Abstract:
:Recent advancements in genetic and proteomic technologies have revealed that more of the genome encodes proteins than originally thought possible. Specifically, some putative long noncoding RNAs (lncRNAs) have been misannotated as noncoding. Numerous lncRNAs have been found to contain short open reading frames (sORFs) which have been overlooked because of their small size. Many of these sORFs encode small proteins or micropeptides with fundamental biological importance. These micropeptides can aid in diverse processes, including cell division, transcription regulation, and cell signaling. Here we discuss strategies for establishing the coding potential of putative lncRNAs and describe various functions of known micropeptides.
journal_name
Mol Cell Bioljournal_title
Molecular and cellular biologyauthors
Hartford CCR,Lal Adoi
10.1128/MCB.00528-19subject
Has Abstractpub_date
2020-02-27 00:00:00issue
6eissn
0270-7306issn
1098-5549pii
MCB.00528-19journal_volume
40pub_type
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