Immunoassays for Measuring Serum Concentrations of Monoclonal Antibodies and Anti-biopharmaceutical Antibodies in Patients.

abstract：:Lopinavir is one of the most-widely used protease inhibitors in the treatment of HIV-1 infected patients. Concentration-effect relationships have been described for both antiviral activity and toxicity. Less is known about patient characteristics that may determine interpatient variability in lopinavir plasma concentr...

journal_title：Therapeutic drug monitoring

authors： van der Leur MR,Burger DM,la Porte CJ,Koopmans PP

更新日期：2006-10-01 00:00:00

abstract：:Hyperlipidemia interferes with spectrophotometric assays of a number of analytes. No interference was found in the assay of gentamicin, phenytoin, or phenobarbital due to turbidity in levels of triglyceride less than or equal to 2,000 mg/dl with the Abbott TDx or Syva enzyme multiplied immunoassay (EMIT) methods. Ther...

journal_title：Therapeutic drug monitoring

authors： Baer DM,Paulson RA

更新日期：1987-01-01 00:00:00

abstract：:Two blood-sampling techniques, capillary and venous, were compared using the EMIT method. No difference was found in reproducibility. However, persistent positive bias of 0.628 micrograms/ml (p less than 0.01) was noted with the capillary sampling method. Any hemolysis that occurred in the capillary sampling technique...

journal_title：Therapeutic drug monitoring

authors： Frazer JF 3rd,Stasiowski P,Boyd GK

更新日期：1983-01-01 00:00:00

abstract：:The authors refer to their experience with alternative matrices to supervise the methadone therapy of heroin abusers. For this purpose, hair, sweat, and urine samples were collected from 10 heroin addicts and from a control group and were submitted to gas chromatographic/mass spectroscopic analysis for methadone and i...

journal_title：Therapeutic drug monitoring

authors： Fucci N,De Giovanni N

更新日期：2007-08-01 00:00:00

abstract：:The emerging nation of South Africa, in common with some other countries, notably Eastern Europe, is heir to decades of neglect with regards to the exposure of the majority of its population to toxic materials. In this short review, the major toxic health hazards are described. For most of these risks there are now pr...

journal_title：Therapeutic drug monitoring

authors： Stewart MJ

更新日期：2002-02-01 00:00:00

abstract：:Therapeutic drug monitoring (TDM) is commonly employed to optimize the dosing of certain drugs, including digoxin, aminoglycosides, theophylline, and phenytoin. Studies were reviewed in order to (a) evaluate the effect of TDM on the occurrence of toxic drug reactions (TDRs) and (b) identify factors that may modify or ...

journal_title：Therapeutic drug monitoring

authors： Ried LD,Horn JR,McKenna DA

更新日期：1990-01-01 00:00:00

abstract：BACKGROUND:Previous reports have suggested that polymorphism of the opioid receptor A118G affects the efficacy of opioid analgesia. The aim of this study was to investigate whether such polymorphism contributed to variability in epidural mixture (sufentanil plus ropivacaine) requirements through patient-controlled epid...

journal_title：Therapeutic drug monitoring

authors： Xu GH,Gao M,Sheng QY,Liu XS,Gu EW

更新日期：2015-02-01 00:00:00

abstract：BACKGROUND:Quality management and accreditation in the analytical laboratory setting are developing rapidly and becoming the standard worldwide. Quality management refers to all the activities used by organizations to ensure product or service consistency. Accreditation is a formal recognition by an authoritative regul...

journal_title：Therapeutic drug monitoring

authors： Fulga N

更新日期：2013-06-01 00:00:00

abstract：:Drugs metabolized by cytochrome CYP3A isoenzymes have wide interindividual variability and normally distributed plasma clearance distributions. This makes precise dosing difficult to achieve clinically, which may compromise safe therapy. We hypothesized that with potent inhibition of CYP3A, we could clinically render ...

journal_title：Therapeutic drug monitoring

authors： Tham LS,Lee HS,Wang L,Yong WP,Fan L,Ong AB,Sukri N,Soo R,Lee SC,Goh BC

更新日期：2006-04-01 00:00:00

abstract：:The role of drug assays for screening, diagnosis, and guiding treatment decisions in overdose patients remains unclear. The use of drug concentration data in clinical toxicology research is more problematic, with studies using drug concentrations to simply confirm ingestion in observational studies or others report dr...

journal_title：Therapeutic drug monitoring

authors： Isbister GK

更新日期：2010-06-01 00:00:00

abstract：:The authors report the use of high-performance liquid chromatography-electrospray-tandem mass spectrometry (HPLC-ESI-MS/MS) for the quantification of indomethacin (IND) in plasma with microscale sample preparation. Plasma samples (100 microL) and mefanamic acid (internal standard [IS]), buffered to pH 3.5, were prepar...

