Experience with cost-effective in-house reagents for the assay of carbamazepine in serum, using the Abbott TDx.

abstract：:Caffeine is a potentially useful alternative to theophylline for the treatment and prevention of apnea of prematurity because of its lower toxicity and longer terminal half-life. Monitoring of salivary caffeine concentrations is less invasive than blood sampling, especially in very sick premature neonates. Caffeine ci...

journal_title：Therapeutic drug monitoring

authors： Lee TC,Charles BG,Steer PA,Flenady VJ

更新日期：1996-06-01 00:00:00

abstract：:Trough levels (TL) of cyclosporine (CS) measured in serum by the polyclonal radioimmunoassay (SR) are useful for dissecting the etiology of clinical events, but they are a poor guide to dosage adjustments. In renal transplant patients immunosuppressed by low doses of prednisone and CS given orally, once-a-day TL (24-h...

journal_title：Therapeutic drug monitoring

authors： Grevel J,Welsh MS,Kahan BD

更新日期：1989-01-01 00:00:00

abstract：:Bayesian estimation (BE) of pharmacokinetic parameters enables the clinician to adjust the dosage of high-dose methotrexate (HDMTX) to correct the inter- and intraindividual variation of concentrations that are responsible for severe toxicity. In this study of 672 HDMTX infusions, we validated an approach that consist...

journal_title：Therapeutic drug monitoring

authors： Pignon T,Lacarelle B,Duffaud F,Guillet P,Catalin J,Durand A,Favre R

更新日期：1995-10-01 00:00:00

abstract：:Three automated immunoassays for digoxin in serum were evaluated--Abbott TDxII, Baxter Stratus, and Behring OPUS. The accuracy and precision of the assays were assessed by weighed-in controls and an external quality control program. Coefficients of variation of all methods in serum were < or = 10% at weighed-in concen...

journal_title：Therapeutic drug monitoring

authors： Dodds HM,Norris RL,Johnson AG,Pond SM

更新日期：1995-02-01 00:00:00

abstract：:An analytical technique using liquid chromatography (LC) coupled with electrospray-mass spectrometry (ESI--MS) has been developed for the simultaneous determination of five protease inhibitors (PIs): saquinavir, indinavir, ritonavir, nelfinavir, and amprenavir; and three non-nucleoside reverse transcriptase inhibitors...

journal_title：Therapeutic drug monitoring

authors： Villani P,Feroggio M,Gianelli L,Bartoli A,Montagna M,Maserati R,Regazzi MB

更新日期：2001-08-01 00:00:00

abstract：:The aim of this study was to assess dose-related steady-state serum concentrations of olanzapine (OLZ) and its metabolites N-desmethyl OLZ (DMO) and 2-hydroxymethyl OLZ (2-OH-OLZ) (assessed by high-performance liquid chromatography) in 122 child and adolescent psychiatric patients (age 16.9 +/- 2.2, range, 10-21 years...

journal_title：Therapeutic drug monitoring

authors： Theisen FM,Haberhausen M,Schulz E,Fleischhaker C,Clement HW,Heinzel-Gutenbrunner M,Remschmidt H

更新日期：2006-12-01 00:00:00

abstract：:The emergence of point-of-care assays enabling bedside testing such as the VerifyNow P2Y12 system might prove useful in clinical settings. The aim of this study was to evaluate the ability of the VerifyNow P2Y12 assay to estimate the inhibition of platelet aggregation provided by clopidogrel in the absence of baseline...

journal_title：Therapeutic drug monitoring

authors： Lordkipanidzé M,Pharand C,Nguyen TA,Schampaert E,Diodati JG

更新日期：2008-06-01 00:00:00

abstract：:The stability of two new immunosuppressants, tacrolimus and cyclosporin G (CsG), was evaluated in whole blood following incubation of patient specimens at ambient temperature or 4 degrees C for time periods of 2 (48 h) and 7 days (168 h) after collection. No decrease in CsG concentrations was noted over a 7-day period...

journal_title：Therapeutic drug monitoring

authors： Annesley TM,Hunter BC,Fidler DR,Giacherio DA

更新日期：1995-08-01 00:00:00

abstract：:5alpha-Reductase inhibitors such as finasteride are prohibited in sports according to the World Anti-Doping Agency. This class of drugs is used therapeutically to treat benign prostatic hyperplasia, as well as male baldness, by decreasing 5alpha-reductase activity. Accordingly, metabolic pathways of endogenous as well...

journal_title：Therapeutic drug monitoring

authors： Thevis M,Geyer H,Mareck U,Flenker U,Schänzer W

更新日期：2007-04-01 00:00:00

abstract：BACKGROUND:Non-vitamin K antagonist oral anticoagulants (NOACs) are approved for several indications for prophylaxis of thromboembolism at fixed oral doses. The analysis of NOAC activity/concentration may be required in special patient populations. Heptest coagulation assay determines both factor Xa and thrombin inhibi...

