Cancer Chemotherapy: The Case for Therapeutic Drug Monitoring.

Abstract:

:The selection of an appropriate therapy and dosing regimen is a significant challenge in the treatment of cancer. Although there are recommended standardized chemotherapy protocols for some types of cancer, protocol changes that usually only occur after large clinical trials demonstrate improvements and individual patients often require dose modifications (amount or interval) or delays in dose administration as toxicities arise. In other areas of medicine, therapeutic drug monitoring is commonly and successfully used to ensure appropriate drug exposure and to limit dose-related toxicities. Currently, the wide pharmacokinetic variability of cytotoxic chemotherapies is addressed clinically by the use of body surface area to determine drug doses; however, this is outdated and demonstrably ineffective for this purpose. This review discusses the challenges of dosing cytotoxic chemotherapies, dose determination strategies for cytotoxic, targeted, and antibody-based biological anticancer drugs, and provides an overview of the recent literature regarding the use of therapeutic drug monitoring in cancer.

journal_name

Ther Drug Monit

authors

Knezevic CE,Clarke W

doi

10.1097/FTD.0000000000000701

subject

Has Abstract

pub_date

2020-02-01 00:00:00

pages

6-19

issue

1

eissn

0163-4356

issn

1536-3694

pii

00007691-202002000-00002

journal_volume

42

pub_type

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