Abstract:
:For the meta-analysis of controlled clinical trials with binary outcome a test statistic for testing an overall treatment effect is proposed, which is based on a refined estimator for the variance of the treatment effect estimator usually used in the random-effects model of meta-analysis. In simulation studies it is shown that the proposed test keeps the prescribed significance level much better than the commonly used tests in the fixed-effects and random-effects model, respectively. Moreover, when using the test it is not necessary to choose between fixed effects and random effects approaches in advance. The proposed method applies in the same way to the analysis of a controlled multi-centre study with binary outcome, including a possible interaction between drugs and centres.
journal_name
Stat Medjournal_title
Statistics in medicineauthors
Hartung J,Knapp Gdoi
10.1002/sim.1009subject
Has Abstractpub_date
2001-12-30 00:00:00pages
3875-89issue
24eissn
0277-6715issn
1097-0258pii
10.1002/sim.1009journal_volume
20pub_type
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