Abstract:
:Ewell and Ibrahim derived the large sample distribution of the logrank statistic under general local alternatives. Their asymptotic results enable us to extend several group sequential designs which allow for early stopping in favour of the null hypothesis to the setting in which the cure rate model is appropriate. In particular, we derive stopping rules for the cure rate model using conditional power, predictive power and repeated confidence intervals methods. We illustrate the methods proposed using a hypothetical phase III clinical trial which is typical for melanoma studies.
journal_name
Stat Medjournal_title
Statistics in medicineauthors
Patricia Bernardo MV,Ibrahim JGdoi
10.1002/1097-0258(20001130)19:22<3023::aid-sim638>subject
Has Abstractpub_date
2000-11-30 00:00:00pages
3023-35issue
22eissn
0277-6715issn
1097-0258pii
10.1002/1097-0258(20001130)19:22<3023::AID-SIM638>journal_volume
19pub_type
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