Interference of digoxin-like immunoreactive substances with TDx digoxin II assay in different patients.

abstract：BACKGROUND:Perampanel is a new antiepileptic drug (AED) that acts as a noncompetitive α-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMPA) receptor antagonist and is mainly metabolized by cytochrome P450 (CYP) 3A4. This study evaluated the influence of concomitant AEDs on the serum concentration profile of pera...

journal_title：Therapeutic drug monitoring

authors： Yamamoto Y,Usui N,Nishida T,Takahashi Y,Imai K,Kagawa Y,Inoue Y

更新日期：2017-08-01 00:00:00

abstract：:The aim of the current study was to compare the pharmacokinetics of phenobarbital (PB) in extensive metabolizers (EMs) and poor metabolizers (PMs) of S-mephenytoin. Ten healthy volunteers (5 EMs and 5 PMs) were given 30 mg PB daily for 14 days. PB and p-hydroxyphenobarbital (p-OHPB) in serum and urine were measured by...

journal_title：Therapeutic drug monitoring

authors： Hadama A,Ieiri I,Morita T,Kimura M,Urae A,Irie S,Kaneda T,Mamiya K,Tashiro N,Higuchi S,Otsubo K

更新日期：2001-04-01 00:00:00

abstract：:The development of inexpensive in-house reagents for the assay of carbamazepine in serum, using a commercially available derivative and antiserum is described. They were adapted for use on the Abbott TDx as direct replacements for commercial reagents. Comparison with a high-performance liquid chromatography method is ...

journal_title：Therapeutic drug monitoring

authors： Colbert DL,Turner GJ

更新日期：1993-06-01 00:00:00

abstract：:Atractyloside poisoning is an infrequent but often fatal form of herbal poisoning, which occurs worldwide but especially in Africa and the Mediterranean regions. The primary mechanism of atractyloside poisoning is known to be inhibition of the mitochondrial ADP transporter. Poisoning in humans may present with either ...

journal_title：Therapeutic drug monitoring

authors： Stewart MJ,Steenkamp V

更新日期：2000-12-01 00:00:00

abstract：:The ability of a pharmacokinetic/pharmacodynamic Bayesian forecasting computer program to predict prothrombin response to warfarin therapy was investigated. The performance of the program was evaluated retrospectively in an inpatient study population of 45 subjects. Predictions of prothrombin response at discharge, ba...

journal_title：Therapeutic drug monitoring

authors： Svec JM,Coleman RW,Mungall DR,Ludden TM

更新日期：1985-01-01 00:00:00

abstract：:The pharmacokinetic parameters of half-life, volume of distribution, and steady-state nortriptyline plasma concentration normalized to a 100-mg/day maintenance dose were calculated in nine smokers and 15 nonsmokers. The mean normalized total nortriptyline concentration for the smokers of 118 +/- 33 ng/ml was significa...

journal_title：Therapeutic drug monitoring

authors： Perry PJ,Browne JL,Prince RA,Alexander B,Tsuang MT

更新日期：1986-01-01 00:00:00

abstract：:Hydroxylation of midazolam (MDZ) is mediated almost exclusively by CYP3A isoforms. The authors describe a high-performance liquid chromatography assay involving MDZ, 1'-hydroxymidazolam, and 4-hydroxymidazolam in plasma. The compounds were eluted on an Ultrasphere ODS, 3-microm particle size, 7.5 cm x 4.6 mm reversed-...

journal_title：Therapeutic drug monitoring

authors： Carrillo JA,Ramos SI,Agundez JA,Martinez C,Benitez J

更新日期：1998-06-01 00:00:00

abstract：:For the evaluation and interpretation of pharmacokinetic data reliable quantitative determinations are a requirement that can only be met by well-characterized and fully validated analytical methods. To cope with these requirements a method is being established that is based on an integrated and automated fiber-optic ...

journal_title：Therapeutic drug monitoring

authors： Gygax D,Botta L,Ehrat M,Graf P,Lefèvre G,Oroszlan P,Pfister C

更新日期：1996-08-01 00:00:00

abstract：:A simple and sensitive column-switching high-performance liquid chromatographic method for the simultaneous determination of itraconazole (ITZ) and its active metabolite, hydroxyitraconazole (HIT) in human plasma is described. ITZ, HIT, and an internal standard, R051012, were extracted from 1 mL of alkalinized plasma ...

journal_title：Therapeutic drug monitoring

authors： Uno T,Shimizu M,Sugawara K,Tateishi T

更新日期：2006-08-01 00:00:00

abstract：:The ring sulfoxidation of thioridazine (THD), a widely used neuroleptic agent, yields two diastereoisomeric pairs, fast- and slow-eluting (FE and SE) thioridazine 5-sulfoxide (THD 5-SO). Until now, studies in which concentrations of these metabolites were measured in THD-treated patients have revealed no significant d...

