Therapeutic drug monitoring in antituberculosis chemotherapy.

abstract：:The selection of an appropriate therapy and dosing regimen is a significant challenge in the treatment of cancer. Although there are recommended standardized chemotherapy protocols for some types of cancer, protocol changes that usually only occur after large clinical trials demonstrate improvements and individual pat...

journal_title：Therapeutic drug monitoring

authors： Knezevic CE,Clarke W

更新日期：2020-02-01 00:00:00

abstract：:A 7.5-year-old girl who was treated with phenobarbital (PHB) for epilepsy was admitted with decreased levels of consciousness. She had been known to have high PHB levels of unknown cause, without symptoms. Her PHB levels were very high, as expected, but primidone levels were also detected although she and her parents ...

journal_title：Therapeutic drug monitoring

authors： Tanoshima R,'t Jong GW,Merlocco A,Simpson J,Friedman JN,Colantonio D,Koren G

更新日期：2013-04-01 00:00:00

abstract：:A simple and rapid liquid chromatography tandem mass spectrometry (HPLC-MS/MS) method for the analysis of voriconazole has been developed. For comparison, serum voriconazole was measured using HPLC and bioassay. For the HPLC-MS/MS assay, samples were prepared in a deep-well block by adding 10 microL of serum to 40 mic...

journal_title：Therapeutic drug monitoring

authors： Keevil BG,Newman S,Lockhart S,Howard SJ,Moore CB,Denning DW

更新日期：2004-12-01 00:00:00

abstract：:The purpose of this study was to construct a population pharmacokinetic (PK) metabolism (MB) model to describe ciprofloxacin (C) concentrations in plasma and vitreous and aqueous humors in 26 patients. Ciprofloxacin was given as a 3-day oral prophylactic treatment to 26 patients before vitrectomy. Plasma, vitreous, an...

journal_title：Therapeutic drug monitoring

authors： Di Marco MP,Chen J,Wainer IW,Ducharme MP

更新日期：2004-08-01 00:00:00

abstract：:The authors report the use of high-performance liquid chromatography-electrospray-tandem mass spectrometry (HPLC-ESI-MS/MS) for the quantification of indomethacin (IND) in plasma with microscale sample preparation. Plasma samples (100 microL) and mefanamic acid (internal standard [IS]), buffered to pH 3.5, were prepar...

journal_title：Therapeutic drug monitoring

authors： Taylor PJ,Jones CE,Dodds HM,Hogan NS,Johnson AG

更新日期：1998-12-01 00:00:00

abstract：:A high-performance liquid chromatographic method for the determination of linezolid in human plasma was developed and validated. After precipitation of plasma proteins with perchloric acid, the protein-free supernatant was separated by isocratic reverse-phase chromatography on a X Bridge C18 column. The mobile phase c...

journal_title：Therapeutic drug monitoring

authors： Cattaneo D,Baldelli S,Conti F,Cozzi V,Clementi E

更新日期：2010-08-01 00:00:00

abstract：:Australia is blessed with a great diversity of unique species in its fresh waters and in the marine environment around its coast. There is evidence that human and natural events are impacting on these species. Such impacts are associated with various agricultural, industrial, and domestic practices and with natural an...

journal_title：Therapeutic drug monitoring

authors： Moore MR,Shaw G

更新日期：2000-02-01 00:00:00

abstract：:A gas chromatography-mass spectrometry (GC-MS)-based screening procedure was developed for the detection of diuretics, uricosurics, and/or their metabolites in human urine after extractive methylation. Phase-transfer catalyst remaining in the organic phase was removed by solid-phase extraction on a diol phase. The com...

journal_title：Therapeutic drug monitoring

authors： Beyer J,Bierl A,Peters FT,Maurer HH

更新日期：2005-08-01 00:00:00

abstract：:The ring sulfoxidation of thioridazine (THD), a widely used neuroleptic agent, yields two diastereoisomeric pairs, fast- and slow-eluting (FE and SE) thioridazine 5-sulfoxide (THD 5-SO). Until now, studies in which concentrations of these metabolites were measured in THD-treated patients have revealed no significant d...

journal_title：Therapeutic drug monitoring

authors： Eap CB,Souche A,Koeb L,Baumann P

更新日期：1991-07-01 00:00:00

abstract：:An isocratic, high-performance liquid chromatography method has been developed for simultaneous determination of the tricyclic antidepressant clomipramine and six metabolites: desmethylclomipramine, 2- and 8-hydroxy-clomipramine, 2- and 8-hydroxydesmethylclomipramine and didesmethyl-clomipramine in plasma and urine. I...