journal_title：Therapeutic drug monitoring

authors： Du S,Harenberg J,Krämer S,Krämer R,Wehling M,Weiss C

更新日期：2015-06-01 00:00:00

abstract：:A simple high-performance liquid chromatography (HPLC) method for the determination of methotrexate (MTX) in biological fluids is described. The assay is rapid, the time required for analysis is less than 30 min, and it is sensitive, up to 0.01 microgram/ml, which is three times below the toxic MTX concentration. Fift...

journal_title：Therapeutic drug monitoring

authors： Najjar TA,Matar KM,Alfawaz IM

更新日期：1992-04-01 00:00:00

abstract：BACKGROUND:Tacrolimus is a narrow therapeutic index medication, which requires therapeutic drug monitoring to optimize dosing based on systemic exposure. MITRA microsampling offers a convenient, minimally invasive approach for the collection of capillary blood samples from a fingerprick versus conventional venous blood...

journal_title：Therapeutic drug monitoring

authors： Undre N,Dawson I,Aluvihare V,Kamar N,Saliba F,Torpey N,Anaokar S,Kazeem G,Hussain I

更新日期：2020-12-03 00:00:00

abstract：:Mycophenolic acid, the active metabolite of the immunosuppressant and antiproliferative agent, mycophenolate mofetil, is primarily metabolized by glucuronidation to the inactive 7-O-glucuronide. Although the uridine diphosphate (UDP) 7-O-glucuronide is the principal excretion product of this drug, carboxyl-linked gluc...

journal_title：Therapeutic drug monitoring

authors： Mackenzie PI

更新日期：2000-02-01 00:00:00

abstract：:The purpose of this study was to construct a population pharmacokinetic (PK) metabolism (MB) model to describe ciprofloxacin (C) concentrations in plasma and vitreous and aqueous humors in 26 patients. Ciprofloxacin was given as a 3-day oral prophylactic treatment to 26 patients before vitrectomy. Plasma, vitreous, an...

journal_title：Therapeutic drug monitoring

authors： Di Marco MP,Chen J,Wainer IW,Ducharme MP

更新日期：2004-08-01 00:00:00

abstract：:Fifteen patients were studied during short-term (5 days at 10-15 mg/m2/day) or long-term (5-104 days at 3 mg/m2/day) doxorubicin infusion. Levels of doxorubicin and metabolites in serum and 24-h timed urine collections were determined by high-performance liquid chromatography. Quantifiable anthracycline levels were id...

journal_title：Therapeutic drug monitoring

authors： Sweatman TW,Lokich JJ,Israel M

更新日期：1989-01-01 00:00:00

abstract：BACKGROUND:The indication for the antiepileptic drug lacosamide (LCM) was recently extended to include children from the age of 4 years. Real-life data on the use and serum concentrations of LCM in children and adolescents are limited. The purpose of this study was to investigate the use of LCM in this patient group in...

journal_title：Therapeutic drug monitoring

authors： Larsen Burns M,Nikanorova M,Baftiu A,Borg Rasmussen J,Johannessen SI,Johannessen Landmark C

更新日期：2019-06-01 00:00:00

abstract：:Urinary excretion of lipocalin-type prostaglandin D synthase (L-PGDS) has been suggested to be a useful biomarker of early diabetic nephropathy. We studied whether L-PGDS is also a marker of gentamicin (GM)-induced renal damage in the "creatinine-blind" range. A prospective study was conducted in 6 patients who were g...

journal_title：Therapeutic drug monitoring

authors： Nakayama H,Echizen H,Gomi T,Shibuya Y,Nakamura Y,Nakano K,Arashi H,Itai T,Ohnishi S,Tanaka M,Orii T

更新日期：2009-02-01 00:00:00

abstract：BACKGROUND:Chronic opioid use and polypharmacy are commonly seen in chronic pain patients presenting for spine procedures. Substance abuse and misuse have also been reported in this patient population. Negative perioperative effects have been found in patients exposed to chronic opioid, alcohol, and recreational substa...

journal_title：Therapeutic drug monitoring

authors： Clavijo CF,Oliva AM,Dingmann C,Kaizer A,Christians U,Burger E,Patel V,Kleck CJ,Vogel SA,Scott BK,Janik DJ,Jameson LC,Ginde AA

更新日期：2021-02-01 00:00:00

abstract：BACKGROUND:The pharmacokinetics of long-acting intramuscular paliperidone in a naturalistic setting is not well documented. The objective of this study was to investigate the relationship between dose and serum concentrations of paliperidone using data from a routine therapeutic drug monitoring service. METHODS:Serum ...

journal_title：Therapeutic drug monitoring

authors： Helland A,Spigset O

更新日期：2017-12-01 00:00:00

abstract：:This study explored the association of 14 single nucleotide polymorphisms in three genes coding for influx transporters (SLC22A1, SLCO1B1, and SLCO1B3), two genes coding for efflux transporters (ABCB1 and ABCG2), and four genes coding for enzymes (CYP2C9, CYP2C19, CYP2D6, and CYP3A5) with the pharmacokinetics of imati...

