An illness-death stochastic model in the analysis of longitudinal dementia data.

abstract：:New combination regimens evaluated in phase II cancer clinical trials often show promising results compared to the standard therapy for a disease system. Selection of patients with a better prognosis can be a prominent factor for this optimism. For most disease systems, prognostic variables that are related to the out...

journal_title：Statistics in medicine

authors： Mazumdar M,Fazzari M,Panageas KS

更新日期：2001-03-30 00:00:00

abstract：:When the event time of interest depends on the censoring time, conventional two-sample test methods, such as the log-rank and Wilcoxon tests, can produce an invalid test result. We extend our previous work on estimation using auxiliary variables to adjust for dependent censoring via multiple imputation, to the compari...

journal_title：Statistics in medicine

authors： Hsu CH,Taylor JM

更新日期：2009-02-01 00:00:00

abstract：:Identification of key factors associated with the risk of developing cardiovascular disease and quantification of this risk using multivariable prediction algorithms are among the major advances made in preventive cardiology and cardiovascular epidemiology in the 20th century. The ongoing discovery of new risk markers...

journal_title：Statistics in medicine

authors： Pencina MJ,D'Agostino RB Sr,D'Agostino RB Jr,Vasan RS

更新日期：2008-01-30 00:00:00

abstract：:Sexually transmitted infections (STIs) with Chlamydia trachomatis, Neisseria gonorrhoeae, and Trichomonas vaginalis are among the most common infectious diseases in the United States, disproportionately affecting young women. Because a significant portion of the infections present no symptoms, infection control relies...

journal_title：Statistics in medicine

authors： Li Z,Liu H,Tu W

更新日期：2015-09-10 00:00:00

abstract：:Testing the equality of 2 proportions for a control group versus a treatment group is a well-researched statistical problem. In some settings, there may be strong historical data that allow one to reliably expect that the control proportion is one, or nearly so. While one-sample tests or comparisons to historical cont...

journal_title：Statistics in medicine

authors： Gabriel EE,Nason M,Fay MP,Follmann DA

更新日期：2018-03-30 00:00:00

abstract：:In lifetime data, like cancer studies, there may be long term survivors, which lead to heavy censoring at the end of the follow-up period. Since a standard survival model is not appropriate to handle these data, a cure model is needed. In the literature, covariate hypothesis tests for cure models are limited to parame...

journal_title：Statistics in medicine

authors： López-Cheda A,Jácome MA,Van Keilegom I,Cao R

更新日期：2020-07-30 00:00:00

abstract：:When asking 'what is known' about a drug or therapy or program at any time, both researchers and practitioners often confront more than a single study. Facing a variety of findings, where conflicts may outweigh agreement, how can a reviewer constructively approach the task? In this discussion, I will outline some ques...

journal_title：Statistics in medicine

authors： Light RJ

更新日期：1987-04-01 00:00:00

abstract：:Combinatorial drugs have been widely applied in disease treatment, especially chemotherapy for cancer, due to its improved efficacy and reduced toxicity compared with individual drugs. The study of combinatorial drugs requires efficient experimental designs and proper follow-up statistical modeling techniques. Linear ...

journal_title：Statistics in medicine

authors： Xiao Q,Wang L,Xu H

更新日期：2019-01-30 00:00:00

abstract：:The statistical analysis of panel count data has recently attracted a great deal of attention, and a number of approaches have been developed. However, most of these approaches are for situations where the observation and follow-up processes are independent of the underlying recurrent event process unconditional or co...

journal_title：Statistics in medicine

authors： Li N,Zhao H,Sun J

更新日期：2013-07-30 00:00:00

abstract：:In a recent Statistics in Medicine paper, Warn, Thompson and Spiegelhalter (WTS) made a comparison between the Bayesian approach to the meta-analysis of binary outcomes and a popular Classical approach that uses summary (two-stage) techniques. They included approximate summary (two-stage) Bayesian techniques in their ...

