When Long Noncoding Becomes Protein Coding.

Abstract:

:Recent advancements in genetic and proteomic technologies have revealed that more of the genome encodes proteins than originally thought possible. Specifically, some putative long noncoding RNAs (lncRNAs) have been misannotated as noncoding. Numerous lncRNAs have been found to contain short open reading frames (sORFs) which have been overlooked because of their small size. Many of these sORFs encode small proteins or micropeptides with fundamental biological importance. These micropeptides can aid in diverse processes, including cell division, transcription regulation, and cell signaling. Here we discuss strategies for establishing the coding potential of putative lncRNAs and describe various functions of known micropeptides.

journal_name

Mol Cell Biol

authors

Hartford CCR,Lal A

doi

10.1128/MCB.00528-19

subject

Has Abstract

pub_date

2020-02-27 00:00:00

issue

6

eissn

0270-7306

issn

1098-5549

pii

MCB.00528-19

journal_volume

40

pub_type

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