Abstract:
:Quantifying socioeconomic disparities and understanding the roots of inequalities are growing topics in cancer research. However, socioeconomic differences are challenging to investigate mainly due to the lack of accurate data at individual-level, while aggregate indicators are only partially informative. We implemented a multiple imputation algorithm within a statistical matching framework that combines diverse sources of data to estimate individual-level associations between income and risk of breast and lung cancer, adjusting for potential confounding factors in Italy. The framework is computationally flexible and can be adapted to similar contexts.
journal_name
Stat Medjournal_title
Statistics in medicineauthors
Mezzetti M,Palli D,Dominici Fdoi
10.1002/sim.8392subject
Has Abstractpub_date
2020-01-15 00:00:00pages
26-44issue
1eissn
0277-6715issn
1097-0258journal_volume
39pub_type
杂志文章abstract::Current methods for statistical analysis of twin studies focus on continuous and dichotomous data, while only limited methodology exists for analysing multinomial data. As a consequence, investigators are often tempted to collapse multinomial data into two categories simply to facilitate the analysis. We address this ...
journal_title:Statistics in medicine
pub_type: 杂志文章
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abstract::Sample size planning should reflect the primary objective of a trial. If the primary objective is prediction, the sample size determination should focus on prediction accuracy instead of power. We present formulas for the determination of training set sample size for survival prediction. Sample size is chosen to contr...
journal_title:Statistics in medicine
pub_type: 杂志文章
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更新日期:2013-02-28 00:00:00
abstract::In order for national statistical offices to maintain the trust of the public to collect data and publish statistics of importance to society and decision-making, it is imperative that respondents (persons or establishments) be guaranteed privacy and confidentiality in return for providing requested confidential data....
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doi:10.1002/sim.2043
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journal_title:Statistics in medicine
pub_type: 杂志文章
doi:10.1002/sim.1138
更新日期:2002-06-30 00:00:00
abstract::We discuss some of the fundamental concepts underlying the development of frailty and random effects models in survival. One of these fundamental concepts was the idea of a frailty model where each subject has his or her own disposition to failure, their so-called frailty, additional to any effects we wish to quantify...
journal_title:Statistics in medicine
pub_type: 杂志文章
doi:10.1002/sim.1259
更新日期:2002-11-15 00:00:00
abstract::Few methods are currently available for group sequential analysis of recurrent events data subject to a terminal event in the clinical trial setting. This research helps fill this gap by developing a completely nonparametric group sequential monitoring procedure for use with the two-sample Tayob and Murray statistic. ...
journal_title:Statistics in medicine
pub_type: 杂志文章
doi:10.1002/sim.8389
更新日期:2019-12-30 00:00:00
abstract::This paper discusses regression analysis of multivariate current status failure time data (The Statistical Analysis of Interval-censoring Failure Time Data. Springer: New York, 2006), which occur quite often in, for example, tumorigenicity experiments and epidemiologic investigations of the natural history of a diseas...
journal_title:Statistics in medicine
pub_type: 杂志文章
doi:10.1002/sim.3715
更新日期:2009-11-30 00:00:00
abstract::When sample size is recalculated using unblinded interim data, use of the usual t-test at the end of a study may lead to an elevated type I error rate. This paper describes a numerical quadrature investigation to calculate the true probability of rejection as a function of the time of the recalculation, the magnitude ...
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更新日期:1999-12-30 00:00:00
abstract::In a typical bioequivalence trial, summary measures of the plasma concentration versus time profile are used to compare two formulations of a drug product. Commonly used measures include area under the curve (AUC), maximum plasma concentration (C(max)) and time to maximum concentration (T(max)). Equivalence of these s...
journal_title:Statistics in medicine
pub_type: 杂志文章
doi:10.1002/1097-0258(20001030)19:20<2855::aid-sim550>
更新日期:2000-10-30 00:00:00
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pub_type: 杂志文章,多中心研究
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journal_title:Statistics in medicine
pub_type: 杂志文章
doi:10.1002/sim.6280
更新日期:2014-11-20 00:00:00
abstract::Between-community variance or community-by-time variance is one of the key factors driving the cost of conducting group randomized trials, which are often very expensive. We investigated empirically whether between-community variance could be reduced by controlling individual- and/or community-level covariates and ide...
