Abstract:
:We propose a new design for dose finding for cytotoxic agents in two ordered groups of patients. By ordered groups, we mean that prior to the study there is clinical information that would indicate that for a given dose one group would be more susceptible to toxicities than patients in the other group. The designs are evaluated relative to two previously proposed designs for ordered groups over a range of scenarios generated randomly from a family of dose-toxicity curves. Copyright © 2016 John Wiley & Sons, Ltd.
journal_name
Stat Medjournal_title
Statistics in medicineauthors
Conaway MR,Wages NAdoi
10.1002/sim.7133subject
Has Abstractpub_date
2017-01-30 00:00:00pages
254-265issue
2eissn
0277-6715issn
1097-0258journal_volume
36pub_type
杂志文章abstract::Sam Greenhouse joined the Census Bureau as a clerk at an interesting time period for the agency. The first use of sampling in the decennial census occurred in 1940. There was a major expansion of the amount of data collected. The organization of the Census Bureau underwent radical changes, including the growth of the ...
journal_title:Statistics in medicine
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journal_title:Statistics in medicine
pub_type: 杂志文章,随机对照试验
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abstract::The recent revision of the Declaration of Helsinki and the existence of many new therapies that affect survival or serious morbidity, and that therefore cannot be denied patients, have generated increased interest in active-control trials, particularly those intended to show equivalence or non-inferiority to the activ...
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journal_title:Statistics in medicine
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pub_type: 杂志文章
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journal_title:Statistics in medicine
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