Abstract:
:Mesothelioma is a rare cancer caused by exposure to asbestos. Belgium has a known long history of asbestos production, resulting in one of the highest mesothelioma mortality rates worldwide. While the production of asbestos has stopped completely, the long latency period of mesothelioma, which can fluctuate between 20 and 40 years after exposure, causes incidences still to be frequent. Mesothelioma's long incubation time affects our assessment of its geographical distribution as well. Since patients' residential locations are likely to change a number of times throughout their lives, the location where the patients develop the disease is often far from the location where they were exposed to asbestos. Using the residential history of patients, we propose the use of a convolution multiple membership model (MMM), which includes both a spatial conditional autoregressive and an unstructured random effect. Pancreatic cancer patients are used as a control population, reflecting the population at risk for mesothelioma. Results show the impact of the residential mobility on the geographical risk estimation, as well as the importance of acknowledging the latency period of a disease. A simulation study was conducted to investigate the properties of the convolution MMM. The robustness of the results for the convolution MMM is assessed via a sensitivity analysis.
journal_name
Stat Medjournal_title
Statistics in medicineauthors
Petrof O,Neyens T,Nuyts V,Nackaerts K,Nemery B,Faes Cdoi
10.1002/sim.8697subject
Has Abstractpub_date
2020-11-20 00:00:00pages
3840-3866issue
26eissn
0277-6715issn
1097-0258journal_volume
39pub_type
杂志文章abstract::A Non-Parametric Maximum Likelihood approach to the estimation of relative risks in the context of disease mapping is discussed and a NPML approximation to conditional autoregressive models is proposed. NPML estimates have been compared to other proposed solutions (Maximum Likelihood via Monte Carlo Scoring, Hierarchi...
journal_title:Statistics in medicine
pub_type: 杂志文章
doi:10.1002/1097-0258(20000915/30)19:17/18<2539::aid-s
更新日期:2000-09-15 00:00:00
abstract::Biomedical studies often measure variables with error. Examples in the literature include investigation of the association between the change in some outcome variable (blood pressure, cholesterol level etc.) and a set of explanatory variables (age, smoking status etc.). Typically, one fits linear regression models to ...
journal_title:Statistics in medicine
pub_type: 杂志文章
doi:10.1002/(sici)1097-0258(19981130)17:22<2597::aid-s
更新日期:1998-11-30 00:00:00
abstract::This paper presents a general approach for simultaneously assessing, from serial data, diagnostic consistency, interrater reliability and incidence of a strictly progressive disease. Observed data are viewed as incomplete: diagnostic errors are not distinguished from true diagnoses. We introduce a broad class of model...
journal_title:Statistics in medicine
pub_type: 杂志文章
doi:10.1002/sim.4780070306
更新日期:1988-03-01 00:00:00
abstract::Hierarchical regression analysis holds much promise for epidemiologic analysis, but has as yet seen limited application because of lack of easily used software and the relatively lengthy run times of preferred fitting methods (such as true maximum likelihood and Bayesian approaches). This paper compares three relative...
journal_title:Statistics in medicine
pub_type: 杂志文章
doi:10.1002/(sici)1097-0258(19970315)16:5<515::aid-sim
更新日期:1997-03-15 00:00:00
abstract::We obtained maximum likelihood estimates (MLEs) of the proportion cured pi c and mean log survival time mu t for a sample of 4355 patients with intraocular melanoma whose survival times subsequent to treatment were assumed to follow a log-normal distribution. Following stratification by tumour size, MLEs of pi c and m...
journal_title:Statistics in medicine
pub_type: 杂志文章
doi:10.1002/sim.4780090814
更新日期:1990-08-01 00:00:00
abstract::The microbiome plays an important role in human health by mediating the path from environmental exposures to health outcomes. The relative abundances of the high-dimensional microbiome data have an unit-sum restriction, rendering standard statistical methods in the Euclidean space invalid. To address this problem, we ...
journal_title:Statistics in medicine
pub_type: 杂志文章
doi:10.1002/sim.8808
更新日期:2021-02-20 00:00:00
abstract::It is often assumed that randomisation will prevent bias in estimation of treatment effects from clinical trials, but this is not true of the semiparametric Proportional Hazards model for survival data when there is underlying risk heterogeneity. Here, a new formula is proposed for estimation of this bias, improving o...
journal_title:Statistics in medicine
pub_type: 杂志文章
doi:10.1002/sim.7343
更新日期:2017-09-20 00:00:00
abstract::Interpretation of the Mantoux test for tuberculous infection can be complicated by cross-reactions caused by infection with non-specific mycobacteria. Thus, the distribution of positive indurations is a mixture of two distributions. To estimate tuberculous infection prevalence, the marginal distribution of indurations...
