Abstract：
:We report that the protein tyrosine phosphatase PTP-PEST is expressed in resting human and mouse CD4(+) and CD8(+) T cells, but not in Jurkat T leukemia cells, and that PTP-PEST protein, but not mRNA, was dramatically downregulated in CD4(+) and CD8(+) primary human T cells upon T cell activation. This was also true in mouse CD4(+) T cells, but less striking in mouse CD8(+) T cells. PTP-PEST reintroduced into Jurkat at levels similar to those in primary human T cells, was a potent inhibitor of TCR-induced transactivation of reporter genes driven by NFAT/AP-1 and NF-kappaB elements and by the entire IL-2 gene promoter. Introduction of PTP-PEST into previously activated primary human T cells also reduced subsequent IL-2 production by these cells in response to TCR and CD28 stimulation. The inhibitory effect of PTP-PEST was associated with dephosphorylation the Lck kinase at its activation loop site (Y394), reduced early TCR-induced tyrosine phosphorylation, reduced ZAP-70 phosphorylation and inhibition of MAP kinase activation. We propose that PTP-PEST tempers T cell activation by dephosphorylating TCR-proximal signaling molecules, such as Lck, and that down-regulation of PTP-PEST may be a reason for the increased response to TCR triggering of previously activated T cells.
journal_name
Mol Immunoljournal_title
Molecular immunologyauthors
Arimura Y,Vang T,Tautz L,Williams S,Mustelin Tdoi
10.1016/j.molimm.2008.03.019subject
Has Abstractpub_date
2008-06-01 00:00:00pages
3074-84issue
11eissn
0161-5890issn
1872-9142pii
S0161-5890(08)00128-4journal_volume
45pub_type
杂志文章abstract：:Scygonadin is a novel antimicrobial peptide, which was originally isolated from the seminal plasma of the mud crab, Scylla serrata. Based on the partial 20-residue NH(2)-terminal sequence of the peptide, H-Gly-Gln-Ala-Leu-Asn-Lys-Leu-Met-Pro-Lys-Ile-Val-Ser-Ala-Ile-Ile-Tyr-Met-Val-Gly-OH, scygonadin was cloned from th...
journal_title：Molecular immunology
pub_type： 杂志文章
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更新日期：2007-03-01 00:00:00
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journal_title：Molecular immunology
pub_type： 杂志文章
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更新日期：1988-09-01 00:00:00
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journal_title：Molecular immunology
pub_type： 杂志文章
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更新日期：2015-08-01 00:00:00
abstract：:Ligation of the B cell Ag receptor (BCR) activates a protein-tyrosine kinase (PTK) and CD45 protein-tyrosine phosphatase (PTPase)-dependent signaling cascade that results in the activation of Ras. This pathway of Ras activation can operate independently of protein kinase C (PKC) activity. Activation of Ras may lead to...
journal_title：Molecular immunology
pub_type： 杂志文章
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更新日期：1996-02-01 00:00:00
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journal_title：Molecular immunology
pub_type： 杂志文章
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更新日期：1996-05-01 00:00:00
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pub_type： 杂志文章
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更新日期：1991-07-01 00:00:00
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journal_title：Molecular immunology
pub_type： 杂志文章
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更新日期：2016-05-01 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2004-02-01 00:00:00
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更新日期：1982-11-01 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2002-02-01 00:00:00
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journal_title：Molecular immunology
pub_type： 杂志文章,评审
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更新日期：2019-08-01 00:00:00
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journal_title：Molecular immunology
pub_type： 杂志文章
doi：10.1016/j.molimm.2009.02.032
更新日期：2009-06-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/0161-5890(85)90147-6
更新日期：1985-07-01 00:00:00
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journal_title：Molecular immunology
pub_type： 杂志文章
doi：10.1016/j.molimm.2006.08.018
更新日期：2007-03-01 00:00:00
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journal_title：Molecular immunology
pub_type： 杂志文章
doi：10.1016/0161-5890(88)90076-4
更新日期：1988-06-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/0161-5890(87)90068-x
更新日期：1987-10-01 00:00:00
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journal_title：Molecular immunology
pub_type： 杂志文章
doi：10.1016/j.molimm.2014.01.002
更新日期：2014-05-01 00:00:00
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journal_title：Molecular immunology
pub_type： 杂志文章
doi：10.1016/j.molimm.2016.05.019
更新日期：2016-07-01 00:00:00
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pub_type： 杂志文章
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更新日期：2017-01-01 00:00:00
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更新日期：1994-04-01 00:00:00
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pub_type： 杂志文章
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更新日期：1982-03-01 00:00:00
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pub_type： 杂志文章
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更新日期：2000-04-01 00:00:00
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更新日期：2013-01-01 00:00:00
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journal_title：Molecular immunology
pub_type： 杂志文章
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更新日期：2004-05-01 00:00:00
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journal_title：Molecular immunology
pub_type： 杂志文章
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更新日期：2019-12-01 00:00:00
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pub_type： 杂志文章
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更新日期：1985-10-01 00:00:00
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journal_title：Molecular immunology
pub_type： 杂志文章
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更新日期：2013-11-01 00:00:00
abstract：:A first report of an XLA patient with a polymorphism in Btk SH3 domain has been identified after sequencing of the entire gene. SH3 domain variants might not be detected due to well characterized mutations outside the domain. ...
journal_title：Molecular immunology
pub_type： 信件
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更新日期：2008-01-01 00:00:00
abstract：:Ankylosing spondylitis (AS) is a chronic inflammatory arthritis that affects the spine and sacroiliac joints. It causes significant disability and is associated with a number of other features including peripheral arthritis, anterior uveitis, psoriasis and inflammatory bowel disease (IBD). Significant progress has bee...
journal_title：Molecular immunology
pub_type： 杂志文章,评审
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更新日期：2014-01-01 00:00:00
abstract：:Dense deposit disease (DDD) is strongly associated with the uncontrolled activation of the complement alternative pathway. Factor H (CFH)-deficient (Cfh(-/-)) mice spontaneously develop C3 deposition along the glomerular basement membrane (GBM) with subsequent development of glomerulonephritis with features of DDD, a ...
journal_title：Molecular immunology
pub_type： 杂志文章
doi：10.1016/j.molimm.2009.03.030
更新日期：2009-06-01 00:00:00
