The N-CoR/histone deacetylase 3 complex is required for repression by thyroid hormone receptor.

abstract：:The active beta-globin genes in chicken erythrocytes, like all active genes, reside in large chromatin domains which are preferentially sensitive to digestion by DNase I. We have recently proposed that the special structure of chromatin in active domains is maintained by torsional stress in the DNA (Villeponteau et al...

journal_title：Molecular and cellular biology

authors： Villeponteau B,Martinson HG

更新日期：1987-05-01 00:00:00

abstract：:Expression of the reaper gene (rpr) correlates with the initiation of apoptosis in Drosophila melanogaster. Transient expression of rpr in the lepidopteran SF-21 cell line induced apoptosis displaying nuclear condensation and fragmentation, oligonucleosomal ladder formation, cell surface blebbing, and apoptotic body f...

journal_title：Molecular and cellular biology

authors： Vucic D,Seshagiri S,Miller LK

更新日期：1997-02-01 00:00:00

abstract：:The serine/threonine kinase Akt is a component of many receptor signal transduction pathways and can prevent cell death following growth factor withdrawal. Here, we show that Akt inhibition of cell death is not dependent on new protein translation. Instead, Akt inhibition of cell death requires glucose hydrolysis thro...

journal_title：Molecular and cellular biology

authors： Rathmell JC,Fox CJ,Plas DR,Hammerman PS,Cinalli RM,Thompson CB

更新日期：2003-10-01 00:00:00

abstract：:Genetic and biochemical experiments have enabled us to more clearly distinguish three genetic loci, emtA, emtB, and emtC, all of which can be altered to give rise to resistance to the protein synthesis inhibitor, emetine, in cultured Chinese hamster cells. Genetic experiments have demonstrated that, unlike the emtB lo...

journal_title：Molecular and cellular biology

authors： Chang S,Wasmuth JJ

更新日期：1983-03-01 00:00:00

abstract：:In Saccharomyces cerevisiae, double-strand breaks (DSBs) activate DNA checkpoint pathways that trigger several responses including a strong G(2)/M arrest. We have previously provided evidence that the phosphatases Ptc2 and Ptc3 of the protein phosphatase 2C type are required for DNA checkpoint inactivation after a DSB...

journal_title：Molecular and cellular biology

authors： Guillemain G,Ma E,Mauger S,Miron S,Thai R,Guérois R,Ochsenbein F,Marsolier-Kergoat MC

更新日期：2007-05-01 00:00:00

abstract：:The transcription factor family of nuclear factor I (NFI) proteins is encoded by four closely related genes: Nfia, Nfib, Nfic, and Nfix. A potential role for NFI proteins in regulating developmental processes has been implicated by their specific expression pattern during embryonic development and by analysis of NFI-d...

journal_title：Molecular and cellular biology

authors： Driller K,Pagenstecher A,Uhl M,Omran H,Berlis A,Gründer A,Sippel AE

更新日期：2007-05-01 00:00:00

abstract：:Muscle creatine kinase (MCK) is expressed at high levels only in skeletal and cardiac muscle tissues. Previous in vitro transfection studies of skeletal muscle myoblasts and fibroblasts had identified two MCK enhancer elements and one proximal promoter element, each of which exhibited expression only in differentiated...

journal_title：Molecular and cellular biology

authors： Johnson JE,Wold BJ,Hauschka SD

更新日期：1989-08-01 00:00:00

abstract：:During investigations on the regulation of the Pax-6 gene, we characterized a cDNA from quail neuroretina showing a 5' untranslated region distinct from that previously described and initiated from an internal promoter. Using RNase protection and primer extension mapping, we localized this second quail Pax-6 promoter,...

journal_title：Molecular and cellular biology

authors： Plaza S,Dozier C,Turque N,Saule S

更新日期：1995-06-01 00:00:00

abstract：:Despite distinct dissimilarities, diverse cancers express several common protumorigenic traits. We present here evidence that the proapoptotic protein Par-4 utilizes one such common tumorigenic trait to become selectively activated and induce apoptosis in cancer cells. Elevated protein kinase A (PKA) activity noted in...

journal_title：Molecular and cellular biology

authors： Gurumurthy S,Goswami A,Vasudevan KM,Rangnekar VM

更新日期：2005-02-01 00:00:00

abstract：:When herpes simplex virus infects permissive cells, the viral regulatory protein VP16 forms a specific complex with HCF-1, a preexisting nuclear protein involved in cell proliferation. The majority of HCF-1 in the cell is a complex of associated amino (HCF-1(N))- and carboxy (HCF-1(C))-terminal subunits that result fr...

journal_title：Molecular and cellular biology

authors： Wilson AC,Boutros M,Johnson KM,Herr W

更新日期：2000-09-01 00:00:00

abstract：:Synonymous single nucleotide polymorphisms (SNPs) within a transcript's coding region produce no change in the amino acid sequence of the protein product and are therefore intuitively assumed to have a neutral effect on protein function. We report that two common variants of high-temperature requirement A1 (HTRA1) tha...