journal_title：Therapeutic drug monitoring

authors： Nielsen KK,Brøsen K

更新日期：1993-04-01 00:00:00

abstract：BACKGROUND:We report a feasibility study based on our large-scale experience with mycophenolate mofetil dose adjustment based on mycophenolic acid interdose area under the curve (AUC) in renal transplant patients. METHODS:Between 2005 and 2010, 13,930 requests for 7090 different patients (outside any clinical trial) w...

journal_title：Therapeutic drug monitoring

authors： Saint-Marcoux F,Vandierdonck S,Prémaud A,Debord J,Rousseau A,Marquet P

更新日期：2011-06-01 00:00:00

abstract：:In the last few years, significant developments have occurred on the key issues involved in oral fluid drug testing. New pharmacokinetic studies have been conducted, optimal cutoffs have been proposed, and new studies have examined the correlation between oral fluid drug concentrations and impairment. Recent studies (...

journal_title：Therapeutic drug monitoring

authors： Pil K,Verstraete A

更新日期：2008-04-01 00:00:00

abstract：BACKGROUND:The objective of this study was to investigate the serum concentrations of olanzapine in relation to age, sex, and other factors in Chinese patients aged between 10 and 90 years. METHODS:Data for 884 olanzapine patients, deposited between 2016 and 2017, were retrieved from the therapeutic drug monitoring da...

journal_title：Therapeutic drug monitoring

authors： Deng SH,Wang ZZ,Lu HY,Li L,Hu JQ,Zhu XQ,Xie HS,Chen HZ,Zhang M,Ni XJ,Qiu C,Shang DW,Wen YG

更新日期：2020-08-01 00:00:00

abstract：:An index of desipramine (DMI) hydroxylation, calculated as the ratio between the amounts of DMI and 2-hydroxydesipramine (2-OH-DMI) excreted in urine after 25 mg orally, was determined in 16 depressed patients. The index varied almost 100-fold between the patients and correlated significantly to the steady-state plasm...

journal_title：Therapeutic drug monitoring

authors： Spina E,Arena A,Pisani F

更新日期：1987-06-01 00:00:00

abstract：:The high incidence of psychiatric illness in the postpartum period and the increasing percentage of women who breastfeed has focused attention on the treatment of breastfeeding women with psychotropic medications and, additionally, the exposure of nursing infants to these medications. Consequently, there has been an i...

journal_title：Therapeutic drug monitoring

authors： Hostetter AL,Stowe ZN,Cox M,Ritchie JC

更新日期：2004-02-01 00:00:00

abstract：:Phenytoin is an anticonvulsant that requires therapeutic drug monitoring. Recently, Bayer HealthCare, Diagnostics Division released a turbidimetric immunoassay of phenytoin on the ADVIA 1650 analyzer. We evaluated the analytic performance of this assay by comparing values obtained in 52 patients receiving Phenytoin us...

journal_title：Therapeutic drug monitoring

authors： Datta P,Scurlock D,Dasgupta A

更新日期：2005-06-01 00:00:00

abstract：BACKGROUND:Oral fluid (OF) is being developed as a specimen for the determination of drug intake as an alternative to serum and plasma. It is generally considered as an attractive specimen due to the noninvasive nature of the sampling procedure and the relation to the free fraction of drug in the blood. These features ...

journal_title：Therapeutic drug monitoring

authors： Neumann J,Beck O,Dahmen N,Böttcher M

更新日期：2018-04-01 00:00:00

abstract：:Mycophenolate mofetil (MMF) is the first drug approved for the prevention of renal allograft rejection in the United States in the last 10 years. MMF is the morpholinoethyl ester of mycophenolic acid (MPA) and is a selective, reversible inhibitor of inosine monophosphate dehydrogenase (IMPDH), an enzyme that is critic...

journal_title：Therapeutic drug monitoring

authors： Pirsch JD,Sollinger HW

更新日期：1996-08-01 00:00:00

abstract：:Bayesian estimation (BE) of pharmacokinetic parameters enables the clinician to adjust the dosage of high-dose methotrexate (HDMTX) to correct the inter- and intraindividual variation of concentrations that are responsible for severe toxicity. In this study of 672 HDMTX infusions, we validated an approach that consist...

journal_title：Therapeutic drug monitoring

authors： Pignon T,Lacarelle B,Duffaud F,Guillet P,Catalin J,Durand A,Favre R

更新日期：1995-10-01 00:00:00

abstract：:To study the effect of pharmacologic agents on the biologic fate of adenosine, a reversed-phase high-performance liquid chromatography (HPLC) assay coupled with a solid-phase extraction (SPE) method was developed for simultaneous determination of plasma adenosine, hypoxanthine, xanthine, inosine, guanosine, and uric a...

