Signal detection in FDA AERS database using Dirichlet process.

abstract：:A significant source of missing data in longitudinal epidemiological studies on elderly individuals is death. Subjects in large scale community-based longitudinal dementia studies are usually evaluated for disease status in study waves, not under continuous surveillance as in traditional cohort studies. Therefore, for...

journal_title：Statistics in medicine

authors： Harezlak J,Gao S,Hui SL

更新日期：2003-05-15 00:00:00

abstract：:We suggest measures to quantify the degrees of necessity and of sufficiency of prognostic factors for dichotomous and for survival outcomes. A cause, represented by certain values of prognostic factors, is considered necessary for an event if, without the cause, the event cannot develop. It is considered sufficient fo...

journal_title：Statistics in medicine

authors： Gleiss A,Schemper M

更新日期：2019-10-15 00:00:00

abstract：:Ewell and Ibrahim derived the large sample distribution of the logrank statistic under general local alternatives. Their asymptotic results enable us to extend several group sequential designs which allow for early stopping in favour of the null hypothesis to the setting in which the cure rate model is appropriate. In...

journal_title：Statistics in medicine

authors： Patricia Bernardo MV,Ibrahim JG

更新日期：2000-11-30 00:00:00

abstract：:Previous work on the consequences of regression to the mean for the interpretation of responses to treatment is extended to the situation where the response measured is the proportional change in some variable. Methods for correcting for the bias are discussed. ...

journal_title：Statistics in medicine

authors： Curnow RN

更新日期：1987-03-01 00:00:00

abstract：:Standard approaches to analysis of randomized controlled trials (RCTs) using Markov models make it difficult to generalize treatment effects to new patient groups and synthesize evidence across trials. This paper demonstrates how pair-wise and mixed treatment comparison meta-analysis can be applied to event history da...

journal_title：Statistics in medicine

authors： Price MJ,Welton NJ,Ades AE

更新日期：2011-01-30 00:00:00

abstract：:This paper models monthly AIDS diagnosis counts in terms of smooth secular trend, calendar month effects, and the number of workdays per month. A parameterization of month effects allows separation of true seasonal effects from a linear trend over the calendar year and an arbitrary June effect. There is strong evidenc...

journal_title：Statistics in medicine

authors： Bacchetti P

更新日期：1994-10-15 00:00:00

abstract：:Increasing numbers of economic evaluations are conducted alongside randomised controlled trials. Such studies include factorial trials, which randomise patients to different levels of two or more factors and can therefore evaluate the effect of multiple treatments alone and in combination. Factorial trials can provide...

journal_title：Statistics in medicine

authors： Dakin H,Gray A

更新日期：2017-08-15 00:00:00

abstract：:Individuals may vary in their responses to treatment, and identification of subgroups differentially affected by a treatment is an important issue in medical research. The risk of misleading subgroup analyses has become well known, and some exploratory analyses can be helpful in clarifying how covariates potentially i...

journal_title：Statistics in medicine

authors： Kim HJ,Lu B,Nehus EJ,Kim MO

更新日期：2019-02-10 00:00:00

abstract：:For robust detection performance, traditional control chart monitoring for biosurveillance is based on input data free of trends, day-of-week effects, and other systematic behaviour. Time series forecasting methods may be used to remove this behaviour by subtracting forecasts from observations to form residuals for al...

journal_title：Statistics in medicine

authors： Burkom HS,Murphy SP,Shmueli G

更新日期：2007-09-30 00:00:00

abstract：:Pattern-mixture models (PMM) and selection models (SM) are alternative approaches for statistical analysis when faced with incomplete data and a nonignorable missing-data mechanism. Both models make empirically unverifiable assumptions and need additional constraints to identify the parameters. Here, we first introduc...

