14-3-3 interaction with histone H3 involves a dual modification pattern of phosphoacetylation.

abstract：:Two alleles of the Drosophila melanogaster Rfc4 (DmRfc4) gene, which encodes subunit 4 of the replication factor C (RFC) complex, cause striking defects in mitotic chromosome cohesion and condensation. These mutations produce larval phenotypes consistent with a role in DNA replication but also result in mitotic chromo...

journal_title：Molecular and cellular biology

authors： Krause SA,Loupart ML,Vass S,Schoenfelder S,Harrison S,Heck MM

更新日期：2001-08-01 00:00:00

abstract：:Clearance of apoptotic cells by phagocytic neighbors is crucial for normal development of multicellular organisms. However, how phagocytes discriminate between healthy and dying cells remains poorly understood. We focus on glial phagocytosis of apoptotic neurons during development of the Drosophila central nervous sys...

journal_title：Molecular and cellular biology

authors： Shklyar B,Levy-Adam F,Mishnaevski K,Kurant E

更新日期：2013-08-01 00:00:00

abstract：:mRNA in the yeast Saccharomyces cerevisiae is primarily degraded through a pathway that is stimulated by removal of the mRNA cap structure. Here we report that a mutation in the SPB8 (YJL124c) gene, initially identified as a suppressor mutation of a poly(A)-binding protein (PAB1) gene deletion, stabilizes the mRNA cap...

journal_title：Molecular and cellular biology

authors： Boeck R,Lapeyre B,Brown CE,Sachs AB

更新日期：1998-09-01 00:00:00

abstract：:C3G, which was identified as a Crk SH3 domain-binding guanine nucleotide-releasing factor, shows sequence similarity to CDC25 and Sos family proteins (S. Tanaka, T. Morishita, Y. Hashimoto, S. Hattori, S. Nakamura, M. Shibuya, K. Matuoka, T. Takenawa, T. Kurata, K. Nagashima, and M. Matsuda, Proc. Natl. Acad. Sci. USA...

journal_title：Molecular and cellular biology

authors： Gotoh T,Hattori S,Nakamura S,Kitayama H,Noda M,Takai Y,Kaibuchi K,Matsui H,Hatase O,Takahashi H

更新日期：1995-12-01 00:00:00

abstract：:The Polycomb group proteins are involved in maintenance of the silenced state of several developmentally regulated genes. These proteins form large aggregates with different subunit compositions. To explore the nature of these complexes and their function, we used the full-length Eed (embryonic ectoderm development) p...

journal_title：Molecular and cellular biology

authors： Denisenko O,Shnyreva M,Suzuki H,Bomsztyk K

更新日期：1998-10-01 00:00:00

abstract：:The chicken immunoglobulin light-chain gene (IgL) encodes only a single variable gene segment capable of recombination. To generate an immune repertoire, chickens diversify this unique rearranged VL gene segment during B-cell development in the bursa of Fabricius. Sequence analysis of IgL cDNAs suggests that both gene...

journal_title：Molecular and cellular biology

authors： Kim S,Humphries EH,Tjoelker L,Carlson L,Thompson CB

更新日期：1990-06-01 00:00:00

abstract：:The products of c-fos and c-jun (Fos and Jun) function in gene regulation by interacting with the AP-1 binding site. Here we have examined the contribution of Fos and Jun toward transcriptional activity by using Fos and Jun polypeptides purified from Escherichia coli. Fos contained a transcriptional activation domain ...

journal_title：Molecular and cellular biology

authors： Abate C,Luk D,Gagne E,Roeder RG,Curran T

更新日期：1990-10-01 00:00:00

abstract：:SCIP is a POU domain transcription factor expressed by glial progenitor cells in the peripheral and central nervous systems (dividing Schwann cells and O-2A cells, respectively), where it appears to act as a repressor of myelin-specific genes. We have isolated genomic clones encoding the rat SCIP gene. Comparison of t...

journal_title：Molecular and cellular biology

authors： Kuhn R,Monuki ES,Lemke G

更新日期：1991-09-01 00:00:00

abstract：:We have used extrachromosomal substrates carrying immunoglobulin heavy-chain S mu and S gamma 3 switch region sequences to study activation and targeting of recombination by a transcriptional enhancer element. Substrates are transiently introduced into activated primary murine B cells, in which recombination involving...

journal_title：Molecular and cellular biology

authors： Leung H,Maizels N

更新日期：1994-02-01 00:00:00

abstract：:The simian virus 40 72-base-pair repeats substituted for the polyomavirus enhancer, allowing replication and transcription in mouse 3T6 but not monkey CV-1 cells. A polyomavirus genome containing the entire simian virus 40 control region replicated at low levels in 3T6 and CV-1 cells; however, transcripts were detecte...