journal_title：Statistics in medicine

authors： O'Rourke K,Altman DG

更新日期：2005-09-15 00:00:00

abstract：:Box-Cox transformation is investigated for regression models for left-censored data. Examples are provided using coronary calcification data from the Multi-Ethnic Study of Atherosclerosis and pharmacokinetic data of a nicotine nasal spray. ...

journal_title：Statistics in medicine

authors： Han C,Kronmal R

更新日期：2004-12-15 00:00:00

abstract：:Much has been published on various aspects of data analysis and reporting from clinical trials within the biopharmaceutical environment. This ranges from regulatory guidelines on the format and content of registration dossiers to recommendations on data presentation and the statistical methodologies that are appropria...

journal_title：Statistics in medicine

authors： Huster WJ,Enas GG

更新日期：1998-08-15 00:00:00

abstract：:Phase II and phase III trials play a crucial role in drug development programs. They are costly and time consuming and, because of high failure rates in late development stages, at the same time risky investments. Commonly, sample size calculation of phase III is based on the treatment effect observed in phase II. The...

journal_title：Statistics in medicine

authors： Kirchner M,Kieser M,Götte H,Schüler A

更新日期：2016-01-30 00:00:00

abstract：:We have formulated the problem of determining whether there has been an upturn in HIV-1 seroconversion incidence over the first five years of follow-up in the Multicenter AIDS Cohort Study (MACS) as that of locating the minimum of a quadratic regression or examination of two-knot piecewise spline models. Under a quadr...

journal_title：Statistics in medicine

authors： Zhou SY,Kingsley LA,Taylor JM,Chmiel JS,He DY,Hoover DR

更新日期：1993-01-30 00:00:00

abstract：:Longitudinal studies are often concerned with estimating the recurrence rate of a non-fatal event. In many cases, only the total number of events occurring during successive time intervals is known. We compared a mixed Poisson-gamma regression method proposed by Thall and a quasi-likelihood method proposed by Zeger an...

journal_title：Statistics in medicine

authors： Stukel TA

更新日期：1993-07-30 00:00:00

abstract：:A decision-theoretic framework is proposed for designing sequential dose-finding trials with multiple outcomes. The optimal strategy is solvable theoretically via backward induction. However, for dose-finding studies involving k doses, the computational complexity is the same as the bandit problem with k-dependent arm...

journal_title：Statistics in medicine

authors： Fan SK,Wang YG

更新日期：2006-05-30 00:00:00

abstract：:The relative concentration index (RCI) and the absolute concentration index (ACI) have been widely used for monitoring health disparities with ranked health determinants. The RCI has been extended to allow value judgments about inequality aversion by Pereira in 1998 and by Wagstaff in 2002. Previous studies of the ext...

journal_title：Statistics in medicine

authors： Yu M,Liu B,Li Y,Zou ZJ,Breen N

更新日期：2019-01-15 00:00:00

abstract：:A relationship between baseline risk and treatment effect is increasingly investigated as a possible explanation of between-study heterogeneity in clinical trial meta-analysis. An approach that is still often applied in the medical literature is to plot the estimated treatment effects against the estimated measures of...

journal_title：Statistics in medicine

authors： Arends LR,Hoes AW,Lubsen J,Grobbee DE,Stijnen T

更新日期：2000-12-30 00:00:00

abstract：:In a variety of biomedical applications, particularly those involving screening for infectious diseases, testing individuals (e.g. blood/urine samples, etc.) in pools has become a standard method of data collection. This experimental design, known as group testing (or pooled testing), can provide a large reduction in ...

journal_title：Statistics in medicine

authors： Chen P,Tebbs JM,Bilder CR

更新日期：2009-10-15 00:00:00

abstract：:Confounding factors are commonly encountered in observational studies. Several confounder-adjusted tests to compare survival between differently exposed subjects were proposed. However, only few studies have compared their performances regarding type I error rates, and no study exists evaluating their type II error ra...

