Aquatic toxicology.

abstract：:In a prospective study over 6 months, the relationship between serum lipid parameters and CsA whole blood trough concentrations was investigated in 39 renal transplant recipients receiving a triple immunosuppressive therapy with cyclosporin (CsA), azathioprine and prednisone. CsA trough concentrations were measured wi...

journal_title：Therapeutic drug monitoring

authors： von Ahsen N,Helmhold M,Schütz E,Eisenhauer T,Armstrong VW,Oellerich M

更新日期：1997-04-01 00:00:00

abstract：:Exposure to mycophenolic acid (MPA) is highly variable among patients on standard dose mycophenolate mofetil (MMF) therapy. In addition, MPA exposure increases with time posttransplant and exposure is predictive for the development of acute rejection. Consequently, therapeutic drug monitoring (TDM) of MPA may improve ...

journal_title：Therapeutic drug monitoring

authors： van Hest RM,Mathot RA,Vulto AG,Ijzermans JN,van Gelder T

更新日期：2006-02-01 00:00:00

abstract：:Immunization of New Zealand white rabbits with a bovine serum albumin conjugate of 7-hydroxy-N-carboxyethyl-N-deshydroxyethylfluphenazine produced highly specific antisera for 7-hydroxyfluphenazine (7-OHFLU). A radioimmunoassay (RIA) was developed using antisera from one of the rabbits that enabled for the first time ...

journal_title：Therapeutic drug monitoring

authors： Aravagiri M,Marder SR,Van Putten T,Hawes EM,McKay G,Midha KK

更新日期：1994-02-01 00:00:00

abstract：:The authors have developed a simple isocratic high-pressure liquid chromatographic (HPLC) assay for the simultaneous determination of lamotrigine and other frequently coadministered antiepileptic drugs in serum samples. Lamotrigine extraction was performed on a reversed-phase Oasis HBL preparation column. The eluates ...

journal_title：Therapeutic drug monitoring

authors： Torra M,Rodamilans M,Arroyo S,Corbella J

更新日期：2000-10-01 00:00:00

abstract：:The high incidence of psychiatric illness in the postpartum period and the increasing percentage of women who breastfeed has focused attention on the treatment of breastfeeding women with psychotropic medications and, additionally, the exposure of nursing infants to these medications. Consequently, there has been an i...

journal_title：Therapeutic drug monitoring

authors： Hostetter AL,Stowe ZN,Cox M,Ritchie JC

更新日期：2004-02-01 00:00:00

abstract：:PROTEASE INHIBITOR TDM: This study examines the importance of therapeutic drug monitoring (TDM) of protease inhibitors (PI) in adults and children infected with the human immunodeficiency virus (HIV). Pediatric patients were included because information in this population is limited. A high performance liquid chromato...

journal_title：Therapeutic drug monitoring

authors： Walson PD,Cox S,Utkin I,Gerber N,Crim L,Brady M,Koranyi K

更新日期：2003-12-01 00:00:00

abstract：PURPOSE:To investigate the predictive value of the risperidone and venlafaxine metabolic ratios and CYP2D6 genotype. METHODS:The determination of risperidone, 9-hydroxyrisperidone, and venlafaxine, O-desmethylvenlafaxine, N-desmethylvenlafaxine and CYP2D6 genotype was performed in 425 and 491 patients, respectively. T...

journal_title：Therapeutic drug monitoring

authors： Mannheimer B,Haslemo T,Lindh JD,Eliasson E,Molden E

更新日期：2016-02-01 00:00:00

abstract：BACKGROUND:There is a high coincidence between obesity and psychiatric disorders including depression. Depressive disorders are commonly treated with antidepressants, including the selective serotonin reuptake inhibitor Lexapro (escitalopram). Although candidates for elective Roux-en-Y gastric bypass (RYGB) surgery may...

journal_title：Therapeutic drug monitoring

authors： Marzinke MA,Petrides AK,Steele K,Schweitzer MA,Magnuson TH,Reinblatt SP,Coughlin JW,Clarke W

更新日期：2015-06-01 00:00:00

abstract：:In 12 institutionalized epilepsy patients who had been treated 19 months (SD +/- 5) with valproic acid, 27.0 mg/kg (SD +/- 11.9), phenytoin, 6.33 mg/kg (SD +/- 1.36), and co-anticonvulsants, the mean percentage of daily free valproic acid was 11.72 (SD +/- 2.10) and of phenytoin 20.39 (SD +/- 3.32). By serial within-d...

journal_title：Therapeutic drug monitoring

authors： Haidukewych D,Rodin EA

更新日期：1981-01-01 00:00:00

abstract：:A high-performance liquid chromatography (HPLC) method was developed for the simultaneous analysis of trimethoprim (TMP), sulphamethoxazole (SMX), and acetylsulphamethoxazole (AcSMX) in small amounts of blood. The method involved precipitation with 50 microL trichloracetic acid (1M) to 125 microL plasma or serum sampl...

