Abstract:
:We have characterized two P-element-induced, lethal mutations in Drosophila melanogaster which affect the larval hemocytes, mediators of the insect immune response. Each mutant displays larval melanotic tumors characteristic of mutations affecting the insect cellular immune system, and the moribund animals develop grossly hypertrophied hematopoietic organs because of increased cell proliferation and extra rounds of endoreduplication in some hematopoietic cells. Surprisingly, these mutations are due to P element insertions in the 5' regulatory region of the Drosophila gene encoding ribosomal protein S6 and cause a reduction of S6 transcript abundance in mutant larvae.
journal_name
Mol Cell Bioljournal_title
Molecular and cellular biologyauthors
Stewart MJ,Denell Rdoi
10.1128/mcb.13.4.2524subject
Has Abstractpub_date
1993-04-01 00:00:00pages
2524-35issue
4eissn
0270-7306issn
1098-5549journal_volume
13pub_type
杂志文章abstract::The muscle LIM protein (MLP) and cofilin 2 (CFL2) are important regulators of striated myocyte function. Mutations in the corresponding genes have been directly associated with severe human cardiac and skeletal myopathies, and aberrant expression patterns have often been observed in affected muscles. Herein, we have i...
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