Improved solid-phase extraction technique for plasma flecainide analysis by high-performance liquid chromatography.

abstract：OBJECTIVE:This naturalistic therapeutic drug monitoring (TDM) study aimed to evaluate the relationship between dosage, serum concentration, and clinical outcome in children and adolescents treated with the serotonin reuptake inhibitor sertraline for different indications. METHODS:Steady-state trough serum concentratio...

journal_title：Therapeutic drug monitoring

authors： Taurines R,Burger R,Wewetzer C,Pfuhlmann B,Mehler-Wex C,Gerlach M,Egberts K

更新日期：2013-02-01 00:00:00

abstract：:Plasma clonazepam (CZP) and its metabolite [7-aminoclonazepam (7ACZP) and 7-acetamidoclonazepam (7AACZP)] concentrations were measured during a single dosing interval in 10 pediatric epilepsy patients (2-18 years, 11-102 kg) who had been receiving CZP therapeutically from 2 weeks to 4 years. These concentrations were ...

journal_title：Therapeutic drug monitoring

authors： Walson PD,Edge JH

更新日期：1996-02-01 00:00:00

abstract：:This study develops a population pharmacokinetic model for lamotrigine (LTG) in Spanish and German patients diagnosed with epilepsy. LTG steady-state plasma concentration data from therapeutic drug monitoring were collected retrospectively from 600 patients, with a total of 1699 plasma drug concentrations. The data we...

journal_title：Therapeutic drug monitoring

authors： Rivas N,Buelga DS,Elger CE,Santos-Borbujo J,Otero MJ,Domínguez-Gil A,García MJ

更新日期：2008-08-01 00:00:00

abstract：:In the last few years, significant developments have occurred on the key issues involved in oral fluid drug testing. New pharmacokinetic studies have been conducted, optimal cutoffs have been proposed, and new studies have examined the correlation between oral fluid drug concentrations and impairment. Recent studies (...

journal_title：Therapeutic drug monitoring

authors： Pil K,Verstraete A

更新日期：2008-04-01 00:00:00

abstract：:Given the high prevalence of the use of medications in daily practice and the large number of people taking antirheumatic agents, the risk of drug-drug interactions and of hepatotoxicity is of concern. Both old and new compounds show such a risk. Nonsteroidal antinflammatory drugs are widely used drugs with potential ...

journal_title：Therapeutic drug monitoring

authors： Anelli MG,Scioscia C,Grattagliano I,Lapadula G

更新日期：2012-12-01 00:00:00

abstract：:Ergotamine has been used for therapeutic purposes since the 1950s, usually to treat vascular headache. It is highly toxic and in large, repeated doses can produce all the symptoms of ergot poisoning. A selective and sensitive method, based on liquid chromatography-tandem mass spectrometry (LC-MS2), has been developed ...

journal_title：Therapeutic drug monitoring

authors： Favretto D,Frison G,Vogliardi S,Ferrara SD

更新日期：2007-06-01 00:00:00

abstract：BACKGROUND/OBJECTIVES:Drug of abuse consumption throughout pregnancy is a serious public health problem and an important economic cost to the health system. The aim of this work was to compare maternal interview and hair analysis to determine drug consumption throughout pregnancy and to study relations among maternal i...

journal_title：Therapeutic drug monitoring

authors： Lendoiro E,González-Colmenero E,Concheiro-Guisán A,de Castro A,Cruz A,López-Rivadulla M,Concheiro M

更新日期：2013-06-01 00:00:00

abstract：:A simple and sensitive column-switching high-performance liquid chromatographic method for the simultaneous determination of itraconazole (ITZ) and its active metabolite, hydroxyitraconazole (HIT) in human plasma is described. ITZ, HIT, and an internal standard, R051012, were extracted from 1 mL of alkalinized plasma ...

journal_title：Therapeutic drug monitoring

authors： Uno T,Shimizu M,Sugawara K,Tateishi T

更新日期：2006-08-01 00:00:00

abstract：BACKGROUND:Valproic acid (VPA) is frequently used together with clozapine (CLZ) as mood-stabilizer or for the prevention of seizures in patients with psychotic disorders. VPA is known to reduce levels of the pharmacologically active CLZ-metabolite N-desmethylclozapine (N-DMC), but factors determining the degree of this...

journal_title：Therapeutic drug monitoring

authors： Smith RL,Kyllesø L,Haslemo T,Andreassen OA,Molden E

更新日期：2019-08-01 00:00:00

abstract：:Ultrafiltration techniques for the separation of bound and free ligand are dependent on minimal amounts of protein-bound drug leakage through the membrane devices. A dye-impregnated test strip protein assay (Chemstrip-9) provides a rapid, visual assessment of membrane protein leakage. The test strips are sensitive to ...

journal_title：Therapeutic drug monitoring

authors： Turley CP,Milligan T

更新日期：1985-01-01 00:00:00

abstract：:Amprenavir is an HIV-1 protease inhibitor with high protein binding (90%) in human plasma. This study was designed to develop an assay to measure the concentration of unbound amprenavir, to study variation with time in patients, and to investigate whether ritonavir and lopinavir, other protease inhibitors that could b...