journal_title：Molecular and cellular biology

authors： Campbell BA,Villarreal LP

更新日期：1985-06-01 00:00:00

abstract：:Nuclear receptor corepressors (N-CoR) and silencing mediator for retinoid and thyroid receptors (SMRT) have both been implicated in thyroid hormone receptor (TR)-mediated repression. Here we show that endogenous N-CoR, TBL1, and histone deacetylase 3 (HDAC3), but not HDAC1, -2, or -4, are recruited to a stably integra...

journal_title：Molecular and cellular biology

authors： Ishizuka T,Lazar MA

更新日期：2003-08-01 00:00:00

abstract：:The proto-oncogene c-myb is essential for a controlled balance between cell growth and differentiation. Aberrant c-Myb activity has been reported for numerous human cancers, and enforced c-Myb transcription can transform cells of lymphoid origin by stimulating cellular proliferation and inhibiting apoptotic pathways. ...

journal_title：Molecular and cellular biology

authors： Nicot C,Mahieux R,Pise-Masison C,Brady J,Gessain A,Yamaoka S,Franchini G

更新日期：2001-11-01 00:00:00

abstract：:Transcriptional silencing at the budding yeast silent mating type (HM) loci and telomeric DNA regions requires Sir2, a conserved NAD-dependent histone deacetylase, Sir3, Sir4, histones H3 and H4, and several DNA-binding proteins. Silencing at the yeast ribosomal DNA (rDNA) repeats requires a complex containing Sir2, N...

journal_title：Molecular and cellular biology

authors： Hoppe GJ,Tanny JC,Rudner AD,Gerber SA,Danaie S,Gygi SP,Moazed D

更新日期：2002-06-01 00:00:00

abstract：:All-trans retinoic acid (RA) induces transforming growth factor beta (TGF-beta)-dependent autocrine growth of mouse embryonic fibroblasts (MEFs). We have used chromatin immunoprecipitation to map 354 RA receptor (RAR) binding loci in MEFs, most of which were similarly occupied by the RAR alpha and RAR gamma receptors....

journal_title：Molecular and cellular biology

authors： Delacroix L,Moutier E,Altobelli G,Legras S,Poch O,Choukrallah MA,Bertin I,Jost B,Davidson I

更新日期：2010-01-01 00:00:00

abstract：:We have developed a system to study mutations that affect xanthine-guanine phosphoribosyltransferase gene (gpt) expression in hypoxanthine-guanine phosphoribosyltransferase-deficient CHO cells that have been transformed by the plasmid vector pSV2gpt. One isolated transformant, designated AS52, carries a single copy of...

journal_title：Molecular and cellular biology

authors： Tindall KR,Stankowski LF Jr,Machanoff R,Hsie AW

更新日期：1984-07-01 00:00:00

abstract：:Recognition of gene promoters by RNA polymerase II is mediated by general transcription factor IID (TFIID), which has been thought to be a static complex and to play a passive role in the regulation of gene expression under the instruction of gene-specific transcription factors. Here we show that transforming growth f...

journal_title：Molecular and cellular biology

authors： Nakagawa T,Hosogane M,Nakagawa M,Morohoshi A,Funayama R,Nakayama K

更新日期：2018-02-12 00:00:00

abstract：:Non-long terminal repeat (LTR) retrotransposons are major components of the higher eukaryotic genome. Most of them have two open reading frames (ORFs): ORF2 encodes mainly the endonuclease and reverse transcriptase domains, but the functional features of ORF1 remain largely unknown. We used telomere-specific non-LTR r...

journal_title：Molecular and cellular biology

authors： Matsumoto T,Hamada M,Osanai M,Fujiwara H

更新日期：2006-07-01 00:00:00

abstract：:Poly(A)-binding protein (PABP) stimulates translation initiation by binding simultaneously to the mRNA poly(A) tail and eukaryotic translation initiation factor 4G (eIF4G). PABP activity is regulated by PABP-interacting (Paip) proteins. Paip1 binds PABP and stimulates translation by an unknown mechanism. Here, we desc...

journal_title：Molecular and cellular biology

authors： Martineau Y,Derry MC,Wang X,Yanagiya A,Berlanga JJ,Shyu AB,Imataka H,Gehring K,Sonenberg N

更新日期：2008-11-01 00:00:00

abstract：:Neurite outgrowth is key to the formation of functional circuits during neuronal development. Neurotrophins, including nerve growth factor (NGF), increase neurite outgrowth in part by altering the function and expression of Ca(2+)-permeable cation channels. Here we report that transient receptor potential vanilloid 2 ...

journal_title：Molecular and cellular biology

authors： Cohen MR,Johnson WM,Pilat JM,Kiselar J,DeFrancesco-Lisowitz A,Zigmond RE,Moiseenkova-Bell VY

更新日期：2015-12-01 00:00:00

abstract：:CD146, an endothelial biomarker, has been shown to be aberrantly upregulated during pathological angiogenesis and functions as a coreceptor for vascular endothelial growth factor receptor 2 (VEGFR-2) to promote disease progression. However, the regulatory mechanisms of CD146 expression during angiogenesis remain uncle...

