A transition model for quality-of-life data with non-ignorable non-monotone missing data.

abstract：:Cost data that arise in the evaluation of health care technologies usually exhibit highly skew, heavy-tailed and, possibly, multi-modal distributions. Distribution-free methods for analysing these data, such as the bootstrap, or those based on the asymptotic normality of sample means, may often lead to inefficient or ...

journal_title：Statistics in medicine

authors： Conigliani C,Tancredi A

更新日期：2005-10-30 00:00:00

abstract：:Many studies have reported large variations in age- and sex-adjusted rates of hospitalizations across small geographic areas. These variations have often been attributed to differences in medical practice style which are not reflected in differences in health care outcomes. There is, however, another potentially impor...

journal_title：Statistics in medicine

authors： Peköz EA,Shwartz M,Iezzoni LI,Ash AS,Posner MA,Restuccia JD

更新日期：2003-05-30 00:00:00

abstract：:Proportional odds regression models for multinomial probabilities based on ordered categories have been generalized in two somewhat different directions. Models having scale as well as location parameters for adjustment of boundaries (on an unobservable, underlying continuum) between categories have been employed in t...

journal_title：Statistics in medicine

authors： Cox C

更新日期：1995-06-15 00:00:00

abstract：:Data on alcohol availability and problems in all cities in Los Angeles County were collected from several different sources and linked together to form a Local Alcohol Availability Database (LAAD). The two major purposes of the project are to provide a city-level alcohol availability and alcohol-related problems datab...

journal_title：Statistics in medicine

authors： MacKinnon DP,Scribner R,Taft KA

更新日期：1995-03-15 00:00:00

abstract：:Obtaining accurate estimates of the performance of a diagnostic test for some population of patients might be difficult when the sample of subjects used for this purpose is not representative for the whole population. Thus, in the motivating example of this paper a test is evaluated by comparing its results with those...

journal_title：Statistics in medicine

authors： Buzoianu M,Kadane JB

更新日期：2008-06-15 00:00:00

abstract：:Clinical trials often assess efficacy by comparing treatments on the basis of two or more event-time outcomes. In the case of cancer clinical trials, progression-free survival (PFS), which is the minimum of the time from randomization to progression or to death, summarizes the comparison of treatments on the hazards f...

journal_title：Statistics in medicine

authors： Finkelstein DM,Schoenfeld DA

更新日期：2014-05-30 00:00:00

abstract：:Risk prediction procedures can be quite useful for the patient's treatment selection, prevention strategy, or disease management in evidence-based medicine. Often, potentially important new predictors are available in addition to the conventional markers. The question is how to quantify the improvement from the new ma...

journal_title：Statistics in medicine

authors： Uno H,Tian L,Cai T,Kohane IS,Wei LJ

更新日期：2013-06-30 00:00:00

abstract：:To update the British growth reference, anthropometric data for weight, height, body mass index (weight/height2) and head circumference from 17 distinct surveys representative of England, Scotland and Wales (37,700 children, age range 23 weeks gestation to 23 years) were analysed by maximum penalized likelihood using ...

journal_title：Statistics in medicine

authors： Cole TJ,Freeman JV,Preece MA

更新日期：1998-02-28 00:00:00

abstract：:Matched-pair designs have been commonly employed in diagnostic, epidemiologic and laboratory studies. For estimation of a ratio of two marginal probabilities in matched-pair data, a Wald-type logarithmic method is computationally simple, but an actual coverage rate is known to be smaller than a nominal one and a lengt...

journal_title：Statistics in medicine

authors： Nam JM

更新日期：2009-10-15 00:00:00

abstract：:Prevalence data provided by cancer registries are generally biased, since the patients that were diagnosed before the starting of the registry's activity cannot be included in the statistics. The relevance of this incompleteness bias is estimated in this paper. Incidence and relative survival are modelled as parametri...