journal_title：Statistics in medicine

authors： Le Borgne F,Giraudeau B,Querard AH,Giral M,Foucher Y

更新日期：2016-03-30 00:00:00

abstract：:In order for national statistical offices to maintain the trust of the public to collect data and publish statistics of importance to society and decision-making, it is imperative that respondents (persons or establishments) be guaranteed privacy and confidentiality in return for providing requested confidential data....

journal_title：Statistics in medicine

authors： Gonzalez JF Jr,Cox LH

更新日期：2005-02-28 00:00:00

abstract：:Propensity score analysis is widely used in observational studies to adjust for confounding and estimate the causal effect of a treatment on the outcome. When the outcome is survival time, there are special considerations on the definition of the causal estimand, point, and variance estimation that have not been thoro...

journal_title：Statistics in medicine

authors： Mao H,Li L,Yang W,Shen Y

更新日期：2018-11-20 00:00:00

abstract：:Studies in health research are commonly carried out in clustered settings, where the individual response data are correlated within clusters. Estimation and modelling of the extent of between-cluster variation contributes to understanding of the current study and to design of future studies. It is common to express be...

journal_title：Statistics in medicine

authors： Turner RM,Omar RZ,Thompson SG

更新日期：2006-05-15 00:00:00

abstract：:A Non-Parametric Maximum Likelihood approach to the estimation of relative risks in the context of disease mapping is discussed and a NPML approximation to conditional autoregressive models is proposed. NPML estimates have been compared to other proposed solutions (Maximum Likelihood via Monte Carlo Scoring, Hierarchi...

journal_title：Statistics in medicine

authors： Biggeri A,Marchi M,Lagazio C,Martuzzi M,Böhning D

更新日期：2000-09-15 00:00:00

abstract：:We analyse the effect of using prevalence rates based on populations with different sizes in the power of spatial independence tests. We compare the well known spatial correlation Moran's index to three indexes obtained after adjusting for population density, one proposed by Oden, another proposed by Waldhör, and a th...

journal_title：Statistics in medicine

authors： Assunção RM,Reis EA

更新日期：1999-08-30 00:00:00

abstract：:Proportional hazards (or Cox) regression is a popular method for modelling the effects of prognostic factors on survival. Use of cubic spline functions to model time-by-covariate interactions in Cox regression allows investigation of the shape of a possible covariate-time dependence without having to specify a specifi...

journal_title：Statistics in medicine

authors： Hess KR

更新日期：1994-05-30 00:00:00

abstract：:Clinical studies that involve the recording of two or more distinct and well-defined events on each subject give rise to multiple event data. Treatment comparisons are usually reported in univariate analyses of time to first event or number of events observed. However, this approach may not uncover the 'full story' of...

journal_title：Statistics in medicine

authors： Barai U,Teoh N

更新日期：1997-04-30 00:00:00

abstract：:Residuals in normal regression are used to assess a model's goodness-of-fit (GOF) and discover directions for improving the model. However, there is a lack of residuals with a characterized reference distribution for censored regression. In this article, we propose to diagnose censored regression with normalized rando...

journal_title：Statistics in medicine

authors： Li L,Wu T,Feng C

更新日期：2020-12-13 00:00:00

abstract：:In a long-running longitudinal study using complex machinery to obtain measurements, it is sometimes necessary to replace the machine. This can result in lack of continuity in the measurements that can overwhelm any treatment effect or time trend. We propose a Bayesian procedure implemented using Markov chain Monte Ca...

journal_title：Statistics in medicine

authors： Ambrosius WT,Hui SL

更新日期：2004-09-30 00:00:00

abstract：:A preference trial is a special form of cross-over trial where clinical conditions determine when patients change treatment, in a prescribed order. This can be modelled using a geometric distribution. The model can be simply fitted using standard logistic regression methodology. The procedure is applied to a trial stu...

journal_title：Statistics in medicine

authors： Lindsey JK,Jones B

更新日期：1996-02-28 00:00:00