Establishing Serum Reference Ranges for Antihypertensive Drugs.

abstract：:The immunosuppressant mycophenolic acid (MPA) used for solid organ transplantation is predominantly metabolized to a pharmacologically inactive phenolic glucuronide (MPAG) and, to a lesser extent, to the pharmacologically active acyl glucuronide (AcMPAG). The recently introduced CEDIA Mycophenolic Acid Assay from Micr...

journal_title：Therapeutic drug monitoring

authors： Shipkova M,Schütz E,Besenthal I,Fraunberger P,Wieland E

更新日期：2010-02-01 00:00:00

abstract：:The purpose of the present study was to examine the effects of rifampicin on the single oral dose pharmacokinetics and pharmacodynamics of brotizolam. Thirteen healthy male volunteers received rifampicin 450 mg/day, or matched placebo, for 7 days in a double-blind randomized crossover manner. On the sixth day they rec...

journal_title：Therapeutic drug monitoring

authors： Ujiie Y,Fukasawa T,Yasui-Furukori N,Suzuki A,Tateishi T,Otani K

更新日期：2006-06-01 00:00:00

abstract：:This study was undertaken to model the relationship between clonazepam plasma concentrations and a central nervous system adverse effect (impairment of the psychomotor performance) following the oral administration of immediate-release tablets of clonazepam in healthy volunteers. Such a (P)pharmacokinetic/(P)pharmacod...

journal_title：Therapeutic drug monitoring

authors： dos Santos FM,Gonçalves JC,Caminha R,da Silveira GE,Neves CS,Gram KR,Ferreira CT,Jacqmin P,Noël F

更新日期：2009-10-01 00:00:00

abstract：:Therapeutic drug monitoring in antituberculosis chemotherapy may play a strategic role in improving outcomes in selected patients. The most important use is in assisting clinicians to optimize therapy to achieve success and minimize toxicity. The other principal indication lies in the management of interaction of anti...

journal_title：Therapeutic drug monitoring

authors： Yew WW

更新日期：1998-10-01 00:00:00

abstract：:An analysis of pH-induced changes of drug binding may contribute to the understanding of the mechanisms involved and the clinical relevance. A literature search was performed, and acceptance criteria set up, to select reported data for quantitative evaluation. The relationship between percentage of unbound drug, fu, a...

journal_title：Therapeutic drug monitoring

authors： Hinderling PH,Hartmann D

更新日期：2005-02-01 00:00:00

abstract：:The aim of this study was to investigate the use of psychotropic medication and therapeutic drug monitoring in a high-security psychiatric unit and to compare the doses and serum concentrations both with the recommended intervals and with the doses and serum concentrations in a control group. One hundred thirty-two pa...

journal_title：Therapeutic drug monitoring

authors： Castberg I,Spigset O

更新日期：2008-10-01 00:00:00

abstract：:The placental and milk transfer of chloroquine was studied in seven subjects and six subjects, respectively. Seven pregnant women at term were administered chloroquine phosphate (5 mg/kg) i.m. The maternal blood and arterial and venous umbilical cord blood were obtained during delivery. The maternal chloroquine blood ...

journal_title：Therapeutic drug monitoring

authors： Akintonwa A,Gbajumo SA,Mabadeje AF

更新日期：1988-01-01 00:00:00

abstract：:We report a clinically relevant suspected interaction between acyclovir and the antiepileptic drugs phenytoin (PHT) and valproic acid (VPA). In a child receiving PHT and VPA therapy, a 6-day acyclovir treatment reduced PHT and VPA plasma concentrations to subtherapeutic values. This probably worsened both clinical sta...

journal_title：Therapeutic drug monitoring

authors： Parmeggiani A,Riva R,Posar A,Rossi PG

更新日期：1995-06-01 00:00:00

abstract：:We evaluated the efficacy, development of adverse effects, and possible correlation between the plasma concentration of carbamazepine (CBZ) and its major metabolite, carbamazepine-10,11-epoxide (CBZ-E), in a group of epileptic patients in whom selective increases in CBZ doses were made. Eighteen patients with refracto...

journal_title：Therapeutic drug monitoring

authors： Semah F,Gimenez F,Longer E,Laplane D,Thuillier A,Baulac M

更新日期：1994-12-01 00:00:00

abstract：:Simplified pharmacokinetic methods have been used to estimate caffeine clearance in subjects with liver disease. There is a need to have a reliable, easy to implement method for research and possible clinical use. This study evaluates the use of Bayesian pharmacokinetic forecasting techniques to estimate caffeine clea...

journal_title：Therapeutic drug monitoring

authors： Denaro CP,Jacob P 3rd,Benowitz NL

更新日期：1998-02-01 00:00:00

abstract：:The ability of a pharmacokinetic/pharmacodynamic Bayesian forecasting computer program to predict prothrombin response to warfarin therapy was investigated. The performance of the program was evaluated retrospectively in an inpatient study population of 45 subjects. Predictions of prothrombin response at discharge, ba...

