The three mouse multidrug resistance (mdr) genes are expressed in a tissue-specific manner in normal mouse tissues.

Abstract:

:The gene responsible for multidrug resistance (mdr), which encodes the P-glycoprotein, is a member of a multigene family. We have identified distinct mdr gene transcripts encoded by three separate mdr genes in the mouse. Expression levels of each mdr gene are dramatically different in various mouse tissues. Specific mdr RNA transcripts of approximately 4.5, 5, and 6 kilobases have been detected. Each of the mdr genes has a specific RNA transcript pattern. These results should be considered in relation to understanding the normal physiological function of the mdr multigene family.

journal_name

Mol Cell Biol

authors

Croop JM,Raymond M,Haber D,Devault A,Arceci RJ,Gros P,Housman DE

doi

10.1128/mcb.9.3.1346

subject

Has Abstract

pub_date

1989-03-01 00:00:00

pages

1346-50

issue

3

eissn

0270-7306

issn

1098-5549

journal_volume

9

pub_type

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