Overexpression of protein kinase C in HT29 colon cancer cells causes growth inhibition and tumor suppression.

abstract：:A new transforming gene has been molecularly cloned from hamster SHOK cells transformed with DNA extracted from a human thyroid carcinoma cell line and named the cot (cancer Osaka thyroid) oncogene. cDNA sequencing disclosed that this oncogene codes for a protein with 415 amino acid residues, and computer matching sho...

journal_title：Molecular and cellular biology

authors： Miyoshi J,Higashi T,Mukai H,Ohuchi T,Kakunaga T

更新日期：1991-08-01 00:00:00

abstract：:Activation of peroxisome proliferator-activated receptor alpha (PPARalpha) leads to hepatocellular proliferation and liver carcinomas. The early events mediating these effects are unknown. A novel mechanism by which PPARalpha regulates gene expression and hepatocellular proliferation was uncovered. MicroRNA (miRNA) ex...

journal_title：Molecular and cellular biology

authors： Shah YM,Morimura K,Yang Q,Tanabe T,Takagi M,Gonzalez FJ

更新日期：2007-06-01 00:00:00

abstract：:The imprinted expression of the H19 and Igf2 genes in the mouse is controlled by an imprinting control center (ICR) whose activity is regulated by parent-of-origin differences in methylation. The only protein that has been implicated in ICR function is the zinc-finger protein CTCF, which binds at multiple sites within...

journal_title：Molecular and cellular biology

authors： Katz DJ,Beer MA,Levorse JM,Tilghman SM

更新日期：2005-05-01 00:00:00

abstract：:Intron-encoded U17a and U17b RNAs are members of the H/ACA-box class of small nucleolar RNAs (snoRNAs) participating in rRNA processing and modification. We have investigated the organization and expression of the U17 locus in human cells and found that intronic U17a and U17b sequences are transcribed as part of the t...

journal_title：Molecular and cellular biology

authors： Pelczar P,Filipowicz W

更新日期：1998-08-01 00:00:00

abstract：:Unique single-stranded regions of simian virus 40 DNA, phage M13 virion DNA, and several homopolymers were used as templates for the synthesis of (p)ppRNA-DNA chains by CV-1 cell DNA primase-DNA polymerase alpha. Intact RNA primers, specifically labeled with an RNA capping enzyme, were typically 6 to 8 ribonucleotides...

journal_title：Molecular and cellular biology

authors： Yamaguchi M,Hendrickson EA,DePamphilis ML

更新日期：1985-05-01 00:00:00

abstract：:Brain disturbances, like injuries or aberrant protein deposits, evoke nucleotide release or leakage from cells, leading to microglial chemotaxis and ingestion. Recent studies have identified P2Y12 purinergic receptors as triggers for microglial chemotaxis and P2Y6 receptors as mediators for phagocytosis. However, pino...

journal_title：Molecular and cellular biology

authors： Li HQ,Chen C,Dou Y,Wu HJ,Liu YJ,Lou HF,Zhang JM,Li XM,Wang H,Duan S

更新日期：2013-11-01 00:00:00

abstract：:In a previous paper, we have shown that in the absence of stress, mouse embryonal carcinoma cells, like mouse early embryo multipotent cells, synthesize high levels of 89- and 70-kilodalton heat shock proteins (HSP)(O. Bensaude and M. Morange, EMBO J. 2:173-177, 1983). We report here the pattern of proteins synthesize...

journal_title：Molecular and cellular biology

authors： Morange M,Diu A,Bensaude O,Babinet C

更新日期：1984-04-01 00:00:00

abstract：:The genetic basis of pancreatic ductal adenocarcinoma, which constitutes the most common type of pancreatic malignancy, involves the sequential activation of oncogenes and inactivation of tumor suppressor genes. Among the pivotal genetic alterations are Ki-RAS oncogene activation and p53 tumor suppressor gene inactiva...

journal_title：Molecular and cellular biology

authors： Deramaudt TB,Takaoka M,Upadhyay R,Bowser MJ,Porter J,Lee A,Rhoades B,Johnstone CN,Weissleder R,Hingorani SR,Mahmood U,Rustgi AK

更新日期：2006-06-01 00:00:00

abstract：:We have identified multiple distinct splicing enhancer elements within protein-coding sequences of the constitutively spliced human beta-globin pre-mRNA. Each of these highly conserved sequences is sufficient to activate the splicing of a heterologous enhancer-dependent pre-mRNA. One of these enhancers is activated by...

journal_title：Molecular and cellular biology

authors： Schaal TD,Maniatis T

更新日期：1999-01-01 00:00:00

abstract：:sra5 mutations in Saccharomyces cerevisiae were previously shown to suppress the inefficient growth of ras2 strains on nonfermentable carbon sources and to result in deficient low-Km cyclic AMP (cAMP) phosphodiesterase activity. We have cloned SRA5 by complementation. It maps to the right arm of chromosome XV, tightly...

