Abstract:
:The current standard of monitoring transplant patients by drug levels is not optimal because it does not take into account the different and individual effects of immunosuppressive drugs on each patient. In this study, the authors tested immune function assays for monitoring transplant patients. Blood was collected from stable renal transplant patients treated with cyclosporin, mycophenolate mofetil, and prednisone (n = 8), and from healthy volunteers (n = 12). Lymphocyte proliferation, expression of T-cell surface activation antigens (CD25, CD71, CD11a, CD95, CD154), production of intracellular cytokines (IL-2, INFgamma, TNFalpha), and lymphocyte subsets (CD4, CD8, CD16, CD20) were assessed by flow cytometry. Lymphocyte proliferation, expression of T-cell surface activation antigens, and production of intracellular cytokines were significantly decreased in transplant recipients compared with healthy control volunteers. The combined effects of several immunosuppressive drugs in renal transplant recipients can be quantitated with immune function assays in whole blood. This new method may be helpful to achieve an optimal level of immunosuppression for each patient.
journal_name
Ther Drug Monitjournal_title
Therapeutic drug monitoringauthors
Stalder M,Bîrsan T,Holm B,Haririfar M,Scandling J,Morris REdoi
10.1097/00007691-200302000-00003subject
Has Abstractpub_date
2003-02-01 00:00:00pages
22-7issue
1eissn
0163-4356issn
1536-3694journal_volume
25pub_type
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journal_title:Therapeutic drug monitoring
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