journal_title：Molecular and cellular biology

authors： Wang P,Luo Y,Duan H,Xing S,Zhang J,Lu D,Feng J,Yang D,Song L,Yan X

更新日期：2013-09-01 00:00:00

abstract：:To study the relationship between oncogenesis by v-src and normal cellular signalling pathways, we determined the effects of v-src on 3T3-TNR9 cells, a Swiss 3T3 variant which does not respond mitogenically to tumor promoters such as 12-O-tetradecanoyl-phorbol-13-acetate (TPA). We found that src was unable to transfor...

journal_title：Molecular and cellular biology

authors： Nori M,Shawver LK,Weber MJ

更新日期：1990-08-01 00:00:00

abstract：:The cytoplasmic domain of the cloned erythropoietin (EPO) receptor (EPOR) contains no protein kinase motif, yet addition of EPO to EPO-responsive cells causes an increase in protein-tyrosine phosphorylation. Here we show that addition of EPO or interleukin-3 (IL-3) to an IL-3-dependent cell line expressing the wild-ty...

journal_title：Molecular and cellular biology

authors： Yoshimura A,Lodish HF

更新日期：1992-02-01 00:00:00

abstract：:One hallmark of tumor formation is the transcriptional upregulation of human telomerase reverse transcriptase, hTERT, and the resultant induction of telomerase activity. However, little is presently understood about how hTERT is differentially activated in tumor cells versus normal somatic cells. Specifically, it is u...

journal_title：Molecular and cellular biology

authors： Goueli BS,Janknecht R

更新日期：2004-01-01 00:00:00

abstract：:The translational GTPases promote initiation, elongation, and termination of protein synthesis by interacting with the ribosome. Mutations that impair GTP hydrolysis by eukaryotic translation initiation factor 5B/initiation factor 2 (eIF5B/IF2) impair yeast cell growth due to failure to dissociate from the ribosome fo...

journal_title：Molecular and cellular biology

authors： Shin BS,Kim JR,Acker MG,Maher KN,Lorsch JR,Dever TE

更新日期：2009-02-01 00:00:00

abstract：:Cells of Candida albicans WO-1 spontaneously switch between a white and opaque CFU, and this phase transition involves a dramatic change in cellular phenotype. By using a differential hybridization screen, an opaque-specific cDNA, Op1a, which represents the transcript of a gene regulated by switching, has been isolate...

journal_title：Molecular and cellular biology

authors： Morrow B,Srikantha T,Soll DR

更新日期：1992-07-01 00:00:00

abstract：:By using a retrovirus-derived vector system, we generated derivatives of the human colon cancer cell line HT29 that stably overexpress a full-length cDNA encoding the beta 1 isoform of rat protein kinase C (PKC). Two of these cell lines, PKC6 and PKC7, displayed an 11- to 15-fold increase in PKC activity when compared...

journal_title：Molecular and cellular biology

authors： Choi PM,Tchou-Wong KM,Weinstein IB

更新日期：1990-09-01 00:00:00

abstract：:Considering the link between plasma high-density lipoprotein (HDL) cholesterol levels and a protective effect against coronary artery disease as well as the suggested beneficial effects of retinoids on the production of the major HDL apolipoprotein (apo), apo A-I, the goal of this study was to analyze the influence of...

journal_title：Molecular and cellular biology

authors： Vu-Dac N,Schoonjans K,Kosykh V,Dallongeville J,Heyman RA,Staels B,Auwerx J

更新日期：1996-07-01 00:00:00

abstract：:To study repair of DNA double-strand breaks (DSBs) in mammalian chromosomes, we designed DNA substrates containing a thymidine kinase (TK) gene disrupted by the 18-bp recognition site for yeast endonuclease I-SceI. Some substrates also contained a second defective TK gene sequence to serve as a genetic donor in recomb...

journal_title：Molecular and cellular biology

authors： Lin Y,Lukacsovich T,Waldman AS

更新日期：1999-12-01 00:00:00

abstract：:We used a transient-expression assay to identify two estrogen response elements (EREs) associated with the major chicken vitellogenin gene (VTGII). Each element was characterized by its ability to confer estrogen responsiveness when cloned in either orientation next to a chimeric reporter gene consisting of the herpes...

journal_title：Molecular and cellular biology

authors： Burch JB,Evans MI,Friedman TM,O'Malley PJ

更新日期：1988-03-01 00:00:00

abstract：:Initiation of T-lymphocyte-mediated immune responses involves two cellular processes: entry into the cell cycle (G(0)-->G(1)) for clonal proliferation and coordinated changes in surface and secreted molecules that mediate effector functions. However, a point during G(0)-->G(1) beyond which T cells are committed to ent...

journal_title：Molecular and cellular biology

authors： Lea NC,Orr SJ,Stoeber K,Williams GH,Lam EW,Ibrahim MA,Mufti GJ,Thomas NS

更新日期：2003-04-01 00:00:00