The relationship between the response of clinical symptoms and plasma olanzapine concentration, based on pharmacogenetics: Juntendo University Schizophrenia Projects (JUSP).

abstract：BACKGROUND:Despite significant interindividual variability in prednisolone pharmacokinetics and potentially serious consequences with inadequate or excessive exposure, monitoring of prednisolone levels is not employed to guide therapy. As ultrahigh-performance liquid chromatography-tandem mass spectrometry methods can ...

journal_title：Therapeutic drug monitoring

authors： Yates CJ,Barraclough KA,McWhinney BC,Ungerer JP,Fullinfaw RO,Colman PG,Fourlanos S,Cohney SJ

更新日期：2014-02-01 00:00:00

abstract：:A 64-year-old man on chronic hemodialysis for end-stage renal disease developed peritoneal carcinomatosis, and palliative chemotherapy with fluorouracil was started. The drug was administered (325 mg/m as IV bolus, at 2 PM) on 2 separate occasions, ie, 1 hour after dialysis and 2 days later, 49 hours after dialysis. T...

journal_title：Therapeutic drug monitoring

authors： Gusella M,Rebeschini M,Cartei G,Ferrazzi E,Ferrari M,Padrini R

更新日期：2005-12-01 00:00:00

abstract：:The present study aims to determine the population pharmacokinetic parameters of cyclosporine (CsA) after multiple oral administration of the microemulsion formulation, Neoral, in kidney transplant patients and to propose a limited sampling strategy to predict AUC(0-4h) using them and the Bayesian method. The AUC(0-4h...

journal_title：Therapeutic drug monitoring

authors： Tokui K,Kimata T,Uchida K,Yuasa H,Hayashi Y,Itatsu T,Nabeshima T

更新日期：2004-06-01 00:00:00

abstract：:Effect of diabetes mellitus on mycophenolic acid (MPA) pharmacokinetics and catalytic activity of inosine monophosphate dehydrogenase (IMPDH) was investigated in maintenance kidney transplant recipients. Demographically matched diabetic (n=9) and nondiabetic (n=9) patients were included in a 12-hour open-label, steady...

journal_title：Therapeutic drug monitoring

authors： Patel CG,Richman K,Yang D,Yan B,Gohh RY,Akhlaghi F

更新日期：2007-12-01 00:00:00

abstract：:Monoclonal antibodies (mAbs) may be used as biopharmaceuticals to treat various diseases, ranging from oncology to inflammatory and cardiovascular affections. Trustworthy analytical methods are necessary to study their pharmacokinetics, both during their development and in post-marketing studies. Because biopharmaceut...

journal_title：Therapeutic drug monitoring

authors： Darrouzain F,Bian S,Desvignes C,Bris C,Watier H,Paintaud G,de Vries A

更新日期：2017-08-01 00:00:00

abstract：:The ring sulfoxidation of thioridazine (THD), a widely used neuroleptic agent, yields two diastereoisomeric pairs, fast- and slow-eluting (FE and SE) thioridazine 5-sulfoxide (THD 5-SO). Until now, studies in which concentrations of these metabolites were measured in THD-treated patients have revealed no significant d...

journal_title：Therapeutic drug monitoring

authors： Eap CB,Souche A,Koeb L,Baumann P

更新日期：1991-07-01 00:00:00

abstract：:Plasma concentration-antidepressant response relationships for dothiepin, nordothiepin, dothiepin-S-oxide, and nordothiepin-S-oxide were investigated in 50 patients (33 women and 17 men), who had had a major depressive episode. Depression and anxiety were assessed at the start of therapy and after 2 and 4 weeks by mea...

journal_title：Therapeutic drug monitoring

authors： Ilett KF,Blythe TH,Hackett LP,Ong RT,Tannenbaum DA,Clarke TM

更新日期：1993-10-01 00:00:00

abstract：:Drugs metabolized by cytochrome CYP3A isoenzymes have wide interindividual variability and normally distributed plasma clearance distributions. This makes precise dosing difficult to achieve clinically, which may compromise safe therapy. We hypothesized that with potent inhibition of CYP3A, we could clinically render ...

journal_title：Therapeutic drug monitoring

authors： Tham LS,Lee HS,Wang L,Yong WP,Fan L,Ong AB,Sukri N,Soo R,Lee SC,Goh BC

更新日期：2006-04-01 00:00:00

abstract：BACKGROUND/OBJECTIVES:Drug of abuse consumption throughout pregnancy is a serious public health problem and an important economic cost to the health system. The aim of this work was to compare maternal interview and hair analysis to determine drug consumption throughout pregnancy and to study relations among maternal i...

journal_title：Therapeutic drug monitoring

authors： Lendoiro E,González-Colmenero E,Concheiro-Guisán A,de Castro A,Cruz A,López-Rivadulla M,Concheiro M

更新日期：2013-06-01 00:00:00

abstract：BACKGROUND:Therapeutic drug monitoring (TDM) involves the measurement of serum drug concentrations to optimize pharmacotherapy. Traditionally, blood pressure measurements alone, and not TDM, have been used to evaluate the antihypertensive drug response. However, approximately 50% of hypertensive patients treated with l...