journal_title：Statistics in medicine

authors： Kaciroti NA,Raghunathan T

更新日期：2014-11-30 00:00:00

abstract：:For clinical trials with multiple treatment arms or endpoints a variety of sequentially rejective, weighted Bonferroni-type tests have been proposed, such as gatekeeping procedures, fixed sequence tests, and fallback procedures. They allow to map the difference in importance as well as the relationship between the var...

journal_title：Statistics in medicine

authors： Bretz F,Maurer W,Brannath W,Posch M

更新日期：2009-02-15 00:00:00

abstract：:Sam Greenhouse joined the Census Bureau as a clerk at an interesting time period for the agency. The first use of sampling in the decennial census occurred in 1940. There was a major expansion of the amount of data collected. The organization of the Census Bureau underwent radical changes, including the growth of the ...

journal_title：Statistics in medicine

authors： Keller J,Clark CZ

更新日期：2003-11-15 00:00:00

abstract：:Pearson's chi-squared, the likelihood-ratio, and Fisher-Freeman-Halton's test statistics are often used to test the association of unordered r x c tables. Asymptotical, exact conditional, or exact conditional with mid-p adjustment methods are commonly used to compute the p-value. We have compared test power and signif...

journal_title：Statistics in medicine

authors： Lydersen S,Pradhan V,Senchaudhuri P,Laake P

更新日期：2007-10-15 00:00:00

abstract：:A general method is presented that allows the researcher to change statistical design elements such as the residual sample size during the course of an experiment, to include an interim analysis for early stopping when no formal rule for early stopping was foreseen, to increase or reduce the number of planned interim ...

journal_title：Statistics in medicine

authors： Müller HH,Schäfer H

更新日期：2004-08-30 00:00:00

abstract：:A study of long term survival of 1487 patients given an allogeneic bone marrow transplant for acute myelogenous leukaemia and 729 patients given a transplant for severe aplastic anaemia was conducted by the International Bone Marrow Transplant Registry. One aim of this study is to determine if the mortality rates of t...

journal_title：Statistics in medicine

authors： Andersen PK,Horowitz MM,Klein JP,Socie G,Stone JV,Zhang MJ

更新日期：1999-06-30 00:00:00

abstract：:Within the rich literature on generalized linear models, substantial efforts have been devoted to models for categorical responses that are either completely ordered or completely unordered. Few studies have focused on the analysis of partially ordered outcomes, which arise in practically every area of study, includin...

journal_title：Statistics in medicine

authors： Zhang Q,Ip EH

更新日期：2012-01-13 00:00:00

abstract：:The article is motivated by a nephrology study in Taiwan, which enrolled hemodialysis patients who suffered from vascular access thrombosis. After treatment, some patients were cured of thrombosis, while some may experience recurrence of either type (acute or nonacute) of vascular access thrombosis. Our major interest...

journal_title：Statistics in medicine

authors： Chen CM,Shen PS,Lin CC,Wu CC

更新日期：2020-11-30 00:00:00

abstract：:Clinical trials utilizing predictive biomarkers have become a research focus in personalized medicine. We investigate the effects of biomarker misclassification on the design and analysis of stratified biomarker clinical trials. For a variety of inference problems including marker-treatment interaction in particular, ...

journal_title：Statistics in medicine

authors： Liu C,Liu A,Hu J,Yuan V,Halabi S

更新日期：2014-08-15 00:00:00

abstract：:The Rvachev-Baroyan-Longini model is a space-time predictive model of the spread of influenza epidemics. It has been applied to 128 cities of the USSR, and more recently, to forecasting the spread of the pandemic of 1968-1969 throughout 52 large cities. It is a deterministic, mass-action, space and time continuous mod...

journal_title：Statistics in medicine

authors： Flahault A,Letrait S,Blin P,Hazout S,Ménarés J,Valleron AJ

更新日期：1988-11-01 00:00:00

abstract：:We study the competing risks model and show that the cause j cumulative incidence function integrated from 0 to τ has a natural interpretation as the expected number of life years lost due to cause j before time τ. This is analogous to the τ-restricted mean lifetime, which is the survival function integrated from 0 to...