journal_title:Statistics in medicine
pub_type: 杂志文章
doi:10.1002/sim.745
更新日期:2001-04-15 00:00:00
abstract::We simulated multinomial AIDS incidence counts from 27 'representative' AIDS epidemics that spanned a period corresponding to previous applications of backcalculation (1 January 1977 to 1 July 1987) and assessed mean square error for several back-calculated estimators of HIV prevalence and short-term AIDS projections....
journal_title:Statistics in medicine
pub_type: 杂志文章
doi:10.1002/sim.4780100802
更新日期:1991-08-01 00:00:00
abstract::Multivariate random length data occur when we observe multiple measurements of a quantitative variable and the variable number of these measurements is also an observed outcome for each experimental unit. For example, for a patient with coronary artery disease, we may observe a number of lesions in that patient's coro...
journal_title:Statistics in medicine
pub_type: 杂志文章
doi:10.1002/(sici)1097-0258(19990130)18:2<199::aid-sim
更新日期:1999-01-30 00:00:00
abstract::Testing the equality of 2 proportions for a control group versus a treatment group is a well-researched statistical problem. In some settings, there may be strong historical data that allow one to reliably expect that the control proportion is one, or nearly so. While one-sample tests or comparisons to historical cont...
journal_title:Statistics in medicine
pub_type: 杂志文章
doi:10.1002/sim.7579
更新日期:2018-03-30 00:00:00
abstract::Identification of treatment selection biomarkers has become very important in cancer drug development. Adaptive enrichment designs have been developed for situations where a unique treatment selection biomarker is not apparent based on the mechanism of action of the drug. With such designs, the eligibility rules may b...
journal_title:Statistics in medicine
pub_type: 杂志文章
doi:10.1002/sim.7422
更新日期:2017-11-20 00:00:00
abstract::To study the spread of sexually transmitted diseases (STDs) using social/sexual mixing models, one must have quantitative information about sexual mixing. An unavoidable complication in gathering such information by survey is that members of the surveyed population will almost certainly have sexual contacts outside th...
journal_title:Statistics in medicine
pub_type: 杂志文章
doi:10.1002/sim.4780111202
更新日期:1992-09-15 00:00:00
abstract::Lower urinary tract symptoms can indicate the presence of urinary tract infection (UTI), a condition that if it becomes chronic requires expensive and time consuming care as well as leading to reduced quality of life. Detecting the presence and gravity of an infection from the earliest symptoms is then highly valuable...
journal_title:Statistics in medicine
pub_type: 杂志文章
doi:10.1002/sim.6786
更新日期:2016-04-15 00:00:00
abstract::Omitted variable bias is discussed in the context of linear models. It is shown that the effect of omitted variables can be controlled in linear models for metric dependent variables by using data from follow-up studies. Two different models for analysing such data are proposed. In the first model the omitted variable...
journal_title:Statistics in medicine
pub_type: 杂志文章
doi:10.1002/sim.4780110906
更新日期:1992-06-30 00:00:00
abstract::This paper investigates the impact on area life tables of the specification of unobserved frailty. Frailty specification may affect both the regression effects of area and individual level covariates, and lead to changes in the value of summary mortality parameters, such as life expectancy. The paper also investigates...
journal_title:Statistics in medicine
pub_type: 杂志文章
doi:10.1002/sim.4780141703
更新日期:1995-09-15 00:00:00
abstract::Multistate models are increasingly being used to model complex disease profiles. By modelling transitions between disease states, accounting for competing events at each transition, we can gain a much richer understanding of patient trajectories and how risk factors impact over the entire disease pathway. In this arti...
journal_title:Statistics in medicine
pub_type: 杂志文章
doi:10.1002/sim.7448
更新日期:2017-12-20 00:00:00
abstract::We consider bivariate survival times for heterogeneous populations, where heterogeneity induces deviations in an individual's risk of an event as well as associations between survival times. The heterogeneity is characterized by a bivariate frailty model. We measure the heterogeneity effects through deviations associa...
journal_title:Statistics in medicine
pub_type: 杂志文章
doi:10.1002/(sici)1097-0258(19990430)18:8<907::aid-sim
更新日期:1999-04-30 00:00:00
abstract::Biostatistical concepts and methods apply to various problems arising in actual U.S. legal cases. These involve: measures of association, assessing the potential effect of omitted variables and the Peters-Belson approach to regression. In particular, we present the inapplicability of Fisher's exact test in the case wh...