journal_title：Therapeutic drug monitoring

authors： Svec JM,Coleman RW,Mungall DR,Ludden TM

更新日期：1985-01-01 00:00:00

abstract：BACKGROUND:The aim of this study was to conduct a population pharmacokinetic (PK) analysis of meropenem and to explore the optimal dosing strategy for meropenem in critically ill patients with acute kidney injury receiving treatment with continuous hemodiafiltration (CHDF). METHODS:Blood samples were obtained on days ...

journal_title：Therapeutic drug monitoring

authors： Niibe Y,Suzuki T,Yamazaki S,Suzuki T,Takahashi N,Hattori N,Nakada TA,Oda S,Ishii I

更新日期：2020-08-01 00:00:00

abstract：:Theophylline clearance was estimated by a single-sample technique in 19 subjects with acute clinical respiratory infections. Mean (+/- SD) theophylline clearance during acute illness was 0.044 +/- 0.011 L X h-1 X kg-1 compared to 0.043 +/- 0.012 L X h-1 X kg-1 1 month later. In a subset of five subjects, single-sample...

journal_title：Therapeutic drug monitoring

authors： Bachmann K,Schwartz J,Martin M,Jauregui L

更新日期：1987-09-01 00:00:00

abstract：:The postulated therapeutic activity of nortriptyline metabolites has prompted investigation of dosage adjustments based on plasma levels of nortriptyline (NT) and its metabolites. The method assumes that metabolite concentrations vary independently of nortriptyline concentrations among patients. This study tests that ...

journal_title：Therapeutic drug monitoring

authors： Lukey BJ,Jones DR,Wright JH,Hurst HE

更新日期：1989-01-01 00:00:00

abstract：BACKGROUND:Dried blood spot (DBS) sampling is a blood collection tool that uses a finger prick to obtain a blood drop on a DBS card. It can be used for therapeutic drug monitoring, a method that uses blood drug concentrations to optimize individual treatment. DBS sampling is believed to be a simpler way of blood collec...

journal_title：Therapeutic drug monitoring

authors： Zuur MA,Veenhof H,Aleksa A,Vanʼt Boveneind-Vrubleuskaya N,Darmawan E,Hasnain MG,Heysell SK,Jongedijk EM,Koster RA,Magis-Escurra C,Martinez N,Molinas G,Mondal D,Mulyani UA,Perwitasari DA,Tsivunchyk A,Touw DJ,Alffenaar JC

更新日期：2019-12-01 00:00:00

abstract：:With the introduction of a cyclosporin monitoring strategy based on the use of a sample collected 2 hours after dosing (C2) rather than the predose sample (C0), there was concern that the differences in blood cyclosporin results from the various assay systems would result in assay-specific target ranges for C2 monitor...

journal_title：Therapeutic drug monitoring

authors： Johnston A,Chusney G,Schütz E,Oellerich M,Lee TD,Holt DW

更新日期：2003-04-01 00:00:00

abstract：:The clinical correlates of methylphenidate blood levels in hyper-active children and normal adults were examined in five studies. Although occasional correlations between blood levels and neuroendocrine response were noted within subjects along the pharmacokinetic time profile of the drug, no significant associations ...

journal_title：Therapeutic drug monitoring

authors： Gualtieri CT,Hicks RE,Patrick K,Schroeder SR,Breese GR

更新日期：1984-01-01 00:00:00

abstract：:Phenytoin is an effective anticonvulsant, but high serum phenytoin concentrations may be associated with serious toxicity. The upper limit for the therapeutic serum concentration of phenytoin is considered to be 80 micromol/L. However, in some situations higher serum concentrations are needed to control seizures. The ...

journal_title：Therapeutic drug monitoring

authors： Kozer E,Parvez S,Minassian BA,Kobayashi J,Verjee Z,Koren G

更新日期：2002-06-01 00:00:00

abstract：:The relationship between changes in cyclosporin (CyA) dose or CyA blood concentration and the reciprocal creatinine concentration was investigated by cross-correlation analysis over the first 3 postoperative months in 32 consecutive heart and heart-lung recipients. Exploratory analysis suggested that early changes in ...

journal_title：Therapeutic drug monitoring

authors： Trull AK,Best NG,Tan KK,Hue KL,Higenbottam TW,Large S,Wallwork J

更新日期：1992-08-01 00:00:00

abstract：:To study the effect of pharmacologic agents on the biologic fate of adenosine, a reversed-phase high-performance liquid chromatography (HPLC) assay coupled with a solid-phase extraction (SPE) method was developed for simultaneous determination of plasma adenosine, hypoxanthine, xanthine, inosine, guanosine, and uric a...