journal_title：Statistics in medicine

authors： Capocaccia R,De Angelis R

更新日期：1997-02-28 00:00:00

abstract：:This paper examines several methods for deriving standardized morbidity ratios (SMR) and attributable fraction (attributable risk percentage) estimates. We show that some of the proposed methods will, in general, produce biased estimators, although the low variance of certain estimators sometimes compensates for their...

journal_title：Statistics in medicine

authors： Greenland S

更新日期：1984-04-01 00:00:00

abstract：:Standard approaches to analysis of randomized controlled trials (RCTs) using Markov models make it difficult to generalize treatment effects to new patient groups and synthesize evidence across trials. This paper demonstrates how pair-wise and mixed treatment comparison meta-analysis can be applied to event history da...

journal_title：Statistics in medicine

authors： Price MJ,Welton NJ,Ades AE

更新日期：2011-01-30 00:00:00

abstract：:The use of outcome-dependent sampling with longitudinal data analysis has previously been shown to improve efficiency in the estimation of regression parameters. The motivating scenario is when outcome data exist for all cohort members but key exposure variables will be gathered only on a subset. Inference with outcom...

journal_title：Statistics in medicine

authors： Zelnick LR,Schildcrout JS,Heagerty PJ

更新日期：2018-06-15 00:00:00

abstract：:Recurrent event data are commonly encountered in health-related longitudinal studies. In this paper time-to-events models for recurrent event data are studied with non-informative and informative censorings. In statistical literature, the risk set methods have been confirmed to serve as an appropriate and efficient ap...

journal_title：Statistics in medicine

authors： Wang MC,Chiang CT

更新日期：2002-02-15 00:00:00

abstract：:When estimating the average effect of a binary treatment (or exposure) on an outcome, methods that incorporate propensity scores, the G-formula, or targeted maximum likelihood estimation (TMLE) are preferred over naïve regression approaches, which are biased under misspecification of a parametric outcome model. In con...

journal_title：Statistics in medicine

authors： Luque-Fernandez MA,Schomaker M,Rachet B,Schnitzer ME

更新日期：2018-07-20 00:00:00

abstract：:Knee replacement is the most commonly used surgical treatment for knee arthritis. It has been reported that knee replacement rates vary across both regions and counties. This paper used data from Medicare patients to develop explanations for the variation. One problem with our data is that we do not have patient level...

journal_title：Statistics in medicine

authors： Zhou XH,Katz BP,Holleman E,Melfi CA,Dittus R

更新日期：1996-09-15 00:00:00

abstract：:The setting of a quarantine time for an emerging infectious disease will depend on current knowledge concerning incubation times. Methods for the analysis of information on incubation times are investigated with a particular focus on inference regarding a possible maximum incubation time, after which an exposed indivi...

journal_title：Statistics in medicine

authors： Farewell VT,Herzberg AM,James KW,Ho LM,Leung GM

更新日期：2005-11-30 00:00:00

abstract：:Inference for randomized clinical trials is generally based on the assumption that outcomes are independently and identically distributed under the null hypothesis. In some trials, particularly in infectious disease, outcomes may be correlated. This may be known in advance (e.g. allowing randomization of family member...

journal_title：Statistics in medicine

authors： Proschan M,Follmann D

更新日期：2008-03-15 00:00:00

abstract：:Exposure to a carcinogen is likely to be reflected by temporal clustering of cancer cases among the community members. Detection of such clustering is a complicated task in general and more so in a small workplace community with low turnover rate. In this study we applied the CUSCORE test and the q-interval statistic ...

journal_title：Statistics in medicine

authors： Chen R,Froom P

更新日期：2003-10-15 00:00:00

abstract：:For the analysis of time to event data in contraceptive studies when individuals are subject to competing causes for discontinuation, some authors have recently advocated the use of the cumulative incidence rate as a more appropriate measure to summarize data than the complement of the Kaplan-Meier estimate of discont...