journal_title：Therapeutic drug monitoring

authors： Barrail A,Le Tiec C,Paci-Bonaventure S,Furlan V,Vincent I,Taburet AM

更新日期：2006-02-01 00:00:00

abstract：:The clinical use of digoxin and phenytoin analyses (in 405 and 152 patients, respectively) furnished by our clinical pharmacological laboratory during a five-month period was evaluated prospectively from request forms. Of first-time analyses of digoxin, 12, 38, and 50% fell above, within, and below our recommended ran...

journal_title：Therapeutic drug monitoring

authors： Bergman U,Rane A,Sjöqvist F,Wiholm BE

更新日期：1981-01-01 00:00:00

abstract：:For many drugs, therapeutic drug monitoring (TDM) has become widely available and accepted as an important component of clinical decision-making in the intensive care nursery setting. This review analyzes the potential factors that can either expand or restrict neonatal TDM. A case is made for the development of pharm...

journal_title：Therapeutic drug monitoring

authors： Giacoia GP

更新日期：1990-07-01 00:00:00

abstract：:The efficacy of low-dose, ritonavir-boosted saquinavir (SQV/rtv) once daily plus 2 nucleoside retrotranscriptase inhibitors (NRTIs) in pregnant human immunodeficiency virus (HIV)-1-infected women was prospectively evaluated, ensuring a SQV minimum concentration (Cmin) >/=100 ng/mL with a therapeutic drug monitoring st...

journal_title：Therapeutic drug monitoring

authors： Lopez-Cortes LF,Ruiz-Valderas R,Rivero A,Camacho A,Marquez-Solero M,Santos J,García-Lazaro M,Viciana P,Rodriguez-Baños J,Ocampo A

更新日期：2007-04-01 00:00:00

abstract：:In 12 institutionalized epilepsy patients who had been treated 19 months (SD +/- 5) with valproic acid, 27.0 mg/kg (SD +/- 11.9), phenytoin, 6.33 mg/kg (SD +/- 1.36), and co-anticonvulsants, the mean percentage of daily free valproic acid was 11.72 (SD +/- 2.10) and of phenytoin 20.39 (SD +/- 3.32). By serial within-d...

journal_title：Therapeutic drug monitoring

authors： Haidukewych D,Rodin EA

更新日期：1981-01-01 00:00:00

abstract：:A simple and rapid liquid chromatography tandem mass spectrometry (HPLC-MS/MS) method for the analysis of voriconazole has been developed. For comparison, serum voriconazole was measured using HPLC and bioassay. For the HPLC-MS/MS assay, samples were prepared in a deep-well block by adding 10 microL of serum to 40 mic...

journal_title：Therapeutic drug monitoring

authors： Keevil BG,Newman S,Lockhart S,Howard SJ,Moore CB,Denning DW

更新日期：2004-12-01 00:00:00

abstract：:Characterization of antibiotic pharmacokinetics in patients with renal insufficiency may be complicated by interfering substances within the assay. We compared three different assays for teicoplanin in serum and dialysate of 10 hemodialysis and six continuous ambulatory peritoneal dialysis (CAPD) patients. The microbi...

journal_title：Therapeutic drug monitoring

authors： Awni WM,St Peter WL,Guay DR,Kenny MT,Matzke GR

更新日期：1991-11-01 00:00:00

abstract：:The aim of this study was to assess dose-related steady-state serum concentrations of olanzapine (OLZ) and its metabolites N-desmethyl OLZ (DMO) and 2-hydroxymethyl OLZ (2-OH-OLZ) (assessed by high-performance liquid chromatography) in 122 child and adolescent psychiatric patients (age 16.9 +/- 2.2, range, 10-21 years...

journal_title：Therapeutic drug monitoring

authors： Theisen FM,Haberhausen M,Schulz E,Fleischhaker C,Clement HW,Heinzel-Gutenbrunner M,Remschmidt H

更新日期：2006-12-01 00:00:00

abstract：:Several lipophilic, cytotoxic drugs, or both, (including anticancer drugs [Vinca alkaloids, doxorubicin, cyclosporin A, and digoxin]) have proven to be actively effluxed by P-glycoprotein (P-gp) expressed at the luminal membrane of the brain capillary endothelial cells, resulting in the very low apparent blood-brain b...

journal_title：Therapeutic drug monitoring

authors： Tsuji A

更新日期：1998-10-01 00:00:00

abstract：BACKGROUND:Infliximab is a chimeric monoclonal antibody that binds to human tumor necrosis factor alpha and which is approved for refractory spondyloarthritis (SpA). Individual adjustment of infliximab dosage may help to improve the therapeutic response in SpA. We investigated whether a knowledge of infliximab serum co...

journal_title：Therapeutic drug monitoring

authors： Méric JC,Mulleman D,Ducourau E,Lauféron F,Miow Lin DC,Watier H,Goupille P,Paintaud G

