Cell-specific interaction of retinoic acid receptors with target genes in mouse embryonic fibroblasts and embryonic stem cells.

abstract：:The human ERCC3 gene, which corrects specifically the nucleotide excision repair defect in human xeroderma pigmentosum group B and cross-complements the repair deficiency in rodent UV-sensitive mutants of group 3, encodes a presumed DNA helicase that is identical to the p89 subunit of the general transcription factor ...

journal_title：Molecular and cellular biology

authors： Ma L,Westbroek A,Jochemsen AG,Weeda G,Bosch A,Bootsma D,Hoeijmakers JH,van der Eb AJ

更新日期：1994-06-01 00:00:00

abstract：:The Drosophila gap gene knirps (kni) is required for abdominal segmentation. It encodes a steroid/thyroid orphan receptor-type transcription factor which is distributed in a broad band of nuclei in the posterior region of the blastoderm. To identify essential domains of the kni protein (KNI), we cloned and sequenced t...

journal_title：Molecular and cellular biology

authors： Gerwin N,La Rosée A,Sauer F,Halbritter HP,Neumann M,Jäckle H,Nauber U

更新日期：1994-12-01 00:00:00

abstract：:Signal transduction by antigen receptors and some Fc receptors requires the activation of a family of receptor-associated transmembrane accessory proteins. One common feature of the cytoplasmic domains of these accessory molecules is the presence is at least two YXXA repeats that are potential sites for interaction wi...

journal_title：Molecular and cellular biology

authors： Burkhardt AL,Costa T,Misulovin Z,Stealy B,Bolen JB,Nussenzweig MC

更新日期：1994-02-01 00:00:00

abstract：:The Wnt-1 proto-oncogene is essential for proper development of the midbrain and is expressed in a spatially and temporally restricted manner during central nervous system development in mice. In vitro, the gene is specifically transcribed during the retinoic acid (RA)-induced neuroectodermal differentiation of the P1...

journal_title：Molecular and cellular biology

authors： St-Arnaud R,Moir JM

更新日期：1993-03-01 00:00:00

abstract：:SR proteins are essential for pre-mRNA splicing in vitro, act early in the splicing pathway, and can influence alternative splice site choice. Here we describe the isolation of both dominant and loss-of-function alleles of B52, the gene for a Drosophila SR protein. The allele B52ED was identified as a dominant second-...

journal_title：Molecular and cellular biology

authors： Peng X,Mount SM

更新日期：1995-11-01 00:00:00

abstract：:The function of the p53 tumor suppressor to inhibit proliferation or initiate apoptosis is often abrogated in tumor cells. Mdm2 and its homolog, Mdm4, are critical inhibitors of p53 that are often overexpressed in human tumors. In mice, loss of Mdm2 or Mdm4 leads to embryonic lethal phenotypes that are completely resc...

journal_title：Molecular and cellular biology

authors： Grier JD,Xiong S,Elizondo-Fraire AC,Parant JM,Lozano G

更新日期：2006-01-01 00:00:00

abstract：:Phosphoinositide-specific phospholipase C (PLC) is a key enzyme in phosphoinositide turnover and is involved in a variety of physiological functions. We analyzed PLCdelta1 knockout mice and found that PLCdelta1 is required for the maintenance of skin homeostasis. However, there were no remarkable abnormalities except ...

journal_title：Molecular and cellular biology

authors： Nakamura Y,Hamada Y,Fujiwara T,Enomoto H,Hiroe T,Tanaka S,Nose M,Nakahara M,Yoshida N,Takenawa T,Fukami K

更新日期：2005-12-01 00:00:00

abstract：:We have analyzed the 5'-flanking region of one of the genes coding for the human acute-phase protein, serum amyloid A (SAA). We found that SAA mRNA could be increased fivefold in transfected cells by treatment with phorbol 12-myristate 13-acetate (PMA). To analyze this observation further, we placed a 265-base-pair 5'...

journal_title：Molecular and cellular biology

authors： Edbrooke MR,Burt DW,Cheshire JK,Woo P

更新日期：1989-05-01 00:00:00

abstract：:A key antioxidant pathway, the Keap1-Nrf2 system, is regulated by p62/Sqstm1 via multiple mechanisms, including gene expression, posttranslational modifications (such as ubiquitination and phosphorylation), and autophagic degradation of p62/Sqstm1 and Keap1. Here we demonstrate a novel mode of regulation of the Keap1-...

journal_title：Molecular and cellular biology

authors： Kageyama S,Saito T,Obata M,Koide RH,Ichimura Y,Komatsu M

更新日期：2018-03-15 00:00:00

abstract：:The generation of two daughter cells with the same genetic information requires error-free chromosome segregation during mitosis. Chromosome transmission fidelity is dependent on spindle structure/function, which requires Asp1 in the fission yeast Schizosaccharomyces pombe Asp1 belongs to the diphosphoinositol pentaki...

journal_title：Molecular and cellular biology

authors： Pascual-Ortiz M,Saiardi A,Walla E,Jakopec V,Künzel NA,Span I,Vangala A,Fleig U

