A novel system for the determination of antidepressant concentrations in human breast milk.

abstract：BACKGROUND:Antiepileptic drug therapeutic regimens often need to be adjusted individually on the basis of serum assays. We aimed to develop a quantitative, fast, and sensitive liquid chromatography-tandem mass spectrometry method to simultaneously analyze carbamazepine, oxcarbazepine, and the 10-11 epoxide carbamazepin...

journal_title：Therapeutic drug monitoring

authors： Lionetto L,Casolla B,Cavallari M,Tisei P,Buttinelli C,Simmaco M

更新日期：2012-02-01 00:00:00

abstract：BACKGROUND:A fast and easy-to-use liquid chromatography-tandem mass spectrometry method for the determination and quantification of 6 triazoles [fluconazole (FLZ), isavuconazole (ISZ), itraconazole (ITZ), hydroxy-itraconazole (OH-ITZ), posaconazole (PSZ), and voriconazole (VRZ)] in human plasma and serum was developed ...

journal_title：Therapeutic drug monitoring

authors： Müller C,Gehlen D,Blaich C,Prozeller D,Liss B,Streichert T,Wiesen MHJ

更新日期：2017-10-01 00:00:00

abstract：:During the past two decades, in association with the commencement of chronic dialysis therapy and prolongation of the uremic state, aluminum toxicity has represented a major cause of morbidity and mortality in uremic patients. The uremic patient has been found to be at higher risk of aluminum loading and toxicity from...

journal_title：Therapeutic drug monitoring

authors： Alfrey AC

更新日期：1993-12-01 00:00:00

abstract：BACKGROUND:Infliximab is a chimeric monoclonal antibody that binds to human tumor necrosis factor alpha and which is approved for refractory spondyloarthritis (SpA). Individual adjustment of infliximab dosage may help to improve the therapeutic response in SpA. We investigated whether a knowledge of infliximab serum co...

journal_title：Therapeutic drug monitoring

authors： Méric JC,Mulleman D,Ducourau E,Lauféron F,Miow Lin DC,Watier H,Goupille P,Paintaud G

更新日期：2011-08-01 00:00:00

abstract：:Based on the principle that vancomycin therapy requires sustained therapeutic concentrations while avoiding high peaks, some authors reported that optimal vancomycin levels could be ensured by measuring trough levels alone (Cmin). The aim of this work was to assess the performance of a one-compartment Bayesian forecas...

journal_title：Therapeutic drug monitoring

authors： Andrés I,López R,Pou L,Piñol F,Pascual C

更新日期：1997-12-01 00:00:00

abstract：:The effect of mycophenolic acid (MPA) in combination with either cyclosporine (CsA) or tacrolimus (TRL) on whole-blood lymphocyte function was assessed in vitro as well as in vivo. For the in vitro studies, rat whole blood was incubated with different concentrations of MPA together with CsA or TRL. In vivo, rats (n = ...

journal_title：Therapeutic drug monitoring

authors： Barten MJ,Shipkova M,Bartsch P,Dhein S,Streit F,Tarnok A,Armstrong VW,Mohr FW,Oellerich M,Gummert JF

更新日期：2005-04-01 00:00:00

abstract：:To study the effect of pharmacologic agents on the biologic fate of adenosine, a reversed-phase high-performance liquid chromatography (HPLC) assay coupled with a solid-phase extraction (SPE) method was developed for simultaneous determination of plasma adenosine, hypoxanthine, xanthine, inosine, guanosine, and uric a...

journal_title：Therapeutic drug monitoring

authors： Feng JD,Yeung PK

更新日期：2000-04-01 00:00:00

abstract：:The immunosuppressant mycophenolic acid (MPA) used for solid organ transplantation is predominantly metabolized to a pharmacologically inactive phenolic glucuronide (MPAG) and, to a lesser extent, to the pharmacologically active acyl glucuronide (AcMPAG). The recently introduced CEDIA Mycophenolic Acid Assay from Micr...

journal_title：Therapeutic drug monitoring

authors： Shipkova M,Schütz E,Besenthal I,Fraunberger P,Wieland E

更新日期：2010-02-01 00:00:00

abstract：:A rapid and sensitive method for the quantitation of valproic acid in tears has been developed using gas chromatography/electron capture negative chemical ionization/mass spectrometry. Valproic acid was converted directly into its pentafluorobenzyl ester derivative without the need to perform any extraction from the b...

journal_title：Therapeutic drug monitoring

authors： Nakajima M,Yamato S,Shimada K,Sato S,Kitagawa S,Honda A,Miyamoto J,Shoda J,Ohya M,Miyazaki H

更新日期：2000-12-01 00:00:00

abstract：:A neurophysiologic test battery (consisting of a 24-hour, seven-channel electroencephalogram [EEG], EEG spectral analysis, multiple sleep latency test, visual evoked potentials, critical flicker fusion, and visual contrast sensitivity) was administered twice to 16 patients with juvenile myoclonic epilepsy (JME) in a d...

