Point mutations in the WD40 domain of Eed block its interaction with Ezh2.

abstract：:Changes in chromatin composition are often a prerequisite for gene induction. Nonallelic histone variants have recently emerged as key players in transcriptional control and chromatin modulation. While the changes in chromatin accessibility and histone posttranslational modification (PTM) distribution that accompany g...

journal_title：Molecular and cellular biology

authors： Sutcliffe EL,Parish IA,He YQ,Juelich T,Tierney ML,Rangasamy D,Milburn PJ,Parish CR,Tremethick DJ,Rao S

更新日期：2009-04-01 00:00:00

abstract：:Within mineralized bone, osteocytes form dendritic processes that travel through canaliculi to make contact with other osteocytes and cells on the bone surface. This three-dimensional syncytium is thought to be necessary to maintain viability, cell-to-cell communication, and mechanosensation. E11/gp38 is the earliest ...

journal_title：Molecular and cellular biology

authors： Zhang K,Barragan-Adjemian C,Ye L,Kotha S,Dallas M,Lu Y,Zhao S,Harris M,Harris SE,Feng JQ,Bonewald LF

更新日期：2006-06-01 00:00:00

abstract：:Human ras genes play central roles in coupling extracellular signals with complex intracellular networks controlling proliferation, differentiation, and apoptosis, among others processes. c-H-ras pre-mRNA can be alternatively processed into two mRNAs due to the inclusion or exclusion of the alternative exon IDX; this ...

journal_title：Molecular and cellular biology

authors： Guil S,Gattoni R,Carrascal M,Abián J,Stévenin J,Bach-Elias M

更新日期：2003-04-01 00:00:00

abstract：:Acidic fibroblast growth factor (FGF) and related family members regulate differentiation in organisms as diverse as Xenopus laevis and mammals. We utilized a well-characterized model of myogenic development to directly assess the importance of endogenously produced FGF in controlling differentiation. A role for endog...

journal_title：Molecular and cellular biology

authors： Fox JC,Hsu AY,Swain JL

更新日期：1994-06-01 00:00:00

abstract：:Oxygen-dependent proteolysis is the primary means of regulating the hypoxia-inducible factor (HIF) family of transcription factors. The alpha-subunit of HIF factor 1 (HIF-1) contains two highly conserved oxygen-dependent degradation domains (402 ODD and 564 ODD), each of which includes a proline that is hydroxylated i...

journal_title：Molecular and cellular biology

authors： Chan DA,Sutphin PD,Yen SE,Giaccia AJ

更新日期：2005-08-01 00:00:00

abstract：:We report that newly synthesized mRNA poly(A) tails are matured to precise lengths by the Pab1p-dependent poly(A) nuclease (PAN) of Saccharomyces cerevisiae. These results provide evidence for an initial phase of mRNA deadenylation that is required for poly(A) tail length control. In RNA 3'-end processing extracts lac...

journal_title：Molecular and cellular biology

authors： Brown CE,Sachs AB

更新日期：1998-11-01 00:00:00

abstract：:Multiple organ systems require epithelial barriers for normal function, and barrier loss is a hallmark of diseases ranging from inflammation to epithelial cancers. However, the molecular processes regulating epithelial barrier maturation are not fully elucidated. After contact, epithelial cells undergo size-reductive ...

journal_title：Molecular and cellular biology

authors： Bolinger MT,Ramshekar A,Waldschmidt HV,Larsen SD,Bewley MC,Flanagan JM,Antonetti DA

更新日期：2016-07-14 00:00:00

abstract：:The p53 tumor suppressor gene product is a sequence-specific DNA-binding protein that is necessary for the G1 arrest of many cell types. Consistent with its role as a cell cycle checkpoint factor, p53 has been shown to be capable of both transcriptional activation and repression. Here we show a new potential role for ...

journal_title：Molecular and cellular biology

authors： Miller SD,Farmer G,Prives C

更新日期：1995-12-01 00:00:00

abstract：:Budding yeast Rad53 is an essential protein kinase that is phosphorylated and activated in a MEC1- and TEL1-dependent manner in response to DNA damage. We studied the role of Rad53 phosphorylation through mutation of consensus phosphorylation sites for upstream kinases Mec1 and Tel1. Alanine substitution of the Rad53 ...

journal_title：Molecular and cellular biology

authors： Lee SJ,Schwartz MF,Duong JK,Stern DF

更新日期：2003-09-01 00:00:00

abstract：:The cellular transcription factor E2F appears to be a target for the regulatory action of the retinoblastoma tumor suppressor gene product. The recent isolation of the E2F1 cDNA clone, which encodes a polypeptide with properties characteristic of E2F, has now allowed a more detailed analysis of the regulation of E2F f...