更新日期：2018-04-16 00:00:00

abstract：:The binding of the U1 small nuclear ribonucleoprotein (snRNP)-specific proteins C, A, and 70K to U1 small nuclear RNA (snRNA) was analyzed. Assembly of U1 snRNAs from bean and soybean and a set of mutant Xenopus U1 snRNAs into U1 snRNPs in Xenopus egg extracts was studied. The ability to bind proteins was analyzed by ...

journal_title：Molecular and cellular biology

authors： Hamm J,van Santen VL,Spritz RA,Mattaj IW

更新日期：1988-11-01 00:00:00

abstract：:Mdm2, a regulator of the tumor suppressor p53, is frequently overexpressed in human malignancies. Mdm2 also has unresolved, p53-independent functions that contribute to tumorigenesis. Here, we show that increased Mdm2 expression induced chromosome/chromatid breaks and delayed DNA double-strand break repair in cells la...

journal_title：Molecular and cellular biology

authors： Bouska A,Lushnikova T,Plaza S,Eischen CM

更新日期：2008-08-01 00:00:00

abstract：:Nascent-polypeptide-associated complex and coactivator alpha (alpha NAC) is a protein shuttling between the nucleus and the cytoplasm. Upon phosphorylation at residue serine 43 by integrin-linked kinase, alpha NAC is translocated to the nuclei of osteoblasts, where it acts as an AP-1 coactivator to increase osteocalci...

journal_title：Molecular and cellular biology

authors： Meury T,Akhouayri O,Jafarov T,Mandic V,St-Arnaud R

更新日期：2010-01-01 00:00:00

abstract：:Adaptive immune signaling can be coupled to stress-activated protein kinase (SAPK)/c-Jun N-terminal kinase (JNK) and NF-kappaB activation by the hematopoietic progenitor kinase 1 (HPK1), a mammalian hematopoiesis-specific Ste20 kinase. To gain insight into the regulation of leukocyte signal transduction, we investigat...

journal_title：Molecular and cellular biology

authors： Arnold R,Patzak IM,Neuhaus B,Vancauwenbergh S,Veillette A,Van Lint J,Kiefer F

更新日期：2005-03-01 00:00:00

abstract：:The interleukin-2 receptor (IL-2R) beta chain (IL-2R beta) is an essential signaling component of high- and intermediate-affinity IL-2Rs. Our laboratory previously reported that a DNA fragment containing 857 bp of 5'-flanking sequence of the human IL-2R beta gene exhibited promoter activity. We have now further charac...

journal_title：Molecular and cellular biology

authors： Lin JX,Bhat NK,John S,Queale WS,Leonard WJ

更新日期：1993-10-01 00:00:00

abstract：:The mechanism by which the maize autonomous Ac transposable element gives rise to nonautonomous Ds elements is largely unknown. Sequence analysis of native maize Ds elements indicates a complex chimeric structure formed through deletions of Ac sequences with or without insertions of Ac-unrelated sequence blocks. These...

journal_title：Molecular and cellular biology

authors： Rubin E,Levy AA

更新日期：1997-11-01 00:00:00

abstract：:By using a model system for cell transformation mediated by the cooperation of the activated H-ras oncogene and the inactivated p53 tumor suppressor gene, rCop-1 was identified by mRNA differential display as a gene whose expression became lost after cell transformation. Homology analysis indicates that rCop-1 belongs...

journal_title：Molecular and cellular biology

authors： Zhang R,Averboukh L,Zhu W,Zhang H,Jo H,Dempsey PJ,Coffey RJ,Pardee AB,Liang P

更新日期：1998-10-01 00:00:00

abstract：:We isolated and characterized LP1.2, a mouse myeloma mutant with a deletion of at least 4 kilobases (kb) immediately 3' of the alpha gene and introduction of at least 5 kb of novel (nonimmunoglobulin) sequence in its place. A 6.2-kb genomic EcoRI fragment from the mutated allele was cloned, and a subfragment was seque...

journal_title：Molecular and cellular biology

authors： Gregor PD,Morrison SL

更新日期：1986-06-01 00:00:00

abstract：:The 2 micron plasmid of Saccharomyces cerevisiae codes for a site-specific recombinase, the FLP protein, that catalyzes efficient recombination across two 599-base-pair (bp) inverted repeats of the plasmid DNA both in vivo and in vitro. We analyzed the interaction of the purified FLP protein with the target sequences ...

journal_title：Molecular and cellular biology

authors： Andrews BJ,McLeod M,Broach J,Sadowski PD

更新日期：1986-07-01 00:00:00

abstract：:To modulate transcription, regulatory factors communicate with basal transcription factors and/or RNA polymerases in a variety of ways. Previously, it has been reported that RNA polymerase II subunit 5 (RPB5) is one of the targets of hepatitis B virus X protein (HBx) and that both HBx and RPB5 specifically interact wi...

