Association of genetic polymorphisms in the influx transporter SLCO1B3 and the efflux transporter ABCB1 with imatinib pharmacokinetics in patients with chronic myeloid leukemia.

abstract：:In the last few years, significant developments have occurred on the key issues involved in oral fluid drug testing. New pharmacokinetic studies have been conducted, optimal cutoffs have been proposed, and new studies have examined the correlation between oral fluid drug concentrations and impairment. Recent studies (...

journal_title：Therapeutic drug monitoring

authors： Pil K,Verstraete A

更新日期：2008-04-01 00:00:00

abstract：:The authors report the use of high-performance liquid chromatography-electrospray-tandem mass spectrometry (HPLC-ESI-MS/MS) for the quantification of indomethacin (IND) in plasma with microscale sample preparation. Plasma samples (100 microL) and mefanamic acid (internal standard [IS]), buffered to pH 3.5, were prepar...

journal_title：Therapeutic drug monitoring

authors： Taylor PJ,Jones CE,Dodds HM,Hogan NS,Johnson AG

更新日期：1998-12-01 00:00:00

abstract：:The immunosuppressive potential of mycophenolic acid (MPA) correlates well with MPA exposure [area under the concentration-time curve (AUC)]. Monitoring MPA AUC is important and helpful for maintaining the efficacy of mycophenolate mofetil while minimizing its side effects, but full MPA AUC monitoring is laborious, co...

journal_title：Therapeutic drug monitoring

authors： Zicheng Y,Xianghui W,Peijun Z,Da X,Weixia Z,Hongzhuan C

更新日期：2007-10-01 00:00:00

abstract：:An index of desipramine (DMI) hydroxylation, calculated as the ratio between the amounts of DMI and 2-hydroxydesipramine (2-OH-DMI) excreted in urine after 25 mg orally, was determined in 16 depressed patients. The index varied almost 100-fold between the patients and correlated significantly to the steady-state plasm...

journal_title：Therapeutic drug monitoring

authors： Spina E,Arena A,Pisani F

更新日期：1987-06-01 00:00:00

abstract：:Whole blood steady-state trough concentrations of cyclosporine were measured by radioimmunoassay (RIA) and TDx assays employing monoclonal antibodies in 82 samples from 39 renal transplant patients. Intra- and interassay coefficients of variation for the new TDx technique averaged 3.2 and 5.4%, respectively. In the co...

journal_title：Therapeutic drug monitoring

authors： Klotz U

更新日期：1991-09-01 00:00:00

abstract：BACKGROUND:Desmopressin (D-amino D-arginine vasopressin: dDAVP) is used for the treatment of patients with hemophilia A and Von Willebrand disease. Studies on the rationale of dosing are scarce and mainly focus on the underlying causes of the vast differences in desmopressin response among individuals. The aim of this ...

journal_title：Therapeutic drug monitoring

authors： de Jager NCB,Heijdra JM,Pistorius M,Kruip MJHA,Leebeek FWG,Cnossen MH,Mathôt RAA

更新日期：2020-12-01 00:00:00

abstract：:To investigate the pharmacokinetics of naloxone in healthy volunteers, we undertook an open-label crossover study in which six male volunteers received naloxone on five occasions: intravenous (0.8 mg), intramuscular (0.8 mg), intranasal (0.8 mg), intravenous (2 mg), and intranasal (2 mg). Samples were collected for 4 ...

journal_title：Therapeutic drug monitoring

authors： Dowling J,Isbister GK,Kirkpatrick CM,Naidoo D,Graudins A

更新日期：2008-08-01 00:00:00

abstract：BACKGROUND:Chronic opioid use and polypharmacy are commonly seen in chronic pain patients presenting for spine procedures. Substance abuse and misuse have also been reported in this patient population. Negative perioperative effects have been found in patients exposed to chronic opioid, alcohol, and recreational substa...

journal_title：Therapeutic drug monitoring

authors： Clavijo CF,Oliva AM,Dingmann C,Kaizer A,Christians U,Burger E,Patel V,Kleck CJ,Vogel SA,Scott BK,Janik DJ,Jameson LC,Ginde AA

更新日期：2021-02-01 00:00:00

abstract：:Euthyroid women experience dramatic changes in their thyroid physiology in order to accommodate the presence of placental and fetal tissues. These adaptations to the pregnant state make it crucial to develop reliable trimester-specific intervals for thyroid parameters. Use of non-pregnant reference intervals could lea...

journal_title：Therapeutic drug monitoring

authors： Bach-Huynh TG,Jonklaas J

更新日期：2006-06-01 00:00:00

abstract：:The emerging nation of South Africa, in common with some other countries, notably Eastern Europe, is heir to decades of neglect with regards to the exposure of the majority of its population to toxic materials. In this short review, the major toxic health hazards are described. For most of these risks there are now pr...

