The utility of the history and clinical signs of poisoning in childhood: a prospective study.

abstract：:The monitoring of plasma olanzapine concentrations has been found to be an important and useful tool for optimizing psychiatric treatment. The present study investigated the effect that clinical factors, such as smoking and age, and functional polymorphisms of UGT1A4, CYP1A2, and CYP2D6 genes have on plasma olanzapine...

journal_title：Therapeutic drug monitoring

authors： Nozawa M,Ohnuma T,Matsubara Y,Sakai Y,Hatano T,Hanzawa R,Shibata N,Arai H

更新日期：2008-02-01 00:00:00

abstract：:Nineteen acutely disturbed psychotic Asian patients were treated with a single intramuscular injection of 50 mg of zuclopenthixol acetate in Viscoleo. Patients were assessed clinically before and after treatment using the Brief Psychiatric Rating Scale (BPRS). Serum zuclopenthixol and the inactive geometric isomer tra...

journal_title：Therapeutic drug monitoring

authors： Tan CH,Low BL,Ng LL,Khoo YM,Lee HS

更新日期：1993-04-01 00:00:00

abstract：:Atractyloside poisoning is an infrequent but often fatal form of herbal poisoning, which occurs worldwide but especially in Africa and the Mediterranean regions. The primary mechanism of atractyloside poisoning is known to be inhibition of the mitochondrial ADP transporter. Poisoning in humans may present with either ...

journal_title：Therapeutic drug monitoring

authors： Stewart MJ,Steenkamp V

更新日期：2000-12-01 00:00:00

abstract：BACKGROUND/OBJECTIVES:Drug of abuse consumption throughout pregnancy is a serious public health problem and an important economic cost to the health system. The aim of this work was to compare maternal interview and hair analysis to determine drug consumption throughout pregnancy and to study relations among maternal i...

journal_title：Therapeutic drug monitoring

authors： Lendoiro E,González-Colmenero E,Concheiro-Guisán A,de Castro A,Cruz A,López-Rivadulla M,Concheiro M

更新日期：2013-06-01 00:00:00

abstract：:Thiopurine methyltransferase (TPMT) is a cytoplasmic enzyme that preferentially catalyzes the S-methylation of aromatic and heterocyclic sulphydryl compounds, such as the thiopurine drugs azathioprine, mercaptopurine, and thioguanine. These drugs form the same terminal metabolites, the thioguanine nucleotides (TGNs). ...

journal_title：Therapeutic drug monitoring

authors： Lennard L

更新日期：1998-10-01 00:00:00

abstract：:The TDx digoxin II immunoassay was used in controls and in patients not taking digoxin or any other cardiac glycoside. We report the frequency of interference thought to be caused by digoxin-like factors (DLFs). We found a high incidence of false-positive results in 15 patients with severe hepatic disease (60% false-p...

journal_title：Therapeutic drug monitoring

authors： Avendaño C,Alvarez JS,Sacristan JA,Adin J,Alsar MJ

更新日期：1991-11-01 00:00:00

abstract：:Major advances in immunosuppression and reductions in the rates of acute rejection have led to increasing graft and patient survival rates during the past two decades. Chronic dysfunction of the renal allograft, however, remains a major clinical problem and probably represents the end result of the complex interplay b...

journal_title：Therapeutic drug monitoring

authors： Kaplan B,Srinivas TR,Meier-Kriesche HU

更新日期：2002-02-01 00:00:00

abstract：BACKGROUND:Analysis of residual gene expression of the nuclear factor of activated T cell (NFAT)-regulated genes has been developed as a pharmacodynamic biomarker to monitor therapy with calcineurin inhibitors. The availability of commercial primer sets (Search-LC) and the well-established assay protocol makes this bio...

journal_title：Therapeutic drug monitoring

authors： Abdel-Kahaar E,Giese T,Sommerer C,Rieger H,Shipkova M,Wieland E

更新日期：2016-12-01 00:00:00

abstract：BACKGROUND:The aim of this study was to conduct a population pharmacokinetic (PK) analysis of meropenem and to explore the optimal dosing strategy for meropenem in critically ill patients with acute kidney injury receiving treatment with continuous hemodiafiltration (CHDF). METHODS:Blood samples were obtained on days ...

journal_title：Therapeutic drug monitoring

authors： Niibe Y,Suzuki T,Yamazaki S,Suzuki T,Takahashi N,Hattori N,Nakada TA,Oda S,Ishii I

更新日期：2020-08-01 00:00:00

abstract：:Differences in product formulations have been shown to affect the therapeutic response by altering the relative bioavailability and pharmacokinetics of a drug. The relative bioavailability and pharmacokinetics of carbamazepine tablets (CBZ) and a chewable tablet formulation were evaluated in 10 normal healthy subjects...

