Identification of rCop-1, a new member of the CCN protein family, as a negative regulator for cell transformation.

abstract：:The amplified CAD genes in N-(phosphonacetyl)-L-aspartate (PALA)-resistant Syrian hamster cells are located in an expanded chromosomal region emanating from the site of the wild-type gene at the tip of the short arm of chromosome B-9. The terminus of B-9 in PALA-sensitive cells contains a cluster of rRNA genes (i.e., ...

journal_title：Molecular and cellular biology

authors： Wahl GM,Vitto L,Rubnitz J

更新日期：1983-11-01 00:00:00

abstract：:We report the development of a novel in vivo transcription assay for trans-acting factors regulating the human gamma- and beta-globin genes. A cDNA coding for the human tissue-type plasminogen activator (t-PA) was inserted into the globin genes. Simian virus 40 small T-antigen splice and polyadenylation signals were i...

journal_title：Molecular and cellular biology

authors： Wrighton N,Grosveld F

更新日期：1988-01-01 00:00:00

abstract：:Hox gene functions are intimately linked to correct developmental expression of the genes. The identification of cis-acting regulatory sequences and their associated trans-acting factors constitutes a key step in deciphering the mechanisms underlying the correct positioning of the functional domain of Hox genes along ...

journal_title：Molecular and cellular biology

authors： Tabariès S,Lapointe J,Besch T,Carter M,Woollard J,Tuggle CK,Jeannotte L

更新日期：2005-02-01 00:00:00

abstract：:The human immunodeficiency virus type 1 Rev protein contains a nuclear export signal (NES) that is required for Rev-mediated RNA export in mammals as well as in the yeast Saccharomyces cerevisiae. The Rev NES has been shown to specifically interact with a human (hRIP/RAB1) and a yeast (yRip1p) protein in the two-hybri...

journal_title：Molecular and cellular biology

authors： Stutz F,Izaurralde E,Mattaj IW,Rosbash M

更新日期：1996-12-01 00:00:00

abstract：:The Rel family of transcription factors participate in a diverse array of processes, including acute responses to injury and infection, lymphocyte differentiation, and embryonic patterning. These proteins show homology in an extended region spanning about 300 amino acids (the Rel homology domain [RHD]). The RHD mediat...

journal_title：Molecular and cellular biology

authors： Tatei K,Levine M

更新日期：1995-07-01 00:00:00

abstract：:Ure2p of Saccharomyces cerevisiae normally functions in blocking utilization of a poor nitrogen source when a good nitrogen source is available. The non-Mendelian genetic element [URE3] is a prion (infectious protein) form of Ure2p, so that overexpression of Ure2p induces the de novo appearance of infectious [URE3]. E...

journal_title：Molecular and cellular biology

authors： Maddelein ML,Wickner RB

更新日期：1999-06-01 00:00:00

abstract：:Two Saccharomyces cerevisiae genes isolated in a differential hybridization screening for DNA damage regulation (DDR genes) were also transcriptionally regulated by heat shock treatment. A 0.45-kilobase transcript homologous to the DDRA2 gene and a 1.25-kilobase transcript homologous to the DDR48 gene accumulated afte...

journal_title：Molecular and cellular biology

authors： McClanahan T,McEntee K

更新日期：1986-01-01 00:00:00

abstract：:The APN1 gene of Saccharomyces cerevisiae encodes the major apurinic/apyrimidinic endonuclease and 3'-repair DNA diesterase in yeast cell extracts. The Apn1 protein is a homolog of Escherichia coli endonuclease IV, which functions in the repair of some oxidative and alkylation damages in that organism. We show here th...

journal_title：Molecular and cellular biology

authors： Ramotar D,Popoff SC,Gralla EB,Demple B

更新日期：1991-09-01 00:00:00

abstract：:Six4 is a member of the Six family genes, homologues of Drosophila melanogaster sine oculis. The gene is thought to be involved in neurogenesis, myogenesis, and development of other organs, based on its specific expression in certain neuronal cells of the developing embryo and in adult skeletal muscles. To elucidate t...

journal_title：Molecular and cellular biology

authors： Ozaki H,Watanabe Y,Takahashi K,Kitamura K,Tanaka A,Urase K,Momoi T,Sudo K,Sakagami J,Asano M,Iwakura Y,Kawakami K

更新日期：2001-05-01 00:00:00

abstract：:The NuA4 histone acetyltransferase (HAT) multisubunit complex is responsible for acetylation of histone H4 and H2A N-terminal tails in yeast. Its catalytic component, Esa1, is essential for cell cycle progression, gene-specific regulation and has been implicated in DNA repair. Almost all NuA4 subunits have clear homol...