journal_title：Therapeutic drug monitoring

authors： Eap CB,Souche A,Koeb L,Baumann P

更新日期：1991-07-01 00:00:00

abstract：BACKGROUND:Anti-T lymphocyte globulin (ATLG) modulates the alloreactivity of T lymphocytes, reducing the risk of immunological posttransplant complications, in particular rejection and graft-versus-host disease, after allogeneic hematopoietic stem cell transplantation (HSCT). We developed and validated a new enzyme-lin...

journal_title：Therapeutic drug monitoring

authors： Montagna M,La Nasa G,Bernardo ME,Piras E,Avanzini MA,Regazzi M,Locatelli F

更新日期：2017-06-01 00:00:00

abstract：BACKGROUND:Desmopressin (D-amino D-arginine vasopressin: dDAVP) is used for the treatment of patients with hemophilia A and Von Willebrand disease. Studies on the rationale of dosing are scarce and mainly focus on the underlying causes of the vast differences in desmopressin response among individuals. The aim of this ...

journal_title：Therapeutic drug monitoring

authors： de Jager NCB,Heijdra JM,Pistorius M,Kruip MJHA,Leebeek FWG,Cnossen MH,Mathôt RAA

更新日期：2020-12-01 00:00:00

abstract：:The interaction between valproic acid (VPA) and phenytoin (DPH) was examined during therapeutic monitoring in an epileptic outpatient population. Gas-liquid chromatographic methods were used to measure DPH and VPA concentrations. (1) In 12 patients on stable DPH regimens, the mean DPH level declined from 19.7 to 15.3 ...

journal_title：Therapeutic drug monitoring

authors： Friel PN,Leal KW,Wilensky AJ

更新日期：1979-01-01 00:00:00

abstract：:A sensitive method for monitoring serum piroxicam (Feldene) is described. The assay requires 1.0 ml of specimen and involves chloroform extraction from an acidified mixture followed by concentration and injection into a liquid chromatograph. Column effluent is monitored at 330 nm. Retention times of piroxicam and the ...

journal_title：Therapeutic drug monitoring

authors： Fraser AD,Woodbury JF

更新日期：1983-06-01 00:00:00

abstract：:Most recent cyclosporine (CsA) pharmacokinetic (PK) studies have focused on noncompartmental analysis. Because CsA undergoes significant first-pass elimination after oral dosing, the most appropriate compartment model may need to take this process into account for the construction of a valid population PK model for Sa...

journal_title：Therapeutic drug monitoring

authors： Ducharme MP,Verret L,Brouillette D,Sirois G

更新日期：1998-04-01 00:00:00

abstract：:A stabilized therapeutic drug monitoring procedure incorporating the novel Empore solid-phase extraction membrane (SPEM) for isolation of the antiarrhythmic drugs mexiletine (MEX) and flecainide (FLEC) from serum is described. Routinely, serum (0.5 ml), adjusted to pH 4.5, is passed through an octyl (C8) SPEM to extra...

journal_title：Therapeutic drug monitoring

authors： Lensmeyer GL,Wiebe DA,Doran TC

更新日期：1992-10-01 00:00:00

abstract：:Six groups of six male Wistar rats were administered methadone in their drinking water over the concentration range 0-0.25 mg/ml. Hair and trunk blood samples were collected after a 6-week period of drug administration. Immunoreactive methadone was measured by radioimmunoassay and methadone and its major metabolite, 2...

journal_title：Therapeutic drug monitoring

authors： Green SJ,Wilson JF

更新日期：1996-12-01 00:00:00

abstract：INTRODUCTION:Enoxaparin is an anticoagulant used in the treatment of thromboembolic diseases. It is a hydrophilic molecule that is, predominantly, eliminated renally with few data to support dosing for subjects with renal impairment and/or obesity. A recently conducted randomized controlled clinical trial compared indi...

journal_title：Therapeutic drug monitoring

authors： Barras MA,Duffull SB,Atherton JJ,Green B

更新日期：2010-08-01 00:00:00

abstract：BACKGROUND:Infliximab is a chimeric monoclonal antibody that binds to human tumor necrosis factor alpha and which is approved for refractory spondyloarthritis (SpA). Individual adjustment of infliximab dosage may help to improve the therapeutic response in SpA. We investigated whether a knowledge of infliximab serum co...

journal_title：Therapeutic drug monitoring

authors： Méric JC,Mulleman D,Ducourau E,Lauféron F,Miow Lin DC,Watier H,Goupille P,Paintaud G

更新日期：2011-08-01 00:00:00

abstract：:A minority of athletes continues to use prohibited drugs in sports to enhance performance. Athletes discovered using these drugs can be subject to severe penalties, often resulting in media and public scrutiny, especially at major events such as the Olympic Games. The International Olympic Committee (IOC) has set out ...