journal_title：Therapeutic drug monitoring

authors： Feng JD,Yeung PK

更新日期：2000-04-01 00:00:00

abstract：:Monoclonal antibodies (mAbs) may be used as biopharmaceuticals to treat various diseases, ranging from oncology to inflammatory and cardiovascular affections. Trustworthy analytical methods are necessary to study their pharmacokinetics, both during their development and in post-marketing studies. Because biopharmaceut...

journal_title：Therapeutic drug monitoring

authors： Darrouzain F,Bian S,Desvignes C,Bris C,Watier H,Paintaud G,de Vries A

更新日期：2017-08-01 00:00:00

abstract：:The TDx digoxin II immunoassay was used in controls and in patients not taking digoxin or any other cardiac glycoside. We report the frequency of interference thought to be caused by digoxin-like factors (DLFs). We found a high incidence of false-positive results in 15 patients with severe hepatic disease (60% false-p...

journal_title：Therapeutic drug monitoring

authors： Avendaño C,Alvarez JS,Sacristan JA,Adin J,Alsar MJ

更新日期：1991-11-01 00:00:00

abstract：:This study examined whether salivary nicotine concentrations would provide a useful index of plasma concentrations in studies of the effects of transdermal nicotine administration. Twenty-four subject smokers abstained from smoking for 12 h prior to admission to a clinical research unit ward and for 36 h while remaini...

journal_title：Therapeutic drug monitoring

authors： Rose JE,Levin ED,Benowitz N

更新日期：1993-10-01 00:00:00

abstract：:It has been suggested that lamotrigine (LTG) may enhance the toxicity of carbamazepine (CBZ) by increasing the concentration of the active metabolite carbamazepine-10,11-epoxide (CBZ-E) in adult patients. The authors investigated this hypothesis in an add-on study in 11 children and 3 adolescents, aged 6-22 years, who...

journal_title：Therapeutic drug monitoring

authors： Eriksson AS,Boreus LO

更新日期：1997-10-01 00:00:00

abstract：:Monitoring plasma concentrations of therapeutic drugs presents special problems when these drugs are metabolized to compounds that have pharmacologic activity. This presentation reviews several methods for evaluating the pharmacologic activity of drug metabolites and describes the impact of active drug metabolites on ...

journal_title：Therapeutic drug monitoring

authors： Atkinson AJ Jr,Stec GP,Lertora JJ,Ruo TI,Thenot JP

更新日期：1980-01-01 00:00:00

abstract：:Palivizumab is a humanized, monoclonal antibody used to protect at-risk infants against respiratory syncytial virus (RSV) infection. The regular dosage scheme causes a low initial trough level and accumulation of the antibody after subsequent injections. Using a simple pharmacokinetic model, the authors devised an alt...

journal_title：Therapeutic drug monitoring

authors： Zaaijer HL,Vandenbroucke-Grauls CM,Franssen EJ

更新日期：2002-06-01 00:00:00

abstract：:Levels of the anticonvulsant drugs phenobarbitone, phenytoin, carbamazepine, and primidone were measured in the plasma and saliva of 202 epileptic children (5 months-18 years old). Gas-liquid chromatography (GLC) and EMIT immunoassay were used to analyse the samples. Saliva to plasma ratios were as follows (means +/- ...

journal_title：Therapeutic drug monitoring

authors： Goldsmith RF,Ouvrier RA

更新日期：1981-01-01 00:00:00

abstract：:Accessing patient's veins for drug level sampling is not always feasible. The use of capillary sampling techniques is often utilized when venous access is hampered. In the therapeutic monitoring of patients, unexpected drug level results often occur that can be caused by a number of different factors. The possibility ...

journal_title：Therapeutic drug monitoring

authors： Murphy JE,Peltier T,Anderson D,Ward ES

更新日期：1990-05-01 00:00:00

abstract：:The efficacy of low-dose, ritonavir-boosted saquinavir (SQV/rtv) once daily plus 2 nucleoside retrotranscriptase inhibitors (NRTIs) in pregnant human immunodeficiency virus (HIV)-1-infected women was prospectively evaluated, ensuring a SQV minimum concentration (Cmin) >/=100 ng/mL with a therapeutic drug monitoring st...

journal_title：Therapeutic drug monitoring

authors： Lopez-Cortes LF,Ruiz-Valderas R,Rivero A,Camacho A,Marquez-Solero M,Santos J,García-Lazaro M,Viciana P,Rodriguez-Baños J,Ocampo A

更新日期：2007-04-01 00:00:00

abstract：BACKGROUND:Hydroxychloroquine (HCQ) is an effective treatment for patients with cutaneous lupus erythematosus (CLE) or systemic lupus erythematosus (SLE) and has been used for these patients in more than 70 nations. However, in Japan, HCQ has not been approved for CLE or SLE. To establish an appropriate therapeutic reg...

journal_title：Therapeutic drug monitoring

authors： Morita S,Takahashi T,Yoshida Y,Yokota N

更新日期：2016-04-01 00:00:00