更新日期：2011-08-01 00:00:00

abstract：:Drugs metabolized by cytochrome CYP3A isoenzymes have wide interindividual variability and normally distributed plasma clearance distributions. This makes precise dosing difficult to achieve clinically, which may compromise safe therapy. We hypothesized that with potent inhibition of CYP3A, we could clinically render ...

journal_title：Therapeutic drug monitoring

authors： Tham LS,Lee HS,Wang L,Yong WP,Fan L,Ong AB,Sukri N,Soo R,Lee SC,Goh BC

更新日期：2006-04-01 00:00:00

abstract：:Theophylline clearance was estimated by a single-sample technique in 19 subjects with acute clinical respiratory infections. Mean (+/- SD) theophylline clearance during acute illness was 0.044 +/- 0.011 L X h-1 X kg-1 compared to 0.043 +/- 0.012 L X h-1 X kg-1 1 month later. In a subset of five subjects, single-sample...

journal_title：Therapeutic drug monitoring

authors： Bachmann K,Schwartz J,Martin M,Jauregui L

更新日期：1987-09-01 00:00:00

abstract：:The aims of this study were to determine the relationship between saliva and plasma methadone concentrations and the influence of variability in saliva pH. Saliva and plasma samples were taken before the daily dose of methadone in 60 patients undergoing methadone maintenance treatment (MMT). Saliva pH was measured imm...

journal_title：Therapeutic drug monitoring

authors： Shiran MR,Hassanzadeh-Khayyat M,Iqbal MZ,Lagundoye O,Seivewright N,Lennard MS,Tucker GT,Rostami-Hodjegan A

更新日期：2005-10-01 00:00:00

abstract：:A radioimmunoassay (RIA) procedure for the determination of sulforidazine in human plasma was developed using an antiserum raised in rabbits immunized with N-(2-carboxyethyl)desmethylsulforidazine-porcine thyroglobulin conjugate. The RIA procedure can measure as low as 40 pg of sulforidazine in a 200-microliter human ...

journal_title：Therapeutic drug monitoring

authors： Chakraborty BS,Hawes EM,Midha KK

更新日期：1988-01-01 00:00:00

abstract：BACKGROUND:Lacosamide (LCM) is one of the newer antiepileptic drugs (AEDs) licensed as add-on treatment for partial epilepsy. Data on LCM pharmacokinetics and interactions are limited and partly contradictory. The purpose of this study was to assess the effect of concomitant AED therapy on steady state plasma concentra...

journal_title：Therapeutic drug monitoring

authors： Contin M,Albani F,Riva R,Candela C,Mohamed S,Baruzzi A

更新日期：2013-12-01 00:00:00

abstract：:After observing the phenomenon clinically, seven post-hemodialysis patients were studied for a rebound effect of gentamicin levels. Serum gentamicin levels were obtained immediately after dialysis and 1 hr postdialysis. An average 25.7% rebound occurred in the serum levels. A slow redistribution of gentamicin out of t...

journal_title：Therapeutic drug monitoring

authors： Bauer LA

更新日期：1982-01-01 00:00:00

abstract：:One tablet containing 755 mg of lithium tryptophanate (10.8 mEq of lithium) was administered to eight healthy volunteers. The main pharmacokinetic parameters for the group of subjects were estimated. Pharmacokinetic parameters (mean +/- SD) from plasma and saliva were respectively: half life (t1/2) 17 +/- 6 vs. 21.8 +...

journal_title：Therapeutic drug monitoring

authors： Obach R,Borja J,Pruñonosa J,Vallès JM,Torrent J,Izquierdo I,Jané F

更新日期：1988-01-01 00:00:00

abstract：BACKGROUND:In children with cystic fibrosis (CF), the currently recommended amikacin dose ranges between 30-35 mg/kg/day; however, data supporting this dosing efficacy is lacking. Herein, the objectives were to develop a non-parametric pharmacokinetic population model (POPPK) for amikacin in children with CF and invest...

journal_title：Therapeutic drug monitoring

authors： Woillard JB,Bouchet S,Fayon M,Marquet P,Monchaud C,Bui S

更新日期：2020-12-17 00:00:00

abstract：:Cefsulodin is a third-generation cephalosporin with a unique specificity for Pseudomonas aeruginosa. To study the pharmacokinetics of this agent in children, a rapid and sensitive high-performance liquid chromatographic micromethod was developed for plasma and urine. Protein was precipitated from plasma with one volum...

journal_title：Therapeutic drug monitoring

authors： Ackers IM,Myers CM,Blumer JL

更新日期：1984-01-01 00:00:00

abstract：INTRODUCTION:Proton pump inhibitors (PPIs) are often prescribed posttransplantation to prevent gastrointestinal complications. A series of recent studies have reported a relationship between PPI comedication and decreased mycophenolic acid (MPA) exposure. The objective of this subanalysis of the CLEAR data set was to d...

journal_title：Therapeutic drug monitoring

authors： Kiberd BA,Wrobel M,Dandavino R,Keown P,Gourishankar S

更新日期：2011-02-01 00:00:00