journal_title：Therapeutic drug monitoring

authors： Rognstad S,Søraas CL,Bergland OU,Høieggen A,Strømmen M,Helland A,Opdal MS

更新日期：2021-02-01 00:00:00

abstract：:In 12 institutionalized epilepsy patients who had been treated 19 months (SD +/- 5) with valproic acid, 27.0 mg/kg (SD +/- 11.9), phenytoin, 6.33 mg/kg (SD +/- 1.36), and co-anticonvulsants, the mean percentage of daily free valproic acid was 11.72 (SD +/- 2.10) and of phenytoin 20.39 (SD +/- 3.32). By serial within-d...

journal_title：Therapeutic drug monitoring

authors： Haidukewych D,Rodin EA

更新日期：1981-01-01 00:00:00

abstract：:Oral posaconazole (PSZ), an azole antifungal drug, was recently introduced for the treatment of invasive fungal infections. The prescription of PSZ together with the immunosuppressant tacrolimus (TRL) was evaluated in 14 lung transplant patients with cystic fibrosis. PSZ inhibited CYP3A4 TRL metabolism, resulting in a...

journal_title：Therapeutic drug monitoring

authors： Berge M,Chevalier P,Benammar M,Guillemain R,Amrein C,Lefeuvre S,Boussaud V,Billaud EM

更新日期：2009-06-01 00:00:00

abstract：BACKGROUND:Anti-T lymphocyte globulin (ATLG) modulates the alloreactivity of T lymphocytes, reducing the risk of immunological posttransplant complications, in particular rejection and graft-versus-host disease, after allogeneic hematopoietic stem cell transplantation (HSCT). We developed and validated a new enzyme-lin...

journal_title：Therapeutic drug monitoring

authors： Montagna M,La Nasa G,Bernardo ME,Piras E,Avanzini MA,Regazzi M,Locatelli F

更新日期：2017-06-01 00:00:00

abstract：:The immunosuppressant mycophenolic acid (MPA) used for solid organ transplantation is predominantly metabolized to a pharmacologically inactive phenolic glucuronide (MPAG) and, to a lesser extent, to the pharmacologically active acyl glucuronide (AcMPAG). The recently introduced CEDIA Mycophenolic Acid Assay from Micr...

journal_title：Therapeutic drug monitoring

authors： Shipkova M,Schütz E,Besenthal I,Fraunberger P,Wieland E

更新日期：2010-02-01 00:00:00

abstract：:Metabolism of thiopurine drugs--azathioprine, 6-mercaptopurine, and 6-thioguanine--has provided a powerful pharmacogenetic model incorporating polymorphism of the enzyme thiopurine methyltransferase (TPMT) and the primary active metabolite, thioguanine nucleotide (TGN). However, a sense of uncertainty about the useful...

journal_title：Therapeutic drug monitoring

authors： Duley JA,Florin TH

更新日期：2005-10-01 00:00:00

abstract：:Since the late 90s, biopharmaceuticals targeting tumor necrosis factor alpha have revolutionized the treatment of moderately to severely active inflammatory bowel disease. The robust efficacy witnessed in many patients stands in stark contrast with the observation of a proportion of patients who fail to respond or who...

journal_title：Therapeutic drug monitoring

authors： Detrez I,Van Stappen T,Martín Arranz MD,Papamichael K,Gils A

更新日期：2017-08-01 00:00:00

abstract：:A case of desmethylimipramine (DMI) overdose is described. The analysis of DMI and its main metabolite, 2-hydroxydesmethylimipramine (2-OH-DMI), in plasma was performed by high performance liquid chromatography with fluorescence detection. Characterization of the elimination kinetics of DMI by using the SAAM 25 comput...

journal_title：Therapeutic drug monitoring

authors： Spina E,Henthorn TK,Eleborg L,Nordin C,Säwe J

更新日期：1985-01-01 00:00:00

abstract：:An original, sensitive, and specific high-performance liquid chromatographic (HPLC) assay was developed for the quantitation of morphine and its two major metabolites, morphine-3-glucuronide (M3G) and morphine-6-glucuronide (M6G), in human plasma and cerebrospinal fluid (CSF) and in rat plasma, using hydromorphone as ...

journal_title：Therapeutic drug monitoring

authors： Wright AW,Watt JA,Kennedy M,Cramond T,Smith MT

更新日期：1994-04-01 00:00:00

abstract：:It is generally accepted that chemical testing of biologic fluids is the most objective means of diagnosis of drug use. The presence of a drug analyte in a biologic specimen can be used to document exposure. The standard for drug testing in toxicology is an immunoassay screen conducted on a urine sample, followed by c...

journal_title：Therapeutic drug monitoring

authors： Kintz P,Samyn N

更新日期：2002-04-01 00:00:00

abstract：:Drug discovery programs are actively exploring for therapeutic agents targeting enzymes and receptors regulating sphingolipid metabolism and biologic functions. FTY720 is a close structural analogue of sphingosine with immunomodulatory properties. After oral administration, FTY720 is phosphorylated by sphingosine kina...