journal_title：Therapeutic drug monitoring

authors： Rønn AM,Mutabingwa TK,Kreisby S,Angelo HR,Fuursted K,Bygbjerg IC

更新日期：1999-12-01 00:00:00

abstract：BACKGROUND:Serum trough concentrations as the sole means of monitoring safety and efficacy of vancomycin are insufficient. The daily area under the curve (AUC24) of serum concentration versus time to minimum inhibitory concentration (MIC) ratio of greater than 400 mg × h/L has emerged as a more robust dosing target. A ...

journal_title：Therapeutic drug monitoring

authors： Lewis P

更新日期：2018-06-01 00:00:00

abstract：:Determination of serum concentrations of certain drugs is becoming increasingly important for optimal patient care. These drugs include many antibiotics, several antiarrhythmics, cardiac glycosides, lithium, phenytoin, some other anticonvulsants, salicylates, and theophylline. Serum level determinations can also be us...

journal_title：Therapeutic drug monitoring

authors： Koch-Weser J

更新日期：1981-01-01 00:00:00

abstract：BACKGROUND:SB2, an infliximab (IFX) biosimilar to the reference infliximab (R.I.) product (Remicade), received approval in the European Union for all IFX indications. Many decision algorithms based on the measurement of IFX trough levels and antibodies to infliximab are being increasingly used to optimize IFX treatment...

journal_title：Therapeutic drug monitoring

authors： Jentzer A,Berger AE,Labetoulle R,Haccourt A,Roblin X,Paul S

更新日期：2018-12-01 00:00:00

abstract：:Assessment of renal function and relating this parameter to amino-glycoside clearance is important for an appropriate individualization of dosage regimens in patients with impaired renal function. However, it has been suggested that in cystic fibrosis (CF), creatinine clearance (CrCl) is not a good predictor of tobram...

journal_title：Therapeutic drug monitoring

authors： Town DJ,Vinks AA,Jacobs F,Heijerman HG,Bakker W

更新日期：1996-10-01 00:00:00

abstract：:Iron overload resulting from transfusion dependency in some patients with chronic anaemia can be prevented by chelation. Deferasirox is an oral alternative to the well studied but inconvenient deferroxamine therapy. The pharmacokinetic parameters of this new drug suggest potential interindividual variability and patie...

journal_title：Therapeutic drug monitoring

authors： Chauzit E,Bouchet S,Micheau M,Mahon FX,Moore N,Titier K,Molimard M

更新日期：2010-08-01 00:00:00

abstract：BACKGROUND:Human immunodeficiency virus (HIV)-infected individuals show large interindividual variation in response to antiretroviral therapy. Efavirenz (EFV) and nevirapine (NVP) are nonnucleoside reverse transcriptase inhibitors, which are prescribed in combination with other antiretroviral therapy in so-called highl...

journal_title：Therapeutic drug monitoring

authors： Heil SG,van der Ende ME,Schenk PW,van der Heiden I,Lindemans J,Burger D,van Schaik RH

更新日期：2012-04-01 00:00:00

abstract：:Plasma clonazepam (CZP) and its metabolite [7-aminoclonazepam (7ACZP) and 7-acetamidoclonazepam (7AACZP)] concentrations were measured during a single dosing interval in 10 pediatric epilepsy patients (2-18 years, 11-102 kg) who had been receiving CZP therapeutically from 2 weeks to 4 years. These concentrations were ...

journal_title：Therapeutic drug monitoring

authors： Walson PD,Edge JH

更新日期：1996-02-01 00:00:00

abstract：:Amprenavir is an HIV-1 protease inhibitor with high protein binding (90%) in human plasma. This study was designed to develop an assay to measure the concentration of unbound amprenavir, to study variation with time in patients, and to investigate whether ritonavir and lopinavir, other protease inhibitors that could b...

journal_title：Therapeutic drug monitoring

authors： Barrail A,Le Tiec C,Paci-Bonaventure S,Furlan V,Vincent I,Taburet AM

更新日期：2006-02-01 00:00:00

abstract：:Plasma levels of 6-mercaptopurine were determined in 22 consecutive children with acute lymphoblastic leukemia on oral remission maintenance therapy during the time period of August 1984 to January 1988. Each child received the drug once daily for up to 3 years and was studied repeatedly (1-12 times). An HPLC method w...

journal_title：Therapeutic drug monitoring

authors： Hayder S,Lafolie P,Björk O,Peterson C

更新日期：1989-11-01 00:00:00

abstract：:The clinical correlates of methylphenidate blood levels in hyper-active children and normal adults were examined in five studies. Although occasional correlations between blood levels and neuroendocrine response were noted within subjects along the pharmacokinetic time profile of the drug, no significant associations ...

journal_title：Therapeutic drug monitoring

authors： Gualtieri CT,Hicks RE,Patrick K,Schroeder SR,Breese GR

更新日期：1984-01-01 00:00:00

abstract：BACKGROUND:Previous reports have suggested that polymorphism of the opioid receptor A118G affects the efficacy of opioid analgesia. The aim of this study was to investigate whether such polymorphism contributed to variability in epidural mixture (sufentanil plus ropivacaine) requirements through patient-controlled epid...