journal_title：Therapeutic drug monitoring

authors： Sundqvist A,Nilsson BY,Tomson T

更新日期：1999-02-01 00:00:00

abstract：BACKGROUND:Quality management and accreditation in the analytical laboratory setting are developing rapidly and becoming the standard worldwide. Quality management refers to all the activities used by organizations to ensure product or service consistency. Accreditation is a formal recognition by an authoritative regul...

journal_title：Therapeutic drug monitoring

authors： Fulga N

更新日期：2013-06-01 00:00:00

abstract：:Prescribed daily doses (PDDs) of antiepileptic drugs (AED) (N03A ATC group) were recorded for drugs used in monotherapy or in combination therapy in the University Hospitals in Ostrava, Czech Republic and Huddinge, Sweden. Plasma concentrations were used as an indicator of the quality of treatment. PDDs were compared ...

journal_title：Therapeutic drug monitoring

authors： Koristkova B,Sjöqvist F,Grundmann M,Bergman U

更新日期：2006-10-01 00:00:00

abstract：:A simple and rapid reversed-phase C-18 high-performance liquid chromatography (HPLC) assay without a prior extraction step for dihydroquinidine (HQD) in serum is described. The method is selective and useful for monitoring HQD and its presumed metabolites, quinidine (QD), N-oxide QD, 3-hydroxy QD (3-OHQD), and 10-11-d...

journal_title：Therapeutic drug monitoring

authors： Camsonne R,Moulin MA,Albessard F,Perault M

更新日期：1984-01-01 00:00:00

abstract：:The authors describe a case of furosemide possibly inhibiting the hypoprothrombinemic effect of warfarin. The initiation of furosemide dosing in a patient receiving a stable dose of warfarin was associated with an 28% decrease in the international normalized ration (INR). Using normal volunteers, two previous controll...

journal_title：Therapeutic drug monitoring

authors： Laizure SC,Madlock L,Cyr M,Self T

更新日期：1997-06-01 00:00:00

abstract：:Racemic methadone is increasingly used to manage cancer pain. The authors studied 13 terminally ill patients with cancer pain, who underwent switching (rotation) from morphine to methadone. The relationship between initial morphine dose and final methadone dose, the pharmacokinetics of R- and S- methadone, and the deg...

journal_title：Therapeutic drug monitoring

authors： Auret K,Roger Goucke C,Ilett KF,Page-Sharp M,Boyd F,Oh TE

更新日期：2006-06-01 00:00:00

abstract：:It is generally accepted that chemical testing of biologic fluids is the most objective means of diagnosis of drug use. The presence of a drug analyte in a biologic specimen can be used to document exposure. The standard for drug testing in toxicology is an immunoassay screen conducted on a urine sample, followed by c...

journal_title：Therapeutic drug monitoring

authors： Kintz P,Samyn N

更新日期：2002-04-01 00:00:00

abstract：:A 64-year-old man with chronic renal insufficiency was hospitalized with dysphagia and inability to keep his head erect 11 months after beginning procainamide hydrochloride (PA) for control of atrial flutter. Evaluation revealed esophageal dysmotility, worsening renal function, and elevated serum PA and N-acetylprocai...

journal_title：Therapeutic drug monitoring

authors： Miller CD,Oleshansky MA,Gibson KF,Cantilena LR

更新日期：1993-06-01 00:00:00

abstract：:Three automated immunoassays for digoxin in serum were evaluated--Abbott TDxII, Baxter Stratus, and Behring OPUS. The accuracy and precision of the assays were assessed by weighed-in controls and an external quality control program. Coefficients of variation of all methods in serum were < or = 10% at weighed-in concen...

journal_title：Therapeutic drug monitoring

authors： Dodds HM,Norris RL,Johnson AG,Pond SM

更新日期：1995-02-01 00:00:00

abstract：:This study was undertaken to model the relationship between clonazepam plasma concentrations and a central nervous system adverse effect (impairment of the psychomotor performance) following the oral administration of immediate-release tablets of clonazepam in healthy volunteers. Such a (P)pharmacokinetic/(P)pharmacod...

journal_title：Therapeutic drug monitoring

authors： dos Santos FM,Gonçalves JC,Caminha R,da Silveira GE,Neves CS,Gram KR,Ferreira CT,Jacqmin P,Noël F

更新日期：2009-10-01 00:00:00

abstract：BACKGROUND:Chronic opioid use and polypharmacy are commonly seen in chronic pain patients presenting for spine procedures. Substance abuse and misuse have also been reported in this patient population. Negative perioperative effects have been found in patients exposed to chronic opioid, alcohol, and recreational substa...

journal_title：Therapeutic drug monitoring

authors： Clavijo CF,Oliva AM,Dingmann C,Kaizer A,Christians U,Burger E,Patel V,Kleck CJ,Vogel SA,Scott BK,Janik DJ,Jameson LC,Ginde AA