journal_title:Statistics in medicine
pub_type: 杂志文章
doi:10.1002/sim.4780141505
更新日期:1995-08-15 00:00:00
abstract::Combining multiple markers can improve classification accuracy compared with using a single marker. In practice, covariates associated with markers or disease outcome can affect the performance of a biomarker or biomarker combination in the population. The covariate-adjusted receiver operating characteristic (ROC) cur...
journal_title:Statistics in medicine
pub_type: 杂志文章
doi:10.1002/sim.7274
更新日期:2017-07-10 00:00:00
abstract::In many medical applications, combining information from multiple biomarkers could yield a better diagnosis than any single one on its own. When there is a lack of a gold standard, an algorithm of classifying subjects into the case and non-case status is necessary for combining multiple markers. The aim of this paper ...
journal_title:Statistics in medicine
pub_type: 杂志文章
doi:10.1002/sim.6780
更新日期:2016-04-15 00:00:00
abstract::We consider methods for selecting the joint specification of the mean and variance functions in statistical models for rates or counts. Based on analyses of diagnosis-specific hospital discharge rates in Michigan, we show that a Poisson model with an extra variance component for the systematic variation is superior to...
journal_title:Statistics in medicine
pub_type: 杂志文章
doi:10.1002/sim.4780100908
更新日期:1991-09-01 00:00:00
abstract::Comparative Poisson trials of prophylactic interventions, such as vaccines, can be lengthy and costly. We evaluate two easily implemented approaches to reduce numbers of disease cases and person years of follow up (N(u+t)) for comparative Poisson trials with fixed numbers of cases (T); (i) altering k the portion of N(...
journal_title:Statistics in medicine
pub_type: 杂志文章
doi:10.1002/sim.1724
更新日期:2004-04-30 00:00:00
abstract::Assessment of equivalence or non-inferiority in accuracy between two diagnostic procedures often involves comparisons of paired areas under the receiver operating characteristic (ROC) curves. With some pre-specified clinically meaningful limits, the current approach to evaluating equivalence is to perform the two one-...
journal_title:Statistics in medicine
pub_type: 杂志文章
doi:10.1002/sim.2358
更新日期:2006-04-15 00:00:00
abstract::Kappa coefficients are measures of correlation between categorical variables often used as reliability or validity coefficients. We recapitulate development and definitions of the K (categories) by M (ratings) kappas (K x M), discuss what they are well- or ill-designed to do, and summarize where kappas now stand with ...
journal_title:Statistics in medicine
pub_type: 杂志文章,评审
doi:10.1002/sim.1180
更新日期:2002-07-30 00:00:00
abstract::Recently, Wu and Follmann developed summary measures to adjust for informative drop-out in longitudinal studies where drop-out depends on the underlying true value of the response. In this paper we evaluate these procedures in the common situation where drop-out depends on the observed responses. We also discuss vario...
journal_title:Statistics in medicine
pub_type: 杂志文章
doi:10.1002/1097-0258(20010115)20:1<93::aid-sim655>3.0
更新日期:2001-01-15 00:00:00
abstract::A relationship between baseline risk and treatment effect is increasingly investigated as a possible explanation of between-study heterogeneity in clinical trial meta-analysis. An approach that is still often applied in the medical literature is to plot the estimated treatment effects against the estimated measures of...
journal_title:Statistics in medicine
pub_type: 杂志文章
doi:10.1002/1097-0258(20001230)19:24<3497::aid-sim830>
更新日期:2000-12-30 00:00:00
abstract::We propose a new design for dose finding for cytotoxic agents in two ordered groups of patients. By ordered groups, we mean that prior to the study there is clinical information that would indicate that for a given dose one group would be more susceptible to toxicities than patients in the other group. The designs are...
journal_title:Statistics in medicine
pub_type: 杂志文章
doi:10.1002/sim.7133
更新日期:2017-01-30 00:00:00
abstract::In multiple-record systems estimation it is usually assumed that all registration relate to the same population. In this paper, we develop a method which can be used when the registrations relate to different populations, in the sense that they cover, for example, different time periods or regions. We show that under ...
journal_title:Statistics in medicine
pub_type: 杂志文章
doi:10.1002/sim.1818
更新日期:2004-07-30 00:00:00
abstract::Statistical modeling methods have had increasing use in drug disposition studies, both to estimate pharmacokinetic parameters and to develop regression models that relate these parameter estimates to patient characteristics. These methods are particularly flexible as they allow non-linearity and sparse within-patient ...
journal_title:Statistics in medicine
pub_type: 杂志文章
doi:10.1002/(sici)1097-0258(19970615)16:11<1241::aid-s
更新日期:1997-06-15 00:00:00