journal_title：Therapeutic drug monitoring

authors： Taylor PJ,Jones CE,Dodds HM,Hogan NS,Johnson AG

更新日期：1998-12-01 00:00:00

abstract：:The interaction between valproic acid (VPA) and phenytoin (DPH) was examined during therapeutic monitoring in an epileptic outpatient population. Gas-liquid chromatographic methods were used to measure DPH and VPA concentrations. (1) In 12 patients on stable DPH regimens, the mean DPH level declined from 19.7 to 15.3 ...

journal_title：Therapeutic drug monitoring

authors： Friel PN,Leal KW,Wilensky AJ

更新日期：1979-01-01 00:00:00

abstract：BACKGROUND:Posaconazole is an azole antifungal agent with a broad spectrum of activity and a manageable side-effect profile. Although the pharmacokinetics of posaconazole have been described in healthy volunteers who received the drug by means of a nasogastric tube or with nutritional supplements, the pharmacokinetics ...

journal_title：Therapeutic drug monitoring

authors： Ray J,Campbell L,Rudham S,Nguyen Q,Marriott D

更新日期：2011-08-01 00:00:00

abstract：BACKGROUND:The objective of this study was to investigate the serum concentrations of olanzapine in relation to age, sex, and other factors in Chinese patients aged between 10 and 90 years. METHODS:Data for 884 olanzapine patients, deposited between 2016 and 2017, were retrieved from the therapeutic drug monitoring da...

journal_title：Therapeutic drug monitoring

authors： Deng SH,Wang ZZ,Lu HY,Li L,Hu JQ,Zhu XQ,Xie HS,Chen HZ,Zhang M,Ni XJ,Qiu C,Shang DW,Wen YG

更新日期：2020-08-01 00:00:00

abstract：:Recently, a semiautomated fluorescence polarization immunoassay (FPIA) for determination of parent cyclosporin (CsA) has been developed for the Abbott AxSYM system. The new CsA assay measures the drug from an extracted whole blood specimen. The authors report here the evaluation of this new assay and the comparison wi...

journal_title：Therapeutic drug monitoring

authors： Sabaté I,Ginard M,González JM,Baró E,Acebes G,Cuadros J,Lirón FJ

更新日期：2000-08-01 00:00:00

abstract：:The pharmacokinetic interaction between chloroquine (CQ) and imipramine was investigated in six healthy volunteers who received 300 mg of CQ, 50 mg of imipramine, and combined doses of both drugs in a randomized, crossover design. Blood and urine samples were collected at predetermined time intervals and were analyzed...

journal_title：Therapeutic drug monitoring

authors： Onyeji CO,Toriola TA,Ogunbona FA

更新日期：1993-02-01 00:00:00

abstract：:Immunization of New Zealand white rabbits with a bovine serum albumin conjugate of 7-hydroxy-N-carboxyethyl-N-deshydroxyethylfluphenazine produced highly specific antisera for 7-hydroxyfluphenazine (7-OHFLU). A radioimmunoassay (RIA) was developed using antisera from one of the rabbits that enabled for the first time ...

journal_title：Therapeutic drug monitoring

authors： Aravagiri M,Marder SR,Van Putten T,Hawes EM,McKay G,Midha KK

更新日期：1994-02-01 00:00:00

abstract：BACKGROUND:Cytochrome P450 3A (CYP3A) isoenzyme metabolic activity varies between individuals and is therefore a possible candidate of influence on the therapeutic outcome of the tyrosine kinase inhibitor imatinib in patients with chronic myeloid leukemia (CML). The aim of this study was to investigate the influence of...

journal_title：Therapeutic drug monitoring

authors： Skoglund K,Richter J,Olsson-Strömberg U,Bergquist J,Aluthgedara W,Ubhayasekera SJ,Vikingsson S,Svedberg A,Söderlund S,Sandstedt A,Johnsson A,Aagesen J,Alsenhed J,Hägg S,Peterson C,Lotfi K,Gréen H

更新日期：2016-04-01 00:00:00

abstract：:One tablet containing 755 mg of lithium tryptophanate (10.8 mEq of lithium) was administered to eight healthy volunteers. The main pharmacokinetic parameters for the group of subjects were estimated. Pharmacokinetic parameters (mean +/- SD) from plasma and saliva were respectively: half life (t1/2) 17 +/- 6 vs. 21.8 +...

journal_title：Therapeutic drug monitoring

authors： Obach R,Borja J,Pruñonosa J,Vallès JM,Torrent J,Izquierdo I,Jané F

更新日期：1988-01-01 00:00:00

abstract：:In the last few years, significant developments have occurred on the key issues involved in oral fluid drug testing. New pharmacokinetic studies have been conducted, optimal cutoffs have been proposed, and new studies have examined the correlation between oral fluid drug concentrations and impairment. Recent studies (...

