Abstract:
:The existence of small numbers of schizophrenia patients with superior ability in specific cognitive domains is implied by meta-analytic evidence as well as by occasional empirical reports. The authors identified 25 patients with superior (i.e., > or =90th percentile) ability on the Vocabulary subtest of the Wechsler Adult Intelligence Scale 3rd edition (Wechsler, 1997). These cognitively advantaged patients were compared with 22 healthy participants performing at the superior level and with 126 schizophrenia patients and 50 healthy participants scoring below the superior range. Verbally superior schizophrenia patients and verbally superior healthy participants had similar cognitive profiles and life skills performance, but diverged markedly in terms of independent "real-world" functioning. Verbally superior patients significantly outperformed more typical patients in other aspects of cognitive performance, life skills, and support requirements. However, severity of positive and negative symptoms was equivalent in the patient groups. Detailed biobehavioral study of cognitively exceptional patients may offer new insights into mechanisms mediating psychotic disorders.
journal_name
Neuropsychologyjournal_title
Neuropsychologyauthors
Heinrichs RW,Miles AA,Smith D,Zargarian T,Vaz SM,Goldberg JO,Ammari Ndoi
10.1037/0894-4105.22.3.321subject
Has Abstractpub_date
2008-05-01 00:00:00pages
321-8issue
3eissn
0894-4105issn
1931-1559pii
2008-05020-005journal_volume
22pub_type
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