journal_title：Therapeutic drug monitoring

authors： Kazlauskas R,Trout G

更新日期：2000-02-01 00:00:00

abstract：:The effect of nonlinear kinetics on the steady-state ratio of serum phenytoin (PHT) to total 5-(p-hydroxyphenyl)-5-phenylhydantoin (p-HPPH) was studied in epileptic patients. In each patient, the ratio increased in a nonlinear fashion in relation to both the PHT dose and the PHT serum level. Patients with longer appar...

journal_title：Therapeutic drug monitoring

authors： Bourgeois BF,Wad N

更新日期：1985-01-01 00:00:00

abstract：BACKGROUND:Valproic acid (VPA) is frequently used together with clozapine (CLZ) as mood-stabilizer or for the prevention of seizures in patients with psychotic disorders. VPA is known to reduce levels of the pharmacologically active CLZ-metabolite N-desmethylclozapine (N-DMC), but factors determining the degree of this...

journal_title：Therapeutic drug monitoring

authors： Smith RL,Kyllesø L,Haslemo T,Andreassen OA,Molden E

更新日期：2019-08-01 00:00:00

abstract：:The current standard of monitoring transplant patients by drug levels is not optimal because it does not take into account the different and individual effects of immunosuppressive drugs on each patient. In this study, the authors tested immune function assays for monitoring transplant patients. Blood was collected fr...

journal_title：Therapeutic drug monitoring

authors： Stalder M,Bîrsan T,Holm B,Haririfar M,Scandling J,Morris RE

更新日期：2003-02-01 00:00:00

abstract：:Mycophenolate mofetil (MMF) is increasingly used for the treatment of autoimmune diseases (AID). In renal transplant recipients, it has been demonstrated that adjustment of the MMF dose according to the area under the plasma concentration versus time curve (AUC) of mycophenolic acid (MPA), the active moiety of MMF, im...

journal_title：Therapeutic drug monitoring

authors： de Winter BC,Neumann I,van Hest RM,van Gelder T,Mathot RA

更新日期：2009-06-01 00:00:00

abstract：:Digitalis-like immunoreactive substances (DLIS) obtained from maternal and umbilical cord plasma at delivery were measured by fluorescence polarization immunoassay (FPIA; TDX, Abbott) and microparticle enzyme immunoassay (MEIA; IMX, Abbott). In each sample, concentrations of dehydroepiandrosterone, dehydroepiandroster...

journal_title：Therapeutic drug monitoring

authors： Ijiri Y,Hayashi T,Kamegai H,Ohi K,Suzuki K,Kitaura Y,Takenaka H

更新日期：2003-04-01 00:00:00

abstract：BACKGROUND:Previous reports have suggested that polymorphism of the opioid receptor A118G affects the efficacy of opioid analgesia. The aim of this study was to investigate whether such polymorphism contributed to variability in epidural mixture (sufentanil plus ropivacaine) requirements through patient-controlled epid...

journal_title：Therapeutic drug monitoring

authors： Xu GH,Gao M,Sheng QY,Liu XS,Gu EW

更新日期：2015-02-01 00:00:00

abstract：:A method for analyzing flecainide in plasma was developed and assessed. Based on the use of C18 extraction columns eight or fewer times, the rapid and simple extraction procedure provided consistent, high-efficiency flecainide extraction (>85%). Using reverse-phase, high-performance liquid chromatography with fluorome...

journal_title：Therapeutic drug monitoring

authors： Wilson KM,Schneider JJ,Ravenscroft PJ

更新日期：1998-08-01 00:00:00

abstract：:Tyrosine kinase inhibitors are the standard of care for the treatment of chronic myeloid leukemia or Philadelphia chromosome-positive acute lymphoblastic leukemia. Dasatinib is a second-generation tyrosine kinase inhibitor that has been shown to be efficacious in treatment of patients with chronic myeloid leukemia or ...

journal_title：Therapeutic drug monitoring

authors： Shayani S

更新日期：2010-12-01 00:00:00

abstract：BACKGROUND:Paclitaxel (PTX; Taxol, Abraxane) is used in many regimens for breast cancer, non-small cell lung cancer (NSCLC), and ovarian cancer. Multiple studies have demonstrated that PTX exhibits a greater than 10-fold interpatient variability of clearance rates when patients are dosed according to body surface area ...

journal_title：Therapeutic drug monitoring

authors： Cline DJ,Zhang H,Lundell GD,Harney RL,Riaz HK,Jarrah J,Li Y,Miyazaki M,Courtney JB,Baburina I,Salamone SJ

更新日期：2013-12-01 00:00:00

abstract：PURPOSE:To investigate the predictive value of the risperidone and venlafaxine metabolic ratios and CYP2D6 genotype. METHODS:The determination of risperidone, 9-hydroxyrisperidone, and venlafaxine, O-desmethylvenlafaxine, N-desmethylvenlafaxine and CYP2D6 genotype was performed in 425 and 491 patients, respectively. T...

journal_title：Therapeutic drug monitoring

authors： Mannheimer B,Haslemo T,Lindh JD,Eliasson E,Molden E

更新日期：2016-02-01 00:00:00