journal_title：Molecular and cellular biology

authors： Cress WD,Johnson DG,Nevins JR

更新日期：1993-10-01 00:00:00

abstract：:Tax corresponds to a 40-kDa transforming protein from the pathogenic retrovirus human T-cell leukemia virus type 1 (HTLV-1) that activates nuclear expression of the NF-kappaB/Rel family of transcription factors by an unknown mechanism. Tax expression promotes N-terminal phosphorylation and degradation of IkappaB alpha...

journal_title：Molecular and cellular biology

authors： Geleziunas R,Ferrell S,Lin X,Mu Y,Cunningham ET Jr,Grant M,Connelly MA,Hambor JE,Marcu KB,Greene WC

更新日期：1998-09-01 00:00:00

abstract：:Methylation-controlled J protein (MCJ) is a newly identified member of the DnaJ family of cochaperones. Hypermethylation-mediated transcriptional silencing of the MCJ gene has been associated with increased chemotherapeutic resistance in ovarian cancer. However, the biology and function of MCJ remain unknown. Here we ...

journal_title：Molecular and cellular biology

authors： Hatle KM,Neveu W,Dienz O,Rymarchyk S,Barrantes R,Hale S,Farley N,Lounsbury KM,Bond JP,Taatjes D,Rincón M

更新日期：2007-04-01 00:00:00

abstract：:We have previously shown that the SIS/platelet-derived growth factor B chain contains a nuclear targeting signal near its C terminus. Here we show that the platelet-derived growth factor A chain also contains a nuclear targeting signal encoded by an exon which is subject to alternative splicing. This sequence is capab...

journal_title：Molecular and cellular biology

authors： Maher DW,Lee BA,Donoghue DJ

更新日期：1989-05-01 00:00:00

abstract：:We have studied the patterns of expression of four B-type cyclins (Clbs), Clb1, Clb2, Clb3, and Clb4, and their ability to activate p34cdc28 during the mitotic and meiotic cell cycles of Saccharomyces cerevisiae. During the mitotic cell cycle, Clb3 and Clb4 were expressed and induced a kinase activity in association w...

journal_title：Molecular and cellular biology

authors： Grandin N,Reed SI

更新日期：1993-04-01 00:00:00

abstract：:The gene responsible for multidrug resistance (mdr), which encodes the P-glycoprotein, is a member of a multigene family. We have identified distinct mdr gene transcripts encoded by three separate mdr genes in the mouse. Expression levels of each mdr gene are dramatically different in various mouse tissues. Specific m...

journal_title：Molecular and cellular biology

authors： Croop JM,Raymond M,Haber D,Devault A,Arceci RJ,Gros P,Housman DE

更新日期：1989-03-01 00:00:00

abstract：:Synonymous single nucleotide polymorphisms (SNPs) within a transcript's coding region produce no change in the amino acid sequence of the protein product and are therefore intuitively assumed to have a neutral effect on protein function. We report that two common variants of high-temperature requirement A1 (HTRA1) tha...

journal_title：Molecular and cellular biology

authors： Jacobo SM,Deangelis MM,Kim IK,Kazlauskas A

更新日期：2013-05-01 00:00:00

abstract：:Meiotic recombination is initiated by the formation of programmed DNA double-strand breaks (DSBs) catalyzed by the Spo11 protein. DSBs are not randomly distributed along chromosomes. To better understand factors that control the distribution of DSBs in budding yeast, we have examined the genome-wide binding and cleava...

journal_title：Molecular and cellular biology

authors： Robine N,Uematsu N,Amiot F,Gidrol X,Barillot E,Nicolas A,Borde V

更新日期：2007-03-01 00:00:00

abstract：:Although both osteoblasts and adipocytes have a common origin, i.e., mesenchymal cells, the molecular mechanisms that define the direction of two different lineages are presently unknown. In this study, we investigated the role of a transcription factor, CCAAT/enhancer binding protein beta (C/EBPbeta), and its isoform...

journal_title：Molecular and cellular biology

authors： Hata K,Nishimura R,Ueda M,Ikeda F,Matsubara T,Ichida F,Hisada K,Nokubi T,Yamaguchi A,Yoneda T

更新日期：2005-03-01 00:00:00

abstract：:To modulate transcription, regulatory factors communicate with basal transcription factors and/or RNA polymerases in a variety of ways. Previously, it has been reported that RNA polymerase II subunit 5 (RPB5) is one of the targets of hepatitis B virus X protein (HBx) and that both HBx and RPB5 specifically interact wi...

journal_title：Molecular and cellular biology

authors： Dorjsuren D,Lin Y,Wei W,Yamashita T,Nomura T,Hayashi N,Murakami S

更新日期：1998-12-01 00:00:00

abstract：:A protein that binds specifically to Saccharomyces cerevisiae centromere DNA element I was purified on the basis of a nitrocellulose filter-binding assay. This protein, termed centromere-binding protein 1 (CP1), was heat stable and renaturable from sodium dodecyl sulfate (SDS), and assays of eluates from SDS gels indi...