journal_title：Molecular and cellular biology

authors： Doyon Y,Selleck W,Lane WS,Tan S,Côté J

更新日期：2004-03-01 00:00:00

abstract：:Enamel mineralization is accompanied by the release of protons into the extracellular matrix, which is buffered to regulate the pH value in the local microenvironment. The present study aimed to investigate the role of microRNA 224 (miR-224) as a regulator of SLC4A4 and CFTR, encoding the key buffering ion transporter...

journal_title：Molecular and cellular biology

authors： Fan Y,Zhou Y,Zhou X,Sun F,Gao B,Wan M,Zhou X,Sun J,Xu X,Cheng L,Crane J,Zheng L

更新日期：2015-08-01 00:00:00

abstract：:The Tor pathway mediates cell growth in response to nutrient availability, in part by inducing ribosomal protein (RP) gene expression via an unknown mechanism. Expression of RP genes coincides with recruitment of the Esa1 histone acetylase to RP gene promoters. We show that inhibition of Tor with rapamycin releases Es...

journal_title：Molecular and cellular biology

authors： Rohde JR,Cardenas ME

更新日期：2003-01-01 00:00:00

abstract：:HO endonuclease-induced double-strand breaks in Saccharomyces cerevisiae can undergo recombination by two distinct and competing pathways. In a plasmid containing a direct repeat, in which one repeat is interrupted by an HO endonuclease cut site, gap repair yields gene conversions while single-strand annealing produce...

journal_title：Molecular and cellular biology

authors： Fishman-Lobell J,Rudin N,Haber JE

更新日期：1992-03-01 00:00:00

abstract：:A tetracycline-regulated reporter system was used to investigate the regulation of cyclooxygenase 2 (Cox-2) mRNA stability by the mitogen-activated protein kinase (MAPK) p38 signaling cascade. The stable beta-globin mRNA was rendered unstable by insertion of the 2, 500-nucleotide Cox-2 3' untranslated region (3' UTR)....

journal_title：Molecular and cellular biology

authors： Lasa M,Mahtani KR,Finch A,Brewer G,Saklatvala J,Clark AR

更新日期：2000-06-01 00:00:00

abstract：:The nuclear receptor steroidogenic factor 1 (SF-1) is essential for adrenal development and steroidogenesis. The atypical orphan nuclear receptor Dax-1 binds to SF-1 and represses SF-1 target genes. Paradoxically, however, loss-of-function mutations of Dax-1 also cause adrenal hypoplasia, suggesting that Dax-1 may fun...

journal_title：Molecular and cellular biology

authors： Xu B,Yang WH,Gerin I,Hu CD,Hammer GD,Koenig RJ

更新日期：2009-04-01 00:00:00

abstract：:We have characterized the role of YPR128cp, the orthologue of human PMP34, in fatty acid metabolism and peroxisomal proliferation in Saccharomyces cerevisiae. YPR128cp belongs to the mitochondrial carrier family (MCF) of solute transporters and is localized in the peroxisomal membrane. Disruption of the YPR128c gene r...

journal_title：Molecular and cellular biology

authors： van Roermund CW,Drissen R,van Den Berg M,Ijlst L,Hettema EH,Tabak HF,Waterham HR,Wanders RJ

更新日期：2001-07-01 00:00:00

abstract：:Spatial control of cytokinesis is essential for proper cell division. The molecular mechanisms that anchor the dynamic assembly and constriction of the cytokinetic ring at the plasma membrane remain unclear. In the fission yeast Schizosaccharomyces pombe, the cytokinetic ring is assembled in the cell middle from corti...

journal_title：Molecular and cellular biology

authors： Guzman-Vendrell M,Baldissard S,Almonacid M,Mayeux A,Paoletti A,Moseley JB

更新日期：2013-01-01 00:00:00

abstract：:CD8+ T-cell apoptosis is essential for the contraction phase of the immune response, yet the initiating signals and precise pathways involved are unresolved. The ST3Gal-I sialyltransferase is a candidate mechanistic component and catalyzes sialic acid addition to core 1 O-glycans during protein O glycosylation. ST3Gal...

journal_title：Molecular and cellular biology

authors： Van Dyken SJ,Green RS,Marth JD

更新日期：2007-02-01 00:00:00

abstract：:Extragenic suppressors of a new temperature-sensitive mutation (act1-4) in the actin gene of Saccharomyces cerevisiae were isolated in an attempt to identify genes whose products interact directly with actin. One suppressor with a cold-sensitive growth phenotype defined the new gene, SAC7, which was mapped, cloned, se...

journal_title：Molecular and cellular biology

authors： Dunn TM,Shortle D

更新日期：1990-05-01 00:00:00

abstract：:Previous work showed that tunicamycin suppresses glycosylation of laminin. In the present work, the role of glycosylation in the secretion of laminin and in the disulfide bonding of laminin subunits was studied, using tunicamycin to inhibit glycosylation. Tunicamycin inhibited extensively the secretion of laminin into...