journal_title：Therapeutic drug monitoring

authors： Maas B,Garnett WR,Pellock JM,Comstock TJ

更新日期：1987-01-01 00:00:00

abstract：:Specific chromatographic methods for the measurement of cyclosporin A, tacrolimus, sirolimus, and everolimus blood levels in patients with organ transplants are time consuming when large numbers of samples must be processed. The authors developed a robust and fast (1 minute) online solid-phase extraction liquid chroma...

journal_title：Therapeutic drug monitoring

authors： Meinitzer A,Gartner G,Pilz S,Stettin M

更新日期：2010-02-01 00:00:00

abstract：:A population pharmacokinetic model was developed after administration of orogastric and/or intravenous indomethacin for the treatment of patent ductus arteriosus in preterm infants. Plasma indomethacin concentrations (n=227) were obtained from 90 preterm infants of median gestational age 27 weeks, mean postnatal age o...

journal_title：Therapeutic drug monitoring

authors： Al Za'abi M,Donovan T,Tudehope D,Woodgate P,Collie LA,Charles B

更新日期：2007-12-01 00:00:00

abstract：:An analysis of pH-induced changes of drug binding may contribute to the understanding of the mechanisms involved and the clinical relevance. A literature search was performed, and acceptance criteria set up, to select reported data for quantitative evaluation. The relationship between percentage of unbound drug, fu, a...

journal_title：Therapeutic drug monitoring

authors： Hinderling PH,Hartmann D

更新日期：2005-02-01 00:00:00

abstract：:The ring sulfoxidation of thioridazine (THD), a widely used neuroleptic agent, yields two diastereoisomeric pairs, fast- and slow-eluting (FE and SE) thioridazine 5-sulfoxide (THD 5-SO). Until now, studies in which concentrations of these metabolites were measured in THD-treated patients have revealed no significant d...

journal_title：Therapeutic drug monitoring

authors： Eap CB,Souche A,Koeb L,Baumann P

更新日期：1991-07-01 00:00:00

abstract：:The relationship between changes in cyclosporin (CyA) dose or CyA blood concentration and the reciprocal creatinine concentration was investigated by cross-correlation analysis over the first 3 postoperative months in 32 consecutive heart and heart-lung recipients. Exploratory analysis suggested that early changes in ...

journal_title：Therapeutic drug monitoring

authors： Trull AK,Best NG,Tan KK,Hue KL,Higenbottam TW,Large S,Wallwork J

更新日期：1992-08-01 00:00:00

abstract：BACKGROUND:Dolutegravir (DTG) is an integrase strand transfer inhibitor, which is a newly approved antiretroviral drug used for the treatment of HIV-infected naive and experienced individuals. Many aspects of DTG pharmacology remain to be studied. Our aim was to develop and fully validate a robust analytical method for...

journal_title：Therapeutic drug monitoring

authors： Wang X,Penchala SD,Amara A,Else L,McClure M,Boffito M

更新日期：2016-06-01 00:00:00

abstract：:A rapid and reliable micro procedure for the high pressure liquid chromatographic analysis of cimetidine. N"-cyano-N-methyl-N'-[2-[[(5-methyl-1H-imidazol-4-yl)methyl]thio]ethyl]guanidine, in serum or plasma is described. The percentage analytical recovery of cimetidine and internal standard (beta-hydroxypropyl-theophy...

journal_title：Therapeutic drug monitoring

authors： Soldin SJ,Fingold DR,Fenje PC,Mahon WA

更新日期：1979-01-01 00:00:00

abstract：:A neurophysiologic test battery (consisting of a 24-hour, seven-channel electroencephalogram [EEG], EEG spectral analysis, multiple sleep latency test, visual evoked potentials, critical flicker fusion, and visual contrast sensitivity) was administered twice to 16 patients with juvenile myoclonic epilepsy (JME) in a d...

journal_title：Therapeutic drug monitoring

authors： Sundqvist A,Nilsson BY,Tomson T

更新日期：1999-02-01 00:00:00

abstract：:A rapid and simultaneous determination of several analgesic antiinflammatory agents--ibuprofen, acetaminophen, indomethacin, and salicylic acid--in human serum was developed by using capillary zone electrophoresis (CZE) coupled with diode-array ultraviolet detection. After precipitation of serum protein with acetonitr...

journal_title：Therapeutic drug monitoring

authors： Makino K,Yano T,Maiguma T,Teshima D,Sendo T,Itoh Y,Oishi R

更新日期：2003-10-01 00:00:00

abstract：:A case of desmethylimipramine (DMI) overdose is described. The analysis of DMI and its main metabolite, 2-hydroxydesmethylimipramine (2-OH-DMI), in plasma was performed by high performance liquid chromatography with fluorescence detection. Characterization of the elimination kinetics of DMI by using the SAAM 25 comput...