journal_title：Molecular and cellular biology

authors： Bram RJ,Kornberg RD

更新日期：1987-01-01 00:00:00

abstract：:A novel pp90rsk Ser/Thr kinase (referred to as RSK3) was cloned from a human cDNA library. The RSK3 cDNA encodes a predicted 733-amino-acid protein with a unique N-terminal region containing a putative nuclear localization signal. RSK3 mRNA was widely expressed (but was predominant in lung and skeletal muscle). By usi...

journal_title：Molecular and cellular biology

authors： Zhao Y,Bjørbaek C,Weremowicz S,Morton CC,Moller DE

更新日期：1995-08-01 00:00:00

abstract：:The Rb protein is known to exert its activity at decision points in the G1 phase of the cell cycle. To investigate whether it may also play some role(s) at later points in the cell cycle, we used a system of rapid inducible gene amplification to conditionally overexpress Rb protein during G2 phase. A cell line express...

journal_title：Molecular and cellular biology

authors： Karantza V,Maroo A,Fay D,Sedivy JM

更新日期：1993-11-01 00:00:00

abstract：:Intracellular degradation of vertebrate ornithine decarboxylase (ODC) is accelerated by polyamines, the products of the pathway controlled by ODC. Antizyme, a reversible, tightly binding protein inhibitor of ODC activity, is believed to be involved in this process. Mouse and Trypanosoma brucei ODCs are structurally si...

journal_title：Molecular and cellular biology

authors： Li X,Coffino P

更新日期：1992-08-01 00:00:00

abstract：:Glucose release from hepatocytes is important for maintenance of blood glucose levels. Glucose-6-phosphate phosphatase, catalyzing the final metabolic step of gluconeogenesis, faces the endoplasmic reticulum (ER) lumen. Thus, glucose produced in the ER has to be either exported from the ER into the cytosol before rele...

journal_title：Molecular and cellular biology

authors： Fehr M,Takanaga H,Ehrhardt DW,Frommer WB

更新日期：2005-12-01 00:00:00

abstract：:The immunoglobulin superfamily recognition molecule L1 plays important functional roles in the developing and adult nervous system. Metalloprotease-mediated cleavage of this adhesion molecule has been shown to stimulate cellular migration and neurite outgrowth. We demonstrate here that L1 cleavage is mediated by two d...

journal_title：Molecular and cellular biology

authors： Maretzky T,Schulte M,Ludwig A,Rose-John S,Blobel C,Hartmann D,Altevogt P,Saftig P,Reiss K

更新日期：2005-10-01 00:00:00

abstract：:We have characterized two P-element-induced, lethal mutations in Drosophila melanogaster which affect the larval hemocytes, mediators of the insect immune response. Each mutant displays larval melanotic tumors characteristic of mutations affecting the insect cellular immune system, and the moribund animals develop gro...

journal_title：Molecular and cellular biology

authors： Stewart MJ,Denell R

更新日期：1993-04-01 00:00:00

abstract：:Mitogen-activated protein (MAP) kinase phosphatase 1 (MKP-1) has been shown to play a critical role in mediating the feedback control of MAP kinase cascades in a variety of cellular processes, including proliferation and stress responsiveness. Although MKP-1 expression is induced by a broad array of extracellular stim...

journal_title：Molecular and cellular biology

authors： Li J,Gorospe M,Hutter D,Barnes J,Keyse SM,Liu Y

更新日期：2001-12-01 00:00:00

abstract：:p105 (NFKB1) acts in a dual way as a cytoplasmic IkappaB molecule and as the source of the NF-kappaB p50 subunit upon processing. p105 can form various heterodimers with other NF-kappaB subunits, including its own processing product, p50, and these complexes are signal responsive. Signaling through the IkappaB kinase ...

journal_title：Molecular and cellular biology

authors： Heissmeyer V,Krappmann D,Hatada EN,Scheidereit C

更新日期：2001-02-01 00:00:00

abstract：:Transcription initiation factor TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. To further understand the role of the 85-kDa TFIID subunit (p85), we have cloned the corresponding cDNA with a probe based on an amino acid sequence of t...

journal_title：Molecular and cellular biology

authors： Kokubo T,Gong DW,Yamashita S,Takada R,Roeder RG,Horikoshi M,Nakatani Y

更新日期：1993-12-01 00:00:00

abstract：:TRAF2 is an adaptor protein that regulates the activation of the c-Jun N-terminal kinase (JNK) and IkappaB kinase (IKK) signaling cascades in response to tumor necrosis factor alpha (TNF-alpha) stimulation. Although the downstream events in TNF-alpha signaling are better understood, the membrane-proximal events are st...

journal_title：Molecular and cellular biology

authors： Blackwell K,Zhang L,Thomas GS,Sun S,Nakano H,Habelhah H

更新日期：2009-01-01 00:00:00