journal_title：Therapeutic drug monitoring

authors： Yamakawa Y,Hamada A,Nakashima R,Yuki M,Hirayama C,Kawaguchi T,Saito H

更新日期：2011-04-01 00:00:00

abstract：BACKGROUND:The Clinical Pharmacology Quality Assurance (CPQA) program provides semiannual proficiency testing (PT) of antiretroviral analytes for 11 US and international clinical pharmacology laboratories (CPLs) to ensure interlaboratory comparability. In this article, we provide estimates of the main sources of variab...

journal_title：Therapeutic drug monitoring

authors： Browne RW,Rosenkranz SL,Wang Y,Taylor CR,DiFrancesco R,Morse GD

更新日期：2019-08-01 00:00:00

abstract：BACKGROUND:Beta-lactams are first-line antibiotics for the management of superficial infections due to burn injury. There is sparse data available on therapeutic drug monitoring (TDM) in patients with burns in a ward setting. This study was conducted to evaluate the utility of a beta-lactam TDM program in a cohort of b...

journal_title：Therapeutic drug monitoring

authors： Patel BM,Paratz J,See NC,Muller MJ,Rudd M,Paterson D,Briscoe SE,Ungerer J,McWhinney BC,Lipman J,Roberts JA

更新日期：2012-04-01 00:00:00

abstract：BACKGROUND:In children with cystic fibrosis (CF), the currently recommended amikacin dose ranges between 30-35 mg/kg/day; however, data supporting this dosing efficacy is lacking. Herein, the objectives were to develop a non-parametric pharmacokinetic population model (POPPK) for amikacin in children with CF and invest...

journal_title：Therapeutic drug monitoring

authors： Woillard JB,Bouchet S,Fayon M,Marquet P,Monchaud C,Bui S

更新日期：2020-12-17 00:00:00

abstract：BACKGROUND:SB2, an infliximab (IFX) biosimilar to the reference infliximab (R.I.) product (Remicade), received approval in the European Union for all IFX indications. Many decision algorithms based on the measurement of IFX trough levels and antibodies to infliximab are being increasingly used to optimize IFX treatment...

journal_title：Therapeutic drug monitoring

authors： Jentzer A,Berger AE,Labetoulle R,Haccourt A,Roblin X,Paul S

更新日期：2018-12-01 00:00:00

abstract：:A rapid and simple procedure based on gas chromatography-mass spectrometry (GC-MS) is described for determination of Delta-tetrahydrocannabinol (THC), 11-hydroxy-Delta-tetrahydrocannabinol (THC-OH) and 11-nor-Delta-tetrahydrocannabinol-9-carboxylic acid (THC-COOH) in meconium using Delta-tetrahydrocannabinol (Delta-TH...

journal_title：Therapeutic drug monitoring

authors： Marchei E,Pellegrini M,Pacifici R,Palmi I,Lozano J,García-Algar O,Pichini S

更新日期：2006-10-01 00:00:00

abstract：:In a prospective study over 6 months, the relationship between serum lipid parameters and CsA whole blood trough concentrations was investigated in 39 renal transplant recipients receiving a triple immunosuppressive therapy with cyclosporin (CsA), azathioprine and prednisone. CsA trough concentrations were measured wi...

journal_title：Therapeutic drug monitoring

authors： von Ahsen N,Helmhold M,Schütz E,Eisenhauer T,Armstrong VW,Oellerich M

更新日期：1997-04-01 00:00:00

abstract：BACKGROUND:No information on the pharmacokinetic characteristics of amlodipine (AML) metabolites is available. This study aimed to develop a method based on isocratic liquid chromatography coupled to tandem mass spectrometry for the simultaneous determination of AML and its 2 major metabolites, dehydroamlodipine (DH-AM...

journal_title：Therapeutic drug monitoring

authors： Taguchi R,Naito T,Sato H,Kawakami J

更新日期：2017-12-01 00:00:00

abstract：:This study develops a population pharmacokinetic model for lamotrigine (LTG) in Spanish and German patients diagnosed with epilepsy. LTG steady-state plasma concentration data from therapeutic drug monitoring were collected retrospectively from 600 patients, with a total of 1699 plasma drug concentrations. The data we...

journal_title：Therapeutic drug monitoring

authors： Rivas N,Buelga DS,Elger CE,Santos-Borbujo J,Otero MJ,Domínguez-Gil A,García MJ

更新日期：2008-08-01 00:00:00

abstract：:Ultrafiltration techniques for the separation of bound and free ligand are dependent on minimal amounts of protein-bound drug leakage through the membrane devices. A dye-impregnated test strip protein assay (Chemstrip-9) provides a rapid, visual assessment of membrane protein leakage. The test strips are sensitive to ...

journal_title：Therapeutic drug monitoring

authors： Turley CP,Milligan T

更新日期：1985-01-01 00:00:00

abstract：:The effect of plasma exchange on the concentrations of total and unbound phenytoin (DPH) was determined in one normal subject and four patients undergoing therapeutic plasma exchange (PE). The average percentage of plasma exchanged ranged from 57 to 70% among the five patients studied. The reduction in DPH concentrati...

journal_title：Therapeutic drug monitoring

authors： Silberstein LE,Shaw LM

更新日期：1986-01-01 00:00:00