journal_title：Therapeutic drug monitoring

authors： Feng JD,Yeung PK

更新日期：2000-04-01 00:00:00

abstract：:The effect of plasma exchange (PE) on the pharmacokinetics of flumequine (Apurone) was studied in eight patients receiving a single oral dose of 800 mg. The maximum concentration (38 micrograms/ml) and time to maximum concentration (2.6 h) values were not significantly altered by PE beginning 3 h after administration ...

journal_title：Therapeutic drug monitoring

authors： Royer-Morrot MJ,Gérard A,Zhiri A,Schooneman F,Dureux JB,Royer RJ

更新日期：1991-07-01 00:00:00

abstract：:Studies examining associations between antidepressant response and plasma levels of bupropion and its metabolites have yielded contradictory findings. There have been no such studies in youth. This study explored such associations in 8 boys and 8 girls, age 11 to 17 years, all prescribed bupropion sustained release (S...

journal_title：Therapeutic drug monitoring

authors： Daviss WB,Perel JM,Brent DA,Axelson DA,Rudolph GR,Gilchrist R,Nuss S,Birmaher B

更新日期：2006-04-01 00:00:00

abstract：:The greater and more consistent absorption of cyclosporine from the microemulsion formulation (Neoral; Novartis Pharmaceuticals Ltd., Frimley, UK) when compared with that from the original form (Sandimmune; Novartis Pharmaceuticals Ltd., Frimley, UK) results in greater systemic exposure. Lung transplant recipients cou...

journal_title：Therapeutic drug monitoring

authors： Trull A,Steel L,Sharples L,Stewart S,Parameshwar J,McNeil K,Wallwork J

更新日期：1999-02-01 00:00:00

abstract：:Mycophenolate mofetil, the oral prodrug of mycophenolic acid, is indicated as immunosuppressive therapy after renal transplantation. To aid in the investigation of pharmacokinetic-pharmacodynamic relationships of mycophenolic acid in the clinical setting, limited blood sampling strategies have been proposed, and model...

journal_title：Therapeutic drug monitoring

authors： Willis C,Taylor PJ,Salm P,Tett SE,Pillans PI

更新日期：2000-10-01 00:00:00

abstract：:The objective of this study was to conduct an assessment of patient and parental preferences and an economic analysis of hospital costs in sampling blood and saliva for therapeutic drug monitoring (TDM). Costs and preferences were evaluated in the course of a study, which compared anticonvulsant concentrations in bloo...

journal_title：Therapeutic drug monitoring

authors： Gorodischer R,Burtin P,Hwang P,Levine M,Koren G

更新日期：1994-10-01 00:00:00

abstract：:Accessing patient's veins for drug level sampling is not always feasible. The use of capillary sampling techniques is often utilized when venous access is hampered. In the therapeutic monitoring of patients, unexpected drug level results often occur that can be caused by a number of different factors. The possibility ...

journal_title：Therapeutic drug monitoring

authors： Murphy JE,Peltier T,Anderson D,Ward ES

更新日期：1990-05-01 00:00:00

abstract：:Sotrastaurin (AEB071) is an investigational immunosuppressant that blocks T-lymphocyte activation through protein kinase C inhibition. It is currently in Phase II of clinical development for the prevention of acute rejection after solid organ transplantation. In renal transplant clinical trials, sotrastaurin has been ...

journal_title：Therapeutic drug monitoring

authors： Kovarik JM,Slade A

更新日期：2010-10-01 00:00:00

abstract：:Linezolid is an antibiotic used to treat infections caused by drug-resistant gram-positive organisms, including vancomycin-resistant Enterococcus faecium, multi-drug resistant Streptococcus pneumoniae, and methicillin-resistant Staphylococcus aureus. The adverse effects of linezolid can include thrombocytopenia and ne...

journal_title：Therapeutic drug monitoring

authors： Rao GG,Konicki R,Cattaneo D,Alffenaar JW,Marriott DJE,Neely M,IATDMCT Antimicrobial Scientific Committee.

更新日期：2020-02-01 00:00:00

abstract：:This report describes a sensitive and specific method for analyzing a serotonin reuptake blocker, citalopram, and its active metabolite, desmethylcitalopram, in human serum. For high-performance liquid chromatography (HPLC) analysis, samples and standards are prepared with ASPEC automatic sample preparator using 100 m...

journal_title：Therapeutic drug monitoring

authors： Akerman KK,Jolkkonen J,Huttunen H,Penttilä I

更新日期：1998-02-01 00:00:00

abstract：:Two blood-sampling techniques, capillary and venous, were compared using the EMIT method. No difference was found in reproducibility. However, persistent positive bias of 0.628 micrograms/ml (p less than 0.01) was noted with the capillary sampling method. Any hemolysis that occurred in the capillary sampling technique...

journal_title：Therapeutic drug monitoring

authors： Frazer JF 3rd,Stasiowski P,Boyd GK

更新日期：1983-01-01 00:00:00