journal_title：Statistics in medicine

authors： Andersen PK

更新日期：2013-12-30 00:00:00

abstract：:The change in c-statistic is frequently used to summarize the change in predictive accuracy when a novel risk factor is added to an existing logistic regression model. We explored the relationship between the absolute change in the c-statistic, Brier score, generalized R(2) , and the discrimination slope when a risk f...

journal_title：Statistics in medicine

authors： Austin PC,Steyerberg EW

更新日期：2013-02-20 00:00:00

abstract：:The problem of testing symmetry about zero has a long and rich history in the statistical literature. We introduce a new test that sequentially discards observations whose absolute value is below increasing thresholds defined by the data. McNemar's statistic is obtained at each threshold and the largest is used as the...

journal_title：Statistics in medicine

authors： Laska E,Meisner M,Wanderling J

更新日期：2012-11-20 00:00:00

abstract：:For time-to-event outcomes, a rich literature exists on the bias introduced by covariate measurement error in regression models, such as the Cox model, and methods of analysis to address this bias. By comparison, less attention has been given to understanding the impact or addressing errors in the failure time outcome...

journal_title：Statistics in medicine

authors： Oh EJ,Shepherd BE,Lumley T,Shaw PA

更新日期：2018-04-15 00:00:00

abstract：:Patient non-compliance and drop-out can bias analyses of clinical trial data. I describe a parametric model for treatment cross-over and drop-out and demonstrate how the concept of ignorability, originally defined for incomplete-data problems, can elucidate sources of bias in clinical trials. I discuss some implicatio...

journal_title：Statistics in medicine

authors： Heitjan DF

更新日期：1999-09-15 00:00:00

abstract：:Determination of the equation that relates an ordered dependent variable to ordered independent variables is sought. One solution, non-parametric discriminant analysis (NPD), involves obtaining the best monotonic step function by means of a computer search procedure. Although one can use alternative selection criteria...

journal_title：Statistics in medicine

authors： Johnston B,Seshia SS

更新日期：1992-06-15 00:00:00

abstract：:We discuss a sample size calculation for a pair-matched case-control study to test for interaction between a specific exposure and a second risk factor. The second risk factor could be either binary or continuous. An algorithm for the calculation of sample size is suggested which is based on a logistic regression mode...

journal_title：Statistics in medicine

authors： Qiu P,Moeschberger ML,Cooke GE,Goldschmidt-Clermont PJ

更新日期：2000-04-15 00:00:00

abstract：:The design of clinical trials often requires knowledge of quantities such as between- and within subject variances about which only imprecise information exists. To provide assurance that the study has the desired power to detect a minimum clinically meaningful difference between treatment groups. Gould, Gould and Shi...

journal_title：Statistics in medicine

authors： Shih WJ,Gould AL

更新日期：1995-10-30 00:00:00

abstract：:A method is presented which allows us to adapt the sample size as well as the number and time points of interim analyses to the treatment difference observed at an interim look during the course of a clinical trial with censored survival time as the endpoint. The method allows the inclusion of data inspections during ...

journal_title：Statistics in medicine

authors： Schäfer H,Müller HH

更新日期：2001-12-30 00:00:00

abstract：:Statistical modeling methods have had increasing use in drug disposition studies, both to estimate pharmacokinetic parameters and to develop regression models that relate these parameter estimates to patient characteristics. These methods are particularly flexible as they allow non-linearity and sparse within-patient ...

journal_title：Statistics in medicine

authors： Roe DJ

更新日期：1997-06-15 00:00:00

abstract：:There are many settings in which the distribution of error in a mismeasured covariate varies with the value of another covariate. Take, for example, the case of HIV phylogenetic cluster size, large values of which are an indication of rapid HIV transmission. Researchers wish to find behavioral correlates of HIV phylog...

journal_title：Statistics in medicine

authors： Parveen N,Moodie E,Brenner B

更新日期：2017-07-30 00:00:00