Abstract:
:Patient non-compliance and drop-out can bias analyses of clinical trial data. I describe a parametric model for treatment cross-over and drop-out and demonstrate how the concept of ignorability, originally defined for incomplete-data problems, can elucidate sources of bias in clinical trials. I discuss some implications of the theory and present simulation examples that illustrate the potential effects of non-ignorable cross-over and drop-out on bias and power.
journal_name
Stat Medjournal_title
Statistics in medicineauthors
Heitjan DFdoi
10.1002/(sici)1097-0258(19990915/30)18:17/18<2421:subject
Has Abstractpub_date
1999-09-15 00:00:00pages
2421-34issue
17-18eissn
0277-6715issn
1097-0258pii
10.1002/(SICI)1097-0258(19990915/30)18:17/18<2421:journal_volume
18pub_type
杂志文章abstract::Clinical trials with multiple endpoints incur increased familywise type I errors. The Bonferroni correction is a common method used to modify the p-values to account for multiple significance testing. For independent endpoints the Bonferroni method is slightly conservative whereas with high correlation the conservatis...
journal_title:Statistics in medicine
pub_type: 杂志文章
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journal_title:Statistics in medicine
pub_type: 杂志文章
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journal_title:Statistics in medicine
pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:2000-11-15 00:00:00
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journal_title:Statistics in medicine
pub_type: 杂志文章
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abstract::In a recent Statistics in Medicine paper, Warn, Thompson and Spiegelhalter (WTS) made a comparison between the Bayesian approach to the meta-analysis of binary outcomes and a popular Classical approach that uses summary (two-stage) techniques. They included approximate summary (two-stage) Bayesian techniques in their ...
journal_title:Statistics in medicine
pub_type: 评论,信件
doi:10.1002/sim.2115
更新日期:2005-09-15 00:00:00
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pub_type: 杂志文章
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pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:2013-11-10 00:00:00
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更新日期:2007-02-10 00:00:00
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pub_type: 杂志文章
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更新日期:2007-08-15 00:00:00
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pub_type: 杂志文章
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更新日期:2016-07-30 00:00:00
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pub_type: 杂志文章
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更新日期:1996-12-30 00:00:00
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pub_type: 杂志文章
doi:10.1002/(SICI)1097-0258(19960730)15:14<1545::AID-S
更新日期:1996-07-30 00:00:00
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pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1002/(sici)1097-0258(19970430)16:8<941::aid-sim
更新日期:1997-04-30 00:00:00
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pub_type: 杂志文章
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更新日期:2005-08-15 00:00:00
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pub_type: 杂志文章
doi:10.1002/(sici)1097-0258(19991215)18:23<3263::aid-s
更新日期:1999-12-15 00:00:00
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journal_title:Statistics in medicine
pub_type: 临床试验,杂志文章,随机对照试验
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pub_type: 杂志文章
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pub_type: 杂志文章
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