journal_title：Therapeutic drug monitoring

authors： Spina E,Henthorn TK,Eleborg L,Nordin C,Säwe J

更新日期：1985-01-01 00:00:00

abstract：:It is generally accepted that chemical testing of biologic fluids is the most objective means of diagnosis of drug use. The presence of a drug analyte in a biologic specimen can be used to document exposure. The standard for drug testing in toxicology is an immunoassay screen conducted on a urine sample, followed by c...

journal_title：Therapeutic drug monitoring

authors： Kintz P,Samyn N

更新日期：2002-04-01 00:00:00

abstract：:This study explored the association of 14 single nucleotide polymorphisms in three genes coding for influx transporters (SLC22A1, SLCO1B1, and SLCO1B3), two genes coding for efflux transporters (ABCB1 and ABCG2), and four genes coding for enzymes (CYP2C9, CYP2C19, CYP2D6, and CYP3A5) with the pharmacokinetics of imati...

journal_title：Therapeutic drug monitoring

authors： Yamakawa Y,Hamada A,Nakashima R,Yuki M,Hirayama C,Kawaguchi T,Saito H

更新日期：2011-04-01 00:00:00

abstract：:OKT3 is a murine monoclonal antibody of the immunoglobulin IgG2a isotype. The target of OKT3, CD3, is a 17-20 kilodalton (kD) molecule that is part of a multimolecular complex found only on mature T cells and medullary thymocytes. This complex is uniquely situated next to the T-cell receptor for antigen. An interactio...

journal_title：Therapeutic drug monitoring

authors： Norman DJ

更新日期：1995-12-01 00:00:00

abstract：:The clinical use of digoxin and phenytoin analyses (in 405 and 152 patients, respectively) furnished by our clinical pharmacological laboratory during a five-month period was evaluated prospectively from request forms. Of first-time analyses of digoxin, 12, 38, and 50% fell above, within, and below our recommended ran...

journal_title：Therapeutic drug monitoring

authors： Bergman U,Rane A,Sjöqvist F,Wiholm BE

更新日期：1981-01-01 00:00:00

abstract：:Toxicity from ingestion of the oleander plant is common. Oleandrin, the oleander glycoside, has structural similarity to cardiac glycoside digoxin and is known to cross react with various digoxin immunoassays. The authors studied the cross reactivity of oleandrin and its deglycosylated congener oleandrigenin with a fl...

journal_title：Therapeutic drug monitoring

authors： Datta P,Dasgupta A

更新日期：1997-08-01 00:00:00

abstract：:A simple high-performance liquid chromatography (HPLC) method for the determination of methotrexate (MTX) in biological fluids is described. The assay is rapid, the time required for analysis is less than 30 min, and it is sensitive, up to 0.01 microgram/ml, which is three times below the toxic MTX concentration. Fift...

journal_title：Therapeutic drug monitoring

authors： Najjar TA,Matar KM,Alfawaz IM

更新日期：1992-04-01 00:00:00

abstract：:A variety of medications are used in treating patients infected with the human immunodeficiency virus (HIV). These medications are used to control viremia and to prevent and treat opportunistic infections. An individual is often required to take numerous drugs at the same time and thus clinicians are confronted with p...

journal_title：Therapeutic drug monitoring

authors： Dasgupta A,Okhuysen PC

更新日期：2001-12-01 00:00:00

abstract：:A study was conducted to determine whether assay-specific quantitative differences exist in the determination of vancomycin serum concentrations obtained from patients with renal dysfunction. Vancomycin serum concentrations were obtained during the first week of therapy for each of three time intervals: 48-96 h, 96-14...

journal_title：Therapeutic drug monitoring

authors： Peckman HJ,Dupuis RE,Sawyer WT,Brouwer KL,Cross RE

更新日期：1996-12-01 00:00:00

abstract：:Their common clinical use, frequency of adverse effects, serious therapeutic indications, treatment failures, and availability of sensitive assays make corticosteroids such as prednisone and prednisolone candidates for therapeutic drug monitoring. Complicating the interpretation of plasma drug concentrations are the f...

journal_title：Therapeutic drug monitoring

authors： Jusko WJ,Rose JQ

更新日期：1980-01-01 00:00:00

abstract：BACKGROUND:Desmopressin (D-amino D-arginine vasopressin: dDAVP) is used for the treatment of patients with hemophilia A and Von Willebrand disease. Studies on the rationale of dosing are scarce and mainly focus on the underlying causes of the vast differences in desmopressin response among individuals. The aim of this ...

journal_title：Therapeutic drug monitoring

authors： de Jager NCB,Heijdra JM,Pistorius M,Kruip MJHA,Leebeek FWG,Cnossen MH,Mathôt RAA

更新日期：2020-12-01 00:00:00