverse event combination is a Poisson random variable with mean proportional to the unknow...

journal_title：Statistics in medicine

authors： Hu N,Huang L,Tiwari RC

更新日期：2015-08-30 00:00:00

abstract：:Clinical prediction models (CPMs) can inform decision making about treatment initiation, which requires predicted risks assuming no treatment is given. However, this is challenging since CPMs are usually derived using data sets where patients received treatment, often initiated postbaseline as "treatment drop-ins." Th...

journal_title：Statistics in medicine

authors： Sperrin M,Martin GP,Pate A,Van Staa T,Peek N,Buchan I

更新日期：2018-12-10 00:00:00

abstract：:Determination of the equation that relates an ordered dependent variable to ordered independent variables is sought. One solution, non-parametric discriminant analysis (NPD), involves obtaining the best monotonic step function by means of a computer search procedure. Although one can use alternative selection criteria...

journal_title：Statistics in medicine

authors： Johnston B,Seshia SS

更新日期：1992-06-15 00:00:00

abstract：:While genome-wide association studies (GWASs) have been widely used to uncover associations between diseases and genetic variants, standard SNP-level GWASs often lack the power to identify SNPs that individually have a moderate effect size but jointly contribute to the disease. To overcome this problem, pathway-based ...

journal_title：Statistics in medicine

authors： Yang Y,Basu S,Zhang L

更新日期：2020-03-15 00:00:00

abstract：:Recurrent event data are commonly encountered in health-related longitudinal studies. In this paper time-to-events models for recurrent event data are studied with non-informative and informative censorings. In statistical literature, the risk set methods have been confirmed to serve as an appropriate and efficient ap...

journal_title：Statistics in medicine

authors： Wang MC,Chiang CT

更新日期：2002-02-15 00:00:00

abstract：:We present an estimate of the kappa-coefficient of agreement between two methods of rating based on matched pairs of binary responses and show that the estimate depends on the common intraclass correlation coefficient between the pairs. Via Monte Carlo simulation, we investigate power of the test of significance on ka...

journal_title：Statistics in medicine

authors： Shoukri MM,Martin SW,Mian IU

更新日期：1995-01-15 00:00:00

abstract：:The 'at least as good as' criterion, introduced by Laster and Johnson for a continuous response variate, is developed here for applications with dichotomous data. This approach is adaptive in nature, as the margin of non-inferiority is not taken as a fixed difference; it varies as a function of the positive control re...

journal_title：Statistics in medicine

authors： Laster LL,Johnson MF,Kotler ML

更新日期：2006-04-15 00:00:00

abstract：:The back-calculation method has been used to estimate the number of HIV infections from AIDS incidence data in a particular population. We present an extension of back calculation that provides estimates of the numbers of HIV infectives in different stages of infection. We model the staging process with a time-depende...

journal_title：Statistics in medicine

authors： Longini IM Jr,Byers RH,Hessol NA,Tan WY

更新日期：1992-04-01 00:00:00

abstract：:Meta-analysis is the methodology for combining findings from similar research studies asking the same question. When the question of interest involves multiple outcomes, multivariate meta-analysis is used to synthesize the outcomes simultaneously taking into account the correlation between the outcomes. Likelihood-bas...

journal_title：Statistics in medicine

authors： Ma Y,Mazumdar M

更新日期：2011-10-30 00:00:00

abstract：:This paper concerns the statistical analysis of certain binary data arising in molecular studies of cancer. In allelic-loss experiments, tumour cell genomes are analysed at informative molecular marker loci to identify deleted chromosomal regions. The resulting binary data are used to infer properties of putative supp...

journal_title：Statistics in medicine

authors： Newton MA,Gould MN,Reznikoff CA,Haag JD

更新日期：1998-07-15 00:00:00