journal_title：Molecular and cellular biology

authors： Howe CC

更新日期：1984-01-01 00:00:00

abstract：:Transcription activation of alpha-specific genes in Saccharomyces cerevisiae is regulated by two proteins, MCM1 and alpha 1, which bind to DNA sequences, called P'Q elements, found upstream of alpha-specific genes. Neither MCM1 nor alpha 1 alone binds efficiently to P'Q elements. Together, however, they bind cooperati...

journal_title：Molecular and cellular biology

authors： Hagen DC,Bruhn L,Westby CA,Sprague GF Jr

更新日期：1993-11-01 00:00:00

abstract：:Aflatoxin B1 (AFB1) is a human hepatotoxin and hepatocarcinogen produced by the mold Aspergillus flavus. In humans, AFB1 is primarily bioactivated by cytochrome P450 1A2 (CYP1A2) and 3A4 to a genotoxic epoxide that forms N7-guanine DNA adducts. A series of yeast haploid mutants defective in DNA repair and cell cycle c...

journal_title：Molecular and cellular biology

authors： Guo Y,Breeden LL,Zarbl H,Preston BD,Eaton DL

更新日期：2005-07-01 00:00:00

abstract：:DNA mismatch repair maintains genomic stability by detecting and correcting mispaired DNA sequences and by signaling cell death when DNA repair fails. The mechanism by which mismatch repair coordinates DNA damage and repair with cell survival or death is not understood, but it suggests the need for regulation. Since t...

journal_title：Molecular and cellular biology

authors： Wu X,Platt JL,Cascalho M

更新日期：2003-05-01 00:00:00

abstract：:Circadian clock genes are regulated through a transcriptional-translational feedback loop. Alterations of the chromatin structure by histone acetyltransferases and histone deacetylases (HDACs) are commonly implicated in the regulation of gene transcription. However, little is known about the transcriptional regulation...

journal_title：Molecular and cellular biology

authors： Naruse Y,Oh-hashi K,Iijima N,Naruse M,Yoshioka H,Tanaka M

更新日期：2004-07-01 00:00:00

abstract：:Transposons have contributed protein coding sequences to a unexpectedly large number of human genes. Except for the V(D)J recombinase and telomerase, all remain of unknown function. Here we investigate the activity of the human SETMAR protein, a highly expressed fusion between a histone H3 methylase and a mariner fami...

journal_title：Molecular and cellular biology

authors： Liu D,Bischerour J,Siddique A,Buisine N,Bigot Y,Chalmers R

更新日期：2007-02-01 00:00:00

abstract：:Interactions between master regulatory pathways provide higher-order controls for cellular regulation. Recently, we reported a C-->T single-nucleotide polymorphism (SNP) in the vascular endothelial growth factor receptor 1 (VEGFR-1/Flt1) promoter that merges human VEGF and p53 pathways. This finding suggested a new la...

journal_title：Molecular and cellular biology

authors： Menendez D,Inga A,Snipe J,Krysiak O,Schönfelder G,Resnick MA

更新日期：2007-04-01 00:00:00

abstract：:In contrast to differentiated somatic cells, mouse embryonal carcinoma (EC) cell lines spontaneously express high levels of major members of the heat shock protein (HSP) family. In addition, some EC cell lines (noninducible) are not able to induce HSP gene transcription and HSP synthesis after a stress. However, after...

journal_title：Molecular and cellular biology

authors： Mezger V,Bensaude O,Morange M

更新日期：1989-09-01 00:00:00

abstract：:For proper male sexual differentiation, anti-Müllerian hormone (AMH) must be tightly regulated during embryonic development to promote regression of the Müllerian duct. However, the molecular mechanisms specifying the onset of AMH in male mammals are not yet clearly defined. A DNA-binding element for the steroidogenic...

journal_title：Molecular and cellular biology

authors： De Santa Barbara P,Bonneaud N,Boizet B,Desclozeaux M,Moniot B,Sudbeck P,Scherer G,Poulat F,Berta P

更新日期：1998-11-01 00:00:00

abstract：:When exposed to 5-azacytidine, marrow stromal cells from active long-term marrow cultures and cell lines derived from simian virus 40-transformed stromal cells rapidly upregulated c-abl and interleukin-6 transcripts while downregulating the expression of collagen I, a major matrix protein. Similar effects occurred wit...

journal_title：Molecular and cellular biology

authors： Andrews DF 3rd,Nemunaitis J,Tompkins C,Singer JW

更新日期：1989-06-01 00:00:00

abstract：:The Werner syndrome protein (WRN) suppresses the loss of telomeres replicated by lagging-strand synthesis by a yet to be defined mechanism. Here, we show that whereas either WRN or the Bloom syndrome helicase (BLM) stimulates DNA polymerase δ progression across telomeric G-rich repeats, only WRN promotes sequential st...

journal_title：Molecular and cellular biology

authors： Li B,Reddy S,Comai L

更新日期：2017-01-19 00:00:00