journal_title：Molecular and cellular biology

authors： Jacobo SM,Deangelis MM,Kim IK,Kazlauskas A

更新日期：2013-05-01 00:00:00

abstract：:The DNA damage checkpoint is tightly controlled. After its activation, the checkpoint machinery is inactivated once lesions are repaired or undergoes adaptation if the DNA damage is unable to be repaired. Protein acetylation has been shown to play an important role in DNA damage checkpoint activation. However, the rol...

journal_title：Molecular and cellular biology

authors： Tao R,Xue H,Zhang J,Liu J,Deng H,Chen YG

更新日期：2013-11-01 00:00:00

abstract：:One hallmark of tumor formation is the transcriptional upregulation of human telomerase reverse transcriptase, hTERT, and the resultant induction of telomerase activity. However, little is presently understood about how hTERT is differentially activated in tumor cells versus normal somatic cells. Specifically, it is u...

journal_title：Molecular and cellular biology

authors： Goueli BS,Janknecht R

更新日期：2004-01-01 00:00:00

abstract：:Three subtypes of retinoic acid receptors (RAR), termed RAR alpha, RAR beta, and RAR gamma, have been described. They are composed of different structural domains, including distinct domains for DNA and ligand binding. RARs specifically bind all-trans-retinoic acid (RA), 9-cis-RA, and retinoid analogs. In this study, ...

journal_title：Molecular and cellular biology

authors： Lamour FP,Lardelli P,Apfel CM

更新日期：1996-10-01 00:00:00

abstract：:Recent advancements in genetic and proteomic technologies have revealed that more of the genome encodes proteins than originally thought possible. Specifically, some putative long noncoding RNAs (lncRNAs) have been misannotated as noncoding. Numerous lncRNAs have been found to contain short open reading frames (sORFs)...

journal_title：Molecular and cellular biology

authors： Hartford CCR,Lal A

更新日期：2020-02-27 00:00:00

abstract：:The differentiation of dental epithelia into enamel-producing ameloblasts or the root epithelial lineage compartmentalizes teeth into crowns and roots. Bmp signaling has been linked to enamel formation, but its role in root epithelial lineage differentiation is unclear. Here we show that cessation of epithelial Bmp si...

journal_title：Molecular and cellular biology

authors： Yang Z,Hai B,Qin L,Ti X,Shangguan L,Zhao Y,Wiggins L,Liu Y,Feng JQ,Chang JY,Wang F,Liu F

更新日期：2013-12-01 00:00:00

abstract：:Here, we demonstrate that elevation of intracellular cyclic AMP (cAMP) in vascular endothelial cells (ECs) by either a direct activator of adenylyl cyclase or endogenous cAMP-mobilizing G protein-coupled receptors inhibited the tyrosine phosphorylation of STAT proteins by an interleukin 6 (IL-6) receptor trans-signali...

journal_title：Molecular and cellular biology

authors： Sands WA,Woolson HD,Milne GR,Rutherford C,Palmer TM

更新日期：2006-09-01 00:00:00

abstract：:A new and rapid purification procedure has been developed for the mammalian 70,000-dalton (70-kDa) heat-shock (or stress) proteins. Both the constitutive 73-kDa protein and the stress-induced 72-kDa protein have been purified by a two-step procedure employing DE52 ion-exchange chromatography followed by affinity chrom...

journal_title：Molecular and cellular biology

authors： Welch WJ,Feramisco JR

更新日期：1985-06-01 00:00:00

abstract：:Double-stranded RNA (dsRNA) accumulates in virus-infected mammalian cells and signals the activation of host defense pathways of the interferon system. We describe here a novel form of dsRNA-triggered signaling that leads to the stimulation of the p38 mitogen-activated protein kinase (p38 MAPK) and the c-Jun NH(2)-ter...

journal_title：Molecular and cellular biology

authors： Iordanov MS,Paranjape JM,Zhou A,Wong J,Williams BR,Meurs EF,Silverman RH,Magun BE

更新日期：2000-01-01 00:00:00

abstract：:We previously observed that nitric oxide (NO) exposure increases the stability of mRNAs encoding heme oxygenase 1 (HO-1) and TIEG-1 in human and mouse fibroblasts. Here, we have used microarrays to look broadly for changes in mRNA stability in response to NO treatment. Using human IMR-90 and mouse NIH 3T3 fibroblasts ...

journal_title：Molecular and cellular biology

authors： Kuwano Y,Rabinovic A,Srikantan S,Gorospe M,Demple B

更新日期：2009-05-01 00:00:00

abstract：:Scaffold attachment factor A (SAF-A), also called heterogenous nuclear ribonuclear protein U (hnRNP-U), is phosphorylated on serine 59 by the DNA-dependent protein kinase (DNA-PK) in response to DNA damage. Since SAF-A, DNA-PK catalytic subunit (DNA-PKcs), and protein phosphatase 6 (PP6), which interacts with DNA-PKcs...