更新日期：2021-02-01 00:00:00

abstract：:This report describes a sensitive and specific method for analyzing a serotonin reuptake blocker, citalopram, and its active metabolite, desmethylcitalopram, in human serum. For high-performance liquid chromatography (HPLC) analysis, samples and standards are prepared with ASPEC automatic sample preparator using 100 m...

journal_title：Therapeutic drug monitoring

authors： Akerman KK,Jolkkonen J,Huttunen H,Penttilä I

更新日期：1998-02-01 00:00:00

abstract：:Mixed-effect modeling has been suggested as a possible tool to detect and describe drug interactions in patient populations receiving drug combinations for the treatment of disease states. The mixed-effect modeling program, NONMEM, was used to measure the effects of the well-known digoxin-quinidine and digoxin-verapam...

journal_title：Therapeutic drug monitoring

authors： Bauer LA,Horn JR,Pettit H

更新日期：1996-02-01 00:00:00

abstract：:A method for analyzing flecainide in plasma was developed and assessed. Based on the use of C18 extraction columns eight or fewer times, the rapid and simple extraction procedure provided consistent, high-efficiency flecainide extraction (>85%). Using reverse-phase, high-performance liquid chromatography with fluorome...

journal_title：Therapeutic drug monitoring

authors： Wilson KM,Schneider JJ,Ravenscroft PJ

更新日期：1998-08-01 00:00:00

abstract：:Nineteen acutely disturbed psychotic Asian patients were treated with a single intramuscular injection of 50 mg of zuclopenthixol acetate in Viscoleo. Patients were assessed clinically before and after treatment using the Brief Psychiatric Rating Scale (BPRS). Serum zuclopenthixol and the inactive geometric isomer tra...

journal_title：Therapeutic drug monitoring

authors： Tan CH,Low BL,Ng LL,Khoo YM,Lee HS

更新日期：1993-04-01 00:00:00

abstract：:The aims of this study were to determine the relationship between saliva and plasma methadone concentrations and the influence of variability in saliva pH. Saliva and plasma samples were taken before the daily dose of methadone in 60 patients undergoing methadone maintenance treatment (MMT). Saliva pH was measured imm...

journal_title：Therapeutic drug monitoring

authors： Shiran MR,Hassanzadeh-Khayyat M,Iqbal MZ,Lagundoye O,Seivewright N,Lennard MS,Tucker GT,Rostami-Hodjegan A

更新日期：2005-10-01 00:00:00

abstract：:Our aim was to evaluate the isolated placental lobule to study maternofetal transplacental digoxin transfer and accumulation in placental tissue in vitro. Digoxin passage across the isolated lobule of 10 human placentas was calculated from repeated fetal and maternal perfusate samples, and placental tissue digoxin con...

journal_title：Therapeutic drug monitoring

authors： Schmolling J,Jung S,Reinsberg J,Schlebusch H

更新日期：1997-02-01 00:00:00

abstract：:We have suggested previously that acute tolerance to the chronotropic effect of cocaine develops and that tolerance is incomplete, such that the heart-rate decline in the presence of stable plasma cocaine concentrations approaches a plateau that exceeds the baseline heart rate. One possible mechanism for heart-rate de...

journal_title：Therapeutic drug monitoring

authors： Ambre JJ

更新日期：1993-12-01 00:00:00

abstract：BACKGROUND:The International Interlaboratory Quality Control PROGRAM for Therapeutic Drug Monitoring of Antiretroviral Drugs in Human Plasma/Serum was initiated in 1999. We have previously published our experience during the first 10 years of the PROGRAM. Since 2010, 3 newly developed antiretroviral agents have been ad...

journal_title：Therapeutic drug monitoring

authors： Burger D,Krens S,Robijns K,Aarnoutse R,Brüggemann R,Touw D

更新日期：2014-12-01 00:00:00

abstract：BACKGROUND:The efficacy of drugs for the treatment of substance-related disorders is moderate at best. Therapeutic drug monitoring (TDM) could be an instrument to improve outcomes. Because TDM for most of those drugs is not established, the authors reviewed the literature and built a rating scale to detect the potentia...

journal_title：Therapeutic drug monitoring

authors： Brünen S,Vincent PD,Baumann P,Hiemke C,Havemann-Reinecke U

更新日期：2011-10-01 00:00:00

abstract：:Hyperlipidemia interferes with spectrophotometric assays of a number of analytes. No interference was found in the assay of gentamicin, phenytoin, or phenobarbital due to turbidity in levels of triglyceride less than or equal to 2,000 mg/dl with the Abbott TDx or Syva enzyme multiplied immunoassay (EMIT) methods. Ther...

journal_title：Therapeutic drug monitoring

authors： Baer DM,Paulson RA

更新日期：1987-01-01 00:00:00