journal_title：Therapeutic drug monitoring

authors： Stewart MJ

更新日期：2002-02-01 00:00:00

abstract：:Immunization of New Zealand white rabbits with a bovine serum albumin conjugate of 7-hydroxy-N-carboxyethyl-N-deshydroxyethylfluphenazine produced highly specific antisera for 7-hydroxyfluphenazine (7-OHFLU). A radioimmunoassay (RIA) was developed using antisera from one of the rabbits that enabled for the first time ...

journal_title：Therapeutic drug monitoring

authors： Aravagiri M,Marder SR,Van Putten T,Hawes EM,McKay G,Midha KK

更新日期：1994-02-01 00:00:00

abstract：:Two published case reports showed that addition of risperidone (1 and 2 mg/d) to a clozapine treatment resulted in a strong increase of clozapine plasma levels. As clozapine is metabolized by cytochrome P450 isozymes, a study was initiated to assess the in vivo interaction potential of risperidone on various cytochrom...

journal_title：Therapeutic drug monitoring

authors： Eap CB,Bondolfi G,Zullino D,Bryois C,Fuciec M,Savary L,Jonzier-Perey M,Baumann P

更新日期：2001-06-01 00:00:00

abstract：:A study was conducted to determine whether assay-specific quantitative differences exist in the determination of vancomycin serum concentrations obtained from patients with renal dysfunction. Vancomycin serum concentrations were obtained during the first week of therapy for each of three time intervals: 48-96 h, 96-14...

journal_title：Therapeutic drug monitoring

authors： Peckman HJ,Dupuis RE,Sawyer WT,Brouwer KL,Cross RE

更新日期：1996-12-01 00:00:00

abstract：:The treatment of rheumatoid arthritis (RA) has largely improved in the biopharmaceutical era. These compounds, primarily tumor necrosis factor (TNF) inhibitors, are effective, but some patients may show poor response, sometimes because of the presence of antidrug antibodies (ADAs). In some instances, clinicians may in...

journal_title：Therapeutic drug monitoring

authors： Medina F,Plasencia C,Goupille P,Ternant D,Balsa A,Mulleman D

更新日期：2017-08-01 00:00:00

abstract：:Australia is blessed with a great diversity of unique species in its fresh waters and in the marine environment around its coast. There is evidence that human and natural events are impacting on these species. Such impacts are associated with various agricultural, industrial, and domestic practices and with natural an...

journal_title：Therapeutic drug monitoring

authors： Moore MR,Shaw G

更新日期：2000-02-01 00:00:00

abstract：:The binding characteristics of the antiepileptic agent and teratogen valproic acid for human serum and human placenta were investigated utilizing equilibrium dialysis of the drugs in serum and in homogenates of whole placenta so that the transplacental transfer of the drug could be better defined. A low-capacity, high...

journal_title：Therapeutic drug monitoring

authors： Bailey DN,Briggs JR

更新日期：2005-06-01 00:00:00

abstract：:It has been suggested that lamotrigine (LTG) may enhance the toxicity of carbamazepine (CBZ) by increasing the concentration of the active metabolite carbamazepine-10,11-epoxide (CBZ-E) in adult patients. The authors investigated this hypothesis in an add-on study in 11 children and 3 adolescents, aged 6-22 years, who...

journal_title：Therapeutic drug monitoring

authors： Eriksson AS,Boreus LO

更新日期：1997-10-01 00:00:00

abstract：:Mycophenolic acid, the active metabolite of the immunosuppressant and antiproliferative agent, mycophenolate mofetil, is primarily metabolized by glucuronidation to the inactive 7-O-glucuronide. Although the uridine diphosphate (UDP) 7-O-glucuronide is the principal excretion product of this drug, carboxyl-linked gluc...

journal_title：Therapeutic drug monitoring

authors： Mackenzie PI

更新日期：2000-02-01 00:00:00

abstract：BACKGROUND:In humans, donepezil (D) is metabolized to 5-O-desmethyl-donepezil (5DD), 6-O-desmethyl-donepezil (6DD), and donepezil-N-oxide (DNox). Although 6DD and DNox are pharmacologically active, the activity of 5DD is unknown. At present, no routine methods are available to detect D and its 3 metabolites simultaneou...

journal_title：Therapeutic drug monitoring

authors： Groppa F,Coin A,De Rosa G,Granziera S,Alexopoulos C,Pamio MV,Padrini R

更新日期：2016-02-01 00:00:00

abstract：:Characterization of antibiotic pharmacokinetics in patients with renal insufficiency may be complicated by interfering substances within the assay. We compared three different assays for teicoplanin in serum and dialysate of 10 hemodialysis and six continuous ambulatory peritoneal dialysis (CAPD) patients. The microbi...

