Abstract:
:This paper presents combinatorial (exact) methods that are useful in the analysis of disease cluster data obtained from small environments, such as buildings and neighbourhoods. Maxwell-Boltzmann and Fermi-Dirac occupancy models are compared in terms of appropriateness of representation of disease incidence patterns (space and/or time) in these environments. The methods are illustrated by a statistical analysis of the incidence pattern of bone fractures in a setting wherein fracture clustering was alleged to be occurring. One of the methodological results derived in this paper is the exact distribution of the maximum cell frequency in occupancy models.
journal_name
Stat Medjournal_title
Statistics in medicineauthors
Grimson RCdoi
10.1002/sim.4780121906subject
Has Abstractpub_date
1993-10-01 00:00:00pages
1773-94issue
19-20eissn
0277-6715issn
1097-0258journal_volume
12pub_type
杂志文章abstract::In a longitudinal study of workers in seven Norwegian aluminium plants, the time to development of asthmatic symptoms could only be determined to lie in the interval between two consecutive health examinations. In a previous paper we analysed the data by survival techniques for interval censored data. In the present p...
journal_title:Statistics in medicine
pub_type: 杂志文章
doi:10.1002/sim.4780131708
更新日期:1994-09-15 00:00:00
abstract::We present an approach for inference on contrasts of clinically meaningful functionals of a survivor distribution (e.g., restricted mean, quantiles) that can avoid strong parametric or semiparametric assumptions on the underlying structure of the data. In this multistage approach, we first use an adaptive predictive m...
journal_title:Statistics in medicine
pub_type: 杂志文章
doi:10.1002/sim.4505
更新日期:2012-07-20 00:00:00
abstract::This article introduces a global hypothesis test intended for studies with multiple endpoints. Our test makes use of a priori predictions about the direction of the result of each endpoint and we weight these predictions using the sample correlation matrix. The global alternative hypothesis concerns a parameter, ...
journal_title:Statistics in medicine
pub_type: 杂志文章
doi:10.1002/sim.8724
更新日期:2020-12-10 00:00:00
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journal_title:Statistics in medicine
pub_type: 杂志文章
doi:10.1002/sim.8377
更新日期:2019-11-30 00:00:00
abstract::For many HIV-infected patients, use of antiretroviral therapy (ART) results in a sustained suppression of plasma viral load to undetectable levels. However, due to lack of antigenic stimulation, this may also result in a gradual loss of cell-mediated immune (CMI) responses that help control HIV infection. In concept, ...
journal_title:Statistics in medicine
pub_type: 杂志文章
doi:10.1002/sim.2555
更新日期:2007-02-10 00:00:00
abstract::We extend the method proposed in a recent work by the Authors for trial-level general surrogate evaluation to allow combinations of biomarkers and provide a procedure for finding the "best" combination of biomarkers based on the absolute prediction error summary of surrogate quality. We use a nonparametric Bayesian mo...
journal_title:Statistics in medicine
pub_type: 杂志文章
doi:10.1002/sim.7996
更新日期:2019-03-30 00:00:00
abstract::In phase 3 clinical trials, ethical and financial concerns motivate sequential analyses in which the data are analyzed prior to completion of the entire planned study. Existing group sequential software accounts for the effects of these interim analyses on the sampling density by assuming that the contribution of subs...
journal_title:Statistics in medicine
pub_type: 杂志文章
doi:10.1002/sim.6306
更新日期:2014-12-20 00:00:00
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journal_title:Statistics in medicine
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更新日期:2017-11-10 00:00:00
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journal_title:Statistics in medicine
pub_type: 杂志文章
doi:10.1002/sim.4780060602
更新日期:1987-09-01 00:00:00
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journal_title:Statistics in medicine
pub_type: 杂志文章
doi:10.1002/sim.3891
更新日期:2010-06-15 00:00:00
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journal_title:Statistics in medicine
pub_type: 杂志文章
doi:10.1002/(sici)1097-0258(19990630)18:12<1529::aid-s
更新日期:1999-06-30 00:00:00
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journal_title:Statistics in medicine
pub_type: 杂志文章
doi:10.1002/sim.968
更新日期:2001-11-30 00:00:00
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journal_title:Statistics in medicine
pub_type: 杂志文章
doi:10.1002/sim.1259
更新日期:2002-11-15 00:00:00
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journal_title:Statistics in medicine
pub_type: 杂志文章
doi:10.1002/sim.1381
更新日期:2003-06-15 00:00:00
abstract::Weak measurement of epidemiologic exposures is an impediment to appreciation of the effects of those exposures. This paper discusses two strategies to assess the true effects of weakly measured exposure. The first is to use external information about the extent of mismeasurement to adjust estimates of the effects of e...
journal_title:Statistics in medicine
pub_type: 杂志文章
doi:10.1002/sim.4780080904
更新日期:1989-09-01 00:00:00
abstract::In standard time-to-event or survival analysis, occurrence times of the event of interest are observed exactly or are right-censored, meaning that it is only known that the event occurred after the last observation time. There are numerous methods available for estimating the survival curve and for testing and estimat...