journal_title：Molecular and cellular biology

authors： Douglas P,Ye R,Morrice N,Britton S,Trinkle-Mulcahy L,Lees-Miller SP

更新日期：2015-08-01 00:00:00

abstract：:Gene expression results from the coordinated actions of transcription factor proteins and coregulators. Estrogen receptor alpha (ERalpha) is a ligand-activated transcription factor that can both activate and repress the expression of genes. Activation of transcription by estrogen-bound ERalpha has been studied in deta...

journal_title：Molecular and cellular biology

authors： Ellison-Zelski SJ,Solodin NM,Alarid ET

更新日期：2009-09-01 00:00:00

abstract：:In the yeast Saccharomyces cerevisiae, sporulation occurs in response to nutritional and genetic signals. The process is initiated when nutrient availability limits mitotic growth, but only in MATa/MAT alpha diploid cells. Under these conditions, the cells express an activator of meiosis (IME1), which is required for ...

journal_title：Molecular and cellular biology

authors： Shah JC,Clancy MJ

更新日期：1992-03-01 00:00:00

abstract：:MAP2K4 encodes a dual-specificity kinase (mitogen-activated protein kinase kinase 4, or MKK4) that is mutated in a variety of human malignancies, but the biochemical properties of the mutant kinases and their roles in tumorigenesis have not been fully elucidated. Here we showed that 8 out of 11 cancer-associated MAP2K...

journal_title：Molecular and cellular biology

authors： Ahn YH,Yang Y,Gibbons DL,Creighton CJ,Yang F,Wistuba II,Lin W,Thilaganathan N,Alvarez CA,Roybal J,Goldsmith EJ,Tournier C,Kurie JM

更新日期：2011-11-01 00:00:00

abstract：:A family of transposable genetic elements in the genome of the frog, Xenopus laevis, is described. They are designated Tx1. Transposability of the elements was deduced by characterization of a chromosomal locus which is polymorphic for the presence or absence of a Tx1 element. Nucleotide sequence analysis suggested th...

journal_title：Molecular and cellular biology

authors： Garrett JE,Carroll D

更新日期：1986-03-01 00:00:00

abstract：:Cell fate specification requires precise coordination of transcription factors and their regulators to achieve fidelity and flexibility in lineage allocation. The transcriptional repressor growth factor independence 1 (GFI1) is comprised of conserved Snail/Slug/Gfi1 (SNAG) and zinc finger motifs separated by a linker ...

journal_title：Molecular and cellular biology

authors： Andrade D,Velinder M,Singer J,Maese L,Bareyan D,Nguyen H,Chandrasekharan MB,Lucente H,McClellan D,Jones D,Sharma S,Liu F,Engel ME

更新日期：2016-05-02 00:00:00

abstract：:Mrc1 is a conserved checkpoint mediator protein that transduces the replication stress signal to the downstream effector kinase. The loss of mrc1 checkpoint activity results in the aberrant activation of late/dormant origins in the presence of hydroxyurea. Mrc1 was also suggested to regulate orders of early origin fir...

journal_title：Molecular and cellular biology

authors： Matsumoto S,Kanoh Y,Shimmoto M,Hayano M,Ueda K,Fukatsu R,Kakusho N,Masai H

更新日期：2017-03-17 00:00:00

abstract：:GIPC is a PDZ protein located on peripheral endosomes that binds to the juxtamembrane region of the TrkA nerve growth factor (NGF) receptor and has been implicated in NGF signaling. We establish here that endogenous GIPC binds to the C terminus of APPL, a Rab5 binding protein, which is a marker for signaling endosomes...

journal_title：Molecular and cellular biology

authors： Varsano T,Dong MQ,Niesman I,Gacula H,Lou X,Ma T,Testa JR,Yates JR 3rd,Farquhar MG

更新日期：2006-12-01 00:00:00

abstract：:Heteroduplexes were prepared from two plasmids, pRH4-14/TK and pRH5-8/TK, containing different amber mutations in the neomycin resistance gene (Neor). The Neor gene was engineered to be expressed in both bacterial and mammalian cells. A functional Neor gene conferred kanamycin resistance to bacteria and resistance to ...

journal_title：Molecular and cellular biology

authors： Folger KR,Thomas K,Capecchi MR

更新日期：1985-01-01 00:00:00

abstract：:Two alternative exons, BEK and K-SAM, code for part of the ligand binding site of fibroblast growth factor receptor 2. Splicing of these exons is mutually exclusive, and the choice between them is made in a tissue-specific manner. We identify here pre-mRNA sequences involved in controlling splicing of the K-SAM exon. ...

journal_title：Molecular and cellular biology

authors： Del Gatto F,Breathnach R

更新日期：1995-09-01 00:00:00