journal_title：Therapeutic drug monitoring

authors： Awni WM,St Peter WL,Guay DR,Kenny MT,Matzke GR

更新日期：1991-11-01 00:00:00

abstract：:A novel liquid chromatography-mass spectrometry (LC-MS) method was developed and validated for quantification of topiramate (TPM) and its metabolites 10-hydroxy topiramate (10-OH-TPM), 9-hydroxy topiramate (9-OH-TPM), and 4,5-O-desisopropylidene topiramate (4,5-diol-TPM) in plasma and urine. The method uses 0.5 mL of ...

journal_title：Therapeutic drug monitoring

authors： Britzi M,Soback S,Isoherranen N,Levy RH,Perucca E,Doose DR,Maryanoff BE,Bialer M

更新日期：2003-06-01 00:00:00

abstract：:Mycophenolate mofetil (MMF) is the first drug approved for the prevention of renal allograft rejection in the United States in the last 10 years. MMF is the morpholinoethyl ester of mycophenolic acid (MPA) and is a selective, reversible inhibitor of inosine monophosphate dehydrogenase (IMPDH), an enzyme that is critic...

journal_title：Therapeutic drug monitoring

authors： Pirsch JD,Sollinger HW

更新日期：1996-08-01 00:00:00

abstract：:For the evaluation and interpretation of pharmacokinetic data reliable quantitative determinations are a requirement that can only be met by well-characterized and fully validated analytical methods. To cope with these requirements a method is being established that is based on an integrated and automated fiber-optic ...

journal_title：Therapeutic drug monitoring

authors： Gygax D,Botta L,Ehrat M,Graf P,Lefèvre G,Oroszlan P,Pfister C

更新日期：1996-08-01 00:00:00

abstract：BACKGROUND:Therapeutic drug monitoring (TDM) involves the measurement of serum drug concentrations to optimize pharmacotherapy. Traditionally, blood pressure measurements alone, and not TDM, have been used to evaluate the antihypertensive drug response. However, approximately 50% of hypertensive patients treated with l...

journal_title：Therapeutic drug monitoring

authors： Rognstad S,Søraas CL,Bergland OU,Høieggen A,Strømmen M,Helland A,Opdal MS

更新日期：2021-02-01 00:00:00

abstract：:Based on the principle that vancomycin therapy requires sustained therapeutic concentrations while avoiding high peaks, some authors reported that optimal vancomycin levels could be ensured by measuring trough levels alone (Cmin). The aim of this work was to assess the performance of a one-compartment Bayesian forecas...

journal_title：Therapeutic drug monitoring

authors： Andrés I,López R,Pou L,Piñol F,Pascual C

更新日期：1997-12-01 00:00:00

abstract：:The performance of the ROCHE FP NAPA reagent, a newly reformulated monoclonal antibody-based fluorescence polarization immunoassay (FPIA) for N-acetylprocainamide, was compared with two commercially available polyclonal antibody-based immunoassays, the Abbott TDx and Syva EMIT. Although excellent correlation was obser...

journal_title：Therapeutic drug monitoring

authors： Laurino JP,McKay J,Fischberg E,Schwenzer K,Kaufman R

更新日期：1994-06-01 00:00:00

abstract：:Caffeine is a potentially useful alternative to theophylline for the treatment and prevention of apnea of prematurity because of its lower toxicity and longer terminal half-life. Monitoring of salivary caffeine concentrations is less invasive than blood sampling, especially in very sick premature neonates. Caffeine ci...

journal_title：Therapeutic drug monitoring

authors： Lee TC,Charles BG,Steer PA,Flenady VJ

更新日期：1996-06-01 00:00:00

abstract：:The authors aimed to evaluate the utility of the history and clinical signs for predicting ingestion of poisons in children. A prospective cohort study was performed of all patients presenting with suspected poisoning to a pediatric emergency department over a 13-month period. Clinical data were collected on a preform...

journal_title：Therapeutic drug monitoring

authors： Hwang CF,Foot CL,Eddie G,Johnson L,Reith DM

更新日期：2003-12-01 00:00:00

abstract：:A minority of athletes continues to use prohibited drugs in sports to enhance performance. Athletes discovered using these drugs can be subject to severe penalties, often resulting in media and public scrutiny, especially at major events such as the Olympic Games. The International Olympic Committee (IOC) has set out ...

journal_title：Therapeutic drug monitoring

authors： Kazlauskas R,Trout G

更新日期：2000-02-01 00:00:00

abstract：BACKGROUND:The indication for the antiepileptic drug lacosamide (LCM) was recently extended to include children from the age of 4 years. Real-life data on the use and serum concentrations of LCM in children and adolescents are limited. The purpose of this study was to investigate the use of LCM in this patient group in...

journal_title：Therapeutic drug monitoring

authors： Larsen Burns M,Nikanorova M,Baftiu A,Borg Rasmussen J,Johannessen SI,Johannessen Landmark C

更新日期：2019-06-01 00:00:00