journal_title：Statistics in medicine

authors： Farley TM,Ali MM,Slaymaker E

更新日期：2001-12-15 00:00:00

abstract：:Methods for dealing with tied event times in the Cox proportional hazards model are well developed. Also, the partial likelihood provides a natural way to handle covariates that change over time. However, ties between event times and the times that discrete time-varying covariates change have not been systematically s...

journal_title：Statistics in medicine

authors： Xin X,Horrocks J,Darlington GA

更新日期：2013-06-30 00:00:00

abstract：:It is often of interest to use observational data to estimate the causal effect of a target exposure or treatment on an outcome. When estimating the treatment effect, it is essential to appropriately adjust for selection bias due to observed confounders using, for example, propensity score weighting. Selection bias du...

journal_title：Statistics in medicine

authors： Parast L,Griffin BA

更新日期：2020-08-15 00:00:00

abstract：:Statistical modeling methods have had increasing use in drug disposition studies, both to estimate pharmacokinetic parameters and to develop regression models that relate these parameter estimates to patient characteristics. These methods are particularly flexible as they allow non-linearity and sparse within-patient ...

journal_title：Statistics in medicine

authors： Roe DJ

更新日期：1997-06-15 00:00:00

abstract：:I discuss alternatives to the one compartment model, delta Yt = alpha + beta exp(- gamma t). Instead of comparing the one and two compartment models, I derive statistics for testing mixtures of the parameters (beta, gamma) in the one compartment model. I apply the proposed methods to the problem of hydrogen clearance ...

journal_title：Statistics in medicine

authors： Zelterman D

更新日期：1989-08-01 00:00:00

abstract：:The correct identification of change-points during ongoing outbreak investigations of infectious diseases is a matter of paramount importance in epidemiology, with major implications for the management of health care resources, public health and, as the COVID-19 pandemic has shown, social live. Onsets, peaks, and infl...

journal_title：Statistics in medicine

authors： Veres-Ferrer EJ,Pavía JM

更新日期：2021-02-20 00:00:00

abstract：:Biomarkers, increasingly used in biomedical studies for the diagnosis and prognosis of acute and chronic diseases, provide insight into the effectiveness of treatments and potential pathways that can be used to guide future treatment targets. The measurement of these markers is often limited by the sensitivity of the ...

journal_title：Statistics in medicine

authors： Lee M,Kong L,Weissfeld L

更新日期：2012-07-30 00:00:00

abstract：:Immigration-death models are proposed to analyse the infection dynamics in longitudinal studies of panels of heavily parasitized human hosts where parasites have been typed at regular intervals by PCR. Immigration refers to the acquisition of a new parasitic genotype, occurring at rate lambda, and death refers to the ...

journal_title：Statistics in medicine

authors： Sama W,Owusu-Agyei S,Felger I,Vounatsou P,Smith T

更新日期：2005-11-15 00:00:00

abstract：:The Box-Cox power exponential (BCPE) distribution, developed in this paper, provides a model for a dependent variable Y exhibiting both skewness and kurtosis (leptokurtosis or platykurtosis). The distribution is defined by a power transformation Y(nu) having a shifted and scaled (truncated) standard power exponential ...

journal_title：Statistics in medicine

authors： Rigby RA,Stasinopoulos DM

更新日期：2004-10-15 00:00:00

abstract：:Conditional power and predictive power provide estimates of the probability of success at the end of the trial based on the information from the interim analysis. The observed value of the time to event endpoint at the interim analysis could be biased for the true treatment effect due to early censoring, leading to a ...

journal_title：Statistics in medicine

authors： Sun L,Wan Y

更新日期：2018-08-15 00:00:00

abstract：:R2 has been criticized as a measure of model performance when predicting a dichotomous outcome, both because its value is often low and because it is sensitive to the prevalence of the event of interest. The C statistic is more widely used to measure model performance in a 0/1 setting. We use a simple parametric famil...

journal_title：Statistics in medicine

authors： Ash A,Shwartz M

更新日期：1999-02-28 00:00:00