journal_title：Molecular and cellular biology

authors： Dorjsuren D,Lin Y,Wei W,Yamashita T,Nomura T,Hayashi N,Murakami S

更新日期：1998-12-01 00:00:00

abstract：:The c-Myc oncoprotein (Myc) controls cell fate by regulating gene transcription in association with a DNA-binding partner, Max. While Max lacks a transcription regulatory domain, the N terminus of Myc contains a transcription activation domain (TAD) that recruits cofactor complexes containing the histone acetyltransfe...

journal_title：Molecular and cellular biology

authors： Faiola F,Liu X,Lo S,Pan S,Zhang K,Lymar E,Farina A,Martinez E

更新日期：2005-12-01 00:00:00

abstract：:We have investigated mitochondrial import and processing of the precursor for human ornithine transcarbamylase (OTC; carbamoylphosphate:L-ornithine carbamoyltransferase, EC 2.1.3.3) in HeLa cells stably transformed with cDNA sequences encoding OTC precursors carrying mutations in their leader peptides. The mutant prec...

journal_title：Molecular and cellular biology

authors： Isaya G,Fenton WA,Hendrick JP,Furtak K,Kalousek F,Rosenberg LE

更新日期：1988-12-01 00:00:00

abstract：:Eucaryotic initiation factor 4A (eIF-4A) is a member of a family of proteins believed to be involved in the ATP-dependent melting of RNA secondary structure. These proteins contain a derivative of the consensus ATP-binding site AXXGXGKT. To assess the importance of the consensus amino acid sequence in eIF-4A for ATP b...

journal_title：Molecular and cellular biology

authors： Rozen F,Pelletier J,Trachsel H,Sonenberg N

更新日期：1989-09-01 00:00:00

abstract：:The upstream activating sequence of the adjacent and divergently transcribed GAL1 and GAL10 genes of Saccharomyces cerevisiae (UASG) contains at least three distinct classes of overlapping transcriptional control sites. The transcription activator GAL4 binds to four related sites in UASG and induces expression of GAL1...

journal_title：Molecular and cellular biology

authors： Finley RL Jr,West RW Jr

更新日期：1989-10-01 00:00:00

abstract：:The Polycomb group (PcG) of proteins represses homeotic gene expression through the assembly of multiprotein complexes on key regulatory elements. The mechanisms mediating complex assembly have remained enigmatic since most PcG proteins fail to bind DNA. We now demonstrate that the human PcG protein dinG interacts wit...

journal_title：Molecular and cellular biology

authors： Tuckfield A,Clouston DR,Wilanowski TM,Zhao LL,Cunningham JM,Jane SM

更新日期：2002-03-01 00:00:00

abstract：:The specific (6;9)(p23;q34) chromosomal translocation is associated with a defined subtype of acute nonlymphocytic leukemia (ANLL). The 9q34 breakpoint is located at the telomeric side of the c-abl gene. Through a combination of chromosome jumping, long-range mapping, and chromosome walking, the chromosome 9 breakpoin...

journal_title：Molecular and cellular biology

authors： von Lindern M,Poustka A,Lerach H,Grosveld G

更新日期：1990-08-01 00:00:00

abstract：:Insulin stimulates glucose transport into fat and muscle cells by increasing the exocytic trafficking rate of the GLUT4 facilitative glucose transporter from intracellular stores to the plasma membrane. Delivery of GLUT4 to the plasma membrane is mediated by formation of functional SNARE complexes containing syntaxin4...

journal_title：Molecular and cellular biology

authors： Kioumourtzoglou D,Gould GW,Bryant NJ

更新日期：2014-04-01 00:00:00

abstract：:The Ets family transcription factor PU.1 is crucial for the regulation of hematopoietic development. Pu.1 is activated in hematopoietic stem cells and is expressed in mast cells, B cells, granulocytes, and macrophages but is switched off in T cells. Many of the transcription factors regulating Pu.1 have been identifie...

journal_title：Molecular and cellular biology

authors： Hoogenkamp M,Krysinska H,Ingram R,Huang G,Barlow R,Clarke D,Ebralidze A,Zhang P,Tagoh H,Cockerill PN,Tenen DG,Bonifer C

更新日期：2007-11-01 00:00:00

abstract：:In this report, we explored the mechanisms underlying keratinocyte-specific and differentiation-specific gene expression in the skin. We have identified five keratinocyte-specific, open chromatin regions that exist within the 6 kb of 5' upstream regulatory sequence known to faithfully recapitulate the strong endogenou...

journal_title：Molecular and cellular biology

authors： Kaufman CK,Sinha S,Bolotin D,Fan J,Fuchs E

更新日期：2002-06-01 00:00:00

abstract：:It is well accepted that for transcriptional silencing in budding yeast, the evolutionarily conserved lysine deacetylase Sir2, in concert with its partner proteins Sir3 and Sir4, establishes a chromatin structure that prevents RNA polymerase II (Pol II) transcription. However, the mechanism of repression remains contr...

journal_title：Molecular and cellular biology

authors： Gao L,Gross DS

更新日期：2008-06-01 00:00:00