journal_title:Statistics in medicine
pub_type: 杂志文章,评审
doi:10.1002/(sici)1097-0258(19980130)17:2<219::aid-sim
更新日期:1998-01-30 00:00:00
abstract::In case-control studies, the Cochran-Armitage (CA) trend test is powerful for detection of an association between a risk allele and a marker. To apply this test, a score should be assigned to the genotypes based on the genetic model. When the underlying genetic model is unknown, the trend test statistic is a function ...
journal_title:Statistics in medicine
pub_type: 杂志文章
doi:10.1002/sim.1474
更新日期:2003-08-30 00:00:00
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journal_title:Statistics in medicine
pub_type: 杂志文章
doi:10.1002/1097-0258(20000830)19:16<2195::aid-sim522>
更新日期:2000-08-30 00:00:00
abstract::We describe how trends in the vaccination coverage at 19 months of age vary by race/ethnicity; explore the extent to which data required to evaluate a child's up-to-date vaccination status is missing as a result of the scattering of vaccination records among many vaccination providers; evaluate how the prevalence of t...
journal_title:Statistics in medicine
pub_type: 杂志文章
doi:10.1002/sim.3223
更新日期:2008-09-10 00:00:00
abstract::We consider the analysis of serial biomarkers to screen and monitor individuals in a given population for onset of a specific disease of interest. The biomarker readings are subject to error. We survey some of the existing literature and concentrate on two recently proposed models. The first is a fully Bayesian hierar...
journal_title:Statistics in medicine
pub_type: 杂志文章
doi:10.1002/(sici)1097-0258(20000229)19:4<617::aid-sim
更新日期:2000-02-29 00:00:00
abstract::This paper models monthly AIDS diagnosis counts in terms of smooth secular trend, calendar month effects, and the number of workdays per month. A parameterization of month effects allows separation of true seasonal effects from a linear trend over the calendar year and an arbitrary June effect. There is strong evidenc...
journal_title:Statistics in medicine
pub_type: 杂志文章
doi:10.1002/sim.4780131905
更新日期:1994-10-15 00:00:00
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journal_title:Statistics in medicine
pub_type: 杂志文章
doi:10.1002/sim.7992
更新日期:2019-03-30 00:00:00
abstract::The aim of this paper is to demonstrate the effect of excluding incomplete observations and competing events when calculating cross-sectional measures of NHS waiting times, and to obtain a more accurate estimate of the 'time-to-admission' of those listed on NHS waiting lists using life-table methods. The official 'tim...
journal_title:Statistics in medicine
pub_type: 杂志文章
doi:10.1002/1097-0258(20000815)19:15<2037::aid-sim606>
更新日期:2000-08-15 00:00:00
abstract::Studies involving longitudinal binary responses are widely applied in the health and biomedical sciences research and frequently analyzed by generalized estimating equations (GEE) method. This article proposes an alternative goodness-of-fit test based on the nonparametric smoothing approach for assessing the adequacy ...
journal_title:Statistics in medicine
pub_type: 杂志文章
doi:10.1002/sim.3315
更新日期:2008-09-30 00:00:00
abstract::This paper discusses design considerations and the role of randomization-based inference in randomized community intervention trials. We stress that longitudinal follow-up of cohorts within communities often yields useful information on the effects of intervention on individuals, whereas cross-sectional surveys can us...
journal_title:Statistics in medicine
pub_type: 杂志文章,评审
doi:10.1002/(SICI)1097-0258(19960615)15:11<1069::AID-S
更新日期:1996-06-15 00:00:00
abstract::This paper describes a method for estimating the risk from a disease over a set of contiguous geographical regions, when data on a potentially important covariate, such as race, are not available. Conditions under which the extra margin can be recovered are suggested. An application to prostate cancer mortality among ...
journal_title:Statistics in medicine
pub_type: 杂志文章
doi:10.1002/1097-0258(20000915/30)19:17/18<2243::aid-s
更新日期:2000-09-15 00:00:00
abstract::Phase II trials often test the null hypothesis H(0): p
journal_title:Statistics in medicine
pub_type: 杂志文章
doi:10.1002/sim.2653
更新日期:2007-03-30 00:00:00
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journal_title:Statistics in medicine
pub_type: 杂志文章,评审
doi:10.1002/sim.4780080908
更新日期:1989-09-01 00:00:00
abstract::Medical costs data with administratively censored observations often arise in cost-effectiveness studies of treatments for life-threatening diseases. Mean of medical costs incurred from the start of a treatment until death or a certain time point after the implementation of treatment is frequently of interest. In many...
journal_title:Statistics in medicine
pub_type: 杂志文章
doi:10.1002/sim.1556
更新日期:2004-11-15 00:00:00
abstract::Maps of estimated disease rates over multiple time periods are useful tools for gaining etiologic insights regarding potential exposures associated with specific locations and times. In this paper, we describe an extension of the Gangnon-Clayton model for spatial clustering to spatio-temporal data. As in the purely sp...
journal_title:Statistics in medicine
pub_type: 杂志文章
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更新日期:2010-09-30 00:00:00