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pub_type: 杂志文章
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更新日期:1999-03-15 00:00:00
abstract::Instrumental variable estimates of causal effects can be biased when using many instruments that are only weakly associated with the exposure. We describe several techniques to reduce this bias and estimate corrected standard errors. We present our findings using a simulation study and an empirical application. For th...
journal_title:Statistics in medicine
pub_type: 杂志文章
doi:10.1002/sim.6358
更新日期:2015-02-10 00:00:00
abstract::The statistical analysis of panel count data has recently attracted a great deal of attention, and a number of approaches have been developed. However, most of these approaches are for situations where the observation and follow-up processes are independent of the underlying recurrent event process unconditional or co...
journal_title:Statistics in medicine
pub_type: 杂志文章
doi:10.1002/sim.5724
更新日期:2013-07-30 00:00:00
abstract::Motivated by a study for soft tissue sarcoma, this article considers the analysis of diseases recurrence and survival. A multivariate frailty hazard model is established for joint modeling of three correlated time-to-event outcomes: local disease recurrence, distant disease recurrence (metastasis), and death. The goal...
journal_title:Statistics in medicine
pub_type: 杂志文章
doi:10.1002/sim.7030
更新日期:2016-11-20 00:00:00
abstract::Given N points or events occurring according to some probability distribution in the unit interval (0, 1), the simple scan statistic is defined to be the maximum number of points in any sub-interval of length d. In many areas, as in epidemiology, it is used to test the null hypothesis that the events are random, again...
journal_title:Statistics in medicine
pub_type: 杂志文章
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更新日期:1996-04-15 00:00:00
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journal_title:Statistics in medicine
pub_type: 杂志文章
doi:10.1002/sim.1724
更新日期:2004-04-30 00:00:00
abstract::Small but important therapeutic effects of new treatments can be most efficiently detected through the study of large randomized prospective series of patients. Such large scale clinical trials are nowadays commonplace. The alternative is years of polemic and debate surrounding several trials each too small to detect ...
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pub_type: 杂志文章
doi:10.1002/sim.4780010105
更新日期:1982-01-01 00:00:00
abstract::Relative survival provides a measure of the proportion of patients dying from the disease under study without requiring the knowledge of the cause of death. We propose an overall strategy based on regression models to estimate the relative survival and model the effects of potential prognostic factors. The baseline ha...
journal_title:Statistics in medicine
pub_type: 杂志文章
doi:10.1002/sim.2656
更新日期:2007-05-10 00:00:00
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journal_title:Statistics in medicine
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doi:10.1002/sim.4780131105
更新日期:1994-06-15 00:00:00
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journal_title:Statistics in medicine
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abstract::The effective dose (ED) is the pharmaceutical dosage required to produce a therapeutic response in a fixed proportion of the patients. When only one drug is considered, the problem is a univariate one and has been well-studied. However, in the multidimensional setting, that is, in the presence of combinations of agent...
journal_title:Statistics in medicine
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doi:10.1002/sim.6226
更新日期:2014-10-30 00:00:00
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journal_title:Statistics in medicine
pub_type: 杂志文章
doi:10.1002/sim.7827
更新日期:2018-10-30 00:00:00
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journal_title:Statistics in medicine
pub_type: 杂志文章
doi:10.1002/sim.7346
更新日期:2017-09-10 00:00:00
abstract::Confounding factors are commonly encountered in observational studies. Several confounder-adjusted tests to compare survival between differently exposed subjects were proposed. However, only few studies have compared their performances regarding type I error rates, and no study exists evaluating their type II error ra...
journal_title:Statistics in medicine
pub_type: 杂志文章
doi:10.1002/sim.6777
更新日期:2016-03-30 00:00:00
abstract::In the medical literature, hundreds of prediction models are being developed to predict health outcomes in individuals. For continuous outcomes, typically a linear regression model is developed to predict an individual's outcome value conditional on values of multiple predictors (covariates). To improve model developm...
journal_title:Statistics in medicine
pub_type: 杂志文章
doi:10.1002/sim.7993
更新日期:2019-03-30 00:00:00
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journal_title:Statistics in medicine
pub_type: 杂志文章
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更新日期:2011-11-20 00:00:00
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journal_title:Statistics in medicine
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