journal_title：Therapeutic drug monitoring

authors： Xu GH,Gao M,Sheng QY,Liu XS,Gu EW

更新日期：2015-02-01 00:00:00

abstract：:The postulated therapeutic activity of nortriptyline metabolites has prompted investigation of dosage adjustments based on plasma levels of nortriptyline (NT) and its metabolites. The method assumes that metabolite concentrations vary independently of nortriptyline concentrations among patients. This study tests that ...

journal_title：Therapeutic drug monitoring

authors： Lukey BJ,Jones DR,Wright JH,Hurst HE

更新日期：1989-01-01 00:00:00

abstract：:Two separate studies were carried out to assess the effect of valproic acid on the steady-state plasma concentrations of clozapine and its major metabolites norclozapine and clozapine N-oxide in psychotic patients. In the first study, concentrations of clozapine and metabolites were compared between patients treated w...

journal_title：Therapeutic drug monitoring

authors： Facciolà G,Avenoso A,Scordo MG,Madia AG,Ventimiglia A,Perucca E,Spina E

更新日期：1999-06-01 00:00:00

abstract：:Designer drugs of the methylenedioxyphenylalkylamine type are increasingly abused. Studies on their metabolism in humans are necessary to develop a reliable gas chromatography--mass spectrometry (GC-MS) screening procedure. Such a method must allow their detection in urine for drug testing in clinical and forensic tox...

journal_title：Therapeutic drug monitoring

authors： Maurer HH

更新日期：1996-08-01 00:00:00

abstract：:Currently no pharmacogenomics-based criteria exist to guide clinicians in identifying individuals who are at risk of hearing loss from cisplatin-based chemotherapy. This review summarizes findings from pharmacogenomic studies that report genetic polymorphisms associated with cisplatin-induced hearing loss and aims to ...

journal_title：Therapeutic drug monitoring

authors： Lee JW,Pussegoda K,Rassekh SR,Monzon JG,Liu G,Hwang S,Bhavsar AP,Pritchard S,Ross CJ,Amstutz U,Carleton BC,CPNDS Clinical Recommendations Group.

更新日期：2016-08-01 00:00:00

abstract：:Therapeutic drug monitoring in antituberculosis chemotherapy may play a strategic role in improving outcomes in selected patients. The most important use is in assisting clinicians to optimize therapy to achieve success and minimize toxicity. The other principal indication lies in the management of interaction of anti...

journal_title：Therapeutic drug monitoring

authors： Yew WW

更新日期：1998-10-01 00:00:00

abstract：:The treatment of rheumatoid arthritis (RA) has largely improved in the biopharmaceutical era. These compounds, primarily tumor necrosis factor (TNF) inhibitors, are effective, but some patients may show poor response, sometimes because of the presence of antidrug antibodies (ADAs). In some instances, clinicians may in...

journal_title：Therapeutic drug monitoring

authors： Medina F,Plasencia C,Goupille P,Ternant D,Balsa A,Mulleman D

更新日期：2017-08-01 00:00:00

abstract：:Caffeine is a potentially useful alternative to theophylline for the treatment and prevention of apnea of prematurity because of its lower toxicity and longer terminal half-life. Monitoring of salivary caffeine concentrations is less invasive than blood sampling, especially in very sick premature neonates. Caffeine ci...

journal_title：Therapeutic drug monitoring

authors： Lee TC,Charles BG,Steer PA,Flenady VJ

更新日期：1996-06-01 00:00:00

abstract：:The effect of mycophenolic acid (MPA) in combination with either cyclosporine (CsA) or tacrolimus (TRL) on whole-blood lymphocyte function was assessed in vitro as well as in vivo. For the in vitro studies, rat whole blood was incubated with different concentrations of MPA together with CsA or TRL. In vivo, rats (n = ...

journal_title：Therapeutic drug monitoring

authors： Barten MJ,Shipkova M,Bartsch P,Dhein S,Streit F,Tarnok A,Armstrong VW,Mohr FW,Oellerich M,Gummert JF

更新日期：2005-04-01 00:00:00

abstract：BACKGROUND:Dried blood spot (DBS) sampling is a blood collection tool that uses a finger prick to obtain a blood drop on a DBS card. It can be used for therapeutic drug monitoring, a method that uses blood drug concentrations to optimize individual treatment. DBS sampling is believed to be a simpler way of blood collec...

journal_title：Therapeutic drug monitoring

authors： Zuur MA,Veenhof H,Aleksa A,Vanʼt Boveneind-Vrubleuskaya N,Darmawan E,Hasnain MG,Heysell SK,Jongedijk EM,Koster RA,Magis-Escurra C,Martinez N,Molinas G,Mondal D,Mulyani UA,Perwitasari DA,Tsivunchyk A,Touw DJ,Alffenaar JC

更新日期：2019-12-01 00:00:00