journal_title：Molecular and cellular biology

authors： Wilson RB,Tatchell K

更新日期：1988-01-01 00:00:00

abstract：:It has previously been demonstrated that the simian virus 40 large T antigen and adenovirus E1A proteins can form complexes with the retinoblastoma susceptibility gene product (RB). We studied the ability of these proteins to bind to mutant RB proteins in vitro. A region of RB spanning residues 379 to 792 was found to...

journal_title：Molecular and cellular biology

authors： Kaelin WG Jr,Ewen ME,Livingston DM

更新日期：1990-07-01 00:00:00

abstract：:CD26 is a T-cell costimulatory molecule with dipeptidyl peptidase IV enzyme activity in its extracellular region. We have previously reported that the addition of recombinant soluble CD26 resulted in enhanced proliferation of human T lymphocytes induced by the recall antigen tetanus toxoid (TT) via upregulation of CD8...

journal_title：Molecular and cellular biology

authors： Ohnuma K,Yamochi T,Uchiyama M,Nishibashi K,Iwata S,Hosono O,Kawasaki H,Tanaka H,Dang NH,Morimoto C

更新日期：2005-09-01 00:00:00

abstract：:Sirtuins are a family of protein deacetylases, deacylases, and ADP-ribosyltransferases that regulate life span, control the onset of numerous age-associated diseases, and mediate metabolic homeostasis. We have uncovered a novel role for the mitochondrial sirtuin SIRT4 in the regulation of hepatic lipid metabolism duri...

journal_title：Molecular and cellular biology

authors： Laurent G,de Boer VC,Finley LW,Sweeney M,Lu H,Schug TT,Cen Y,Jeong SM,Li X,Sauve AA,Haigis MC

更新日期：2013-11-01 00:00:00

abstract：:Aberrant activation of the Wnt/β-catenin pathway and polo-like kinase 1 (Plk1) overexpression represent two common events in prostate cancer with relevant functional implications. This minireview analyzes their potential therapeutic significance in prostate cancer based on their role as androgen receptor (AR) signalin...

journal_title：Molecular and cellular biology

authors： Cristóbal I,Rojo F,Madoz-Gúrpide J,García-Foncillas J

更新日期：2016-05-31 00:00:00

abstract：:Cell numbers are regulated by a balance among proliferation, growth arrest, and programmed cell death. A profound example of cell homeostasis, controlled throughout life, is the complex process of blood cell development, yet little is understood about the intracellular mechanisms that regulate blood cell growth arrest...

journal_title：Molecular and cellular biology

authors： Selvakumaran M,Lin HK,Sjin RT,Reed JC,Liebermann DA,Hoffman B

更新日期：1994-04-01 00:00:00

abstract：:Colon carcinomas appear to arise from the cumulative effect of mutations to several genes (APC, DCC, p53, ras, hMLH1, and hMSH2). By using novel colonic epithelial cell lines derived from the Immorto mouse, named the YAMC (young adult mouse colon) cell line, and an Immorto-Min mouse hybrid, named the IMCE (Immorto-Min...

journal_title：Molecular and cellular biology

authors： D'Abaco GM,Whitehead RH,Burgess AW

更新日期：1996-03-01 00:00:00

abstract：:The expression of the c-jun proto-oncogene is rapidly induced in response to mitogens acting on a large variety of cell surface receptors. The resulting functional activity of c-Jun proteins appears to be critical for cell proliferation. Recently, we have shown that a large family of G protein-coupled receptors (GPCRs...

journal_title：Molecular and cellular biology

authors： Marinissen MJ,Chiariello M,Pallante M,Gutkind JS

更新日期：1999-06-01 00:00:00

abstract：:The opposing effects on proliferation mediated by G-protein-coupled receptor isoforms differing in their COOH termini could be correlated with the abilities of the receptors to differentially activate p38, implicated in apoptotic events, or phosphatidylinositol 3-kinase (PI 3-K), which provides a source of survival si...

journal_title：Molecular and cellular biology

authors： Sellers LA,Alderton F,Carruthers AM,Schindler M,Humphrey PP

更新日期：2000-08-01 00:00:00

abstract：:The Saccharomyces cerevisiae CDC25 gene and closely homologous genes in other eukaryotes encode guanine nucleotide exchange factors for Ras proteins. We have determined the minimal region of the budding yeast CDC25 gene capable of activity in vivo. The region required for full biological activity is approximately 450 ...

journal_title：Molecular and cellular biology

authors： Lai CC,Boguski M,Broek D,Powers S

更新日期：1993-03-01 00:00:00

abstract：:Up to 70% of human genes are associated with regions of nonmethylated DNA called CpG islands (S. Saxonov, P. Berg, and D. L. Brutlag, Proc. Natl. Acad. Sci. U. S. A. 103:1412-1417, 2006). Usually associated with the 5' end of genes, CpG islands are thought to impact gene expression. We previously demonstrated that the...