journal_title：Therapeutic drug monitoring

authors： Kovarik JM,Schmouder RL,Slade AJ

更新日期：2004-12-01 00:00:00

abstract：:Steady state serum concentrations of risperidone and 9-hydroxyrisperidone (9-OH-risperidone), the active moiety, were measured in 42 patients. The concentration-to-dose ratios (C/D) varied by a factor of 20, from 1.8 to 36.8 (nmol/l)/(mg/24 hours), and 90% of the active moiety was constituted of 9-OH-risperidone. No c...

journal_title：Therapeutic drug monitoring

authors： Olesen OV,Licht RW,Thomsen E,Bruun T,Viftrup JE,Linnet K

更新日期：1998-08-01 00:00:00

abstract：:The use of alternative strategies to the traditional pre-dose/trough (C0) blood sampling for cyclosporine (CsA) therapeutic drug monitoring has the potential to revolutionize analytical practices which have, in many centers, been established for some 20 years. While the C0 sample has previously been recommended, curre...

journal_title：Therapeutic drug monitoring

authors： Morris RG,Russ GR,Cervelli MJ,Juneja R,McDonald SP,Mathew TH

更新日期：2002-08-01 00:00:00

abstract：:In a phase I-II study, the authors evaluated the intracellular pharmacokinetics, toxicity, and efficiency of a high dose of mitoxantrone given as first induction in acute non-lymphocytic leukemia. Twenty-two patients with previously untreated de novo ANLL were included and received 30 or 40 mg/m2 mitoxantrone on day 1...

journal_title：Therapeutic drug monitoring

authors： Möllgård L,Tidefelt U,Sundman-Engberg B,Löfgren C,Lehman S,Paul C

更新日期：1998-12-01 00:00:00

abstract：:The ability of a pharmacokinetic/pharmacodynamic Bayesian forecasting computer program to predict prothrombin response to warfarin therapy was investigated. The performance of the program was evaluated retrospectively in an inpatient study population of 45 subjects. Predictions of prothrombin response at discharge, ba...

journal_title：Therapeutic drug monitoring

authors： Svec JM,Coleman RW,Mungall DR,Ludden TM

更新日期：1985-01-01 00:00:00

abstract：:The authors refer to their experience with alternative matrices to supervise the methadone therapy of heroin abusers. For this purpose, hair, sweat, and urine samples were collected from 10 heroin addicts and from a control group and were submitted to gas chromatographic/mass spectroscopic analysis for methadone and i...

journal_title：Therapeutic drug monitoring

authors： Fucci N,De Giovanni N

更新日期：2007-08-01 00:00:00

abstract：:Differences in product formulations have been shown to affect the therapeutic response by altering the relative bioavailability and pharmacokinetics of a drug. The relative bioavailability and pharmacokinetics of carbamazepine tablets (CBZ) and a chewable tablet formulation were evaluated in 10 normal healthy subjects...

journal_title：Therapeutic drug monitoring

authors： Maas B,Garnett WR,Pellock JM,Comstock TJ

更新日期：1987-01-01 00:00:00

abstract：:A high-performance liquid chromatographic method for the determination of linezolid in human plasma was developed and validated. After precipitation of plasma proteins with perchloric acid, the protein-free supernatant was separated by isocratic reverse-phase chromatography on a X Bridge C18 column. The mobile phase c...

journal_title：Therapeutic drug monitoring

authors： Cattaneo D,Baldelli S,Conti F,Cozzi V,Clementi E

更新日期：2010-08-01 00:00:00

abstract：:A computer-based approach for estimating pharmacokinetic data and predicting plasma drug concentrations based on two measurements of plasma drug concentrations was compared with a standard two-point method for estimating aminoglycoside (AG) pharmacokinetic parameters. The computer-based technique was also used to pred...

journal_title：Therapeutic drug monitoring

authors： Bachmann K,Pongsin V,Forney R Jr,Gronau G

更新日期：1985-01-01 00:00:00

abstract：:Lamotrigine (LG), phenytoin (PY), carbamazepine (CM), and carbamazepine epoxide (CE) are measured with an optimized procedure that uses thin sorbent extraction disks and a highly selective, sterically protected bonded silica high-performance liquid chromatography (HPLC) column. Routinely, serum (200 microliters at pH ...

journal_title：Therapeutic drug monitoring

authors： Lensmeyer GL,Gidal BE,Wiebe DA

更新日期：1997-06-01 00:00:00

abstract：:A minority of athletes continues to use prohibited drugs in sports to enhance performance. Athletes discovered using these drugs can be subject to severe penalties, often resulting in media and public scrutiny, especially at major events such as the Olympic Games. The International Olympic Committee (IOC) has set out ...

journal_title：Therapeutic drug monitoring

authors： Kazlauskas R,Trout G

更新日期：2000-02-01 00:00:00