journal_title：Therapeutic drug monitoring

authors： Pil K,Verstraete A

更新日期：2008-04-01 00:00:00

abstract：BACKGROUND:Several reports of loss of efficacy or adverse effects have been described after generic substitution of antipsychotics. To date, studies comparing serum drug levels in patients switched to generic antipsychotics in a standard clinical setting are lacking. The aim of this study was to investigate if switchin...

journal_title：Therapeutic drug monitoring

authors： Italiano D,Bruno A,Santoro V,Lanza G,Muscatello MR,Zoccali R,Spina E

更新日期：2015-12-01 00:00:00

abstract：:Assessment of renal function and relating this parameter to amino-glycoside clearance is important for an appropriate individualization of dosage regimens in patients with impaired renal function. However, it has been suggested that in cystic fibrosis (CF), creatinine clearance (CrCl) is not a good predictor of tobram...

journal_title：Therapeutic drug monitoring

authors： Town DJ,Vinks AA,Jacobs F,Heijerman HG,Bakker W

更新日期：1996-10-01 00:00:00

abstract：:The use of alternative strategies to the traditional pre-dose/trough (C0) blood sampling for cyclosporine (CsA) therapeutic drug monitoring has the potential to revolutionize analytical practices which have, in many centers, been established for some 20 years. While the C0 sample has previously been recommended, curre...

journal_title：Therapeutic drug monitoring

authors： Morris RG,Russ GR,Cervelli MJ,Juneja R,McDonald SP,Mathew TH

更新日期：2002-08-01 00:00:00

abstract：:The pharmacokinetics of rifampicin (RMP) and its principal active metabolite desacetylrifampicin (DA-RMP) were studied in six subjects, ranging in age from 78 to 95 years, after single oral doses of 10 mg/kg RMP. The maximal plasma concentrations (Cmax) and the elimination half-lives (t 1/2 beta) of RMP are 8.83 +/- 1...

journal_title：Therapeutic drug monitoring

authors： Advenier C,Gobert C,Houin G,Bidet D,Richelet S,Tillement JP

更新日期：1983-01-01 00:00:00

abstract：:Measurement of whole blood and plasma levels of cyclosporin A (CsA) by radioimmunoassay in kidney transplant recipients receiving the drug showed that CsA concentrations in plasma increased nonlinearly when whole blood levels of the drug exceeded 1,000 ng/ml. At low plasma levels (less than 200 ng/ml), most of the CsA...

journal_title：Therapeutic drug monitoring

authors： Agarwal RP,McPherson RA,Threatte GA

更新日期：1985-01-01 00:00:00

abstract：:The authors aimed to evaluate the utility of the history and clinical signs for predicting ingestion of poisons in children. A prospective cohort study was performed of all patients presenting with suspected poisoning to a pediatric emergency department over a 13-month period. Clinical data were collected on a preform...

journal_title：Therapeutic drug monitoring

authors： Hwang CF,Foot CL,Eddie G,Johnson L,Reith DM

更新日期：2003-12-01 00:00:00

abstract：:Results of phenobarbital analyses are presented for 14 patients with chronic renal failure, and compared using gas-liquid chromatography (GLC), enzyme immunoassay (EIA), and fluorescence polarization immunoassay (FPIA). Correlation of FPIA with GLC and EIA was poor. ...

journal_title：Therapeutic drug monitoring

authors： Bridges RR,Jennison TA

更新日期：1984-01-01 00:00:00

abstract：:Steady state serum concentrations of risperidone and 9-hydroxyrisperidone (9-OH-risperidone), the active moiety, were measured in 42 patients. The concentration-to-dose ratios (C/D) varied by a factor of 20, from 1.8 to 36.8 (nmol/l)/(mg/24 hours), and 90% of the active moiety was constituted of 9-OH-risperidone. No c...

journal_title：Therapeutic drug monitoring

authors： Olesen OV,Licht RW,Thomsen E,Bruun T,Viftrup JE,Linnet K

更新日期：1998-08-01 00:00:00

abstract：:Mixed-effect modeling has been suggested as a possible tool to detect and describe drug interactions in patient populations receiving drug combinations for the treatment of disease states. The mixed-effect modeling program, NONMEM, was used to measure the effects of the well-known digoxin-quinidine and digoxin-verapam...

journal_title：Therapeutic drug monitoring

authors： Bauer LA,Horn JR,Pettit H

更新日期：1996-02-01 00:00:00

abstract：:Prescribed daily doses (PDDs) of antiepileptic drugs (AED) (N03A ATC group) were recorded for drugs used in monotherapy or in combination therapy in the University Hospitals in Ostrava, Czech Republic and Huddinge, Sweden. Plasma concentrations were used as an indicator of the quality of treatment. PDDs were compared ...

journal_title：Therapeutic drug monitoring

authors： Koristkova B,Sjöqvist F,Grundmann M,Bergman U

更新日期：2006-10-01 00:00:00