journal_title：Molecular and cellular biology

authors： Zhou JC,Blackledge NP,Farcas AM,Klose RJ

更新日期：2012-01-01 00:00:00

abstract：:Our recent studies implicated key and distinct roles for the highly related RalA and RalB small GTPases (82% sequence identity) in pancreatic ductal adenocarcinoma (PDAC) tumorigenesis and invasive and metastatic growth, respectively. How RalB may promote PDAC invasion and metastasis has not been determined. In light ...

journal_title：Molecular and cellular biology

authors： Neel NF,Rossman KL,Martin TD,Hayes TK,Yeh JJ,Der CJ

更新日期：2012-04-01 00:00:00

abstract：:Drosophila sine oculis and eyes absent genes synergize in compound-eye formation. The murine homologues of these genes, Six and Eya, respectively, show overlapping expression patterns during development. We hypothesized that Six and Eya proteins cooperate to regulate their target genes. Cotransfection assays were perf...

journal_title：Molecular and cellular biology

authors： Ohto H,Kamada S,Tago K,Tominaga SI,Ozaki H,Sato S,Kawakami K

更新日期：1999-10-01 00:00:00

abstract：:Genomic instability, including the ability to undergo gene amplification, is a hallmark of neoplastic cells. Similar to normal cells, "nonpermissive" REF52 cells do not develop resistance to N-(phosphonacetyl)-L-aspartate (PALA), an inhibitor of the synthesis of pyrimidine nucleotides, through amplification of cad, th...

journal_title：Molecular and cellular biology

authors： Chernova OB,Chernov MV,Ishizaka Y,Agarwal ML,Stark GR

更新日期：1998-01-01 00:00:00

abstract：:Two-dimensional protein gels were used to systematically assess changes in gene expression in Friend erythroleukemia cells after exposure to inducers of differentiation. A rapid decrease in expression of the stress protein HSP70 was observed after exposure to inducers. The kinetics of this change suggest that it may b...

journal_title：Molecular and cellular biology

authors： Hensold JO,Housman DE

更新日期：1988-05-01 00:00:00

abstract：:In the absence of telomerase, telomeres erode, provoking accumulation of DNA damage and death by senescence. Rare survivors arise, however, due to Rad52-based amplification of telomeric sequences by homologous recombination. The present study reveals that in budding yeast cells, postsenescence survival relying on ampl...

journal_title：Molecular and cellular biology

authors： Grandin N,Charbonneau M

更新日期：2009-02-01 00:00:00

abstract：:RNA polymerase III (pol III) transcripts of the highly repeated mouse B2 gene family are increased in many oncogenically transformed murine cell lines. In cells transformed by simian virus 40, the small, cytoplasmic B2 RNAs are present at 20-fold-higher levels than in normal cells (M. R. D. Scott, K. Westphal, and P. ...

journal_title：Molecular and cellular biology

authors： Carey MF,Singh K,Botchan M,Cozzarelli NR

更新日期：1986-09-01 00:00:00

abstract：:The mammalian signal recognition particle (SRP) is a small cytoplasmic ribonucleoprotein required for the cotranslational targeting of secretory proteins to the endoplasmic reticulum membrane. The heterodimeric protein subunit SRP9/14 was previously shown to be essential for SRP to cause pausing in the elongation of s...

journal_title：Molecular and cellular biology

authors： Strub K,Moss J,Walter P

更新日期：1991-08-01 00:00:00

abstract：:The nucleotide sequence of 5'-noncoding and N-terminal coding regions of two coordinately regulated, repressible acid phosphatase genes from Saccharomyces cerevisiae were determined. These unlinked genes encode different, but structurally related polypeptides of molecular weights 60,000 and 56,000. The DNA sequences o...

journal_title：Molecular and cellular biology

authors： Thill GP,Kramer RA,Turner KJ,Bostian KA

更新日期：1983-04-01 00:00:00

abstract：:The mTOR signaling complex integrates signals from growth factors and nutrient availability to control cell growth and proliferation, in part through effects on the protein-synthetic machinery. Protein synthesis rates fluctuate throughout the cell cycle but diminish significantly during the G(2)/M transition. The fate...

journal_title：Molecular and cellular biology

authors： Ramírez-Valle F,Badura ML,Braunstein S,Narasimhan M,Schneider RJ

更新日期：2010-07-01 00:00:00

abstract：:Bone morphogenetic protein 7 (BMP7) stimulates renal branching morphogenesis via p38 mitogen-activated protein kinase (p38(MAPK)) and activating transcription factor 2 (ATF-2) (M. C. Hu, D. Wasserman, S. Hartwig, and N. D. Rosenblum, J. Biol. Chem. 279:12051-12059, 2004). Here, we demonstrate a novel role for integrin...

journal_title：Molecular and cellular biology

authors： Leung-Hagesteijn C,Hu MC,Mahendra AS,Hartwig S,Klamut HJ,Rosenblum ND,Hannigan GE

更新日期：2005-05-01 00:00:00